| FullText URL | fulltext.pdf |
|---|---|
| Author | Yoshioka, Takahiro| Shien, Kazuhiko| Takeda, Tatsuaki| Takahashi, Yuta| Kurihara, Eisuke| Ogoshi, Yusuke| Namba, Kei| Torigoe, Hidejiro| Sato, Hiroki| Tomida, Shuta| Yamamoto, Hiromasa| Soh, Junichi| Fujiwara, Toshiyoshi| Toyooka, Shinichi| |
| Keywords | afatinib gastric cancer HER2 MET YES1 |
| Published Date | 2019-06-04 |
| Publication Title | Cancer Science |
| Volume | volume110 |
| Issue | issue8 |
| Publisher | Wiley Open Access |
| Start Page | 2549 |
| End Page | 2557 |
| ISSN | 1347-9032 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 The Authors. |
| File Version | publisher |
| PubMed ID | 31162771 |
| DOI | 10.1111/cas.14089 |
| Web of Science KeyUT | 000478616800022 |
| Related Url | isVersionOf https://doi.org/10.1111/cas.14089 |
| FullText URL | fulltext20210607-4.pdf table1-20210607-4.pdf table2-20210607-4.pdf figure-20210607-4.pdf |
|---|---|
| Author | Kikuchi, Satoru| Kagawa, Tetsuya| Kuroda, Shinji| Nishizaki, Masahiko| Takata, Nobuo| Kuwada, Kazuya| Shoji, Ryohei| Kakiuchi, Yoshihiko| Mitsuhashi, Toshiharu| Umeda, Yuzo| Noma, Kazuhiro| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| Keywords | Endoscopic surgical skill quantification system Qualified surgeon Laparoscopic distal gastrectomy Gastric cancer Cumulative sum analysis |
| Note | This is a post-peer-review, pre-copyedit version of an article published in [Surgery Today]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00595-021-02309-2| |
| Published Date | 2021-5-29 |
| Publication Title | Surgery Today |
| Volume | volume51 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 1978 |
| End Page | 1984 |
| ISSN | 0941-1291 |
| NCID | AA10824685 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Springer Nature Singapore Pte Ltd. 2021 |
| File Version | author |
| PubMed ID | 34050804 |
| DOI | 10.1007/s00595-021-02309-2 |
| Web of Science KeyUT | 000655944300001 |
| Related Url | isVersionOf https://doi.org/10.1007/s00595-021-02309-2 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hata, Nanako| Shigeyasu, Kunitoshi| Umeda, Yuzo| Yano, Shuya| Takeda, Sho| Yoshida, Kazuhiro| Fuji, Tomokazu| Yoshida, Ryuichi| Yasui, Kazuya| Umeda, Hibiki| Takahashi, Toshiaki| Kondo, Yoshitaka| Kishimoto, Hiroyuki| Mori, Yoshiko| Teraishi, Fuminori| Yamamoto, Hideki| Michiue, Hiroyuki| Nakamura, Keiichiro| Tazawa, Hiroshi| Fujiwara, Toshiyoshi| |
| Note | The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-023-29397-z| |
| Published Date | 2023-02-06 |
| Publication Title | Scientific Reports |
| Volume | volume13 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 2078 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 36747029 |
| DOI | 10.1038/s41598-023-29397-z |
| Web of Science KeyUT | 000989985700018 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-023-29397-z |
| Author | Kojima, Toru| Hashimoto, Yuuri| Watanabe, Yuichi| Kagawa, Shunsuke| Uno, Futoshi| Kuroda, Shinji| Tazawa, Hiroshi| Kyo, Satoru| Mizuguchi, Hiroyuki| Urata, Yasuo| Tanaka, Noriaki| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2009-10-01 |
| Publication Title | The Journal of Clinical Investigation |
| Volume | volume119 |
| Issue | issue10 |
| Content Type | Journal Article |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Takagi, Kosei| Umeda, Yuzo| Kuise, Takashi| Yoshida, Ryuichi| Yoshida, Kazuhiro| Yasui, Kazuya| Tani, Yuma| Yagi, Takahito| Fujiwara, Toshiyoshi| |
| Keywords | Hanging maneuver Laparoscopic Liver resection |
| Published Date | 2020-10-08 |
| Publication Title | International Journal of Surgery Case Reports |
| Volume | volume76 |
| Publisher | Elsevier |
| Start Page | 251 |
| End Page | 253 |
| ISSN | 2210-2612 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Author(s). |
| File Version | publisher |
