Author Hashimoto, Yuuri| Tazawa, Hiroshi| Teraishi, Fuminori| Kojima, Toru| Watanabe, Yuichi| Uno, Futoshi| Yano, Shuya| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Published Date 2012-06-15
Publication Title PLoS ONE
Volume volume7
Issue issue6
Content Type Journal Article
JaLCDOI 10.18926/AMO/47265
FullText URL 65_6_395.pdf
Author Harada, Sosuke| Sato, Shuhei| Suzuki, Etsuji| Okumura, Yoshihiro| Hiraki, Takao| Gobara, Hideo| Mimura, Hidefumi| Kanazawa, Susumu| Kaji, Mitsumasa| Fujiwara, Toshiyoshi|
Abstract The aim of the present study was to assess the diagnostic usefulness of Fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in the prediction of local recurrence of malignant lung tumors by analyzing the pre-radiofrequency ablation (RFA) maximal standardized uptake value (SUVmax). We performed a historical cohort study of consecutive malignant lung tumors treated by RFA from January 2007 to May 2008 at Okayama University Hospital. We selected only lung tumors examined by PET/CT within 90 days before RFA and divided them (10 primary and 29 metastatic) into 3 groups according to their tertiles of SUVmax. We calculated recurrence odds ratios in the medium group and the high group compared to the low group using multivariate logistic analysis. After we examined the relationship between SUVmax and recurrence in a crude model, we adjusted for some factors. Tumors with higher SUVmax showed higher recurrence odds ratios (medium group;1.84, high group;4.14, respectively). The tumor size also increased the recurrence odds ratio (2.67);we thought this was mainly due to selection bias because we excluded tumors less than 10mm in diameter. This study demonstrated the pre-RFA SUVmax in PET/CT may be a prognostic factor for local recurrence of malignant lung tumors.
Keywords fluorodeoxyglucose (FDG) positron emission tomography (PET) standardized uptake value (SUV) radiofrequency ablation (RFA) lung
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2011-12
Volume volume65
Issue issue6
Publisher Okayama University Medical School
Start Page 395
End Page 402
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2011 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 22189480
Web of Science KeyUT 000298516900006
JaLCDOI 10.18926/AMO/49669
FullText URL 67_2_105.pdf
Author Alafate, Aierken| Shinya, Takayoshi| Okumura, Yoshihiro| Sato, Shuhei| Hiraki, Takao| Ishii, Hiroaki| Gobara, Hideo| Kato, Katsuya| Fujiwara, Toshiyoshi| Miyoshi, Shinichiro| Kaji, Mitsumasa| Kanazawa, Susumu|
Abstract We retrospectively evaluated the accumulation of fluorodeoxy glucose (FDG) in pulmonary malignancies without local recurrence during 2-year follow-up on positron emission tomography (PET)/computed tomography (CT) after radiofrequency ablation (RFA). Thirty tumors in 25 patients were studied (10 non-small cell lung cancers;20 pulmonary metastatic tumors). PET/CT was performed before RFA, 3 months after RFA, and 6 months after RFA. We assessed the FDG accumulation with the maximum standardized uptake value (SUVmax) compared with the diameters of the lesions. The SUVmax had a decreasing tendency in the first 6 months and, at 6 months post-ablation, FDG accumulation was less affected by inflammatory changes than at 3 months post-RFA. The diameter of the ablated lesion exceeded that of the initial tumor at 3 months post-RFA and shrank to pre-ablation dimensions by 6 months post-RFA. SUVmax was more reliable than the size measurements by CT in the first 6 months after RFA, and PET/CT at 6 months post-RFA may be more appropriate for the assessment of FDG accumulation than that at 3 months post-RFA.
