FullText URL fulltext.pdf
Author Uotani, Koji| Tazawa, Hiroshi| Hasei, Joe| Fujiwara, Tomohiro| Yoshida, Aki| Yamakawa, Yasuaki| Omori, Toshinori| Sugiu, Kazuhisa| Komatsubara, Tadashi| Kondo, Hiroya| Morita, Takuya| Kiyono, Masahiro| Yokoo, Suguru| Hata, Toshiaki| Kunisada, Toshiyuki| Takeda, Ken| Urata, Yasuo| Fujiwara, Toshiyoshi| Ozaki, Toshifumi|
Published Date 2024-02-20
Publication Title PLoS ONE
Volume volume19
Issue issue2
Publisher Public Library of Science
Start Page e0298292
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 Uotani et al.
File Version publisher
PubMed ID 38377118
DOI 10.1371/journal.pone.0298292
Web of Science KeyUT 001176939600021
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0298292
Author Shigeyasu, Kunitoshi| Tazawa, Hiroshi| Hashimoto, Yuuri| Mori, Yoshiko| Nishizaki, Masahiko| Kishimoto, Hiroyuki| Nagasaka, Takeshi| Kuroda, Shinji| Urata, Yasuo| Goel, Ajay| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Published Date 2014-05-28
Publication Title Gut
Content Type Journal Article
FullText URL fulltext.pdf
Author Katsube, Ryoichi| Noma, Kazuhiro| Ohara, Toshiaki| Nishiwaki, Noriyuki| Kobayashi, Teruki| Komoto, Satoshi| Sato, Hiroaki| Kashima, Hajime| Kato, Takuya| Kikuchi, Satoru| Tazawa, Hiroshi| Kagawa, Shunsuke| Shirakawa, Yasuhiro| Kobayashi, Hisataka| Fujiwara, Toshiyoshi|
Published Date 2021-01-18
Publication Title Scientific Reports
Volume volume11
Issue issue1
Publisher Nature Research
Start Page 1693
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2021
File Version publisher
PubMed ID 33462372
DOI 10.1038/s41598-021-81465-4
Web of Science KeyUT 000612156600008
Related Url isVersionOf https://doi.org/10.1038/s41598-021-81465-4
FullText URL fulltext.pdf
Author Tani, Yuma| Sato, Hiroki| Yoshida, Ryuichi| Yasui, Kazuya| Umeda, Yuzo| Yoshida, Kazuhiro| Fuji, Tomokazu| Kumano, Kenjiro| Takagi, Kosei| Kagoura, Masaaki| Yagi, Takahito| Fujiwara, Toshiyoshi|
Keywords Hepatocellular carcinoma Peritoneal dissemination Indocyanine green fluorescence
Published Date 2022-06-06
Publication Title Journal Of Medical Case Reports
Volume volume16
Issue issue1
Publisher BMC
Start Page 222
ISSN 1752-1947
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022.
File Version publisher
PubMed ID 35659738
DOI 10.1186/s13256-022-03440-5
Web of Science KeyUT 000807221800001
Related Url isVersionOf https://doi.org/10.1186/s13256-022-03440-5
FullText URL fulltext.pdf
Author Yano, Shuya| Tazawa, Hiroshi| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| Hoffman, Robert M.|
Keywords cell cycle fluorescent proteins FUCCI imaging targeted cancer therapy quiescent cancer cells decoy chemotherapy
Published Date 2020-09-17
Publication Title Cancers
Volume volume12
Issue issue9
Publisher MDPI
Start Page 2655
ISSN 2072-6694
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 32957652
DOI 10.3390/cancers12092655
Web of Science KeyUT 000580315800001
Related Url isVersionOf https://doi.org/10.3390/cancers12092655
FullText URL fulltext.pdf
Author Ito, Atene| Kagawa, Shunsuke| Sakamoto, Shuichi| Kuwada, Kazuya| Kajioka, Hiroki| Yoshimoto, Masashi| Kikuchi, Satoru| Kuroda, Shinji| Yoshida, Ryuichi| Tazawa, Hiroshi| Fujiwara, Toshiyoshi|
Keywords Extracellular vesicles Gastric cancer Tumor-associated macrophages Tumor microenvironment
Published Date 2021-01-28
Publication Title BMC Cancer
Volume volume21
Issue issue1
Publisher BMC
Start Page 102
ISSN 1471-2407
NCID AA12034763
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2021
File Version publisher
PubMed ID 33509150
DOI 10.1186/s12885-021-07816-6
Web of Science KeyUT 000615987400002
Related Url isVersionOf https://doi.org/10.1186/s12885-021-07816-6
JaLCDOI 10.18926/AMO/46628
FullText URL 65_3_169.pdf
Author Takeda, Masanori| Nagasaka, Takeshi| Dong-Sheng, Sun| Nishie, Hiroyuki| Oka, Tetsuhiro| Yamada, Eiji| Mori, Yoshiko| Shigeyasu, Kunitoshi| Morikawa, Tatsuya| Mizobuchi, Satoshi| Fujiwara, Toshiyoshi|
