JaLCDOI 10.18926/AMO/40501
FullText URL 64_5_267.pdf
Author Sagara, Hidenori| Sendo, Toshiaki| Gomita, Yutaka|
Abstract In the runway model of intracranial self-stimulation (ICSS) experimentation, the experimental animal is timed in running a fixed distance to depress a lever that releases electrical stimulation to an electrode implanted along its medial forebrain bundle. This ICSS has both a reward and a motivational component. Using the runway method and priming stimulation, we designed an experimental method for directly measuring motivation. An assessment of pharmacological agents that are known to influence motivational states was also undertaken. Using the experimental methods that we created, we observed prominent changes in running speed when animals were exposed to methamphetamine and nicotine. According to these data, the runway method employing intracranial self-stimulation behavior may be useful for the evaluation of substances that act on motivation. We review the underlying neuropharmacological and anatomical functions associated with our experimental methods. We hope that this technique will be used to scientifically evaluate the impact of drugs and/or therapeutic interventions on human motivation.
Keywords intracranial self-stimulation behavior motivational effect methamphetamine nicotine
Amo Type Review
Published Date 2010-10
Publication Title Acta Medica Okayama
Volume volume64
Issue issue5
Publisher Okayama University Medical School
Start Page 267
End Page 275
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2010 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 20975759
Web of Science KeyUT 000283563300001
Author Fujiwara, Satoko| Sendo, Toshiaki|
Published Date 2007-09-03
Publication Title 岡山医学会雑誌
Volume volume119
Issue issue2
Content Type Journal Article
Author Sato, Tomoaki| Ueshima, Satoshi| Sendo, Toshiaki|
Published Date 2007-09-03
Publication Title 岡山医学会雑誌
Volume volume119
Issue issue2
Content Type Journal Article
Author Matsunaga, Hisashi| Sendo, Toshiaki|
Published Date 2008-01-04
Publication Title 岡山医学会雑誌
Volume volume119
Issue issue3
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Author Yokohari, Hideko| Okazaki, Masatoshi| Sendo, Toshiaki|
Published Date 2008-08-01
Publication Title 岡山医学会雑誌
Volume volume120
Issue issue2
Content Type Journal Article
Author Katsube, Risa| Sendo, Toshiaki|
Published Date 2008-12-01
Publication Title 岡山医学会雑誌
Volume volume120
Issue issue3
Content Type Journal Article
Author Nawa, Hideki| Sendo, Toshiaki|
Published Date 2009-04-01
Publication Title 岡山医学会雑誌
Volume volume121
Issue issue1
Content Type Journal Article
Author Sendo, Toshiaki|
Published Date 2009-08-03
Publication Title 岡山医学会雑誌
Volume volume121
Issue issue2
Content Type Journal Article
Author Kuroda, Satoshi| Isozaki, Hideko| Matsunaga, Hisashi| Sendo, Toshiaki|
Published Date 2009-12-01
Publication Title 岡山医学会雑誌
Volume volume121
Issue issue3
Content Type Journal Article
Author Kawasaki, Yoichi| Matsunaga, Hisashi| Sendo, Toshiaki|
Published Date 2010-04-01
Publication Title 岡山医学会雑誌
Volume volume122
Issue issue1
Content Type Journal Article
Author Miyazaki, Toshiaki| Nishikori, Atsumi| Matsunaga, Hisashi| Sendo, Toshiaki|
Published Date 2010-08-02
Publication Title 岡山医学会雑誌
Volume volume122
Issue issue2
Content Type Journal Article
Author Ezumi, Satoru| Kuroda, Satoshi| Matsunaga, Hisashi| Sendo, Toshiaki|
Published Date 2010-12-01
Publication Title 岡山医学会雑誌
Volume volume122
Issue issue3
Content Type Journal Article
Author Taira, Kentaro| Matsunaga, Hisashi| Sendo, Toshiaki|
Published Date 2011-04-01
Publication Title 岡山医学会雑誌
Volume volume123
Issue issue1
Content Type Journal Article
Author Kajizono, Makoto| Maeda, Megumu| Fujiwara, Satoko| Matsunaga, Hisashi| Sendo, Toshiaki|
Published Date 2011-08-01
Publication Title 岡山医学会雑誌
Volume volume123
Issue issue2
Content Type Journal Article
Author Kawashima, Rieko| Matsunaga, Hisashi| Sendo, Toshiaki|
Published Date 2011-12-01
Publication Title 岡山医学会雑誌
Volume volume123
Issue issue3
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Author Kitagawa, Kohei| Matsunaga, Hisashi| Sendo, Toshiaki|
Published Date 2012-04-01
Publication Title 岡山医学会雑誌
Volume volume124
Issue issue1
Content Type Journal Article
Author Nishimiya, Yusuke| Konuma, Toshimitsu| Tasaka, Ken| Sendo, Toshiaki|
Published Date 2012-08-01
Publication Title 岡山医学会雑誌
Volume volume124
Issue issue2
Content Type Journal Article
Author Yamaji, Kazuhiko| Sendo, Toshiaki|
Published Date 2012-12-03
Publication Title 岡山医学会雑誌
Volume volume124
Issue issue3
Content Type Journal Article
Author Kuroda, Satoshi| Sendo, Toshiaki|
Published Date 2013-04-01
Publication Title 岡山医学会雑誌
Volume volume125
Issue issue1
Content Type Journal Article
Author Okazaki, Masatoshi| Sendo, Toshiaki|
Published Date 2013-12-02
Publication Title 岡山医学会雑誌
Volume volume125
Issue issue3
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