| JaLCDOI | 10.18926/AMO/30940 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Sagara, Hidenori| Kitamura, Yoshihisa| Esumi, Satoru| Sendo, Toshiaki| Araki, Hiroaki| Gomita, Yutaka| |
| Abstract | It is well known that priming stimulation promotes the motivational effects of intracranial self-stimulation(ICSS) behavior. An experimental methodology using the runway method could separately study the reward and motivational effects of ICSS behavior. In the present study, we examined the motivational effect of nicotine as measured by the runway method using priming stimulation of ICSS behavior. Electrodes were implanted chronically into the medial forebrain bundle (MFB) in rats. A lever for stimulation of the MFB was set on the opposite side of the start box in the apparatus, and rats were trained to get a reward stimulation (50-200 microA, 0.2 ms, 60 Hz) of MFB when the goal lever was pressed. After the rats were trained to press the lever, a priming stimulation of the MFB was performed. After receiving the priming stimulation, rats were placed at the start box of the runway apparatus, and the running time duration until the goal lever was pressed was measured. Subcutaneous injection of nicotine at a dose of 0.2mg/kg produced an increase in running speed to obtain the reward stimulation, and priming stimulation facilitated the motivational effect to obtain the electrical brain stimulation reward in the rats. These results suggest that nicotine significantly enhanced the motivational effect on ICSS behavior as determined using the runway method. The runway method using priming stimulation of ICSS behavior may become the new experimental methodology with which to measure the motivational effect of some drugs. |
| Keywords | intracranial self-stimulation runway nicotine priming stimulation motivational effect |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2008-08 |
| Volume | volume62 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 227 |
| End Page | 233 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 18766205 |
| Web of Science KeyUT | 000258680900002 |
| JaLCDOI | 10.18926/AMO/40129 |
|---|---|
| FullText URL | 64_4_219.pdf |
| Author | Doi, Maho| Miyazaki, Ikuko| Nagamachi, Tomoko| Shinomiya, Kazuaki| Matsunaga, Hisashi| Sendo, Toshiaki| Kawasaki, Hiromu| Asanuma, Masato| Gomita, Yutaka| Kitamura, Yoshihisa| |
| Abstract | We examined the influence of chronic adrenocorticotropic hormone (ACTH) treatment on the number of Ki-67-positive cells in the dentate gyrus of the hippocampus in rats. ACTH treatment for 14 days decreased the number of such cells. The administration of imipramine or lithium alone for 14 days had no effect in saline-treated rats. The effect of ACTH was blocked by the administration of imipramine. Furthermore, the coadministration of imipramine and lithium for 14 days significantly increased the number of Ki-67-positive cells in both the saline and ACTH-treated rats. The coadministration of imipramine and lithium normalized the cell proliferation in the dentate gyrus of the hippocampus in rats treated with ACTH. |
| Keywords | ACTH imipramine lithium proliferation Ki-67 |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2010-08 |
| Volume | volume64 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 219 |
| End Page | 223 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 20802538 |
| Web of Science KeyUT | 000281384400002 |
| JaLCDOI | 10.18926/AMO/40501 |
|---|---|
| FullText URL | 64_5_267.pdf |
| Author | Sagara, Hidenori| Sendo, Toshiaki| Gomita, Yutaka| |
| Abstract | In the runway model of intracranial self-stimulation (ICSS) experimentation, the experimental animal is timed in running a fixed distance to depress a lever that releases electrical stimulation to an electrode implanted along its medial forebrain bundle. This ICSS has both a reward and a motivational component. Using the runway method and priming stimulation, we designed an experimental method for directly measuring motivation. An assessment of pharmacological agents that are known to influence motivational states was also undertaken. Using the experimental methods that we created, we observed prominent changes in running speed when animals were exposed to methamphetamine and nicotine. According to these data, the runway method employing intracranial self-stimulation behavior may be useful for the evaluation of substances that act on motivation. We review the underlying neuropharmacological and anatomical functions associated with our experimental methods. We hope that this technique will be used to scientifically evaluate the impact of drugs and/or therapeutic interventions on human motivation. |
| Keywords | intracranial self-stimulation behavior motivational effect methamphetamine nicotine |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2010-10 |
| Volume | volume64 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 267 |
| End Page | 275 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2010 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 20975759 |
| Web of Science KeyUT | 000283563300001 |
| JaLCDOI | 10.18926/AMO/51868 |
|---|---|
| FullText URL | 67_5_319.pdf |
| Author | Murakawa, Kiminaka| Sato, Tomoaki| Maeda, Yoshinobu| Kitamura, Yoshihisa| Tanimoto, Mitsune| Sendo, Toshiaki| |
