FullText URL fulltext20221020-1.pdf figure20221020-1.pdf table20221020-1.pdf ASO_Takata_Supplementary.pdf
Author Takata, Nobuo| Kikuchi, Satoru| Kuroda, Shinji| Tanabe, Shunsuke| Maeda, Naoaki| Noma, Kazuhiro| Takahashi, Ayako| Umeda, Yuzo| Shikata, Kenichi| Ozaki, Kazuhide| Fujiwara, Toshiyoshi|
Keywords Gastric cancer Gastrectomy Body weight loss Skeletal muscle loss Nutritional counseling
Note This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1245/s10434-022-12572-3| This fulltext is available in Sep. 2023.|
Published Date 2022-09-25
Publication Title Annals of Surgical Oncology
Volume volume30
Issue issue2
Publisher Springer Science and Business Media LLC
Start Page 1110
End Page 1118
ISSN 1068-9265
NCID AA11016573
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Society of Surgical Oncology 2022
File Version author
PubMed ID 36161371
DOI 10.1245/s10434-022-12572-3
Web of Science KeyUT 000858651900003
Related Url isVersionOf https://doi.org/10.1245/s10434-022-12572-3
FullText URL fulltext20210608-1.pdf highlights20210608-1.pdf figure20210608-1.pdf table20210608-1.pdf supplement20210608-1.pdf
Author Kuroda, Shinji| Kikuchi, Satoru| Kakiuchi, Yoshihiko| Watanabe, Megumi| Kuwada, Kazuya| Tsumura, Tomoko| Nishizaki, Masahiko| Kagawa, Shunsuke| Hinotsu, Shiro| Fujiwara, Toshiyoshi|
Note This is an Accepted Manuscript of an article published by Elsevier BV. © 2021 IJS Publishing Group Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.ijsu.2021.105946] . |
Published Date 2021-5
Publication Title International Journal of Surgery
Volume volume89
Publisher Elsevier BV
Start Page 105946
ISSN 1743-9191
NCID AA12063080
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 IJS Publishing Group Ltd.
File Version author
PubMed ID 33892160
DOI 10.1016/j.ijsu.2021.105946
Web of Science KeyUT 000651625600016
Related Url isVersionOf https://doi.org/10.1016/j.ijsu.2021.105946
FullText URL fulltext.pdf
Author Kojima, Toru| Umeda, Yuzo| Fuji, Tomokazu| Niguma, Takefumi| Satoh, Daisuke| Endo, Yoshikatsu| Sui, Kenta| Inagaki, Masaru| Oishi, Masahiro| Ota, Tetsuya| Hioki, Katsuyoshi| Matsuda, Tadakazu| Aoki, Hideki| Hirai, Ryuji| Kimura, Masashi| Yagi, Takahito| Fujiwara, Toshiyoshi|
Published Date 2020-09-03
Publication Title PLOS ONE
Volume volume15
Issue issue9
Publisher PUBLIC LIBRARY SCIENCE
Start Page e0238392
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 Kojima et al.
File Version publisher
PubMed ID 32881910
DOI 10.1371/journal.pone.0238392
Web of Science KeyUT 000571063300054
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0238392
FullText URL fulltext.pdf
Author Tanimoto, Terutaka| Tazawa, Hiroshi| Ieda, Takeshi| Nouso, Hiroshi| Tani, Morimichi| Oyama, Takanori| Urata, Yasuo| Kagawa, Shunsuke| Noda, Takuo| Fujiwara, Toshiyoshi|
Keywords neuroblastoma MYCN hTERT adenovirus E2F1
Published Date 2020-09-25
Publication Title Molecular Therapy - Oncolytics
Volume volume18
Publisher Cell Press
Start Page 14
End Page 23
ISSN 2372-7705
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Author(s).
File Version publisher
PubMed ID 32637577
DOI 10.1016/j.omto.2020.05.015
Web of Science KeyUT 000575168700002
Related Url isVersionOf https://doi.org/10.1016/j.omto.2020.05.015
FullText URL fulltext.pdf
Author Kikuchi, Satoru| Matsusaki, Takashi| Mitsuhashi, Toshiharu| Kuroda, Shinji| Kashima, Hajime| Takata, Nobuo| Mitsui, Ema| Kakiuchi, Yoshihiko| Noma, Kazuhiro| Umeda, Yuzo| Morimatsu, Hiroshi| Fujiwara, Toshiyoshi|
Published Date 2024-01-18
Publication Title BJS Open
Volume volume8
Issue issue1
Publisher Oxford University Press
Start Page zrad161
ISSN 2474-9842
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2024.
