| FullText URL | fulltext.pdf |
|---|---|
| Author | Fujiwara, Tomohiro| Healey, John| Ogura, Koichi| Yoshida, Aki| Kondo, Hiroya| Hata, Toshiaki| Kure, Miho| Tazawa, Hiroshi| Nakata, Eiji| Kunisada, Toshiyuki| Fujiwara, Toshiyoshi| Ozaki, Toshifumi| |
| Keywords | sarcoma tumor-associated macrophage prognosis clinical trial immunotherapy |
| Published Date | 2021-03-03 |
| Publication Title | Cancers |
| Volume | volume13 |
| Issue | issue5 |
| Publisher | MDPI |
| Start Page | 1086 |
| ISSN | 2072-6694 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 by the authors. |
| File Version | publisher |
| PubMed ID | 33802565 |
| NAID | 120007008531 |
| DOI | 10.3390/cancers13051086 |
| Web of Science KeyUT | 000627955600001 |
| Related Url | isVersionOf https://doi.org/10.3390/cancers13051086 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Takagi, Kosei| Umeda, Yuzo| Yoshida, Ryuichi| Fuji, Tomokazu| Yasui, Kazuya| Yagi, Takahito| Fujiwara, Toshiyoshi| |
| Keywords | Choledochal cyst Congenital biliary dilatation Robot Surgical approach |
| Published Date | 2023-10 |
| Publication Title | Asian Journal of Surgery |
| Volume | volume46 |
| Issue | issue10 |
| Publisher | Elsevier |
| Start Page | 4399 |
| End Page | 4402 |
| ISSN | 1015-9584 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 Asian Surgical Association and Taiwan Robotic Surgery Association. |
| File Version | publisher |
| PubMed ID | 36801184 |
| DOI | 10.1016/j.asjsur.2023.02.021 |
| Web of Science KeyUT | 001088748000001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.asjsur.2023.02.021 |
| JaLCDOI | 10.18926/AMO/48268 |
|---|---|
| FullText URL | 66_2_177.pdf.pdf |
| Author | Utsumi, Masashi| Matsuda, Hiroaki| Sadamori, Hiroshi| Shinoura, Susumu| Umeda, Yuzo| Yoshida, Ryuichi| Satoh, Daisuke| Hashimoto, Masaaki| Yagi, Takahito| Fujiwara, Toshiyoshi| |
| Abstract | We report 4 cases of surgical resection of metachronous lymph node (LN) metastases from hepatocellular carcinoma (HCC) following hepatectomy. Clinicopathological features and results of LN dissection were investigated in the 4 patients. One patient was found to have a single metastasis in the mediastinal LNs, another had multiple metastases in the mediastinal and abdominal LNs, and the other 2 had single metastases in the abdominal LN. The locations of the abdominal LN metastases were behind the pancreas head in 2 patients and around the abdominal aorta in 1 patient. They all underwent surgical resection of metastatic LNs and had no postoperative complications. The 3 patients whose LN metastases were solitary have been alive for more than 2 years after LN resection, and one of them is free from recurrence. The patient with multiple LN metastases died 13 months after LN resection due to carcinomatosis. With the expectation of long-term survival, a single metachronous LN metastasis from HCC after hepatectomy should be resected in patients without uncontrollable intrahepatic or extrahepatic tumors. |
| Keywords | hepatocellular carcinoma lymph node metastasis hepatectomy |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-04 |
| Volume | volume66 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 177 |
| End Page | 182 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22525476 |
| Web of Science KeyUT | 000303175300011 |
| JaLCDOI | 10.18926/AMO/54421 |
|---|---|
| FullText URL | 70_3_213.pdf |
| Author | Kikuchi, Satoru| Kagawa, Shunsuke| Ohara, Toshiaki| Kubota, Tetsushi| Kuwada, Kazuya| Kagawa, Tetsuya| Kuroda, Shinji| Shirakawa, Yasuhiro| Nishizaki, Masahiko| Fujiwara, Toshiyoshi| |
