Author Kawasaki, Yoichi| Matsunaga, Hisashi| Sendo, Toshiaki|
Published Date 2010-04-01
Publication Title 岡山医学会雑誌
Volume volume122
Issue issue1
Content Type Journal Article
JaLCDOI 10.18926/AMO/30940
FullText URL fulltext.pdf
Author Sagara, Hidenori| Kitamura, Yoshihisa| Esumi, Satoru| Sendo, Toshiaki| Araki, Hiroaki| Gomita, Yutaka|
Abstract <p>It is well known that priming stimulation promotes the motivational effects of intracranial self-stimulation(ICSS) behavior. An experimental methodology using the runway method could separately study the reward and motivational effects of ICSS behavior. In the present study, we examined the motivational effect of nicotine as measured by the runway method using priming stimulation of ICSS behavior. Electrodes were implanted chronically into the medial forebrain bundle (MFB) in rats. A lever for stimulation of the MFB was set on the opposite side of the start box in the apparatus, and rats were trained to get a reward stimulation (50-200 microA, 0.2 ms, 60 Hz) of MFB when the goal lever was pressed. After the rats were trained to press the lever, a priming stimulation of the MFB was performed. After receiving the priming stimulation, rats were placed at the start box of the runway apparatus, and the running time duration until the goal lever was pressed was measured. Subcutaneous injection of nicotine at a dose of 0.2mg/kg produced an increase in running speed to obtain the reward stimulation, and priming stimulation facilitated the motivational effect to obtain the electrical brain stimulation reward in the rats. These results suggest that nicotine significantly enhanced the motivational effect on ICSS behavior as determined using the runway method. The runway method using priming stimulation of ICSS behavior may become the new experimental methodology with which to measure the motivational effect of some drugs.</p>
Keywords intracranial self-stimulation runway nicotine priming stimulation motivational effect
Amo Type Original Article
Published Date 2008-08
Publication Title Acta Medica Okayama
Volume volume62
Issue issue4
Publisher Okayama University Medical School
Start Page 227
End Page 233
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 18766205
Web of Science KeyUT 000258680900002
Author Miyazaki, Toshiaki| Nishikori, Atsumi| Matsunaga, Hisashi| Sendo, Toshiaki|
Published Date 2010-08-02
Publication Title 岡山医学会雑誌
Volume volume122
Issue issue2
Content Type Journal Article
JaLCDOI 10.18926/AMO/40501
FullText URL 64_5_267.pdf
Author Sagara, Hidenori| Sendo, Toshiaki| Gomita, Yutaka|
Abstract In the runway model of intracranial self-stimulation (ICSS) experimentation, the experimental animal is timed in running a fixed distance to depress a lever that releases electrical stimulation to an electrode implanted along its medial forebrain bundle. This ICSS has both a reward and a motivational component. Using the runway method and priming stimulation, we designed an experimental method for directly measuring motivation. An assessment of pharmacological agents that are known to influence motivational states was also undertaken. Using the experimental methods that we created, we observed prominent changes in running speed when animals were exposed to methamphetamine and nicotine. According to these data, the runway method employing intracranial self-stimulation behavior may be useful for the evaluation of substances that act on motivation. We review the underlying neuropharmacological and anatomical functions associated with our experimental methods. We hope that this technique will be used to scientifically evaluate the impact of drugs and/or therapeutic interventions on human motivation.
Keywords intracranial self-stimulation behavior motivational effect methamphetamine nicotine
Amo Type Review
Published Date 2010-10
Publication Title Acta Medica Okayama
Volume volume64
Issue issue5
Publisher Okayama University Medical School
Start Page 267
End Page 275
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2010 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 20975759
Web of Science KeyUT 000283563300001
Author Ezumi, Satoru| Kuroda, Satoshi| Matsunaga, Hisashi| Sendo, Toshiaki|
Published Date 2010-12-01
Publication Title 岡山医学会雑誌
Volume volume122
Issue issue3
Content Type Journal Article
Author Taira, Kentaro| Matsunaga, Hisashi| Sendo, Toshiaki|
Published Date 2011-04-01
Publication Title 岡山医学会雑誌
Volume volume123
Issue issue1
Content Type Journal Article
Author Kajizono, Makoto| Maeda, Megumu| Fujiwara, Satoko| Matsunaga, Hisashi| Sendo, Toshiaki|
Published Date 2011-08-01
Publication Title 岡山医学会雑誌
Volume volume123
