| Author | Shinomiya, Kazuaki| Kitamura, Yoshihisa| Ueshima, Satoshi| Satoh, Tomoaki| Sendo, Toshiaki| |
|---|---|
| Published Date | 2008-05-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume120 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Sagara, Hidenori| Kitamura, Yoshihisa| Sendo, Toshiaki| Gomita, Yutaka| |
|---|---|
| Published Date | 2007-05-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Fujiwara, Satoko| Sendo, Toshiaki| |
|---|---|
| Published Date | 2007-09-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Sato, Tomoaki| Ueshima, Satoshi| Sendo, Toshiaki| |
|---|---|
| Published Date | 2007-09-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Matsunaga, Hisashi| Sendo, Toshiaki| |
|---|---|
| Published Date | 2008-01-04 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Yokohari, Hideko| Okazaki, Masatoshi| Sendo, Toshiaki| |
|---|---|
| Published Date | 2008-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume120 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Katsube, Risa| Sendo, Toshiaki| |
|---|---|
| Published Date | 2008-12-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume120 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Nawa, Hideki| Sendo, Toshiaki| |
|---|---|
| Published Date | 2009-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume121 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Sendo, Toshiaki| |
|---|---|
| Published Date | 2009-08-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume121 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Kuroda, Satoshi| Isozaki, Hideko| Matsunaga, Hisashi| Sendo, Toshiaki| |
|---|---|
| Published Date | 2009-12-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume121 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Kawasaki, Yoichi| Matsunaga, Hisashi| Sendo, Toshiaki| |
|---|---|
| Published Date | 2010-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume122 |
| Issue | issue1 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/30940 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Sagara, Hidenori| Kitamura, Yoshihisa| Esumi, Satoru| Sendo, Toshiaki| Araki, Hiroaki| Gomita, Yutaka| |
| Abstract | <p>It is well known that priming stimulation promotes the motivational effects of intracranial self-stimulation(ICSS) behavior. An experimental methodology using the runway method could separately study the reward and motivational effects of ICSS behavior. In the present study, we examined the motivational effect of nicotine as measured by the runway method using priming stimulation of ICSS behavior. Electrodes were implanted chronically into the medial forebrain bundle (MFB) in rats. A lever for stimulation of the MFB was set on the opposite side of the start box in the apparatus, and rats were trained to get a reward stimulation (50-200 microA, 0.2 ms, 60 Hz) of MFB when the goal lever was pressed. After the rats were trained to press the lever, a priming stimulation of the MFB was performed. After receiving the priming stimulation, rats were placed at the start box of the runway apparatus, and the running time duration until the goal lever was pressed was measured. Subcutaneous injection of nicotine at a dose of 0.2mg/kg produced an increase in running speed to obtain the reward stimulation, and priming stimulation facilitated the motivational effect to obtain the electrical brain stimulation reward in the rats. These results suggest that nicotine significantly enhanced the motivational effect on ICSS behavior as determined using the runway method. The runway method using priming stimulation of ICSS behavior may become the new experimental methodology with which to measure the motivational effect of some drugs.</p> |
| Keywords | intracranial self-stimulation runway nicotine priming stimulation motivational effect |
| Amo Type | Original Article |
| Published Date | 2008-08 |
| Publication Title | Acta Medica Okayama |
| Volume | volume62 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 227 |
| End Page | 233 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 18766205 |
| Web of Science KeyUT | 000258680900002 |
| Author | Kitamura, Yoshihisa| Akiyama, Kozue| Kitagawa, Kouhei| Shibata, Kazuhiko| Kawasaki, Hiromu| Suemaru, Katsuya| Araki, Hiroaki| Sendo, Toshiaki| Gomita, Yutaka| |
|---|---|
| Published Date | 2008-05-20 |
| Publication Title | Pharmacology Biochemistry and Behavior |
| Volume | volume89 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Miyazaki, Toshiaki| Nishikori, Atsumi| Matsunaga, Hisashi| Sendo, Toshiaki| |
|---|---|
| Published Date | 2010-08-02 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume122 |
| Issue | issue2 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/40129 |
|---|---|
| FullText URL | 64_4_219.pdf |
| Author | Doi, Maho| Miyazaki, Ikuko| Nagamachi, Tomoko| Shinomiya, Kazuaki| Matsunaga, Hisashi| Sendo, Toshiaki| Kawasaki, Hiromu| Asanuma, Masato| Gomita, Yutaka| Kitamura, Yoshihisa| |
| Abstract | We examined the influence of chronic adrenocorticotropic hormone (ACTH) treatment on the number of Ki-67-positive cells in the dentate gyrus of the hippocampus in rats. ACTH treatment for 14 days decreased the number of such cells. The administration of imipramine or lithium alone for 14 days had no effect in saline-treated rats. The effect of ACTH was blocked by the administration of imipramine. Furthermore, the coadministration of imipramine and lithium for 14 days significantly increased the number of Ki-67-positive cells in both the saline and ACTH-treated rats. The coadministration of imipramine and lithium normalized the cell proliferation in the dentate gyrus of the hippocampus in rats treated with ACTH. |
| Keywords | ACTH imipramine lithium proliferation Ki-67 |
| Amo Type | Original Article |
| Published Date | 2010-08 |
| Publication Title | Acta Medica Okayama |
| Volume | volume64 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 219 |
| End Page | 223 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 20802538 |
| Web of Sience KeyUT | 000281384400002 |
| JaLCDOI | 10.18926/AMO/40501 |
|---|---|
| FullText URL | 64_5_267.pdf |
| Author | Sagara, Hidenori| Sendo, Toshiaki| Gomita, Yutaka| |
| Abstract | In the runway model of intracranial self-stimulation (ICSS) experimentation, the experimental animal is timed in running a fixed distance to depress a lever that releases electrical stimulation to an electrode implanted along its medial forebrain bundle. This ICSS has both a reward and a motivational component. Using the runway method and priming stimulation, we designed an experimental method for directly measuring motivation. An assessment of pharmacological agents that are known to influence motivational states was also undertaken. Using the experimental methods that we created, we observed prominent changes in running speed when animals were exposed to methamphetamine and nicotine. According to these data, the runway method employing intracranial self-stimulation behavior may be useful for the evaluation of substances that act on motivation. We review the underlying neuropharmacological and anatomical functions associated with our experimental methods. We hope that this technique will be used to scientifically evaluate the impact of drugs and/or therapeutic interventions on human motivation. |
| Keywords | intracranial self-stimulation behavior motivational effect methamphetamine nicotine |
| Amo Type | Review |
| Published Date | 2010-10 |
| Publication Title | Acta Medica Okayama |
| Volume | volume64 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 267 |
| End Page | 275 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2010 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 20975759 |
| Web of Science KeyUT | 000283563300001 |
| Author | Ezumi, Satoru| Kuroda, Satoshi| Matsunaga, Hisashi| Sendo, Toshiaki| |
|---|---|
| Published Date | 2010-12-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume122 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Taira, Kentaro| Matsunaga, Hisashi| Sendo, Toshiaki| |
|---|---|
| Published Date | 2011-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume123 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Kajizono, Makoto| Maeda, Megumu| Fujiwara, Satoko| Matsunaga, Hisashi| Sendo, Toshiaki| |
|---|---|
| Published Date | 2011-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume123 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Okazaki, Masatoshi| Sendo, Toshiaki| |
|---|---|
| Published Date | 2013-12-02 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume125 |
| Issue | issue3 |
| Content Type | Journal Article |