| Abstract | A 69-year-old man underwent endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) at the lesser curvature in the angle of stomach. Histological examination revealed tub1, pM, ly0, v0, pLM(-), pVM(-), and the resection was considered curative. The scar after ESD was followed by esophagogastroduodenoscopy (EGD) and biopsy. Twenty months later, EGD showed an ulcerative lesion in the vicinity of the ESD scar, and histological examination of the biopsy specimen showed adenocarcinoma. A distal gastrectomy with lymph node dissection was then performed. Postoperative pathology showed tub1, pM, pN0, ly0, v0, and Stage 1A. Skip lesions were seen in the specimen resected by ESD, and the histological review confirmed so-called “dysplasia-like atypia” (DLA) between the lesions. It has been reported recently that in DLA, the dysplasia-like change involves only the bases of the pits, without upper pit or surface epithelium involvement, and it is said that the rate of DLA is higher in gastric cancer patients. We speculated that a precancerous lesion close to the resected cancer developed into a local recurrence. |
| Keywords | dysplasia-like atypia early gastric cancer endoscopic submucosal dissection local recurrence |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-06 |
| Volume | volume70 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 213 |
| End Page | 216 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27339211 |
| Web of Science KeyUT | 000379406100009 |
| FullText URL | fulltext20210601-1.pdf |
|---|---|
| Author | Soga, Yoshihiko| Shirakawa, Yasuhiro| Fujiwara, Toshiyoshi| Ashiwa, Takako| Morimatsu, Hiroshi| |
| Keywords | perioperative management nutrition dental oral management |
| Note | This is a post-peer-review, pre-copyedit version of an article published in Current Oral Health Reports. The final authenticated version is available online at: http://dx.doi.org/10.1007/s40496-019-0217-3.| |
| Published Date | 2019-04-15 |
| Publication Title | Current Oral Health Reports |
| Volume | volume6 |
| Issue | issue2 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 70 |
| End Page | 75 |
| ISSN | 2196-3002 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| NAID | 120007042397 |
| DOI | 10.1007/s40496-019-0217-3 |
| Related Url | isVersionOf https://doi.org/10.1007/s40496-019-0217-3 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yano, Shuya| Tazawa, Hiroshi| Kishimoto, Hiroyuki| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| Hoffman, Robert M.| |
| Keywords | cancer cell cycle fluorescent proteins FUCCI imaging adenovirus oncolytic virotherapy cancer stem cell mouse model orthotopic |
| Published Date | 2021-01-17 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume22 |
| Issue | issue2 |
| Publisher | MDPI |
| Start Page | 879 |
| ISSN | 1422-0067 |
| NCID | AA12038549 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 by the authors. |
| File Version | publisher |
| PubMed ID | 33477279 |
| DOI | 10.3390/ijms22020879 |
| Web of Science KeyUT | 000611296000001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms22020879 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Komatsu, Yasuhiro| Shigeyasu, Kunitoshi| Yano, Shuya| Takeda, Sho| Takahashi, Kazutaka| Hata, Nanako| Umeda, Hibiki| Yoshida, Kazuhiro| Mori, Yoshiko| Yasui, Kazuya| Yoshida, Ryuichi| Kondo, Yoshitaka| Kishimoto, Hiroyuki| Teraishi, Fuminori| Umeda, Yuzo| Kagawa, Shunsuke| Michiue, Hiroyuki| Tazawa, Hiroshi| Goel, Ajay| Fujiwara, Toshiyoshi| |
| Published Date | 2022-08-08 |
| Publication Title | Scientific Reports |
| Volume | volume12 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 13540 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © TheAuthor(s)2022 |
| File Version | publisher |
| PubMed ID | 35941214 |
| DOI | 10.1038/s41598-022-17773-0 |
| Web of Science KeyUT | 000837764800013 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-022-17773-0 |
| JaLCDOI | 10.18926/AMO/53024 |
|---|---|
| FullText URL | 68_6_349.pdf |
