Author Hao, Hui-fang| Takaoka, Munenori| Bao, Xiao-hong| Wang, Zhi-gang| Tomono, Yasuko| Sakurama, Kazufumi| Ohara, Toshiaki| Fukazawa, Takuya| Yamatsuji, Tomoki| Fujiwara, Toshiyoshi| Naomoto, Yoshio|
Published Date 2012-07-13
Publication Title Biochemical and Biophysical Research Communications
Volume volume423
Issue issue4
Content Type Journal Article
FullText URL fulltext.pdf
Author Fuji, Tomokazu| Umeda, Yuzo| Takagi, Kosei| Yoshida, Ryuichi| Yoshida, Kazuhiro| Yasui, Kazuya| Matsumoto, Kazuyuki| Kato, Hironari| Yagi, Takahito| Fujiwara, Toshiyoshi|
Keywords Pancreatic intraductal neoplasms Pancreatectomy Recurrence
Published Date 2022-05-29
Publication Title BMC Cancer
Volume volume22
Issue issue1
Publisher BMC
Start Page 588
ISSN 1471-2407
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022.
File Version publisher
PubMed ID 35643422
DOI 10.1186/s12885-022-09650-w
Web of Science KeyUT 000801165400001
Related Url isVersionOf https://doi.org/10.1186/s12885-022-09650-w
FullText URL fulltext.pdf
Author Araki, Hiroyuki| Tazawa, Hiroshi| Kanaya, Nobuhiko| Kajiwara, Yoshinori| Yamada, Motohiko| Hashimoto, Masashi| Kikuchi, Satoru| Kuroda, Shinji| Yoshida, Ryuichi| Umeda, Yuzo| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Published Date 2022-12-15
Publication Title Molecular Therapy - Oncolytics
Volume volume27
Publisher Cell Press
Start Page 3
End Page 13
ISSN 2372-7705
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Author(s).
File Version publisher
PubMed ID 36212775
DOI 10.1016/j.omto.2022.09.003
Web of Science KeyUT 000870232500001
Related Url isVersionOf https://doi.org/10.1016/j.omto.2022.09.003
FullText URL fulltext20210628-1.pdf Figure_20210628-1.pdf Supple_Figure_20210628-1.pdf Supple_Table_20210628-1.pdf
Author Sugiu, Kazuhisa| Tazawa, Hiroshi| Hasei, Joe| Yamakawa, Yasuaki| Omori, Toshinori| Komatsubara, Tadashi| Mochizuki, Yusuke| Kondo, Hiroya| Osaki, Shuhei| Fujiwara, Tomohiro| Yoshida, Aki| Kunisada, Toshiyuki| Ueda, Koji| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi|
Keywords Osteosarcoma Chemoresistance MDR1 Oncolytic adenovirus p53
Note This is a post-peer-review, pre-copyedit version of an article published in Cancer Chemotherapy and Pharmacology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00280-021-04310-5|
Published Date 2021-6-10
Publication Title Cancer Chemotherapy and Pharmacology
Volume volume88
Issue issue3
Publisher Springer Science and Business Media LLC
Start Page 513
End Page 524
ISSN 0344-5704
NCID AA00598397
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 34114067
DOI 10.1007/s00280-021-04310-5
Web of Science KeyUT 000659839700002
Related Url isVersionOf https://doi.org/10.1007/s00280-021-04310-5
FullText URL fulltext.pdf
Author Omori, Toshinori| Tazawa, Hiroshi| Yamakawa, Yasuaki| Osaki, Shuhei| Hasei, Joe| Sugiu, Kazuhisa| Komatsubara, Tadashi| Fujiwara, Tomohiro| Yoshida, Aki| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi|
Keywords Gastric yolk sac Tumor-like carcinoma Adenocarcinoma; Alpha-fetoprotein
Published Date 2021-04-22
Publication Title PLoS ONE
Volume volume16
Issue issue4
Publisher Public Library Science
Start Page e0250643
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 Omori et al.