File Version publisher
PubMed ID 38242571
DOI 10.1093/bjsopen/zrad161
Web of Science KeyUT 001148373800007
Related Url isVersionOf https://doi.org/10.1093/bjsopen/zrad161
Author Itoh, Mitsuya| Iwamoto, Takayuki| Matsuoka, Junji| Nogami, Tomohiro| Motoki, Takayuki| Shien, Tadahiko| Taira, Naruto| Niikura, Naoki| Hayashi, Naoki| Ohtani, Shoichiro| Higaki, Kenji| Fujiwara, Toshiyoshi| Doihara, Hiroyoshi| Symmans, W. Fraser| Pusztai, Lajos|
Published Date 2014-01
Publication Title Breast Cancer Research and Treatment
Volume volume143
Issue issue2
Content Type Journal Article
JaLCDOI 10.18926/AMO/46628
FullText URL 65_3_169.pdf
Author Takeda, Masanori| Nagasaka, Takeshi| Dong-Sheng, Sun| Nishie, Hiroyuki| Oka, Tetsuhiro| Yamada, Eiji| Mori, Yoshiko| Shigeyasu, Kunitoshi| Morikawa, Tatsuya| Mizobuchi, Satoshi| Fujiwara, Toshiyoshi|
Abstract Secreted frizzled-related protein 2, (SFRP2) is a Wnt inhibitor whose promoter CpGs were recently found to be methylated at high frequency in colorectal cancers (CRCs). We hypothesized that the pattern of SFRP2 methylation may differ throughout the promoter during progressive tumorigenesis. Using combined bisulfite restriction analysis (COBRA), two methylation-sensitive regions (Regions A and B) of the SFRP2 promoter were investigated in 569 specimens of colorectal tissue:222 CRCs, 103 adenomatous polyps (APs), 208 normal colonic mucosa from CRC patients (N-Cs), and 36 normal colonic mucosa from subjects with no evidence of colorectal neoplasia at colonoscopy (N-Ns). Extensive (including both Regions A and B) and partial (either Region A or B) SFRP2 methylation levels were found in 61.7% and 24.8% of CRCs, 8.7% and 37.9% of APs, 3.9% and 39.9% of N-Cs, and 0% and 30.6% of N-Ns, respectively. Extensive methylation of the SFRP2 promoter was present primarily in CRCs, while partial methylation was common in APs. Whereas APs with the KRAS mutant showed no correlation to any pattern of SFRP2 methylation, extensive methylation of the SFRP2 promoter was significantly associated with KRAS mutant CRCs (p<.0001), suggesting that genetic alteration in the RAS-RAF pathway might precede the spread of CpG methylation through the SFRP2 promoter, which is observed in over 60% of advanced colorectal tumors.
Keywords BRAF/KRAS mutations promoter methylation colorectal cancer
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2011-06
Volume volume65
Issue issue3
Publisher Okayama University Medical School
Start Page 169
End Page 177
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2011 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 21709714
Web of Science KeyUT 000292017500003
FullText URL fulltext.pdf
Author Ito, Atene| Kagawa, Shunsuke| Sakamoto, Shuichi| Kuwada, Kazuya| Kajioka, Hiroki| Yoshimoto, Masashi| Kikuchi, Satoru| Kuroda, Shinji| Yoshida, Ryuichi| Tazawa, Hiroshi| Fujiwara, Toshiyoshi|
Keywords Extracellular vesicles Gastric cancer Tumor-associated macrophages Tumor microenvironment
Published Date 2021-01-28
Publication Title BMC Cancer
Volume volume21
Issue issue1
Publisher BMC
Start Page 102
ISSN 1471-2407
NCID AA12034763
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2021
File Version publisher
PubMed ID 33509150
DOI 10.1186/s12885-021-07816-6
Web of Science KeyUT 000615987400002
Related Url isVersionOf https://doi.org/10.1186/s12885-021-07816-6
FullText URL fulltext.pdf
Author Yano, Shuya| Tazawa, Hiroshi| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| Hoffman, Robert M.|
Keywords cell cycle fluorescent proteins FUCCI imaging targeted cancer therapy quiescent cancer cells decoy chemotherapy
Published Date 2020-09-17
Publication Title Cancers
Volume volume12
Issue issue9
Publisher MDPI
Start Page 2655
ISSN 2072-6694
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 32957652
DOI 10.3390/cancers12092655
Web of Science KeyUT 000580315800001
Related Url isVersionOf https://doi.org/10.3390/cancers12092655
FullText URL fulltext.pdf
Author Tani, Yuma| Sato, Hiroki| Yoshida, Ryuichi| Yasui, Kazuya| Umeda, Yuzo| Yoshida, Kazuhiro| Fuji, Tomokazu| Kumano, Kenjiro| Takagi, Kosei| Kagoura, Masaaki| Yagi, Takahito| Fujiwara, Toshiyoshi|
Keywords Hepatocellular carcinoma Peritoneal dissemination Indocyanine green fluorescence
Published Date 2022-06-06
Publication Title Journal Of Medical Case Reports
Volume volume16
Issue issue1
Publisher BMC
Start Page 222
ISSN 1752-1947
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022.