Keywords fluorodeoxy glucose (FDG) positron emission tomography (PET) standardized uptake value (SUV) radiofrequency ablation (RFA) non-small cell lung cancer (NSCLC)
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2013-04
Volume volume67
Issue issue2
Publisher Okayama University Medical School
Start Page 105
End Page 112
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23603927
Web of Science KeyUT 000317801700005
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/50688
FullText URL fulltext.pdf figures.pdf SuppleFigures.pdf
Author Mochizuki, Yusuke| Tazawa, Hiroshi| Demiya, Koji| Kure, Miho| Kondo, Hiroya| Komatsubara, Tadashi| Sugiu, Kazuhisa| Hasei, Joe| Yoshida, Aki| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi|
Keywords Oncolytic adenovirus hTERT Immunogenic cell death ATP CD8
Note This is a post-peer-review, pre-copyedit version of an article published in Cancer Immunology, Immunotherapy. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00262-020-02774-7.|
Published Date 2020-11-05
Publication Title Cancer Immunology, Immunotherapy
Volume volume70
Publisher Springer
Start Page 1405
End Page 1417
ISSN 0340-7004
NCID AA00598499
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 33151368
DOI 10.1007/s00262-020-02774-7
Web of Science KeyUT 000586350500002
Related Url isVersionOf https://doi.org/10.1007/s00262-020-02774-7
FullText URL fulltext.pdf Figures.pdf Suppl_Material_Methods.pdf Suppl_Figures.pdf Legend_suppl_figures.pdf Suppl_Table.pdf
Author Kajioka, Hiroki| Kagawa, Shunsuke| Ito, Atene| Yoshimoto, Masashi| Sakamoto, Shuichi| Kikuchi, Satoru| Kuroda, Shinji| Yoshida, Ryuichi| Umeda, Yuzo| Noma, Kazuhiro| Tazawa, Hiroshi| Fujiwara, Toshiyoshi|
Keywords HMGB1 Epithelial to mesenchymal transition Phorbol 12-myristate 13-acetate Ischemia-reperfusion model
Note This fulltext is available in January, 2022.|
Published Date 2021-01-28
Publication Title Cancer Letters
Volume volume497
Publisher Elsevier
Start Page 1
End Page 3
ISSN 0304-3835
NCID AA00598513
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 33065249
DOI 10.1016/j.canlet.2020.10.015
Web of Science KeyUT 000596072900001
Related Url isVersionOf https://doi.org/10.1016/j.canlet.2020.10.015
Author Takagi, Kosei| Yagi, Takahito| Shinoura, Susumu| Umeda, Yuzo| Yoshida, Ryuichi| Nobuoka, Daisuke| Watanabe, Nobuyuki| Kuise, Takashi| Fuji, Tomokazu| Araki, Hiroyuki| Fujiwara, Toshiyoshi|
Published Date 2017-02
Publication Title Acta Medica Okayama
Volume volume71
Issue issue1
Content Type Journal Article
JaLCDOI 10.18926/AMO/54830
FullText URL fulltext.pdf
Author Takagi, Kosei| Umeda, Yuzo| Yoshida, Ryuichi| Yagi, Takahito| Fujiwara, Toshiyoshi| Zureikat, Amer H.| Hogg, Melissa E.| Koerkamp, Bas Groot|
Keywords Pancreatoduodenectomy Robotic surgery Training
Published Date 2021-02-19
Publication Title World Journal of Surgical Oncology
Volume volume19
Issue issue1
Publisher BMC
Start Page 55
ISSN 1477-7819
NCID AA12048269
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2021
File Version publisher
PubMed ID 33608019
DOI 10.1186/s12957-021-02167-9
Web of Science KeyUT 000621197800003
Related Url isVersionOf https://doi.org/10.1186/s12957-021-02167-9
FullText URL fulltext20220131-2.pdf
Author Kanaya, Nobuhiko| Kuroda, Shinji| Kakiuchi, Yoshihiko| Takeda, Sho| Kikuchi, Satoru| Noma, Kazuhiro| Yoshida, Ryuichi| Umeda, Yuzo| Teraishi, Fuminori| Nishizaki, Masahiko| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Keywords Gastric cancer D2 lymphadenectomy Suprapancreatic lymphadenectomy Posterior hepatic plexus Distal gastrectomy
Note This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00423-022-02437-4|
Published Date 2022-1-12
Publication Title Langenbeck's Archives of Surgery
Volume volume407
Issue issue2
Publisher Springer Science and Business Media LLC
Start Page 871
End Page 877
ISSN 1435-2443
NCID AA11211080
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022
File Version author
PubMed ID 35022835
DOI 10.1007/s00423-022-02437-4
Web of Science KeyUT 000741939500003
Related Url isVersionOf https://doi.org/10.1007/s00423-022-02437-4
FullText URL fulltext.pdf
Author Tamaki, Ayano| Tani, Yuma| Sato, Hiroki| Yoshida, Ryuichi| Yasui, Kazuya| Horiguchi, Shigeru| Kuise, Takashi| Umeda, Yuzo| Yoshida, Kazuhiro| Fuji, Tomokazu| Kumano, Kenjiro| Takagi, Kosei| Yagi, Takahito| Fujiwara, Toshiyoshi|
Keywords Mixed neuroendocrine-non-neuroendocrine neoplasm Adjuvant chemotherapy Ampulla of vater Distal bile duct
Published Date 2022-03-02
Publication Title Surgical Case Reports
Volume volume8
Issue issue1
Publisher Springer
Start Page 38
ISSN 2198-7793
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022.