| Abstract | Graft-versus-host disease (GVHD) is a major concern in transplantation patients. Gut GVHD is accompanied by diarrhea, abdominal pain, and/or melena. Although oral treatment with corticosteroids (CSs) is effective in treating gut GVHD, it can cause adverse reactions that affect the entire body. Topical administration of CSs can be effective in treating diseases in which lesions are limited locally, because adverse reactions can then be alleviated. In this study, we examine and discuss an enteric-coated beclomethasone dipropionate (BDP) capsule (BDP-EC) formulated at Okayama University Hospital. The BDP-EC did not dissolve in solution 1 (pH1.2), and began disintegrating in solution 2 (pH6.8) after 5min, with a mean dissolution rate at 15min of 85%. We then used the capsule to treat a patient who developed gut GVHD after allogeneic hematopoietic stem cell transplantation. Clinically, the frequency of diarrhea decreased after BDP-EC administration. In addition, we were able to decrease the prednisolone equivalent dose. Symptoms associated with adverse reactions to BDP were not observed during the hospitalization period. These findings suggest that the administration of BDP-EC in the early stages of gut GVHD may allow a reduction in the initial doses of systemic CSs. |
| Keywords | beclomethasone intestinal graft-versus-host disease enteric-coated capsule in-hospital formulation |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-10 |
| Volume | volume67 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 319 |
| End Page | 324 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24145732 |
| Web of Science KeyUT | 000325836100006 |
| JaLCDOI | 10.18926/AMO/52893 |
|---|---|
| FullText URL | 68_5_255.pdf |
| Author | Esumi, Satoru| Kawasaki, Yoichi| Gomita, Yutaka| Kitamura, Yoshihisa| Sendo, Toshiaki| |
| Abstract | Motivation incorporates several psychological aspects that produce reward-related and learning behaviors. Although reward-related behavior is reported to be mediated by the dopaminergic reward pathway, the involvement of dopaminergic systems in motivated behavior has not been fully clarified. Several experimental methodologies for motivational behavior have been reported, but pharmacological characteristics seem to vary among these methodologies. In this review, we attempt to summarize three main concepts:(1) the relationship of dopamine neuron physiology with motivated behavior, (2) the pharmacological characteristics of the runway intracranial self-stimulation model, and (3) the behavioral distinction of disparate motivated behaviors. |
| Keywords | motivation reward dopamine operant behavior intracranial self-stimulation |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-10 |
| Volume | volume68 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 255 |
| End Page | 262 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25338481 |
| Web of Science KeyUT | 000343269300001 |
| JaLCDOI | 10.18926/AMO/60368 |
|---|---|
| FullText URL | 74_4_301.pdf |
| Author | Takahashi, Kei| Kitamura, Yoshihisa| Ushio, Soichiro| Sendo, Toshiaki| |
| Abstract | Ketamine has been clinically proven to ameliorate depression, including treatment-resistant depression. The detailed mechanism of action of ketamine in treatment-resistant depression remains unclear. We examined the effects of ketamine on the immobility times of adrenocorticotropic hormone (ACTH)-treated rats during the forced swim test, and we explored the mechanism by which ketamine acts in this model. We investigated the neuroanatomical site of action by microinjecting ketamine into the medial prefrontal cortex of rats. A significant reduction of the rats’ immobility during the forced swim test was observed after the intraperitoneal injection of ketamine in both saline- and ACTH-treated rats. The microinjection of ketamine into the medial prefrontal cortex also decreased immobility during the forced swim test in both saline- and ACTH-treated rats. The immobility-decreasing effect of intraperitoneally injected ketamine was blocked by administering WAY100635, a 5-HT1A receptor antagonist, into the medial prefrontal cortex. These findings contribute to the evidence that ketamine can be useful against treatment-resistant depressive conditions. The immobility-reducing effects of ketamine might be mediated by 5-HT1A receptor activity in the medial prefrontal cortex. |
| Keywords | ketamine adrenocorticotropic hormone forced swim test medial prefrontal cortex 5-HT1A receptor |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-08 |
| Volume | volume74 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 301 |
| End Page | 306 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32843761 |
| Web of Science KeyUT | 000562508700005 |
| NAID | 120006880207 |
| JaLCDOI | 10.18926/AMO/61215 |
|---|---|
| FullText URL | 74_6_545.pdf |
| Author | Tatebe, Yasuhisa| Kanamitsu, Kiichiro| Kanzaki, Hirotaka| Ishida, Hisashi| Fujiwara, Kaori| Washio, Kana| Kitamura, Yoshihisa| Sendo, Toshiaki| Shimada, Akira| Tsukahara, Hirokazu| |
| Abstract | Polymorphisms in methotrexate transporter pathways have been associated with methotrexate toxicities and clearance. Recent genome-wide association studies have revealed that the SLCO1B1 T521C variant is associated with methotrexate elimination. We present a case of a pediatric patient with acute lymphoblastic leukemia who suffered from persistently high plasma methotrexate concentrations and acute kidney injuries after the admin-istration of a medium dose of methotrexate. Subsequent genetic analysis showed that he was a carrier of dys-functional genetic variants associated with methotrexate clearance. This case highlights that polymorphisms of methotrexate transporter pathways can adversely affect methotrexate elimination in a clinically significant manner. |