File Version publisher
PubMed ID 33886686
NAID 120007045007
DOI 10.1371/journal.pone.0250643
Web of Science KeyUT 000644138300019
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0250643
FullText URL fulltext.pdf
Author Koujima, Takeshi| Tazawa, Hiroshi| Ieda, Takeshi| Araki, Hiroyuki| Fushimi, Takuro| Shoji, Ryohei| Kuroda, Shinji| Kikuchi, Satoru| Yoshida, Ryuichi| Umeda, Yuzo| Teraishi, Fuminori| Urata, Yasuo| Mizuguchi, Hiroyuki| Fujiwara, Toshiyoshi|
Published Date 2020-06-26
Publication Title Molecular Therapy - Oncolytics
Volume volume17
Publisher Cell Press
Start Page 107
End Page 117
ISSN 2372-7705
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Author(s).
File Version publisher
PubMed ID 32322667
DOI 10.1016/j.omto.2020.03.016
Web of Science KeyUT 000544101600010
Related Url isVersionOf https://doi.org/10.1016/j.omto.2020.03.016
JaLCDOI 10.18926/AMO/52006
FullText URL 67_6_333.pdf
Author Tazawa, Hiroshi| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Abstract Autophagy is a catabolic process that produces energy through lysosomal degradation of intracellular organelles. Autophagy functions as a cytoprotective factor under physiological conditions such as nutrient deprivation, hypoxia, and interruption of growth factors. On the other hand, infection with pathogenic viruses and bacteria also induces autophagy in infected cells. Oncolytic virotherapy with replication-competent viruses is thus a promising strategy to induce tumor-specific cell death. Oncolytic adenoviruses induce autophagy and subsequently contribute to cell death rather than cell survival in tumor cells. We previously developed a telomerase-specific replication-competent oncolytic adenovirus, OBP-301, which induces cell lysis in tumor cells with telomerase activities. OBP-301-mediated cytopathic activity is significantly associated with induction of autophagy biomarkers. In this review, we focus on the tumor-suppressive role and molecular basis of autophagic machinery induced by oncolytic adenoviruses. Addition of tumor-specific promoters and modification of the fiber knob of adenoviruses supports the oncolytic adenovirus-mediated autophagic cell death. Autophagy is cooperatively regulated by the E1-dependent activation pathway, E4-dependent inhibitory pathway, and microRNA-dependent fine-tuning. Thus, future exploration of the functional role and molecular mechanisms underlying oncolytic adenovirus-induced autophagy would provide novel insights and improve the therapeutic potential of oncolytic adenoviruses.
Keywords oncolytic adenovirus autophagy E2F1 microRNA
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2013-12
Volume volume67
Issue issue6
Publisher Okayama University Medical School
Start Page 333
End Page 342
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 24356717
Web of Science KeyUT 000328915700001
JaLCDOI 10.18926/AMO/66160
FullText URL 77_6_665.pdf
Author Sakurai, Atsunobu| Uka, Mayu| Iguchi, Toshihiro| Tomita, Koji| Matsui, Yusuke| Kakiuchi, Yoshihiko| Kuroda, Shinji| Fujiwara, Toshiyoshi| Hiraki, Takao|
Abstract We report the case details of a 65-year-old Japanese man with an omental abscess that was discovered 43 days after he underwent a laparoscopic proximal gastrectomy for gastric cancer. His chief complaint was mild abdominal pain that had persisted for several days. The abscess was diagnosed as a rare postoperative complication. We hesitated to perform a reoperation given the invasiveness of general anesthesia and surgery, plus the possibility of postoperative adhesions and because the patient’s general condition was stable and he had only mild abdominal pain. Percutaneous drainage using a 10.2-F catheter was performed with the patient under conscious sedation and computed tomography–fluoroscopy guidance, with no complications. After the procedure, the size of the abscess cavity was remarkably reduced, and 23 days later the catheter was withdrawn.