File Version publisher
PubMed ID 35235080
DOI 10.1186/s40792-022-01386-w
Web of Science KeyUT 000763394800001
Related Url isVersionOf https://doi.org/10.1186/s40792-022-01386-w
FullText URL fulltext.pdf
Author Takagi, Kosei| Umeda, Yuzo| Yoshida, Ryuichi| Fuji, Tomokazu| Yasui, Kazuya| Kimura, Jiro| Hata, Nanako| Yagi, Takahito| Fujiwara, Toshiyoshi|
Keywords pancreatoduodenectomy robotic surgery gastrojejunostomy delayed gastric emptying
Published Date 2023-01-16
Publication Title Journal Of Clinical Medicine
Volume volume12
Issue issue2
Publisher MDPI
Start Page 732
ISSN 2077-0383
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 by the authors.
File Version publisher
PubMed ID 36675661
DOI 10.3390/jcm12020732
Web of Science KeyUT 000914818600001
Related Url isVersionOf https://doi.org/10.3390/jcm12020732
FullText URL fulltext.pdf
Author Takagi, Kosei| Umeda, Yuzo| Yoshida, Ryuichi| Fuji, Tomokazu| Yasui, Kazuya| Kimura, Jiro| Hata, Nanako| Mishima, Kento| Yagi, Takahito| Fujiwara, Toshiyoshi|
Keywords robotic surgery pancreatoduodenectomy surgical approach superior mesenteric artery pancreatic cancer
Published Date 2022-11-30
Publication Title Journal Of Clinical Medicine
Volume volume11
Issue issue23
Publisher MDPI
Start Page 7112
ISSN 2077-0383
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 36498684
DOI 10.3390/jcm11237112
Web of Science KeyUT 000896167800001
Related Url isVersionOf https://doi.org/10.3390/jcm11237112
JaLCDOI 10.18926/AMO/54419
FullText URL 70_3_197.pdf
Author Takagi, Kosei| Yagi, Takahito| Yoshida, Ryuichi| Shinoura, Susumu| Umeda, Yuzo| Nobuoka, Daisuke| Kuise, Takashi| Watanabe, Nobuyuki| Sui, Kenta| Fuji, Tomokazu| Fujiwara, Toshiyoshi|
Abstract The operative mortality and morbidity of pancreaticoduodenectomy (PD) remain high. We analyzed PD patientsʼ clinical characteristics and surgical outcomes and discuss how PD clinical outcomes could be improved. We retrospectively reviewed the cases of 400 patients who underwent a PD between January 1998 and April 2014 at Okayama University Hospital, a very-high-volume center. We identified and compared the clinical outcomes between two time periods (period 1: 1998-2006 vs. period 2: 2007-2014). The total postoperative mortality and major complication rates were 0.75 and 15.8 , respectively, and the median postoperative length of stay (LOS) was 32 days. Subsequently, patients who underwent a PD during period 2 had a significantly shorter LOS than those who underwent a PD during period 1 (29 days vs. 38.5 days, p<0.001). The incidence of mortality and major complications did not differ between the two periods. In our multivariate analysis, period 1 was an independent factor associated with a long LOS (p<0.001). The improvement of the surgical procedure and perioperative care might be related to the shorter LOS in period 2 and ot the consistently maintained low mortality rate after PD. The development of multimodal strategies to accelerate postoperative recovery may further improve PDʼs clinical outcomes.