| Keywords | methotrexate polymorphism drug elimination acute kidney injury acute lymphoblastic leukemia |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-12 |
| Volume | volume74 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 545 |
| End Page | 550 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33361876 |
| Web of Science KeyUT | 000601203600012 |
| NAID | 120006948942 |
| JaLCDOI | 10.18926/AMO/63410 |
|---|---|
| FullText URL | 76_2_167.pdf |
| Author | Higashionna, Tsukasa| Ushio, Soichiro| Esumi, Satoru| Murakawa, Kiminaka| Kitamura, Yoshihisa| Sendo, Toshiaki| |
| Abstract | Febrile neutropenia (FN) is a serious side effect in patients undergoing cancer chemotherapy and frequently proves fatal. Since infection control is crucial in the management of FN, the antimicrobial agent cefozopran (CZOP) has been recommended but not approved for routine use in clinical care of FN in Japan. However, few studies of CZOP in the management of FN have used a thrice daily dose schedule. The aim of this study was to retrospectively compare the efficacy and safety of CZOP at a dose of 1 g three times daily to those of cefepime (CFPM) in the treatment of FN in our lung cancer patients. The response rates of the CZOP and CFPM groups were 89.5% (17/19 cases) and 83.0% (39/47 cases), respectively, with no significant difference between the two groups. The median duration of antimicrobial treatment was 6 days (4-10 days) in the CZOP group and 7 days (3-13 days) in the CFPM group, with no significant difference between groups. The incidence rates of adverse events were 21.1% (4/19 cases) in the CZOP group and 19.1% (9/47 cases) in the CFPM group. No adverse events of Grade 3 or higher were observed in either group. The findings of the present study suggest that CZOP administration at a dose of 1 g three times per day as an antimicrobial treatment alternative against FN. |
| Keywords | febrile neutropenia cefozopran cefepime lung cancer retrospective |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-04 |
| Volume | volume76 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 167 |
| End Page | 172 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35503444 |
| Web of Science KeyUT | 000792374900008 |
| Author | Shinomiya, Kazuaki| Kitamura, Yoshihisa| Ueshima, Satoshi| Satoh, Tomoaki| Sendo, Toshiaki| |
|---|---|
| Published Date | 2008-05-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume120 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Sagara, Hidenori| Kitamura, Yoshihisa| Sendo, Toshiaki| Gomita, Yutaka| |
|---|---|
| Published Date | 2007-05-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Fujiwara, Satoko| Sendo, Toshiaki| |
|---|---|
| Published Date | 2007-09-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Sato, Tomoaki| Ueshima, Satoshi| Sendo, Toshiaki| |
|---|---|
| Published Date | 2007-09-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Matsunaga, Hisashi| Sendo, Toshiaki| |
|---|---|
| Published Date | 2008-01-04 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Yokohari, Hideko| Okazaki, Masatoshi| Sendo, Toshiaki| |
|---|---|
| Published Date | 2008-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume120 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Katsube, Risa| Sendo, Toshiaki| |
|---|---|
| Published Date | 2008-12-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume120 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Nawa, Hideki| Sendo, Toshiaki| |
|---|---|
| Published Date | 2009-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume121 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Sendo, Toshiaki| |
|---|---|
| Published Date | 2009-08-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume121 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Kuroda, Satoshi| Isozaki, Hideko| Matsunaga, Hisashi| Sendo, Toshiaki| |
|---|---|
| Published Date | 2009-12-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume121 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Kawasaki, Yoichi| Matsunaga, Hisashi| Sendo, Toshiaki| |
|---|---|
| Published Date | 2010-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume122 |
| Issue | issue1 |
| Content Type | Journal Article |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kitamura, Yoshihisa| Akiyama, Kozue| Kitagawa, Kouhei| Shibata, Kazuhiko| Kawasaki, Hiromu| Suemaru, Katsuya| Araki, Hiroaki| Sendo, Toshiaki| Gomita, Yutaka| |
| Keywords | Imipramine Carbamazepine ACTH 5-HT2A receptor Forced swim test Wet-dog shakes Treatment–resistant |
| Note | Published with permission from the copyright holder. This is a author's copy,as published in Pharmacology Biochemistry and Behavior , 2008, volume 89, issue 3, pp235-240. | |
| Published Date | 2008-05-20 |
| Publication Title | Pharmacology Biochemistry and Behavior |
| Volume | volume89 |
| Issue | issue3 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| DOI | 10.1016/j.pbb.2007.12.015 |
| Web of Science KeyUT | 000255311600001 |