Keywords drainage omental abscess omental infarction proximal gastrectomy
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2023-12
Volume volume77
Issue issue6
Publisher Okayama University Medical School
Start Page 665
End Page 669
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38145942
Web of Science KeyUT 001164631200013
JaLCDOI 10.18926/AMO/53675
FullText URL 69_5_291.pdf
Author Sugiu, Kumi| Iwamoto, Takayuki| Kelly, Catherine M.| Watanabe, Naoki| Motoki, Takayuki| Itoh, Mitsuya| Ohtani, Shoichiro| Higaki, Kenji| Imada, Takako| Yuasa, Takeshi| Omori, Masako| Sonobe, Hiroshi| Fujiwara, Toshiyoshi| Matsuoka, Junji|
Abstract Although in the neoadjuvant setting for estrogen receptor (ER)-positive breast cancers, chemotherapy or hormone therapy alone does not result in satisfactory tumor response, it is unknown whether concurrent chemo-endocrine therapy is superior to chemotherapy alone in clinical outcomes. We conducted a randomized phase II trial to test the responses of ER-positive patients to concurrent administration of chemo-endocrine therapy in the neoadjuvant setting. Women with stage II-III, ER-positive, invasive breast cancer (n=28) received paclitaxel followed by fluorouracil, epirubicin, cyclophosphamide (T-FEC) and were randomized to receive concurrent chemo-endocrine therapy consisting of goserelin administered subcutaneously for premenopausal women or an aromatase inhibitor for postmenopausal women. The primary endpoint was the pathological complete response (pCR) rate after neoadjuvant therapy. Twenty-eight patients were randomized. There were no significant differences in pCR rate between the concurrent group (12.5%;2/16) and the chemotherapy alone group (8.3%;1/12). Tumor size after therapy was significantly reduced in the concurrent therapy group (p=0.035), but not in the chemotherapy-alone group (p=0.622). Neoadjuvant chemotherapy with concurrent hormone therapy provided no significant improvement in pCR rate in ER-positive breast cancers. These preliminary results should be followed up by further studies.
Keywords breast cancer neoadjuvant chemotherapy concurrent hormone therapy estrogen receptor positive tumor response
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2015-10
Volume volume69
Issue issue5
Publisher Okayama University Medical School
Start Page 291
End Page 299
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 26490026
Web of Science KeyUT 000365519600005
FullText URL AnnGastroenterolSurg_3_4_396.pdf
Author Fujiwara, Toshiyoshi|
Keywords adenovirus clinical trial esophageal cancer radiotherapy telomerase
Published Date 2019-07-05
Publication Title Annals of gastroenterological surgery
Volume volume3
Issue issue4
Publisher John Wiley & Sons
Start Page 396
End Page 404
ISSN 24750328
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2019 The Authors
File Version publisher
PubMed ID 31346579
DOI 10.1002/ags3.12270
Web of Science KeyUT 000475745100009
Related Url isVersionOf https://doi.org/10.1002/ags3.12270
Author Fujiwara, Y.| Yamada, T.| Naomoto, Y.| Yamatsuji, T.| Shirakawa, Y.| Tanabe, S.| Noma, K.| Kimura, T.| Aoki, H.| Matsukawa, H.| Kimura, M.| Nonaka, Y.| Sasaki, H.| Onoda, T.| Otawa, Y.| Takaoka, M.| Fukazawa, T.| Ohno, Y.| Fujiwara, T.|
Published Date 2013-12
Publication Title Journal of Hospital Infection
Volume volume85
Issue issue4
Content Type Journal Article
FullText URL AGS3_1_96.pdf SI.pdf
Author Kuroda, Shinji| Choda, Yasuhiro| Otsuka, Shinya| Ueyama, Satoshi| Tanaka, Norimitsu| Muraoka, Atsushi| Hato, Shinji| Kimura, Toshikazu| Tanakaya, Kohji| Kikuchi, Satoru| Tanabe, Shunsuke| Noma, Kazuhiro| Nishizaki, Masahiko| Kagawa, Shunsuke| Shirakawa, Yasuhiro| Kamikawa, Yasuaki| Fujiwara, Toshiyoshi|
Keywords Kamikawa procedure antireflux surgery double‐flap technique esophagogastrostomy proximal gastrectomy
Published Date 2018-10-11
Publication Title Annals of Gastroenterological Surgery
Volume volume3
Issue issue1
Publisher Woley
Start Page 96
End Page 103
ISSN 2475-0328
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2018 The Authors
File Version publisher
PubMed ID 30697614
DOI 10.1002/ags3.12216
Web of Science KeyUT 000456643500012
Related Url isVersionOf https://doi.org/10.1002/ags3.12216
FullText URL fulltext.pdf
Author Ogawa, Toshihiro| Kikuchi, Satoru| Tabuchi, Motoyasu| Mitsui, Ema| Une, Yuta| Tazawa, Hiroshi| Kuroda, Shinji| Noma, Kazuhiro| Ohara, Toshiaki| Kagawa, Shunsuke| Urata, Yasuo| Fujiwara, Toshiyoshi|
Published Date 2022-06-16
Publication Title Molecular Therapy-Oncolytics
Volume volume25
Publisher Cell Press
Start Page 249
End Page 261
ISSN 2372-7705
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Author(s).