Abstract Secreted frizzled-related protein 2, (SFRP2) is a Wnt inhibitor whose promoter CpGs were recently found to be methylated at high frequency in colorectal cancers (CRCs). We hypothesized that the pattern of SFRP2 methylation may differ throughout the promoter during progressive tumorigenesis. Using combined bisulfite restriction analysis (COBRA), two methylation-sensitive regions (Regions A and B) of the SFRP2 promoter were investigated in 569 specimens of colorectal tissue:222 CRCs, 103 adenomatous polyps (APs), 208 normal colonic mucosa from CRC patients (N-Cs), and 36 normal colonic mucosa from subjects with no evidence of colorectal neoplasia at colonoscopy (N-Ns). Extensive (including both Regions A and B) and partial (either Region A or B) SFRP2 methylation levels were found in 61.7% and 24.8% of CRCs, 8.7% and 37.9% of APs, 3.9% and 39.9% of N-Cs, and 0% and 30.6% of N-Ns, respectively. Extensive methylation of the SFRP2 promoter was present primarily in CRCs, while partial methylation was common in APs. Whereas APs with the KRAS mutant showed no correlation to any pattern of SFRP2 methylation, extensive methylation of the SFRP2 promoter was significantly associated with KRAS mutant CRCs (p<.0001), suggesting that genetic alteration in the RAS-RAF pathway might precede the spread of CpG methylation through the SFRP2 promoter, which is observed in over 60% of advanced colorectal tumors.
Keywords BRAF/KRAS mutations promoter methylation colorectal cancer
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2011-06
Volume volume65
Issue issue3
Publisher Okayama University Medical School
Start Page 169
End Page 177
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2011 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 21709714
Web of Science KeyUT 000292017500003
Author Itoh, Mitsuya| Iwamoto, Takayuki| Matsuoka, Junji| Nogami, Tomohiro| Motoki, Takayuki| Shien, Tadahiko| Taira, Naruto| Niikura, Naoki| Hayashi, Naoki| Ohtani, Shoichiro| Higaki, Kenji| Fujiwara, Toshiyoshi| Doihara, Hiroyoshi| Symmans, W. Fraser| Pusztai, Lajos|
Published Date 2014-01
Publication Title Breast Cancer Research and Treatment
Volume volume143
Issue issue2
Content Type Journal Article
FullText URL fulltext.pdf
Author Kikuchi, Satoru| Matsusaki, Takashi| Mitsuhashi, Toshiharu| Kuroda, Shinji| Kashima, Hajime| Takata, Nobuo| Mitsui, Ema| Kakiuchi, Yoshihiko| Noma, Kazuhiro| Umeda, Yuzo| Morimatsu, Hiroshi| Fujiwara, Toshiyoshi|
Published Date 2024-01-18
Publication Title BJS Open
Volume volume8
Issue issue1
Publisher Oxford University Press
Start Page zrad161
ISSN 2474-9842
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2024.
File Version publisher
PubMed ID 38242571
DOI 10.1093/bjsopen/zrad161
Web of Science KeyUT 001148373800007
Related Url isVersionOf https://doi.org/10.1093/bjsopen/zrad161
FullText URL fulltext.pdf
Author Tanimoto, Terutaka| Tazawa, Hiroshi| Ieda, Takeshi| Nouso, Hiroshi| Tani, Morimichi| Oyama, Takanori| Urata, Yasuo| Kagawa, Shunsuke| Noda, Takuo| Fujiwara, Toshiyoshi|
Keywords neuroblastoma MYCN hTERT adenovirus E2F1
Published Date 2020-09-25
Publication Title Molecular Therapy - Oncolytics
Volume volume18
Publisher Cell Press
Start Page 14
End Page 23
ISSN 2372-7705
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Author(s).
File Version publisher
PubMed ID 32637577
DOI 10.1016/j.omto.2020.05.015
Web of Science KeyUT 000575168700002
Related Url isVersionOf https://doi.org/10.1016/j.omto.2020.05.015
FullText URL fulltext.pdf
Author Kojima, Toru| Umeda, Yuzo| Fuji, Tomokazu| Niguma, Takefumi| Satoh, Daisuke| Endo, Yoshikatsu| Sui, Kenta| Inagaki, Masaru| Oishi, Masahiro| Ota, Tetsuya| Hioki, Katsuyoshi| Matsuda, Tadakazu| Aoki, Hideki| Hirai, Ryuji| Kimura, Masashi| Yagi, Takahito| Fujiwara, Toshiyoshi|
Published Date 2020-09-03
Publication Title PLOS ONE
Volume volume15
Issue issue9
Publisher PUBLIC LIBRARY SCIENCE
Start Page e0238392
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 Kojima et al.
