Fujiwara, Toshiyoshi - OU Author List - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

Multidisciplinary oncolytic virotherapy for gastrointestinal cancer

FullText URL	AnnGastroenterolSurg_3_4_396.pdf
Author	Fujiwara, Toshiyoshi\|
Keywords	adenovirus clinical trial esophageal cancer radiotherapy telomerase
Published Date	2019-07-05
Publication Title	Annals of gastroenterological surgery
Volume	volume3
Issue	issue4
Publisher	John Wiley & Sons
Start Page	396
End Page	404
ISSN	24750328
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2019 The Authors
File Version	publisher
PubMed ID	31346579
DOI	10.1002/ags3.12270
Web of Science KeyUT	000475745100009
Related Url	isVersionOf https://doi.org/10.1002/ags3.12270

Intraperitoneal cancer-immune microenvironment promotes peritoneal dissemination of gastric cancer

FullText URL	OncoImmunol_8_12_1671760.pdf
Author	Sakamoto, Shuichi\| Kagawa, Shunsuke\| Kuwada, Kazuya\| Ito, Atene\| Kajioka, Hiroki\| Kakiuchi, Yoshihiko\| Watanabe, Megumi\| Kagawa, Tetsuya\| Yoshida, Ryuichi\| Kikuchi, Satoru\| Kuroda, Shinji\| Tazawa, Hiroshi\| Fujiwara, Toshiyoshi\|
Keywords	Gastric cancer tumor-associated macrophages tumor microenvironment peritoneal dissemination
Published Date	2019-10-22
Publication Title	OncoImmunology
Volume	volume8
Issue	issue12
Publisher	TAYLOR & FRANCIS
Start Page	e1671760
ISSN	2162402X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2019 The Author(s).
File Version	publisher
DOI	10.1080/2162402X.2019.1671760
Web of Science KeyUT	000494085400001
Related Url	isVersionOf https://doi.org/10.1080/2162402X.2019.1671760

A Novel Combination Cancer Therapy with Iron Chelator Targeting Cancer Stem Cells via Suppressing Stemness

FullText URL	cancers_11_2_177.pdf
Author	Katsura, Yuki\| Ohara, Toshiaki\| Noma, Kazuhiro\| Ninomiya, Takayuki\| Kashima, Hajime\| Kato, Takuya\| Sato, Hiroaki\| Komoto, Satoshi\| Narusaka, Toru\| Tomono, Yasuko\| Xing, Boyi\| Chen, Yuehua\| Tazawa, Hiroshi\| Kagawa, Shunsuke\| Shirakawa, Yasuhiro\| Kasai , Tomonari\| Seno, Masaharu\| Matsukawa, Akihiro\| Fujiwara, Toshiyoshi\|
Keywords	cancer stem cells combination therapy iron stemness
Published Date	2019-02-03
Publication Title	Cancers
Volume	volume11
Issue	issue2
Publisher	MDPI
Start Page	177
ISSN	2072-6694
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2019 by the authors
File Version	publisher
PubMed ID	30717462
DOI	10.3390/cancers11020177
Web of Science KeyUT	000460747200051
Related Url	isVersionOf https://doi.org/10.3390/cancers11020177

Multicenter retrospective study to evaluate the efficacy and safety of the double-flap technique as antireflux esophagogastrostomy after proximal gastrectomy (rD-FLAP Study)

FullText URL	AGS3_1_96.pdf SI.pdf
Author	Kuroda, Shinji\| Choda, Yasuhiro\| Otsuka, Shinya\| Ueyama, Satoshi\| Tanaka, Norimitsu\| Muraoka, Atsushi\| Hato, Shinji\| Kimura, Toshikazu\| Tanakaya, Kohji\| Kikuchi, Satoru\| Tanabe, Shunsuke\| Noma, Kazuhiro\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Shirakawa, Yasuhiro\| Kamikawa, Yasuaki\| Fujiwara, Toshiyoshi\|
Keywords	Kamikawa procedure antireflux surgery double‐flap technique esophagogastrostomy proximal gastrectomy
Published Date	2018-10-11
Publication Title	Annals of Gastroenterological Surgery
Volume	volume3
Issue	issue1
Publisher	Woley
Start Page	96
End Page	103
ISSN	2475-0328
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2018 The Authors
File Version	publisher
PubMed ID	30697614
DOI	10.1002/ags3.12216
Web of Science KeyUT	000456643500012
Related Url	isVersionOf https://doi.org/10.1002/ags3.12216