File Version publisher
PubMed ID 35615263
DOI 10.1016/j.omto.2022.04.009
Web of Science KeyUT 000800437000008
Related Url isVersionOf https://doi.org/10.1016/j.omto.2022.04.009
Author Yoshida, Ryosuke| Tazawa, Hiroshi| Hashimoto, Yuuri| Yano, Shuya| Onishi, Teppei| Sasaki, Tsuyoshi| Shirakawa, Yasuhiro| Kishimoto, Hiroyuki| Uno, Futoshi| Nishizaki, Masahiko| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Published Date 2012-11
Publication Title Cancer Immunology, Immunotherapy
Volume volume61
Issue issue11
Content Type Journal Article
Author Kondo, Yoshitaka| Nagasaka, Takeshi| Kobayashi, Satoru| Kobayashi, Naoya| Fujiwara, Toshiyoshi|
Published Date 2014-03
Publication Title Hepato-Gastroenterology
Volume volume61
Issue issue130
Content Type Journal Article
FullText URL fulltext20210608.pdf
Author Umeda, Hibiki| Kikuchi, Satoru| Kuroda, Shinji| Yano, Shuya| Tanaka, Takehiro| Noma, Kazuhiro| Nishizaki, Masahiko| Kagawa, Shunsuke| Umeda, Yuzo| Fujiwara, Toshiyoshi|
Keywords Gastric yolk sac Tumor-like carcinoma Adenocarcinoma Alpha-fetoprotein
Published Date 2021-05-06
Publication Title Surgical Case Reports
Volume volume7
Issue issue1
Publisher Springer
Start Page 111
ISSN 2198-7793
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2021.
File Version publisher
PubMed ID 33956241
NAID 120007045008
DOI 10.1186/s40792-021-01199-3
Web of Science KeyUT 000656467700001
Related Url isVersionOf https://doi.org/10.1186/s40792-021-01199-3
FullText URL fulltext20240219-05.pdf
Author Hashimoto, Masashi| Kuroda, Shinji| Kanaya, Nobuhiko| Kadowaki, Daisuke| Yoshida, Yusuke| Sakamoto, Masaki| Hamada, Yuki| Sugimoto, Ryoma| Yagi, Chiaki| Ohtani, Tomoko| Kumon, Kento| Kakiuchi, Yoshihiko| Yasui, Kazuya| Kikuchi, Satoru| Yoshida, Ryuichi| Tazawa, Hiroshi| Kagawa, Shunsuke| Yagi, Takahito| Urata, Yasuo| Fujiwara, Toshiyoshi|
Note The version of record of this article, first published in British Journal of Cancer, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41416-024-02583-0|
Published Date 2024-02-05
Publication Title British Journal of Cancer
Volume volume130
Issue issue7
Publisher Springer Science and Business Media LLC
Start Page 1187
End Page 1195
ISSN 0007-0920
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2024
File Version publisher
PubMed ID 38316993
DOI 10.1038/s41416-024-02583-0
Web of Science KeyUT 001156904400001
Related Url isVersionOf https://doi.org/10.1038/s41416-024-02583-0
JaLCDOI 10.18926/AMO/61906
FullText URL 75_2_231.pdf
Author Endo, Motochika| Yano, Shuya| Asano, Hiroaki| Takeda, Sho| Hamada, Yuki| Kondo, Yoshitaka| Kuroda, Shinji| Shigeyasu, Kunitoshi| Kikuchi, Satoru| Tanaka, Takehiro| Teraishi, Fuminori| Nishizaki, Masahiko| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Abstract Targeted therapies for malignant melanoma have improved patients’ prognoses. A primary gastrointestinal malignant melanoma is very rare, with no standard treatment strategy. We treated a 78-year-old Japanese female with advanced primary gastrointestinal melanoma of the descending colon and gallbladder. We administered a multidisciplinary treatment: surgical resection of the descending colon and gallbladder tumors, resection of the metastatic lymph nodes behind the pancreas head, and immune checkpoint antibody-blockade therapy (nivolumab) for ~4 years. PET/CT demonstrated no recurrent lesion for > 3 years. Multidisciplinary therapies (e.g., surgery, chemotherapy, radiotherapy, target therapy, and immune checkpoint antibody-blockade therapy) can successfully treat primary gastrointestinal malignant melanoma.