Issue issue2
Content Type Journal Article
Author Kawashima, Rieko| Matsunaga, Hisashi| Sendo, Toshiaki|
Published Date 2011-12-01
Publication Title 岡山医学会雑誌
Volume volume123
Issue issue3
Content Type Journal Article
Author Kitagawa, Kohei| Matsunaga, Hisashi| Sendo, Toshiaki|
Published Date 2012-04-01
Publication Title 岡山医学会雑誌
Volume volume124
Issue issue1
Content Type Journal Article
Author Nishimiya, Yusuke| Konuma, Toshimitsu| Tasaka, Ken| Sendo, Toshiaki|
Published Date 2012-08-01
Publication Title 岡山医学会雑誌
Volume volume124
Issue issue2
Content Type Journal Article
Author Yamaji, Kazuhiko| Sendo, Toshiaki|
Published Date 2012-12-03
Publication Title 岡山医学会雑誌
Volume volume124
Issue issue3
Content Type Journal Article
Author Makita, Takashi| Kitamura, Yoshihisa| Sendo, Toshiaki|
Published Date 2013-04-01
Publication Title 岡山医学会雑誌
Volume volume125
Issue issue1
Content Type Journal Article
Author Kurata, Yasuko| Fujiwara, Satoko| Kajizono, Makoto| Aoyagi, Megumu| Kitamura, Yoshihisa| Sendo, Toshiaki|
Published Date 2013-08-01
Publication Title 岡山医学会雑誌
Volume volume125
Issue issue2
Content Type Journal Article
Author Esumi, Satoru| Sagara, Hidenori| Nakamoto, Akihiko| Kawasaki, Yoichi| Gomita, Yutaka| Sendo, Toshiaki|
Published Date 2013-04-15
Publication Title Behavioural Brain Research
Volume volume243
Content Type Journal Article
JaLCDOI 10.18926/AMO/51868
FullText URL 67_5_319.pdf
Author Murakawa, Kiminaka| Sato, Tomoaki| Maeda, Yoshinobu| Kitamura, Yoshihisa| Tanimoto, Mitsune| Sendo, Toshiaki|
Abstract Graft-versus-host disease (GVHD) is a major concern in transplantation patients. Gut GVHD is accompanied by diarrhea, abdominal pain, and/or melena. Although oral treatment with corticosteroids (CSs) is effective in treating gut GVHD, it can cause adverse reactions that affect the entire body. Topical administration of CSs can be effective in treating diseases in which lesions are limited locally, because adverse reactions can then be alleviated. In this study, we examine and discuss an enteric-coated beclomethasone dipropionate (BDP) capsule (BDP-EC) formulated at Okayama University Hospital. The BDP-EC did not dissolve in solution 1 (pH1.2), and began disintegrating in solution 2 (pH6.8) after 5min, with a mean dissolution rate at 15min of 85%. We then used the capsule to treat a patient who developed gut GVHD after allogeneic hematopoietic stem cell transplantation. Clinically, the frequency of diarrhea decreased after BDP-EC administration. In addition, we were able to decrease the prednisolone equivalent dose. Symptoms associated with adverse reactions to BDP were not observed during the hospitalization period. These findings suggest that the administration of BDP-EC in the early stages of gut GVHD may allow a reduction in the initial doses of systemic CSs.
Keywords beclomethasone intestinal graft-versus-host disease enteric-coated capsule in-hospital formulation
Amo Type Case Report
Published Date 2013-10
Publication Title Acta Medica Okayama
Volume volume67
Issue issue5
Publisher Okayama University Medical School
Start Page 319
End Page 324
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 24145732
Web of Science KeyUT 000325836100006
Author Esumi, Satoru| Sagara, Hidenori| Nakamoto, Akihiko| Kawasaki, Yoichi| Gomita, Yutaka| Sendo, Toshiaki|
Published Date 2013-12-02
Publication Title 岡山医学会雑誌
Volume volume125
Issue issue3
Content Type Journal Article
Author Okazaki, Masatoshi| Sendo, Toshiaki|
Published Date 2013-12-02
Publication Title 岡山医学会雑誌
Volume volume125
Issue issue3
Content Type Journal Article
Author Haruta, Yusuke| Kawasaki, Yoichi| Kitamura, Yoshihisa| Sendo, Toshiaki|
Published Date 2013-12-02
Publication Title 岡山医学会雑誌
Volume volume125
Issue issue3
Content Type Journal Article
Title Alternative Drug interaction (29. drug interaction of steroids)
FullText URL 126_59.pdf
Author Hayashi, Youko| Nawa, Hideki| Kitamura, Yoshihisa| Sendo, Toshiaki|
Publication Title 岡山医学会雑誌
Published Date 2014-04-01
Volume volume126
Issue issue1
Start Page 59
End Page 63
ISSN 0030-1558
Related Url http://www.okayama-u.ac.jp/user/oma/
language 日本語
Copyright Holders Copyright (c) 2014 岡山医学会
File Version publisher
DOI 10.4044/joma.126.59
Title Alternative Drug interaction (30. combination with therapeutic drugs for chronic pain)
FullText URL 126_159.pdf
Author Ogawa, Atsushi| Kitamura, Yoshihisa| Sendo, Toshiaki|
Publication Title 岡山医学会雑誌
Published Date 2014-08-01
Volume volume126
Issue issue2
Start Page 159
End Page 163
ISSN 0030-1558
language 日本語
Copyright Holders Copyright (c) 2014 岡山医学会
File Version publisher
DOI 10.4044/joma.126.159
NAID 130004685269