Assistant-Based Standardization of Prone Position Thoracoscopic Esophagectomy

JaLCDOI	10.18926/AMO/52407
FullText URL	68_2_111.pdf
Author	Shirakawa, Yasuhiro\| Noma, Kazuhiro\| Maeda, Naoaki\| Katsube, Ryoichi\| Tanabe, Shunsuke\| Ohara, Toshiaki\| Sakurama, Kazufumi\| Fujiwara, Toshiyoshi\|
Abstract	Thoracoscopic esophagectomy in the prone position (TEPP) might enable solo-surgery in cases requiring resection of the esophagus and the surrounding lymph nodes due to the associated advantages of good exposure of the surgical field and ergonomic considerations for the surgeon. However, no one approach can be for all patients requiring extensive lymphadenectomy. We recently developed an assistant-based procedure to standardize exposure of the surgical field. Patients were divided into 1 of 2 groups:a pre-standardization group (n＝37) and a post-standardization group (n＝28). The thoracoscopic operative time was significantly shorter (p＝0.0037) in the post-standardization group (n＝28; 267±31min) than in the pre-standardization group (n＝37;301±53min). Further, learning curve analysis using the moving average method showed stabilization of the thoracoscopic operative time after the standardization. No significant differences were found in the number of mediastinal lymph nodes dissected or intraoperative blood loss between the 2 groups. There were also no significant differences in the complication rate. Assistant-based surgery and standardization of the procedure resulted in a well-exposed and safe surgical field. TEPP decreased the operative time, even in patients requiring extensive lymphadenectomy.
Keywords	thoracoscopic esophagectomy prone position standardization
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2014-04
Volume	volume68
Issue	issue2
Publisher	Okayama University Medical School
Start Page	111
End Page	117
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2014 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	24743786
Web of Science KeyUT	000334652700006

Visualization of epithelial-mesenchymal transition in an inflammatory microenvironment-colorectal cancer network

Author	Ieda, Takeshi\| Tazawa, Hiroshi\| Okabayashi, Hiroki\| Yano, Shuya\| Shigeyasu, Kunitoshi\| Kuroda, Shinji\| Ohara, Toshiaki\| Noma, Kazuhiro\| Kishimoto, Hiroyuki\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Shirakawa, Yasuhiro\| Saitou, Takashi\| Imamura, Takeshi\| Fujiwara, Toshiyoshi\|
Published Date	2019-11-8
Publication Title	Scientific Reports
Volume	volume9
Publisher	Nature Publishing Group
Start Page	16378
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2019
File Version	publisher
PubMed ID	31705021
DOI	10.1038/s41598-019-52816-z
Web of Science KeyUT	000495372900001
Related Url	isVersionOf https://doi.org/10.1038/s41598-019-52816-z

ZD1839 (Gefitinib, 'Iressa'), an epidermal growth factor receptor-tyrosine kinase inhibitor, enhances the anti-cancer effects of TRAIL in human esophageal squamous cell carcinoma

Author	Teraishi, Fuminori\| Kagawa, Shunsuke\| Watanabe, Takanori\| Tango, Yasuhisa\| Kawashima, Takeshi\| Umeoka, Tatsuo\| Nisizaki, Masahiko\| Tanaka, Noriaki\| Fujiwara, Toshiyoshi\|
Published Date	2005-08-01
Publication Title	FEBS Letters
Volume	volume579
Issue	issue19
Content Type	Journal Article