| Author | Yamamoto, Tsuyoshi| Kajikawa, Yutaka| Otani, Satoru| Yamada, Yuki| Takemoto, Syunji| Hirota, Minoru| Ikeda, Masae| Iwagaki, Hiromi| Saito, Shinya| Fujiwara, Toshiyoshi| |
| Abstract | Accumulated studies have shown that ω-3 polyunsaturated fatty acids such as eicosapentaenoic acid (EPA) have protective roles against inflammatory responses such as hyperlipidemia, diabetes mellitus (DM) and cardiovascular diseases. Here we examined the effects of administering EPA to hyperlipidemic patients and other patients undergoing cardiac surgery to determine whether this treatment would increase plasma EPA levels and to clarify the association between EPA treatment and adiponectin production in hyperlipidemic patients. We also assessed the effect of preoperative EPA administration on postoperative adverse events such as postoperative atrial fibrillation (POAF) and postoperative infection in the cardiac surgery patients. The EPA administration significantly increased the serum EPA concentrations in both patient populations (p＜0.001). In the hyperlipidemic patients, the EPA administration significantly increased plasma adiponectin levels (p＜0.05), accompanied by a decrease in insulin resistance designated by the HOMA-IR (homeostasis model assessment of insulin resistance) score (p＜0.05) and Hs-CRP (high sensitivity C-reactive protein) value (p＜0.05). In the cardiac surgery patients, no significant effect of EPA on cardiac adverse events such as POAF was observed. However, our results clearly demonstrated that both the neutrophil-to-lymphocyte ratio and the 2nd-line antibiotic requirement in the EPA group were significantly decreased compared to the untreated control group (p＜0.05). We suggest that EPA administration may exert anti-inflammatory effects in patients with hyperlipidemia and in those undergoing cardiac surgery, possibly through an increase in plasma adiponectin levels. |
| Keywords | eicosapentaenoic acid adiponectin hyperlipidemic patients cardiac surgery atrial fibrillation |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-12 |
| Volume | volume68 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 349 |
| End Page | 361 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25519029 |
| Web of Science KeyUT | 000346882200005 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/53125 |
| JaLCDOI | 10.18926/AMO/53524 |
|---|---|
| FullText URL | 69_3_173.pdf |
| Author | Shirakawa, Yasuhiro| Noma, Kazuhiro| Ohara, Toshiaki| Kashima, Hajime| Maeda, Naoaki| Tanabe, Shunsuke| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| Abstract | A chyle leak can occur as a complication after neck or chest surgery. Such a leak prolongs the hospital stay and is sometimes life-threatening. The treatment options are conservative management, interventional radiologic embolization, and surgery. Thoracoscopic ligation of the thoracic duct has emerged as a promising and definitive treatment. The case of a 65-year-old Japanese male patient with a rare congenital right aortic arch (typeⅢB1 of Edwardʼs classification) and a severe chyle leak that occurred after a total pharyngolaryngo-esophagectomy (TPLE) is described. The chyle leak was successfully managed by thoracoscopic ligation of the thoracic duct via a left-side approach with the patient in the prone position. |
| Keywords | chyle leak thoracic duct thoracoscopy prone position |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2015-06 |
| Volume | volume69 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 173 |
| End Page | 176 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26101193 |
| Web of Science KeyUT | 000356903000006 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kakiuchi, Yoshihiko| Kuroda, Shinji| Kikuchi, Satoru| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| Keywords | Gastric cancer (GC) elderly stage IA comorbidity Charlson comorbidity index (CCI) |
