JaLCDOI 10.18926/AMO/52893
FullText URL 68_5_255.pdf
Author Esumi, Satoru| Kawasaki, Yoichi| Gomita, Yutaka| Kitamura, Yoshihisa| Sendo, Toshiaki|
Abstract Motivation incorporates several psychological aspects that produce reward-related and learning behaviors. Although reward-related behavior is reported to be mediated by the dopaminergic reward pathway, the involvement of dopaminergic systems in motivated behavior has not been fully clarified. Several experimental methodologies for motivational behavior have been reported, but pharmacological characteristics seem to vary among these methodologies. In this review, we attempt to summarize three main concepts:(1) the relationship of dopamine neuron physiology with motivated behavior, (2) the pharmacological characteristics of the runway intracranial self-stimulation model, and (3) the behavioral distinction of disparate motivated behaviors.
Keywords motivation reward dopamine operant behavior intracranial self-stimulation
Amo Type Review
Published Date 2014-10
Publication Title Acta Medica Okayama
Volume volume68
Issue issue5
Publisher Okayama University Medical School
Start Page 255
End Page 262
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2014 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25338481
Web of Sience KeyUT 000343269300001
Author Kitamura, Yoshihisa| Akiyama, Kozue| Kitagawa, Kouhei| Shibata, Kazuhiko| Kawasaki, Hiromu| Suemaru, Katsuya| Araki, Hiroaki| Sendo, Toshiaki| Gomita, Yutaka|
Published Date 2008-05-20
Publication Title Pharmacology Biochemistry and Behavior
Volume volume89
Issue issue3
Content Type Journal Article
Author Esumi, Satoru| Sagara, Hidenori| Nakamoto, Akihiko| Kawasaki, Yoichi| Gomita, Yutaka| Sendo, Toshiaki|
Published Date 2013-04-15
Publication Title Behavioural Brain Research
Volume volume243
Content Type Journal Article
JaLCDOI 10.18926/AMO/40129
FullText URL 64_4_219.pdf
Author Doi, Maho| Miyazaki, Ikuko| Nagamachi, Tomoko| Shinomiya, Kazuaki| Matsunaga, Hisashi| Sendo, Toshiaki| Kawasaki, Hiromu| Asanuma, Masato| Gomita, Yutaka| Kitamura, Yoshihisa|
Abstract We examined the influence of chronic adrenocorticotropic hormone (ACTH) treatment on the number of Ki-67-positive cells in the dentate gyrus of the hippocampus in rats. ACTH treatment for 14 days decreased the number of such cells. The administration of imipramine or lithium alone for 14 days had no effect in saline-treated rats. The effect of ACTH was blocked by the administration of imipramine. Furthermore, the coadministration of imipramine and lithium for 14 days significantly increased the number of Ki-67-positive cells in both the saline and ACTH-treated rats. The coadministration of imipramine and lithium normalized the cell proliferation in the dentate gyrus of the hippocampus in rats treated with ACTH.
Keywords ACTH imipramine lithium proliferation Ki-67
Amo Type Original Article
Published Date 2010-08
Publication Title Acta Medica Okayama
Volume volume64
Issue issue4
Publisher Okayama University Medical School
Start Page 219
End Page 223
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 20802538
Web of Sience KeyUT 000281384400002
JaLCDOI 10.18926/AMO/40501
FullText URL 64_5_267.pdf
Author Sagara, Hidenori| Sendo, Toshiaki| Gomita, Yutaka|
Abstract In the runway model of intracranial self-stimulation (ICSS) experimentation, the experimental animal is timed in running a fixed distance to depress a lever that releases electrical stimulation to an electrode implanted along its medial forebrain bundle. This ICSS has both a reward and a motivational component. Using the runway method and priming stimulation, we designed an experimental method for directly measuring motivation. An assessment of pharmacological agents that are known to influence motivational states was also undertaken. Using the experimental methods that we created, we observed prominent changes in running speed when animals were exposed to methamphetamine and nicotine. According to these data, the runway method employing intracranial self-stimulation behavior may be useful for the evaluation of substances that act on motivation. We review the underlying neuropharmacological and anatomical functions associated with our experimental methods. We hope that this technique will be used to scientifically evaluate the impact of drugs and/or therapeutic interventions on human motivation.