Immune Modulation by Telomerase-Specific Oncolytic Adenovirus Synergistically Enhances Antitumor Efficacy with Anti-PD1 Antibody

FullText URL	fulltext.pdf Graphical_Abstract.pptx Figure1-6.pdf Supp_Info.pdf
Author	Kanaya, Nobuhiko\| Kuroda, Shinji\| Kakiuchi, Yoshihiko\| Kumon, Kento\| Tsumura, Tomoko\| Hashimoto, Masashi\| Morihiro, Toshiaki\| Kubota, Tetsushi\| Aoyama, Katsuyuki\| Kikuchi, Satoru\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Tazawa, Hiroshi\| Mizuguchi, Hiroyuki\| Urata, Yasuo\| Fujiwara, Toshiyoshi\|
Keywords	immune checkpoint programmed death-1 oncolytic adenovirus combined immunotherapy immunogenic cell death tumor infiltrating lymphocytes CD8 abscopal effect
Published Date	2020-01-10
Publication Title	Molecular Therapy
Volume	volume28
Issue	issue3
Publisher	Cell Press
Start Page	794
End Page	804
ISSN	15250016
NCID	AA11475060
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
File Version	author
PubMed ID	31991110
DOI	10.1016/j.ymthe.2020.01.003
Web of Science KeyUT	000518887200012
Related Url	isVersionOf https://doi.org/10.1016/j.ymthe.2020.01.003

便中メチル化DNA検出による消化器がんスクリーニング：消化器がんを非侵襲的にスクリーニングすることは可能か？

Author	Nagasaka, Takeshi\| Tanaka, Noriaki\| Sun, Dong-Sheng\| Naomoto, Yoshio\| Mastubara, Nagahide\| Yagi, Takahito\| Fujiwara, Toshiyoshi\|
Published Date	2010-08-02
Publication Title	岡山医学会雑誌
Volume	volume122
Issue	issue2
Content Type	Journal Article

Acquired resistance mechanisms to afatinib in HER2-amplified gastric cancer cells

FullText URL	fulltext.pdf
Author	Yoshioka, Takahiro\| Shien, Kazuhiko\| Takeda, Tatsuaki\| Takahashi, Yuta\| Kurihara, Eisuke\| Ogoshi, Yusuke\| Namba, Kei\| Torigoe, Hidejiro\| Sato, Hiroki\| Tomida, Shuta\| Yamamoto, Hiromasa\| Soh, Junichi\| Fujiwara, Toshiyoshi\| Toyooka, Shinichi\|
Keywords	afatinib gastric cancer HER2 MET YES1
Published Date	2019-06-04
Publication Title	Cancer Science
Volume	volume110
Issue	issue8
Publisher	Wiley Open Access
Start Page	2549
End Page	2557
ISSN	1347-9032
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2019 The Authors.
File Version	publisher
PubMed ID	31162771
DOI	10.1111/cas.14089
Web of Science KeyUT	000478616800022
Related Url	isVersionOf https://doi.org/10.1111/cas.14089

DV200 Index for Assessing RNA Integrity in Next-Generation Sequencing

FullText URL	fulltext.pdf
Author	Matsubara, Takehiro\| Soh, Junichi\| Morita, Mizuki\| Uwabo, Takahiro\| Tomida, Shuta\| Fujiwara, Toshiyoshi\| Kanazawa, Susumu\| Toyooka, Shinichi\| Hirasawa, Akira\|
Published Date	2020-02-27
Publication Title	BioMed Research International
Volume	volume2020
Publisher	Hindawi
Start Page	9349132
ISSN	2314-6133
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2020 Takehiro Matsubara et al.
File Version	publisher
PubMed ID	32185225
DOI	10.1155/2020/9349132
Web of Science KeyUT	000522222100002
Related Url	isVersionOf https://doi.org/10.1155/2020/9349132

Bone and Soft-Tissue Sarcoma: A New Target for Telomerase-Specific Oncolytic Virotherapy