| Published Date | 2022-10 |
| Publication Title | Journal of Gastrointestinal Oncology |
| Volume | volume13 |
| Issue | issue5 |
| Publisher | AME Publishing Company |
| Start Page | 2178 |
| End Page | 2185 |
| ISSN | 2078-6891 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Journal of Gastrointestinal Oncology. |
| File Version | publisher |
| PubMed ID | 36388703 |
| DOI | 10.21037/jgo-22-527 |
| Web of Science KeyUT | 000864732300001 |
| Related Url | isVersionOf https://doi.org/10.21037/jgo-22-527 |
| Author | Kakiuchi, Yoshihiko| Kuroda, Shinji| Choda, Yasuhiro| Otsuka, Shinya| Ueyama, Satoshi| Tanaka, Norimitsu| Muraoka, Atsushi| Hato, Shinji| Kamikawa, Yasuaki| Fujiwara, Toshiyoshi| |
|---|---|
| Keywords | Double -flap technique Gastric cancer Prognostic factor Prognostic nutritional index Proximal gastrectomy |
| Note | © 2023 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Sep. 2024.| |
| Published Date | 2023-10 |
| Publication Title | Surgical Oncology |
| Volume | volume50 |
| Publisher | Elsevier BV |
| Start Page | 101990 |
| ISSN | 0960-7404 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 Elsevier Ltd. |
| File Version | author |
| PubMed ID | 37717376 |
| DOI | 10.1016/j.suronc.2023.101990 |
| Web of Science KeyUT | 001082185900001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.suronc.2023.101990 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Matsuda, Tatsuo| Umeda, Yuzo| Matsuda, Tadakazu| Endo, Yoshikatsu| Sato, Daisuke| Kojima, Toru| Sui, Kenta| Inagaki, Masaru| Ota, Tetsuya| Hioki, Masayoshi| Oishi, Masahiro| Kimura, Masashi| Murata, Toshihiro| Ishido, Nobuhiro| Yagi, Takahito| Fujiwara, Toshiyoshi| |
| Keywords | Intrahepatic cholangiocarcinoma Postoperative complication Prognostic nutritional index |
| Published Date | 2021-06-16 |
| Publication Title | BMC Cancer |
| Volume | volume21 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 708 |
| ISSN | 1471-2407 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s). 2021 |
| File Version | publisher |
| PubMed ID | 34130648 |
| DOI | 10.1186/s12885-021-08424-0 |
| Web of Science KeyUT | 000664089600001 |
| Related Url | isVersionOf https://doi.org/10.1186/s12885-021-08424-0 |
| Author | Huang, P| Kaku, H| Chen, J| Kashiwakura, Y| Saika, T| Nasu, Y| Urata, Y| Fujiwara, T| Watanabe, M| Kumon, H| |
|---|---|
| Published Date | 2010-07 |
| Publication Title | Cancer Gene Therapy |
| Volume | volume17 |
| Issue | issue7 |
| Content Type | Journal Article |
| FullText URL | fulltext20210831-3.pdf |
|---|---|
| Author | Shirakawa, Yasuhiro| Tazawa, Hiroshi| Tanabe, Shunsuke| Kanaya, Nobuhiko| Noma, Kazuhiro| Koujima, Takeshi| Kashima, Hajime| Kato, Takuya| Kuroda, Shinji| Kikuchi, Satoru| Kagawa, Shunsuke| Katsui, Kuniaki| Kanazawa, Susumu| Urata, Yasuo| Fujiwara, Toshiyoshi| |
| Keywords | Telomerase adenovirus radiotherapy esophageal cancer immunotherapy |
| Note | © 2021 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.ejca.2021.04.043] .| |
| Published Date | 2021-8 |
| Publication Title | European Journal of Cancer |
| Volume | volume153 |
| Publisher | Elsevier BV |
| Start Page | 98 |
| End Page | 108 |
| ISSN | 0959-8049 |
| NCID | AA1075407X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 Elsevier Ltd. |
| File Version | author |
| PubMed ID | 34153720 |
| DOI | 10.1016/j.ejca.2021.04.043 |
| Web of Science KeyUT | 000686051300013 |
| Related Url | isVersionOf https://doi.org/10.1016/j.ejca.2021.04.043 |
| Author | Hanzawa, Shunya| Kikuchi, Satoru| Kuroda, Shinji| Shoji, Ryohei| Kashima, Hajime| Matsumi, Yuki| Takahashi, Ayako| Kakiuchi, Yoshihiko| Takagi, Kosei| Tanabe, Shunsuke| Noma, Kazuhiro| Kagawa, Shunsuke| Shikata, Kenichi| Fujiwara, Toshiyoshi| |
|---|---|