Keywords pancreaticoduodenectomy surgical outcome mortality major complication length of stay
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2016-06
Volume volume70
Issue issue3
Publisher Okayama University Medical School
Start Page 197
End Page 203
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27339209
Web of Science KeyUT 000379406100007
JaLCDOI 10.18926/AMO/49672
FullText URL 67_2_123.pdf
Author Tanabe, Shunsuke| Shirakawa, Yasuhiro| Takehara, Yuko| Maeda, Naoaki| Katsube, Ryoichi| Ohara, Toshiaki| Sakurama, Kazufumi| Noma, Kazuhiro| Fujiwara, Toshiyoshi|
Abstract An 80-year-old woman, who had been administered α-glucosidase inhibitor for diabetes, was brought to the hospital with the sensation of abdominal fullness and pain. Abdominal computed tomography indicated pneumatosis cystoides intestinalis (PCI) in the small intestinal wall, with free air within the abdomen. A blood examination showed no increases in white blood cells or C-reactive protein level. The patientʼs condition improved with conservative therapy. PCI with pneumoperitoneum induced by α-glucosidase inhibitor is rare, with only 27 cases (excluding the present case) reported in Japan to date. In PCI with pneumoperitoneum, differentiation from gastrointestinal perforation is important and following the clinical symptoms over time is vital.
Keywords pneumatosis cystoides intestinalis pneumoperitoneum α-glucosidase inhibitor
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2013-04
Volume volume67
Issue issue2
Publisher Okayama University Medical School
Start Page 123
End Page 128
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23603930
Web of Science KeyUT 000317801700008
JaLCDOI 10.18926/AMO/54514
FullText URL 70_4_327.pdf
Author Watanabe, Mototsugu| Yamamoto, Hiromasa| Eikawa, Shingo| Shien, Kazuhiko| Shien, Tadahiko| Soh, Junichi| Hotta, Katsuyuki| Wada, Jun| Hinotsu, Shiro| Fujiwara, Toshiyoshi| Kiura, Katsuyuki| Doihara, Hiroyoshi| Miyoshi, Shinichiro| Udono, Heiichiro| Toyooka, Shinichi|
Abstract A study to evaluate the effect of metformin on the immune system was commenced in July 2014. Metformin is one of the most commonly prescribed drugs for type 2 diabetes, and previous studies have reported that metformin has an anti-tumor effect. The aim of this study is to evaluate the efficacy of metformin on the immune system in human cancer patients in vivo. The primary outcome parameter will be the rate change in the population of CD8+ T cells, which produce multiple cytokines.
Keywords metformin CD8+ T cells cancer immunology
Amo Type Clinical Study Protocols
Publication Title Acta Medica Okayama
Published Date 2016-08
Volume volume70
Issue issue4
Publisher Okayama University Medical School
Start Page 327
End Page 330
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27549683
Web of Science KeyUT 000384748600018
FullText URL fulltext.pdf
Author Maeda, Naoaki| Shirakawa, Yasuhiro| Tanabe, Shunsuke| Sakurama, Kazufumi| Noma, Kazuhiro| Fujiwara, Toshiyoshi|
Published Date 2020-06-26
Publication Title World Journal of Surgical Oncology
Volume volume18
Issue issue1
Publisher BMC
Start Page 143
ISSN 1477-7819
NCID AA12048269
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2020
File Version publisher
PubMed ID 32591002
DOI 10.1186/s12957-020-01908-6
Web of Science KeyUT 000545948700003
Related Url isVersionOf https://doi.org/10.1186/s12957-020-01908-6
FullText URL fulltext.pdf
Author Tsumura, Tomoko| Kuroda, Shinji| Nishizaki, Masahiko| Kikuchi, Satoru| Kakiuchi, Yoshihiko| Takata, Nobuo| Ito, Atene| Watanabe, Megumi| Kuwada, Kazuya| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Published Date 2020-11-12
Publication Title PLoS ONE
Volume volume15
Issue issue11
Publisher Public Library of Science
Start Page e0242223
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 Tsumura et al.