FullText URL	fulltext.pdf
Author	Tazawa, Hiroshi\| Hasei, Joe\| Yano, Shuya\| Kagawa, Shunsuke\| Ozaki, Toshifumi\| Fujiwara, Toshiyoshi\|
Keywords	oncolytic adenovirus hTERT autophagy GFP p53
Published Date	2020-02-18
Publication Title	Cancers
Volume	volume12
Issue	issue2
Publisher	MDPI
ISSN	2072-6694
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2020 by the authors.
File Version	publisher
PubMed ID	32085583
DOI	10.3390/cancers12020478
Web of Science KeyUT	000522477300224
Related Url	isVersionOf https://doi.org/10.3390/cancers12020478

Oncolytic Virus-Mediated Targeting of the ERK Signaling Pathway Inhibits Invasive Propensity in Human Pancreatic Cancer

FullText URL	fulltext.pdf
Author	Koujima, Takeshi\| Tazawa, Hiroshi\| Ieda, Takeshi\| Araki, Hiroyuki\| Fushimi, Takuro\| Shoji, Ryohei\| Kuroda, Shinji\| Kikuchi, Satoru\| Yoshida, Ryuichi\| Umeda, Yuzo\| Teraishi, Fuminori\| Urata, Yasuo\| Mizuguchi, Hiroyuki\| Fujiwara, Toshiyoshi\|
Published Date	2020-06-26
Publication Title	Molecular Therapy - Oncolytics
Volume	volume17
Publisher	Cell Press
Start Page	107
End Page	117
ISSN	2372-7705
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2020 The Author(s).
File Version	publisher
PubMed ID	32322667
DOI	10.1016/j.omto.2020.03.016
Web of Science KeyUT	000544101600010
Related Url	isVersionOf https://doi.org/10.1016/j.omto.2020.03.016

Skeletal muscle loss in the postoperative acute phase after esophageal cancer surgery as a new prognostic factor

FullText URL	fulltext.pdf
Author	Maeda, Naoaki\| Shirakawa, Yasuhiro\| Tanabe, Shunsuke\| Sakurama, Kazufumi\| Noma, Kazuhiro\| Fujiwara, Toshiyoshi\|
Published Date	2020-06-26
Publication Title	World Journal of Surgical Oncology
Volume	volume18
Issue	issue1
Publisher	BMC
Start Page	143
ISSN	1477-7819
NCID	AA12048269
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s). 2020
File Version	publisher
PubMed ID	32591002
DOI	10.1186/s12957-020-01908-6
Web of Science KeyUT	000545948700003
Related Url	isVersionOf https://doi.org/10.1186/s12957-020-01908-6

第32回日本バイオセラピィ学会学術集会総会報告

Title Alternative	The 32th Annual Meeting of the Japan Society for Biological Therapy
FullText URL	132_41.pdf
Author	Fujiwara, Toshiyoshi\|
Publication Title	Journal of Okayama Medical Association
Published Date	2020-04-01
Volume	volume132
Issue	issue1
Start Page	41
End Page	43
ISSN	0030-1558
Related Url	isVersionOf https://doi.org/10.4044/joma.132.41
language	Japanese
Copyright Holders	Copyright (c) 2020 岡山医学会
File Version	publisher
DOI	10.4044/joma.132.41
NAID	130007840310

Laparoscopic liver resection of segment seven: A case report and review of surgical techniques

FullText URL	fulltext.pdf
Author	Takagi, Kosei\| Kuise, Takashi\| Umeda, Yuzo\| Yoshida, Ryuichi\| Teraishi, Fuminori\| Yagi, Takahito\| Fujiwara, Toshiyoshi\|
Keywords	Laparoscopic Liver Segment seven
Published Date	2020
Publication Title	International Journal of Surgery Case Reports
Volume	volume73
Publisher	Elsevier
Start Page	168
End Page	171
ISSN	2210-2612
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2020 The Author(s).
File Version	publisher
PubMed ID	32688239
DOI	10.1016/j.ijscr.2020.06.107
Web of Science KeyUT	000558775100010
Related Url	isVersionOf https://doi.org/10.1016/j.ijscr.2020.06.107