File Version publisher
PubMed ID 32881910
DOI 10.1371/journal.pone.0238392
Web of Science KeyUT 000571063300054
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0238392
FullText URL fulltext20210608-1.pdf highlights20210608-1.pdf figure20210608-1.pdf table20210608-1.pdf supplement20210608-1.pdf
Author Kuroda, Shinji| Kikuchi, Satoru| Kakiuchi, Yoshihiko| Watanabe, Megumi| Kuwada, Kazuya| Tsumura, Tomoko| Nishizaki, Masahiko| Kagawa, Shunsuke| Hinotsu, Shiro| Fujiwara, Toshiyoshi|
Note This is an Accepted Manuscript of an article published by Elsevier BV. © 2021 IJS Publishing Group Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.ijsu.2021.105946] . |
Published Date 2021-5
Publication Title International Journal of Surgery
Volume volume89
Publisher Elsevier BV
Start Page 105946
ISSN 1743-9191
NCID AA12063080
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 IJS Publishing Group Ltd.
File Version author
PubMed ID 33892160
DOI 10.1016/j.ijsu.2021.105946
Web of Science KeyUT 000651625600016
Related Url isVersionOf https://doi.org/10.1016/j.ijsu.2021.105946
FullText URL fulltext20221020-1.pdf figure20221020-1.pdf table20221020-1.pdf ASO_Takata_Supplementary.pdf
Author Takata, Nobuo| Kikuchi, Satoru| Kuroda, Shinji| Tanabe, Shunsuke| Maeda, Naoaki| Noma, Kazuhiro| Takahashi, Ayako| Umeda, Yuzo| Shikata, Kenichi| Ozaki, Kazuhide| Fujiwara, Toshiyoshi|
Keywords Gastric cancer Gastrectomy Body weight loss Skeletal muscle loss Nutritional counseling
Note This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1245/s10434-022-12572-3| This fulltext is available in Sep. 2023.|
Published Date 2022-09-25
Publication Title Annals of Surgical Oncology
Volume volume30
Issue issue2
Publisher Springer Science and Business Media LLC
Start Page 1110
End Page 1118
ISSN 1068-9265
NCID AA11016573
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Society of Surgical Oncology 2022
File Version author
PubMed ID 36161371
DOI 10.1245/s10434-022-12572-3
Web of Science KeyUT 000858651900003
Related Url isVersionOf https://doi.org/10.1245/s10434-022-12572-3
FullText URL fulltext.pdf
Author Sato, Hiroaki| Noma, Kazuhiro| Ohara, Toshiaki| Kawasaki, Kento| Akai, Masaaki| Kobayashi, Teruki| Nishiwaki, Noriyuki| Narusaka, Toru| Komoto, Satoshi| Kashima, Hajime| Katsura, Yuki| Kato, Takuya| Kikuchi, Satoru| Tazawa, Hiroshi| Kagawa, Shunsuke| Shirakawa, Yasuhiro| Kobayashi, Hisataka| Fujiwara, Toshiyoshi|
Published Date 2022-11-23
Publication Title Scientific Reports
Volume volume12
Issue issue1
Publisher Nature Portfolio
Start Page 20152
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022
File Version publisher
PubMed ID 36418422
DOI 10.1038/s41598-022-24313-3
Web of Science KeyUT 000887936300054
Related Url isVersionOf https://doi.org/10.1038/s41598-022-24313-3
Author Yoshimoto, Masashi| Kagawa, Shunsuke| Kajioka, Hiroki| Taniguchi, Atsuki| Kuroda, Shinji| Kikuchi, Satoru| Kakiuchi, Yoshihiko| Yagi, Tomohiko| Nogi, Shohei| Teraishi, Fuminori| Shigeyasu, Kunitoshi| Yoshida, Ryuichi| Umeda, Yuzo| Noma, Kazuhiro| Tazawa, Hiroshi| Fujiwara, Toshiyoshi|
Keywords Aspirin Ticagrelor P-selectin Platelet Time-lapse imaging
Note © 2023 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Jul. 2024.|
Published Date 2023-07-28
Publication Title Cancer Letters
Volume volume567
Publisher Elsevier BV
Start Page 216260
ISSN 0304-3835
NCID AA00598513
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Elsevier B.V.