Keywords intracranial self-stimulation behavior motivational effect methamphetamine nicotine
Amo Type Review
Published Date 2010-10
Publication Title Acta Medica Okayama
Volume volume64
Issue issue5
Publisher Okayama University Medical School
Start Page 267
End Page 275
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2010 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 20975759
Web of Sience KeyUT 000283563300001
FullText URL K0005463_other1.pdf
Author iguchi, Yuji | Uchitomi, Yosuke| Fujimori, Maiko| Koyama, Toshihiro| Kataoka, Hitomi| Kitamura, Yoshihisa| Sendo, Toshiaki| Inagaki, Masatoshi|
Keywords Empathy Hospital pharmacist Japan Pharmaceutical care
Note The final publication is available at Springer| 岡山大学審査学位副論文|
Published Date 2015-12
Publication Title International Journal of Clinical Pharmacy
Volume volume37
Issue issue6
Publisher Springer
Start Page 1258
End Page 1266
ISSN 2210-7703
NCID AA12633112
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version author
PubMed ID 26441314
Web of Sience KeyUT 000363490100042
Related Url https://doi.org/10.1007/s11096-015-0204-2 http://ousar.lib.okayama-u.ac.jp/55016
Author Esumi, Satoru| Sagara, Hidenori| Nakamoto, Akihiko| Kawasaki, Yoichi| Gomita, Yutaka| Sendo, Toshiaki|
Published Date 2013-12-02
Publication Title 岡山医学会雑誌
Volume volume125
Issue issue3
Content Type Journal Article
Author Fujiwara, Satoko| Sendo, Toshiaki|
Published Date 2007-09-03
Publication Title 岡山医学会雑誌
Volume volume119
Issue issue2
Content Type Journal Article
JaLCDOI 10.18926/AMO/30940
FullText URL fulltext.pdf
Author Sagara, Hidenori| Kitamura, Yoshihisa| Esumi, Satoru| Sendo, Toshiaki| Araki, Hiroaki| Gomita, Yutaka|
Abstract <p>It is well known that priming stimulation promotes the motivational effects of intracranial self-stimulation(ICSS) behavior. An experimental methodology using the runway method could separately study the reward and motivational effects of ICSS behavior. In the present study, we examined the motivational effect of nicotine as measured by the runway method using priming stimulation of ICSS behavior. Electrodes were implanted chronically into the medial forebrain bundle (MFB) in rats. A lever for stimulation of the MFB was set on the opposite side of the start box in the apparatus, and rats were trained to get a reward stimulation (50-200 microA, 0.2 ms, 60 Hz) of MFB when the goal lever was pressed. After the rats were trained to press the lever, a priming stimulation of the MFB was performed. After receiving the priming stimulation, rats were placed at the start box of the runway apparatus, and the running time duration until the goal lever was pressed was measured. Subcutaneous injection of nicotine at a dose of 0.2mg/kg produced an increase in running speed to obtain the reward stimulation, and priming stimulation facilitated the motivational effect to obtain the electrical brain stimulation reward in the rats. These results suggest that nicotine significantly enhanced the motivational effect on ICSS behavior as determined using the runway method. The runway method using priming stimulation of ICSS behavior may become the new experimental methodology with which to measure the motivational effect of some drugs.</p>
Keywords intracranial self-stimulation runway nicotine priming stimulation motivational effect
Amo Type Original Article
Published Date 2008-08
Publication Title Acta Medica Okayama
Volume volume62
Issue issue4
Publisher Okayama University Medical School
Start Page 227
End Page 233
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 18766205
Web of Sience KeyUT 000258680900002
JaLCDOI 10.18926/AMO/51868
FullText URL 67_5_319.pdf
Author Murakawa, Kiminaka| Sato, Tomoaki| Maeda, Yoshinobu| Kitamura, Yoshihisa| Tanimoto, Mitsune| Sendo, Toshiaki|
Abstract Graft-versus-host disease (GVHD) is a major concern in transplantation patients. Gut GVHD is accompanied by diarrhea, abdominal pain, and/or melena. Although oral treatment with corticosteroids (CSs) is effective in treating gut GVHD, it can cause adverse reactions that affect the entire body. Topical administration of CSs can be effective in treating diseases in which lesions are limited locally, because adverse reactions can then be alleviated. In this study, we examine and discuss an enteric-coated beclomethasone dipropionate (BDP) capsule (BDP-EC) formulated at Okayama University Hospital. The BDP-EC did not dissolve in solution 1 (pH1.2), and began disintegrating in solution 2 (pH6.8) after 5min, with a mean dissolution rate at 15min of 85%. We then used the capsule to treat a patient who developed gut GVHD after allogeneic hematopoietic stem cell transplantation. Clinically, the frequency of diarrhea decreased after BDP-EC administration. In addition, we were able to decrease the prednisolone equivalent dose. Symptoms associated with adverse reactions to BDP were not observed during the hospitalization period. These findings suggest that the administration of BDP-EC in the early stages of gut GVHD may allow a reduction in the initial doses of systemic CSs.