| PubMed ID | 33053483 |
| DOI | 10.1016/j.ijscr.2020.10.002 |
| Related Url | isVersionOf https://doi.org/10.1016/j.ijscr.2020.10.002 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kuroda, Shinji| Ishida, Michihiro| Choda, Yasuhiro| Muraoka, Atsushi| Hato, Shinji| Kagawa, Tetsuya| Tanaka, Norimitsu| Mitsuhashi, Toshiharu| Kakiuchi, Yoshihiko| Kikuchi, Satoru| Nishizaki, Masahiko| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| Keywords | anti-reflux surgery double-flap technique gastric cancer Kamikawa procedure proximal gastrectomy |
| Published Date | 2024-02-22 |
| Publication Title | Annals of Gastroenterological Surgery |
| Publisher | Wiley |
| ISSN | 2475-0328 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 The Authors. |
| File Version | publisher |
| DOI | 10.1002/ags3.12783 |
| Web of Science KeyUT | 001174392500001 |
| Related Url | isVersionOf https://doi.org/10.1002/ags3.12783 |
| JaLCDOI | 10.18926/AMO/54601 |
|---|---|
| FullText URL | 70_5_401.pdf |
| Author | Kuroda, Shinji| Kikuchi, Satoru| Nishizaki, Masahiko| Kagawa, Shunsuke| Hinotsu, Shiro| Fujiwara, Toshiyoshi| |
| Abstract | Although intermittent pneumatic compression (IPC) has become common as perioperative prophylaxis for venous thromboembolism (VTE) consisting of pulmonary thromboembolism (PE) and deep vein thrombosis (DVT), the prophylactic effect against VTE, especially lethal PE, is not yet satisfactory. Therefore, pharmacologic prophylaxis, such as with enoxaparin, is desirable. While the efficacy and safety of enoxaparin have been proven in several clinical trials, concern about bleeding with longterm (at least 7 days) use have potentially decreased its widespread adoption. We have launched a phase II study to evaluate the efficacy and safety of short-term (3 days) enoxaparin, in which a total of 70 gastric cancer patients undergoing gastrectomy will be recruited, and the primary endpoint is the incidence of DVT. This study could contribute to making pharmacologic prophylaxis for VTE more common. |
| Keywords | venous thromboembolism enoxaparin short-term use gastric cancer surgery |
| Amo Type | Clinical Study Protocols |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-10 |
| Volume | volume70 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 401 |
| End Page | 404 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27777435 |
| Web of Science KeyUT | 000388098700012 |
| JaLCDOI | 10.18926/AMO/46626 |
|---|---|
| FullText URL | 65_3_151.pdf |
| Author | Fujiwara, Toshiyoshi| |
| Abstract | Replication-selective tumor-specific viruses constitute a novel approach for treatment of neoplastic disease. These vectors are designed to induce virus-mediated lysis of tumor cells after selective viral propagation within the tumor. Human telomerase is highly active in more than 85ｵ of primary cancers, regardless of their tissue origins, and its activity correlates closely with human telomerase reverse transcriptase (hTERT) expression. We constructed an attenuated adenovirus 5 vector (Telomelysin, OBP-301), in which the hTERT promoter element drives expression of E1 genes. Since only tumor cells that express telomerase activity would activate this promoter, the hTERT proximal promoter would allow for preferential expression of viral genes in tumor cells, leading to selective viral replication and oncolytic cell death. Lymphatic invasion is a major route for cancer cell dissemination, and adequate treatment of locoregional lymph nodes is required for curative treatment in patients with gastrointestinal tumors. We demonstrated that intratumoral injection of Telomelysin mediates effective in vivo purging of metastatic tumor cells from regional lymph nodes. Moreover, using noninvasive whole-body imaging, we found that intratumoral injection of Telomelysin followed by regional irradiation induces a substantial antitumor effect, resulting from tumor cell-specific radiosensitization, in an orthotopic human esophageal cancer xenograft model. These results illustrate the potential of oncolytic virotherapy as a promising strategy in the management of human gastrointestinal cancer. |