| Note | This is an Accepted Manuscript of an article published by Taylor & Francis in Nutrition and Cancer on 15 Apr 2024, available at: https://doi.org/10.1080/01635581.2024.2340782.| This fulltext file will be available in Apr. 2025.| |
| Published Date | 2024-04-15 |
| Publication Title | Nutrition and Cancer |
| Publisher | Informa UK Limited |
| ISSN | 0163-5581 |
| NCID | AA00325612 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 38619145 |
| DOI | 10.1080/01635581.2024.2340782 |
| Web of Science KeyUT | 001202947500001 |
| Related Url | isVersionOf https://doi.org/10.1080/01635581.2024.2340782 |
| JaLCDOI | 10.18926/AMO/66930 |
|---|---|
| FullText URL | 78_2_197.pdf |
| Author | Teraishi, Fuminori| Matsumi, Yuki| Tachibana, Kota| Watanabe, Toshiyuki| Fujiwara, Toshiyoshi| |
| Abstract | A 90-year-old Japanese woman who had been aware of a subcutaneous mass on the right perineal region for 5 years was referred to our hospital for further examination and treatment because of the rapid growth of the mass and bleeding that began 3 months earlier. A biopsy of the mass revealed a diagnosis of well-differentiated squamous cell carcinoma. On preoperative examination, the tumor was 90×40 mm in size and was suspected to have partially invaded the levator ani muscle and external sphincter. Since a preoperative cardiac evaluation indicated severe aortic stenosis, we performed transcatheter aortic valve implantation. A radical resection was then performed with general anesthesia. The skin and subcutaneous tissue defects were reconstructed with a posterior gluteal-thigh propeller flap, and a sigmoid colostomy was created. The patient had a good postoperative course and was transferred to a rehabilitation facility 28 days after the surgery. Epidermal cysts are a common benign tumor, and clinicians should keep in mind that these cysts can become malignant. |
| Keywords | squamous cell carcinoma epidermoid cyst gluteal thigh flap |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 197 |
| End Page | 200 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688838 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kawasaki, Kento| Noma, Kazuhiro| Kato, Takuya| Ohara, Toshiaki| Tanabe, Shunsuke| Takeda, Yasushige| Matsumoto, Hijiri| Nishimura, Seitaro| Kunitomo, Tomoyoshi| Akai, Masaaki| Kobayashi, Teruki| Nishiwaki, Noriyuki| Kashima, Hajime| Maeda, Naoaki| Kikuchi, Satoru| Tazawa, Hiroshi| Shirakawa, Yasuhiro| Fujiwara, Toshiyoshi| |
| Keywords | Esophageal cancer Cancer-associated fibroblasts Programmed cell death 1 Program cell death ligand 1 Immune checkpoint inhibitors |
| Note | The version of record of this article, first published in Cancer Immunology, Immunotherapy, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00262-023-03531-2| |
| Published Date | 2023-09-05 |
| Publication Title | Cancer Immunology, Immunotherapy |
| Volume | volume72 |
| Issue | issue11 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 3787 |
| End Page | 3802 |
| ISSN | 0340-7004 |
| NCID | AA00598499 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 37668710 |
| DOI | 10.1007/s00262-023-03531-2 |
| Web of Science KeyUT | 001062743200002 |
| Related Url | isVersionOf https://doi.org/10.1007/s00262-023-03531-2 |
| FullText URL | SR9_1_4633.pdf |
|---|---|
| Author | Morihiro, Toshiaki| Kuroda, Shinji| Kanaya, Nobuhiko| Kakiuchi, Yoshihiko| Kubota, Tetsushi| Aoyama, Katsuyuki| Tanaka, Takehiro| Kikuch, Satoru| Nagasaka, Takeshi| Nishizaki, Masahiko| Kagawa, Shunsuke| Tazawa, Hiroshi| Fujiwara, Toshiyoshi| |
| Published Date | 2019-3-15 |
| Publication Title | Scientific Reports |
| Volume | volume9 |
| Publisher | Nature Publishing Group |
| Start Page | 4633 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2019 |
| File Version | publisher |
| PubMed ID | 30874607 |