File Version publisher
PubMed ID 33180871
DOI 10.1371/journal.pone.0242223
Web of Science KeyUT 000593948000022
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0242223
JaLCDOI 10.18926/AMO/54594
FullText URL 70_5_363.pdf
Author Takagi, Kosei| Yagi, Takahito| Yoshida, Ryuichi| Shinoura, Susumu| Umeda, Yuzo| Nobuoka, Daisuke| Kuise, Takashi| Watanabe, Nobuyuki| Fujiwara, Toshiyoshi|
Abstract Sarcopenia following liver surgery has been reported as a predictor of poor prognosis. Here we investigated predictors of outcomes in patients with hepatocellular carcinoma (HCC) and attempted to establish a new comprehensive preoperative assessment protocol. We retrospectively analyzed the cases of 254 patients who underwent curative hepatectomy for HCC with Child-Pugh classification A at our hospital between January 2007 and December 2013. Sarcopenia was evaluated by computed tomography measurement. The influence of sarcopenia on outcomes was evaluated. We used multivariate analyses to assess the impact of prognostic factors associated with outcomes, including sarcopenia. Of the 254 patients, 118 (46.5%) met the criteria for sarcopenia, and 32 had an American Society of Anesthesiologists (ASA) physical status ≥3. The sarcopenic group had a significantly lower 5-year overall survival rate than the non-sarcopenic group (58.2% vs. 82.4% , p=0.0002). In multivariate analyses of prognostic factors, sarcopenia was an independent predictor of poor survival (hazard ratio [HR]=2.28, p=0.002) and poor ASA status (HR=3.17, p=0.001). Sarcopenia and poor ASA status are independent preoperative predictors for poor outcomes after hepatectomy. The preoperative identification of sarcopenia and ASA status might enable the development of comprehensive approaches to assess surgical eligibility.
Keywords sarcopenia American Society of Anesthesiologists physical status hepatectomy hepatocellular carcinoma prognostic factor
Amo Type Original Articles
Publication Title Acta Medica Okayama
Published Date 2016-10
Volume volume70
Issue issue5
Publisher Okayama University Medical School
Start Page 363
End Page 370
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27777428
Web of Science KeyUT 000388098700005
FullText URL fulltext.pdf
Author Matsumoto, Tasuku| Noma, Kazuhiro| Maeda, Naoaki| Kato, Takuya| Moriwake, Kazuya| Kawasaki, Kento| Hashimoto, Masashi| Tanabe, Shunsuke| Shirakawa, Yasuhiro| Fujiwara, Toshiyoshi|
Keywords T4 esophageal cancer Chemoradiotherapy Esophagectomy Two-stage operation
Note The version of record of this article, first published in Surgical Case Reports, is available online at Publisher’s website: http://dx.doi.org/10.1186/s40792-023-01692-x|
Published Date 2023-06-26
Publication Title Surgical Case Reports
Volume volume9
Issue issue1
Publisher Springer
Start Page 119
ISSN 2198-7793
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2023.
File Version publisher
PubMed ID 37358692
DOI 10.1186/s40792-023-01692-x
Web of Science KeyUT 001016770100001
Related Url isVersionOf https://doi.org/10.1186/s40792-023-01692-x
Author Nishizaki, Masahiko| Fujiwara, Yasuhiro| Chouda, Yasuhiro| Kanazawa, Takashi| Ninomiya, Motoki| Fujiwara, Toshiyoshi|
Published Date 2012-04-01
Publication Title 岡山医学会雑誌
Volume volume124
Issue issue1
Content Type Journal Article
FullText URL fulltext.pdf
Author Takagi, Kosei| Umeda, Yuzo| Yoshida, Ryuichi| Fuji, Tomokazu| Yasui, Kazuya| Kimura, Jiro| Hata, Nanako| Yagi, Takahito| Fujiwara, Toshiyoshi|
Keywords robotic surgery minimally invasive surgery hepato-pancreato-biliary surgery Pfannenstiel incision
Published Date 2023-03-02
Publication Title Journal of Clinical Medicine
Volume volume12
Issue issue5
Publisher MDPI
Start Page 1971
ISSN 2077-0383
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 by the authors.
File Version publisher
PubMed ID 36902758
DOI 10.3390/jcm12051971
Web of Science KeyUT 000947498100001
Related Url isVersionOf https://doi.org/10.3390/jcm12051971