File Version author
PubMed ID 37295551
DOI 10.1016/j.canlet.2023.216260
Web of Science KeyUT 001020524700001
Related Url isVersionOf https://doi.org/10.1016/j.canlet.2023.216260
Author Hasei, Joe| Sasaki, Tsuyoshi| Tazawa, Hiroshi| Osaki, Shuhei| Yamakawa, Yasuaki| Kunisada, Toshiyuki| Yoshida, Aki| Hashimoto, Yuuri| Onishi, Teppei| Uno, Futoshi| Kagawa, Shunsuke| Urata, Yasuo| Ozaki, Toshifumi| Fujiwara, Toshiyoshi|
Published Date 2013-03
Publication Title Molecular Cancer Therapeutics
Volume volume12
Issue issue3
Content Type Journal Article
FullText URL fulltext.pdf
Author Oda, Naohiro| Tabata, Masahiro| Uno, Masatoshi| Umeda, Yuzo| Kato, Hironari| Kubo, Toshio| Senoo, Satoru| Yagi, Takahito| Fujiwara, Toshiyoshi| Maeda, Yoshinobu| Kiura, Katsuyuki|
Keywords pancreas mucinous cystadenocarcinoma carboplatin paclitaxel
Published Date 2021-09-15
Publication Title Internal Medicine
Volume volume60
Issue issue18
Publisher The Japanese Society of Internal Medicine
Start Page 2967
End Page 2971
ISSN 0918-2918
NCID AA10827774
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 The Japanese Society of Internal Medicine
File Version publisher
PubMed ID 33814494
DOI 10.2169/internalmedicine.6730-20
Web of Science KeyUT 000697279400013
Related Url isVersionOf https://doi.org/10.2169/internalmedicine.6730-20
JaLCDOI 10.18926/AMO/62394
FullText URL 75_4_431.pdf
Author Kunitomi, Toshiki| Nasu, Junichirou| Minami, Daisuke| Iwamoto, Takayuki| Nishie, Hiroyuki| Saito, Shinya| Fujiwara, Toshiyoshi| Matsuoka, Junji|
Abstract This study aimed to evaluate whether there are differences in the attitudes and practices of cancer pain manage-ment between medical oncologists and palliative care physicians. An online nationwide survey was used to collect responses from board-certified medical oncologists and palliative care physicians in Japan. The survey questionnaire comprised 30 questions. The differences in responses between medical oncologists and palliative care physicians were examined. Out of the 1,227 questionnaires sent, 522 (42.5%) were returned. After apply-ing the exclusion criteria, 445 questionnaires (medical oncologists: n = 283; palliative care physicians: n = 162) were retained for analysis. Among the questions about potential barriers to optimal cancer pain man-agement, both medical oncologists and palliative care physicians considered the reluctance of patients to take opioids due to fear of adverse effects as the greatest barrier. Significantly different ratings between medical oncologists and palliative care physicians were observed on 5 of the 8 questions in this area. Significantly differ-ent ratings were observed for all questions concerning pain specialists and their knowledge. For effective cancer pain management, it is important to account for differences in attitudes and practice between medical oncolo-gists and palliative care physicians.
Keywords cancer pain management opioid medical oncologist palliative care physician barriers
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2021-08
Volume volume75
Issue issue4
Publisher Okayama University Medical School
Start Page 431
End Page 437
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 34511609
Web of Science KeyUT 000697944600004
NAID 120007146037
FullText URL fulltext.pdf
Author Matsubara, Takehiro| Soh, Junichi| Morita, Mizuki| Uwabo, Takahiro| Tomida, Shuta| Fujiwara, Toshiyoshi| Kanazawa, Susumu| Toyooka, Shinichi| Hirasawa, Akira|
Published Date 2020-02-27
Publication Title BioMed Research International
Volume volume2020
Publisher Hindawi
Start Page 9349132
ISSN 2314-6133
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 Takehiro Matsubara et al.
File Version publisher
PubMed ID 32185225
DOI 10.1155/2020/9349132
Web of Science KeyUT 000522222100002
Related Url isVersionOf https://doi.org/10.1155/2020/9349132
FullText URL fulltext.pdf
Author Komoto, Satoshi| Noma, Kazuhiro| Kato, Takuya| Kobayashi, Teruki| Nishiwaki, Noriyuki| Narusaka, Toru| Sato, Hiroaki| Katsura, Yuki| Kashima, Hajime| Kikuchi, Satoru| Ohara, Toshiaki| Tazawa, Hiroshi| Fujiwara, Toshiyoshi|
Keywords cancer-associated fibroblast chemotherapy radiotherapy esophageal cancer tumor microenvironment
Published Date 2023-05-30
Publication Title Cancers
Volume volume15
Issue issue11
Publisher MDPI
Start Page 2971
ISSN 2072-6694
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 by the authors.
File Version publisher
PubMed ID 37296933
DOI 10.3390/cancers15112971
Web of Science KeyUT 001006082400001
Related Url isVersionOf https://doi.org/10.3390/cancers15112971