| DOI | 10.1038/s41598-019-41177-2 |
| Web of Science KeyUT | 000461303000015 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-019-41177-2 |
| JaLCDOI | 10.18926/AMO/63425 |
|---|---|
| FullText URL | 76_2_203.pdf |
| Author | Masuda, Tomoya| Tazawa, Hiroshi| Hashimoto, Yuuri| Ieda, Takeshi| Kikuchi, Satoru| Kuroda, Shinji| Noma, Kazuhiro| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| Abstract | The epithelial-mesenchymal transition (EMT), a normal biological process by which epithelial cells acquire a mesenchymal phenotype, is associated with migration, metastasis, and chemoresistance in cancer cells, and with poor prognosis in patients with esophageal cancer. However, therapeutic strategies to inhibit EMT in tumor environments remain elusive. Here, we show the therapeutic potential of telomerase-specific replication- competent oncolytic adenovirus OBP-301 in human esophageal cancer TE4 and TE6 cells with an EMT phenotype. Transforming growth factor-β (TGF-β) administration induced the EMT phenotype with spindleshaped morphology, upregulation of mesenchymal markers and EMT transcription factors, migration, and chemoresistance in TE4 and TE6 cells. OBP-301 significantly inhibited the EMT phenotype via E1 accumulation. EMT cancer cells were susceptible to OBP-301 via massive autophagy induction. OBP-301 suppressed tumor growth and lymph node metastasis of TE4 cells co-inoculated with TGF-β-secreting fibroblasts. Our results suggest that OBP-301 inhibits the TGF-β-induced EMT phenotype in human esophageal cancer cells. OBP-301-mediated E1A overexpression is a promising antitumor strategy to inhibit EMT-mediated esophageal cancer progression. |
| Keywords | esophageal cancer EMT TGF-β oncolytic adenovirus E1A |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-04 |
| Volume | volume76 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 203 |
| End Page | 215 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35503449 |
| Web of Science KeyUT | 000792291900003 |
| JaLCDOI | 10.18926/AMO/54981 |
|---|---|
| FullText URL | 71_2_127.pdf |
| Author | Shirakawa, Yasuhiro| Noma, Kazuhiro| Maeda, Naoaki| Tanabe, Shunsuke| Kuroda, Shinji| Kagawa, Shunsuke| Katsui, Kuniaki| Katayama, Norihisa| Kanazawa, Susumu| Fujiwara, Toshiyoshi| |
| Abstract | Currently, chemoradiation is the most widely used nonsurgical treatment for esophageal cancer. However, some patients, particularly the very elderly or those with severe vital organ dysfunction, face difficulty with the chemotherapy component. We therefore examined the outcome of radiation therapy (RT) alone for patients with esophageal cancer at our facility. Between January 2005 and December 2014, 84 patients underwent RT at our hospital, and 78 of these patients received concomitant chemotherapy. The remaining 6 patients underwent RT alone; these patients were considered to be high-risk and to have no lymph node metastasis (stage I). Five of them received irradiation up to a curative dose: 4 showed a complete response (CR) and 1 showed a partial response (PR). Of the patients exhibiting CR, 3 are currently living recurrence-free, whereas 1 patient underwent endoscopic submucosal dissection (ESD) as salvage therapy for local recurrence, with no subsequent recurrence. High-risk stage I esophageal cancer patients can be treated radically with RT alone under certain conditions. In the future, to broaden the indications for RT monotherapy to include some degree of advanced cancers, a novel concurrent therapy should be identified. |
| Keywords | esophageal cancer radiation therapy high-risk patient |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2017-04 |
| Volume | volume71 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 127 |
| End Page | 133 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28420894 |
