| Author | Sagara, Hidenori| Kitamura, Yoshihisa| Sendo, Toshiaki| Gomita, Yutaka| |
|---|---|
| Published Date | 2007-05-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Fujiwara, Satoko| Sendo, Toshiaki| |
|---|---|
| Published Date | 2007-09-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Sato, Tomoaki| Ueshima, Satoshi| Sendo, Toshiaki| |
|---|---|
| Published Date | 2007-09-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Matsunaga, Hisashi| Sendo, Toshiaki| |
|---|---|
| Published Date | 2008-01-04 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Yokohari, Hideko| Okazaki, Masatoshi| Sendo, Toshiaki| |
|---|---|
| Published Date | 2008-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume120 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Katsube, Risa| Sendo, Toshiaki| |
|---|---|
| Published Date | 2008-12-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume120 |
| Issue | issue3 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/40501 |
|---|---|
| FullText URL | 64_5_267.pdf |
| Author | Sagara, Hidenori| Sendo, Toshiaki| Gomita, Yutaka| |
| Abstract | In the runway model of intracranial self-stimulation (ICSS) experimentation, the experimental animal is timed in running a fixed distance to depress a lever that releases electrical stimulation to an electrode implanted along its medial forebrain bundle. This ICSS has both a reward and a motivational component. Using the runway method and priming stimulation, we designed an experimental method for directly measuring motivation. An assessment of pharmacological agents that are known to influence motivational states was also undertaken. Using the experimental methods that we created, we observed prominent changes in running speed when animals were exposed to methamphetamine and nicotine. According to these data, the runway method employing intracranial self-stimulation behavior may be useful for the evaluation of substances that act on motivation. We review the underlying neuropharmacological and anatomical functions associated with our experimental methods. We hope that this technique will be used to scientifically evaluate the impact of drugs and/or therapeutic interventions on human motivation. |
| Keywords | intracranial self-stimulation behavior motivational effect methamphetamine nicotine |
| Amo Type | Review |
| Published Date | 2010-10 |
| Publication Title | Acta Medica Okayama |
| Volume | volume64 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 267 |
| End Page | 275 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2010 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 20975759 |
| Web of Science KeyUT | 000283563300001 |
| JaLCDOI | 10.18926/AMO/51868 |
|---|---|
| FullText URL | 67_5_319.pdf |
| Author | Murakawa, Kiminaka| Sato, Tomoaki| Maeda, Yoshinobu| Kitamura, Yoshihisa| Tanimoto, Mitsune| Sendo, Toshiaki| |
| Abstract | Graft-versus-host disease (GVHD) is a major concern in transplantation patients. Gut GVHD is accompanied by diarrhea, abdominal pain, and/or melena. Although oral treatment with corticosteroids (CSs) is effective in treating gut GVHD, it can cause adverse reactions that affect the entire body. Topical administration of CSs can be effective in treating diseases in which lesions are limited locally, because adverse reactions can then be alleviated. In this study, we examine and discuss an enteric-coated beclomethasone dipropionate (BDP) capsule (BDP-EC) formulated at Okayama University Hospital. The BDP-EC did not dissolve in solution 1 (pH1.2), and began disintegrating in solution 2 (pH6.8) after 5min, with a mean dissolution rate at 15min of 85%. We then used the capsule to treat a patient who developed gut GVHD after allogeneic hematopoietic stem cell transplantation. Clinically, the frequency of diarrhea decreased after BDP-EC administration. In addition, we were able to decrease the prednisolone equivalent dose. Symptoms associated with adverse reactions to BDP were not observed during the hospitalization period. These findings suggest that the administration of BDP-EC in the early stages of gut GVHD may allow a reduction in the initial doses of systemic CSs. |
| Keywords | beclomethasone intestinal graft-versus-host disease enteric-coated capsule in-hospital formulation |
| Amo Type | Case Report |
| Published Date | 2013-10 |
| Publication Title | Acta Medica Okayama |
| Volume | volume67 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 319 |
| End Page | 324 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24145732 |
| Web of Science KeyUT | 000325836100006 |
| JaLCDOI | 10.18926/AMO/52893 |
|---|---|
| FullText URL | 68_5_255.pdf |
| Author | Esumi, Satoru| Kawasaki, Yoichi| Gomita, Yutaka| Kitamura, Yoshihisa| Sendo, Toshiaki| |