| Keywords | telomerase adenovirus metastasis lymph node colorectal cancer |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-06 |
| Volume | volume65 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 151 |
| End Page | 162 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21709712 |
| Web of Science KeyUT | 000292017500001 |
| FullText URL | cancers_11_2_177.pdf |
|---|---|
| Author | Katsura, Yuki| Ohara, Toshiaki| Noma, Kazuhiro| Ninomiya, Takayuki| Kashima, Hajime| Kato, Takuya| Sato, Hiroaki| Komoto, Satoshi| Narusaka, Toru| Tomono, Yasuko| Xing, Boyi| Chen, Yuehua| Tazawa, Hiroshi| Kagawa, Shunsuke| Shirakawa, Yasuhiro| Kasai , Tomonari| Seno, Masaharu| Matsukawa, Akihiro| Fujiwara, Toshiyoshi| |
| Keywords | cancer stem cells combination therapy iron stemness |
| Published Date | 2019-02-03 |
| Publication Title | Cancers |
| Volume | volume11 |
| Issue | issue2 |
| Publisher | MDPI |
| Start Page | 177 |
| ISSN | 2072-6694 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 by the authors |
| File Version | publisher |
| PubMed ID | 30717462 |
| DOI | 10.3390/cancers11020177 |
| Web of Science KeyUT | 000460747200051 |
| Related Url | isVersionOf https://doi.org/10.3390/cancers11020177 |
| Author | Yano, Shuya| Tazawa, Hiroshi| Hashimoto, Yuuri| Shirakawa, Yasuhiro| Kuroda, Shinji| Nishizaki, Masahiko| Kishimoto, Hiroyuki| Uno, Futoshi| Nagasaka, Takeshi| Urata, Yasuo| Kagawa, Shunsuke| Hoffman, Robert M.| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2013-12-01 |
| Publication Title | Clinical Cancer Research |
| Volume | volume19 |
| Issue | issue23 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/53672 |
|---|---|
| FullText URL | 69_5_267.pdf |
| Author | Inada, Ryo| Nagasaka, Takeshi| Kondo, Yoshitaka| Watanabe, Ayako| Toshima, Toshiaki| Kubota, Nobuhito| Kikuchi, Satoru| Ishida, Michihiro| Kuroda, Shinji| Mori, Yoshiko| Kishimoto, Hiroyuki| Fujiwara, Toshiyoshi| |
| Abstract | The aim of this single-institution, retrospective, observational case-control study was to evaluate the safety and feasibility of laparoscopic proctocolectomy (PC) for ulcerative colitis (UC), by comparing it with a case-control series of open PC. Twenty UC patients who underwent laparoscopic PC were retrospectively compared with the open PC group of 12 patients matched for age, sex, and urgency of the operation. In the laparoscopic PC group, the operative time was significantly longer, but the amount of blood loss was significantly smaller. The open PC patients underwent an intraoperative blood transfusion significantly more often, and the serum C-reactive protein level on the first postoperative day was significantly higher in the open PC group. In the laparoscopic PC group, the rate of severe postoperative morbidities, grades 3 and 4 on the Clavien-Dindo classification, was significantly lower, and the median length of hospital stay was significantly shorter. Laparoscopic PC for patients with UC showed superior perioperative outcomes to open PC, except for longer operative time. |
| Keywords | laparoscopic surgery total proctocolectomy open proctocolectomy ulcerative colitis case-matched study |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2015-10 |
| Volume | volume69 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 267 |
| End Page | 273 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26490023 |
| Web of Science KeyUT | 000365519600002 |
| JaLCDOI | 10.18926/AMO/64368 |
|---|---|
| FullText URL | 77_1_91.pdf |