Keywords beclomethasone intestinal graft-versus-host disease enteric-coated capsule in-hospital formulation
Amo Type Case Report
Published Date 2013-10
Publication Title Acta Medica Okayama
Volume volume67
Issue issue5
Publisher Okayama University Medical School
Start Page 319
End Page 324
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 24145732
Web of Sience KeyUT 000325836100006
Author Yamaji, Kazuhiko| Kawasaki, Yoichi| Yoshitome, Kei| Matsunaga, Hisashi| Sendo, Toshiaki|
Published Date 2012-10
Publication Title Biological & Pharmaceutical Bulletin
Volume volume35
Issue issue10
Content Type Journal Article
Author Hayashi, Keiichiro| Ueshima, Satoshi| Ouchida, Mamoru| Mashimo, Tomoji| Nishiki, Teiichi| Sendo, Toshiaki| Serikawa, Tadao| Matsui, Hideki| Ohmori, Iori|
Published Date 2011-05
Publication Title Epilepsia
Volume volume52
Issue issue5
Content Type Journal Article
Author Okazaki, Masatoshi| Sendo, Toshiaki|
Published Date 2013-12-02
Publication Title 岡山医学会雑誌
Volume volume125
Issue issue3
Content Type Journal Article
Author Zamami, Yoshito| Koyama, Toshihiro| Aiba, Tetsuya| Amano, Manabu| Ando, Tetsuaki| Kurata, Naomi| Nawa, Hideki| Nakura, Hironori| Kitamura, Yoshihisa| Sendo, Toshiaki|
Published Date 2014
Publication Title 静脈経腸栄養
Volume volume29
Issue issue4
Content Type Journal Article
Title Alternative Drug interaction (39. Drug interaction in prostate cancer therapy)
Author Kanzaki, Hirotaka| Tanaka, Yuta| Maruo, Akinori| Nishihara, Shigeki | Kitamura, Yoshihisa| Sendo, Toshiaki|
Publication Title Journal of Okayama Medical Association
Published Date 2017-08-01
Volume volume129
Issue issue2
Start Page 131
End Page 136
ISSN 0030-1558
Related Url https://doi.org/10.4044/joma.129.131
language 日本語
Copyright Holders Copyright (c) 2017 岡山医学会
File Version publisher
DOI 10.4044/joma.129.131
Author Sato, Tomoaki| Ueshima, Satoshi| Sendo, Toshiaki|
Published Date 2007-09-03
Publication Title 岡山医学会雑誌
Volume volume119
Issue issue2
Content Type Journal Article
Author Matsunaga, Hisashi| Sendo, Toshiaki|
Published Date 2008-01-04
Publication Title 岡山医学会雑誌
Volume volume119
Issue issue3
Content Type Journal Article
Author Yokohari, Hideko| Okazaki, Masatoshi| Sendo, Toshiaki|
Published Date 2008-08-01
Publication Title 岡山医学会雑誌
Volume volume120
Issue issue2
Content Type Journal Article
Author Katsube, Risa| Sendo, Toshiaki|
Published Date 2008-12-01
Publication Title 岡山医学会雑誌
Volume volume120
Issue issue3
Content Type Journal Article
Author Yamaji, Kazuhiko| Sendo, Toshiaki|
Published Date 2012-12-03
Publication Title 岡山医学会雑誌
Volume volume124
Issue issue3
Content Type Journal Article