File Version publisher
PubMed ID 35659738
DOI 10.1186/s13256-022-03440-5
Web of Science KeyUT 000807221800001
Related Url isVersionOf https://doi.org/10.1186/s13256-022-03440-5
FullText URL fulltext.pdf
Author Katsube, Ryoichi| Noma, Kazuhiro| Ohara, Toshiaki| Nishiwaki, Noriyuki| Kobayashi, Teruki| Komoto, Satoshi| Sato, Hiroaki| Kashima, Hajime| Kato, Takuya| Kikuchi, Satoru| Tazawa, Hiroshi| Kagawa, Shunsuke| Shirakawa, Yasuhiro| Kobayashi, Hisataka| Fujiwara, Toshiyoshi|
Published Date 2021-01-18
Publication Title Scientific Reports
Volume volume11
Issue issue1
Publisher Nature Research
Start Page 1693
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2021
File Version publisher
PubMed ID 33462372
DOI 10.1038/s41598-021-81465-4
Web of Science KeyUT 000612156600008
Related Url isVersionOf https://doi.org/10.1038/s41598-021-81465-4
Author Shigeyasu, Kunitoshi| Tazawa, Hiroshi| Hashimoto, Yuuri| Mori, Yoshiko| Nishizaki, Masahiko| Kishimoto, Hiroyuki| Nagasaka, Takeshi| Kuroda, Shinji| Urata, Yasuo| Goel, Ajay| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Published Date 2014-05-28
Publication Title Gut
Content Type Journal Article
FullText URL fulltext.pdf
Author Uotani, Koji| Tazawa, Hiroshi| Hasei, Joe| Fujiwara, Tomohiro| Yoshida, Aki| Yamakawa, Yasuaki| Omori, Toshinori| Sugiu, Kazuhisa| Komatsubara, Tadashi| Kondo, Hiroya| Morita, Takuya| Kiyono, Masahiro| Yokoo, Suguru| Hata, Toshiaki| Kunisada, Toshiyuki| Takeda, Ken| Urata, Yasuo| Fujiwara, Toshiyoshi| Ozaki, Toshifumi|
Published Date 2024-02-20
Publication Title PLoS ONE
Volume volume19
Issue issue2
Publisher Public Library of Science
Start Page e0298292
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 Uotani et al.
File Version publisher
PubMed ID 38377118
DOI 10.1371/journal.pone.0298292
Web of Science KeyUT 001176939600021
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0298292
FullText URL fulltext.pdf
Author Takagi, Kosei| Umeda, Yuzo| Yoshida, Ryuichi| Yoshida, Kazuhiro| Yasui, Kazuya| Sato, Hiroki| Yagi, Takahito| Fujiwara, Toshiyoshi|
Keywords Accessory papilla of the duodenum Neuroendocrine tumor Carcinoid tumor
Published Date 2021-06-30
Publication Title Surgical Case Reports
Volume volume7
Issue issue1
Publisher Springer
Start Page 156
ISSN 2198-7793
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2021.