| Author | Takahashi, Toshiaki| Kakiuchi, Yoshihiko| Kikuch, Satoru| Kuroda, Shinji| Takeda, Sho| Shigeyasu, Kunitoshi| Kondo, Yoshitaka| Teraishi, Fuminori| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| Abstract | An annular pancreas is a rare anomaly of the pancreas, defined as pancreatic tissue that totally or partly encircles the duodenum, usually the descending portion. A 76-year-old man who was diagnosed with gastric cancer cT3N0M0 Stage IIB underwent laparoscopic distal gastrectomy with D2 lymph node dissection. Intraoperatively, the dorsal half of the duodenal bulb was seen to be half surrounded by the pancreas, and a non-typical annular pancreas was diagnosed. Because of the risk to the pancreas, it was considered impossible to perform anastomosis by a linear stapler as in the usual laparoscopic procedure. Therefore, we performed laparoscopically assisted distal gastrectomy and Billroth-I reconstruction using a circular stapler, and the surgery was completed without difficulties. His postoperative course was good despite the development of a pancreatic fistula, which was an International Study Group for Pancreas Fistula biochemical leak. Some APs can be diagnosed preoperatively, but the rarer subtypes such as ours are more difficult to visualize on imaging. In gastrectomy, it is both oncologically important and technically challenging to perform lymph node dissection around the pancreas. In this case with an especially proximal pancreas, a circular stapler was considered better suited for gastroduodenal anastomosis and required a broader field than that afforded by laparoscopy. A case of non-typical annular pancreas diagnosed during laparoscopic gastric surgery is described. |
| Keywords | annular pancreas gastric cancer laparoscopic distal gastrectomye |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-02 |
| Volume | volume77 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 91 |
| End Page | 95 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36849152 |
| Web of Science KeyUT | 000952978000002 |
| Title Alternative | Thoracoscopic esophagectomy was effective in a case of lower esophageal stenosis due to recurrence of achalasia after myotomy 40 years previously |
|---|---|
| FullText URL | 129_41.pdf |
| Author | Katsura, Yuki| Shirakawa, Yasuhiro| Tanabe, Shunsuke| Maeda, Naomi| Noma, Kazuhiro| Fujiwara, Toshiyoshi| |
| Abstract | When planning surgery for achalasia, it is important to plan for adequate myotomy and prevention of reflux. However, achalasia may recur if the procedure was inadequate or in patients with a long-term course. The present case is a 68-year-old woman who underwent myotomy of the lower esophageal sphincter 40 years ago, but recently reported difficulty in swallowing. Dilatation of the thoracic esophagus and stenosis of the abdominal esophagus were identified by examination, and the patient was diagnosed with recurrence of achalasia. After percutaneous endoscopic gastrostomy was performed to recover nutritional status, thoracoscopic esophagectomy was carried out. The patient'spost-operative course was uneventful and oral intake was enabled. At the time of writing, there has been no re-recurrence. There is no standard therapy for post-operative recurrence of achalasia. We believe that thoracoscopic esophagectomy for the recurrence of achalasia is a safe and minimally invasive alternative to conventional surgery. |
| Keywords | 食道アカラシア (achalasia) 再手術 (reoperation) 食道亜全摘 (esophagectomy) |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2017-04-03 |
| Volume | volume129 |
| Issue | issue1 |
| Start Page | 41 |
| End Page | 44 |
| ISSN | 0030-1558 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2017 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.129.41 |
| NAID | 130005632071 |