| Abstract | Motivation incorporates several psychological aspects that produce reward-related and learning behaviors. Although reward-related behavior is reported to be mediated by the dopaminergic reward pathway, the involvement of dopaminergic systems in motivated behavior has not been fully clarified. Several experimental methodologies for motivational behavior have been reported, but pharmacological characteristics seem to vary among these methodologies. In this review, we attempt to summarize three main concepts:(1) the relationship of dopamine neuron physiology with motivated behavior, (2) the pharmacological characteristics of the runway intracranial self-stimulation model, and (3) the behavioral distinction of disparate motivated behaviors. |
| Keywords | motivation reward dopamine operant behavior intracranial self-stimulation |
| Amo Type | Review |
| Published Date | 2014-10 |
| Publication Title | Acta Medica Okayama |
| Volume | volume68 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 255 |
| End Page | 262 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25338481 |
| Web of Science KeyUT | 000343269300001 |
| Author | Miyazaki, Toshiaki| Nishikori, Atsumi| Matsunaga, Hisashi| Sendo, Toshiaki| |
|---|---|
| Published Date | 2010-08-02 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume122 |
| Issue | issue2 |
| Content Type | Journal Article |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kitamura, Yoshihisa| Akiyama, Kozue| Kitagawa, Kouhei| Shibata, Kazuhiko| Kawasaki, Hiromu| Suemaru, Katsuya| Araki, Hiroaki| Sendo, Toshiaki| Gomita, Yutaka| |
| Keywords | Imipramine Carbamazepine ACTH 5-HT2A receptor Forced swim test Wet-dog shakes Treatment–resistant |
| Note | Published with permission from the copyright holder.<br> This is a author's copy,as published in Pharmacology Biochemistry and Behavior , 2008, volume 89, issue 3, pp235-240.<br> | |
| Published Date | 2008-05-20 |
| Publication Title | Pharmacology Biochemistry and Behavior |
| Volume | volume89 |
| Issue | issue3 |
| Content Type | Journal Article |
| language | 英語 |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| DOI | 10.1016/j.pbb.2007.12.015 |
| Web of Science KeyUT | 000255311600001 |
| Author | Nawa, Hideki| Sendo, Toshiaki| |
|---|---|
| Published Date | 2009-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume121 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Sendo, Toshiaki| |
|---|---|
| Published Date | 2009-08-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume121 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Ezumi, Satoru| Kuroda, Satoshi| Matsunaga, Hisashi| Sendo, Toshiaki| |
|---|---|
| Published Date | 2010-12-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume122 |
| Issue | issue3 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/40129 |
|---|---|
| FullText URL | 64_4_219.pdf |
| Author | Doi, Maho| Miyazaki, Ikuko| Nagamachi, Tomoko| Shinomiya, Kazuaki| Matsunaga, Hisashi| Sendo, Toshiaki| Kawasaki, Hiromu| Asanuma, Masato| Gomita, Yutaka| Kitamura, Yoshihisa| |
| Abstract | We examined the influence of chronic adrenocorticotropic hormone (ACTH) treatment on the number of Ki-67-positive cells in the dentate gyrus of the hippocampus in rats. ACTH treatment for 14 days decreased the number of such cells. The administration of imipramine or lithium alone for 14 days had no effect in saline-treated rats. The effect of ACTH was blocked by the administration of imipramine. Furthermore, the coadministration of imipramine and lithium for 14 days significantly increased the number of Ki-67-positive cells in both the saline and ACTH-treated rats. The coadministration of imipramine and lithium normalized the cell proliferation in the dentate gyrus of the hippocampus in rats treated with ACTH. |
| Keywords | ACTH imipramine lithium proliferation Ki-67 |
| Amo Type | Original Article |
| Published Date | 2010-08 |
| Publication Title | Acta Medica Okayama |
| Volume | volume64 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 219 |
| End Page | 223 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 20802538 |
| Web of Science KeyUT | 000281384400002 |
| Author | Taira, Kentaro| Matsunaga, Hisashi| Sendo, Toshiaki| |
|---|---|
| Published Date | 2011-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume123 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Kuroda, Satoshi| Isozaki, Hideko| Matsunaga, Hisashi| Sendo, Toshiaki| |
|---|---|
| Published Date | 2009-12-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume121 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Kajizono, Makoto| Maeda, Megumu| Fujiwara, Satoko| Matsunaga, Hisashi| Sendo, Toshiaki| |
|---|---|
| Published Date | 2011-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume123 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Kawashima, Rieko| Matsunaga, Hisashi| Sendo, Toshiaki| |
|---|---|
| Published Date | 2011-12-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume123 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Shinomiya, Kazuaki| Kitamura, Yoshihisa| Ueshima, Satoshi| Satoh, Tomoaki| Sendo, Toshiaki| |
|---|---|
| Published Date | 2008-05-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume120 |
| Issue | issue1 |
| Content Type | Journal Article |