File Version publisher
PubMed ID 34191176
DOI 10.1186/s40792-021-01241-4
Web of Science KeyUT 000671314900002
Related Url isVersionOf https://doi.org/10.1186/s40792-021-01241-4
FullText URL fulltext.pdf
Author Yoshida, Kazuhiro| Umeda, Yuzo| Iwamuro, Masaya| Matsumoto, Kazuyuki| Kato, Hironari| Uka, Mayu| Matsui, Yusuke| Yoshida, Ryuichi| Kuise, Takashi| Yasui, Kazuya| Takagi, Kosei| Araki, Hiroyuki| Yagi, Takahito| Fujiwara, Toshiyoshi|
Keywords Hemobilia Bile duct resection Hepatectomy Endoscopic balloon tamponade Case report
Published Date 2020-12-01
Publication Title BMC Surgery
Volume volume20
Issue issue1
Publisher BMC
Start Page 307
ISSN 1471-2482
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2020.
File Version publisher
PubMed ID 33261613
DOI 10.1186/s12893-020-00981-8
Web of Science KeyUT 000595042700001
Related Url isVersionOf https://doi.org/10.1186/s12893-020-00981-8
JaLCDOI 10.18926/AMO/52898
FullText URL 68_5_291.pdf
Author Tsuzaki, Ryuichiro| Takaki, Akinobu| Yagi, Takahito| Ikeda, Fusao| Koike, Kazuko| Iwasaki, Yoshiaki| Shiraha, Hidenori| Miyake, Yasuhiro| Sadamori, Hiroshi| Shinoura, Susumu| Umeda, Yuzo| Yoshida, Ryuichi| Nobuoka, Daisuke| Utsumi, Masashi| Nakayama, Eiichi| Fujiwara, Toshiyoshi| Yamamoto, Kazuhide|
Abstract It is not known how the immune system targets hepatitis C virus (HCV)-infected HLA-mismatched hepatocytes under immune-suppressed conditions after orthotopic liver transplantation (OLT). In addition, the relationship between the HCV-specific immune response and IL28B variants as predictors of HCV clearance has not been well-characterized. We determined the IL28B polymorphisms for 57 post-OLT HCV carriers, and we assessed the HCV-specific immune responses by measuring the peripheral blood mononuclear cell-derived HCV-specific interferon-gamma (IFN-γ) response using an enzyme-linked immunospot assay. At 1-3 years after OLT, patients with no active hepatitis showed higher total spots on the immunospot assay. At>3 years after OLT, patients with resolved HCV showed higher levels of core, NS3, NS5A, and total spots compared to the chronic hepatitis patients. The IL28B major genotype in the donors correlated with higher spot counts for NS5A and NS5B proteins at 1-3 years after OLT. In the post-OLT setting, the HCV-specific immune response could be strongly induced in patients with no active hepatitis with an IL28B major donor or sustained virological response. Strong immune responses in the patients with no active hepatitis could only be maintained for 3 years and diminished later. It may be beneficial to administer IFN treatment starting 3 years after OLT, to induce the maximum immunological effect.
Keywords interferon gamma ELISPOT assay single nucleotide polymorphisms dendritic cell CD4 T cell
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2014-10
Volume volume68
Issue issue5
Publisher Okayama University Medical School
Start Page 291
End Page 302
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2014 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25338486
Web of Science KeyUT 000343269300006
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/53129
FullText URL fulltext.pdf Graphical_Abstract.pptx Figure1-6.pdf Supp_Info.pdf
Author Kanaya, Nobuhiko| Kuroda, Shinji| Kakiuchi, Yoshihiko| Kumon, Kento| Tsumura, Tomoko| Hashimoto, Masashi| Morihiro, Toshiaki| Kubota, Tetsushi| Aoyama, Katsuyuki| Kikuchi, Satoru| Nishizaki, Masahiko| Kagawa, Shunsuke| Tazawa, Hiroshi| Mizuguchi, Hiroyuki| Urata, Yasuo| Fujiwara, Toshiyoshi|
Keywords immune checkpoint programmed death-1 oncolytic adenovirus combined immunotherapy immunogenic cell death tumor infiltrating lymphocytes CD8 abscopal effect
Published Date 2020-01-10
Publication Title Molecular Therapy
Volume volume28
Issue issue3
Publisher Cell Press
Start Page 794
End Page 804
ISSN 15250016
NCID AA11475060