Keywords primary gastrointestinal melanoma laparoscopic surgery immune checkpoint antibody-blockade inhibitor
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2021-04
Volume volume75
Issue issue2
Publisher Okayama University Medical School
Start Page 231
End Page 238
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33953431
NAID 120007029881
JaLCDOI 10.18926/AMO/65152
FullText URL 77_2_209.pdf
Author Sakamoto, Masaki| Teraishi, Fuminori| Shigeyasu Kunitoshi| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Abstract A 70-year-old male with anal pain and fever was diagnosed with rectal cancer perforation and abscess in the right gluteus maximus (GM) muscle. He underwent a transverse colon colostomy followed by preoperative capecitabine+oxaliplatin. Some local control was achieved but a residual abscess was observed in the right GM muscle. To secure circumferential resection margin by tumor reduction, he received chemoradiotherapy as total neoadjuvant therapy (TNT) and underwent laparoscopic abdominoperineal resection, D3 lymph node dissection, combined coccyx resection, and partial resection of the right GM muscle. The skin defect and pelvic dead space were filled with a right lateral vastus lateral great muscle flap. Histopathologically, the resected specimen showed no tumor cells in the primary tumor or lymph nodes, indicating a pathological complete response (pCR). This case suggests that TNT might improve the R0 resection and pCR rates and overall survival.
Keywords locally advanced rectal cancer total neoadjuvant therapy lateral vastus lateral great muscle flap
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2023-04
Volume volume77
Issue issue2
Publisher Okayama University Medical School
Start Page 209
End Page 213
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37094960
Web of Science KeyUT 000982563800003
FullText URL fulltext20211015-3.pdf figure20211015-3.pdf Suppl_Information20211015-3.pdf
Author Kakiuchi, Yoshihiko| Kuroda, Shinji| Kanaya, Nobuhiko| Kumon, Kento| Tsumura, Tomoko| Hashimoto, Masashi| Yagi, Chiaki| Sugimoto, Ryoma| Hamada, Yuki| Kikuchi, Satoru| Nishizaki, Masahiko| Kagawa, Shunsuke| Tazawa, Hiroshi| Urata, Yasuo| Fujiwara, Toshiyoshi|
Keywords Extracellular vesicles Exosome Abscopal effect Oncolytic adenovirus Local treatment Systemic delivery Drug delivery system
Note © 2021 The American Society of Gene and Cell Therapy. This manuscript version is made available under the CC-BY-NC-ND 4.0 License.http://creativecommons.org/licenses/by-nc-nd/4.0/.This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.ymthe.2021.05.015] .|
Published Date 2021-05-21
Publication Title Molecular Therapy
Volume volume29
Issue issue10
Publisher The American Society of Gene and Cell Therapy
Start Page 2920
End Page 2930
ISSN 15250016
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 The American Society of Gene and Cell Therapy.
File Version author
PubMed ID 34023506
DOI 10.1016/j.ymthe.2021.05.015
Web of Science KeyUT 000708324600008
Related Url isVersionOf https://doi.org/10.1016/j.ymthe.2021.05.015