Intratumoral peptide injection enhances tumor cell antigenicity recognized by cytotoxic T lymphocytes: a potential option for improvement in antigen-specific cancer immunotherapy

Author	Nobuoka, Daisuke\| Yoshikawa, Toshiaki\| Takahashi, Mari\| Iwama, Tatsuaki\| Horie, Kazutaka\| Shimomura, Manami\| Suzuki, Shiro\| Sakemura, Noriko\| Nakatsugawa, Munehide\| Sadamori, Hiroshi\| Yagi, Takahito\| Fujiwara, Toshiyoshi\| Nakatsura, Tetsuya\|
Published Date	2013-04
Publication Title	Cancer Immunology, Immunotherapy
Volume	volume62
Issue	issue4
Content Type	Journal Article

消化器がんと分子標的治療薬

Author	Nagasaka, Takeshi\| Fujiwara, Toshiyoshi\|
Published Date	2013-08-01
Publication Title	岡山医学会雑誌
Volume	volume125
Issue	issue2
Content Type	Journal Article

A novel modified hanging maneuver in laparoscopic left hemihepatectomy

FullText URL	fulltext.pdf
Author	Takagi, Kosei\| Umeda, Yuzo\| Kuise, Takashi\| Yoshida, Ryuichi\| Yoshida, Kazuhiro\| Yasui, Kazuya\| Tani, Yuma\| Yagi, Takahito\| Fujiwara, Toshiyoshi\|
Keywords	Hanging maneuver Laparoscopic Liver resection
Published Date	2020-10-08
Publication Title	International Journal of Surgery Case Reports
Volume	volume76
Publisher	Elsevier
Start Page	251
End Page	253
ISSN	2210-2612
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2020 The Author(s).
File Version	publisher
PubMed ID	33053483
DOI	10.1016/j.ijscr.2020.10.002
Related Url	isVersionOf https://doi.org/10.1016/j.ijscr.2020.10.002

Oncolytic Adenovirus-Induced Autophagy: Tumor-Suppressive Effect and Molecular Basis

JaLCDOI	10.18926/AMO/52006
FullText URL	67_6_333.pdf
Author	Tazawa, Hiroshi\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
Abstract	Autophagy is a catabolic process that produces energy through lysosomal degradation of intracellular organelles. Autophagy functions as a cytoprotective factor under physiological conditions such as nutrient deprivation, hypoxia, and interruption of growth factors. On the other hand, infection with pathogenic viruses and bacteria also induces autophagy in infected cells. Oncolytic virotherapy with replication-competent viruses is thus a promising strategy to induce tumor-specific cell death. Oncolytic adenoviruses induce autophagy and subsequently contribute to cell death rather than cell survival in tumor cells. We previously developed a telomerase-specific replication-competent oncolytic adenovirus, OBP-301, which induces cell lysis in tumor cells with telomerase activities. OBP-301-mediated cytopathic activity is significantly associated with induction of autophagy biomarkers. In this review, we focus on the tumor-suppressive role and molecular basis of autophagic machinery induced by oncolytic adenoviruses. Addition of tumor-specific promoters and modification of the fiber knob of adenoviruses supports the oncolytic adenovirus-mediated autophagic cell death. Autophagy is cooperatively regulated by the E1-dependent activation pathway, E4-dependent inhibitory pathway, and microRNA-dependent fine-tuning. Thus, future exploration of the functional role and molecular mechanisms underlying oncolytic adenovirus-induced autophagy would provide novel insights and improve the therapeutic potential of oncolytic adenoviruses.
Keywords	oncolytic adenovirus autophagy E2F1 microRNA
Amo Type	Review
Publication Title	Acta Medica Okayama
Published Date	2013-12
Volume	volume67
Issue	issue6
Publisher	Okayama University Medical School
Start Page	333
End Page	342
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2013 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	24356717
Web of Science KeyUT	000328915700001