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 31991110
DOI 10.1016/j.ymthe.2020.01.003
Web of Science KeyUT 000518887200012
Related Url isVersionOf https://doi.org/10.1016/j.ymthe.2020.01.003
JaLCDOI 10.18926/AMO/31570
FullText URL fulltext.pdf
Author Matsuoka, Junji| Sakagami, Kenichi| Fujiwara, Toshiyoshi| Onoda, Tadashi| Idani, Hitoshi| Gochi, Akira| Orita, Kunzo|
Abstract

A sustained release system for interleukin-2 (IL-2), and IL-2 mini-pellet (IL-2 mp), was developed by fusing IL-2 into a needle shaped collagen. Serum concentration of IL-2 after a single subcutaneous injection of the IL-2 mp into C57BL/6 mice remained elevated longer than after an injection of aqueous IL-2. IL-2 in the serum became undetectable by 6h after a subcutaneous injection of 1 x 10(6) unit of IL-2 in phosphate-buffered saline (PBS). In contrast, after a single subcutaneous injection of IL-2 mp containing the same amount of IL-2, the concentration of IL-2 increased to its maximum at 6h after injection, then began to decrease gradually. IL-2 was detected even on the third day after a single subcutaneous injection of one IL-2 mp. Augmentation of NK activity and generation of IL-2 activated killer cells were observed in the spleen from day 1--day 3 after a single subcutaneous injection of IL-2 mp into C57BL/6 mice. This activation was not observed following a single subcutaneous injection of the same amount of IL-2 in PBS. Adoptive immunotherapy by a single subcutaneous injection of IL-2 mp followed by intravenous injections of in vitro cultured IL-2 activated killer cells showed better results in decreasing the number of metastases of Lewis lung carcinoma in C57BL/6 mice than immunotherapy using IL-2 solution.(ABSTRACT TRUNCATED AT 250 WORDS)

Keywords IL-2 drug delivery system immunotherapy mouse
Amo Type Article
Publication Title Acta Medica Okayama
Published Date 1993-04
Volume volume47
Issue issue2
Publisher Okayama University Medical School
Start Page 79
End Page 84
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
File Version publisher
Refereed True
PubMed ID 8506753
Web of Science KeyUT A1993LA45200002
FullText URL fulltext.pdf
Author Takagi, Kosei| Noma, Kazuhiro| Nagai, Yasuo| Kikuchi, Satoru| Umeda, Yuzo| Yoshida, Ryuichi| Fuji, Tomokazu| Yasui, Kazuya| Tanaka, Takehiro| Kashima, Hajime| Yagi, Takahito| Fujiwara, Toshiyoshi|
Keywords ampullary carcinoma carcinomas of the papilla of Vater cancer-associated fibroblast outcome survival recurrence
Published Date 2023-03-16
Publication Title Frontiers in Oncology
Volume volume13
Publisher Frontiers Media
Start Page 1072106
ISSN 2234-943X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Takagi, Noma, Nagai, Kikuchi, Umeda, Yoshida, Fuji, Yasui, Tanaka, Kashima, Yagi and Fujiwara.
File Version publisher
PubMed ID 37007101
DOI 10.3389/fonc.2023.1072106
Web of Science KeyUT 000961528000001
Related Url isVersionOf https://doi.org/10.3389/fonc.2023.1072106
FullText URL fulltext20210928-1.pdf
Author Umeda, Yuzo| Mitsuhashi, Toshiharu| Kojima, Toru| Satoh, Daisuke| Sui, Kenta| Endo, Yoshikatsu| Inagaki, Masaru| Oishi, Masahiro| Yagi, Takahito| Fujiwara, Toshiyoshi|
Keywords intrahepatic cholangiocarcinoma lymph node excision multicenter study propensity score retrospective studies
Note This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.|
Published Date 2021-9-16
Publication Title Journal of Hepato-Biliary-Pancreatic Sciences
Publisher Wiley
Start Page 1
End Page 13
ISSN 1868-6974
NCID AA12507209
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 The Authors. Journal of Hepato-Biliary-Pancreatic Sciences published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Hepato-Biliary-Pancreatic Surgery.
File Version publisher
PubMed ID 34473411
DOI 10.1002/jhbp.1038
Web of Science KeyUT 000696321700001
Related Url isVersionOf https://doi.org/10.1002/jhbp.1038