Author Makita, Takashi| Kitamura, Yoshihisa| Sendo, Toshiaki|
Published Date 2013-04-01
Publication Title 岡山医学会雑誌
Volume volume125
Issue issue1
Content Type Journal Article
Author Kurata, Yasuko| Fujiwara, Satoko| Kajizono, Makoto| Aoyagi, Megumu| Kitamura, Yoshihisa| Sendo, Toshiaki|
Published Date 2013-08-01
Publication Title 岡山医学会雑誌
Volume volume125
Issue issue2
Content Type Journal Article
JaLCDOI 10.18926/AMO/51868
FullText URL 67_5_319.pdf
Author Murakawa, Kiminaka| Sato, Tomoaki| Maeda, Yoshinobu| Kitamura, Yoshihisa| Tanimoto, Mitsune| Sendo, Toshiaki|
Abstract Graft-versus-host disease (GVHD) is a major concern in transplantation patients. Gut GVHD is accompanied by diarrhea, abdominal pain, and/or melena. Although oral treatment with corticosteroids (CSs) is effective in treating gut GVHD, it can cause adverse reactions that affect the entire body. Topical administration of CSs can be effective in treating diseases in which lesions are limited locally, because adverse reactions can then be alleviated. In this study, we examine and discuss an enteric-coated beclomethasone dipropionate (BDP) capsule (BDP-EC) formulated at Okayama University Hospital. The BDP-EC did not dissolve in solution 1 (pH1.2), and began disintegrating in solution 2 (pH6.8) after 5min, with a mean dissolution rate at 15min of 85%. We then used the capsule to treat a patient who developed gut GVHD after allogeneic hematopoietic stem cell transplantation. Clinically, the frequency of diarrhea decreased after BDP-EC administration. In addition, we were able to decrease the prednisolone equivalent dose. Symptoms associated with adverse reactions to BDP were not observed during the hospitalization period. These findings suggest that the administration of BDP-EC in the early stages of gut GVHD may allow a reduction in the initial doses of systemic CSs.
Keywords beclomethasone intestinal graft-versus-host disease enteric-coated capsule in-hospital formulation
Amo Type Case Report
Published Date 2013-10
Publication Title Acta Medica Okayama
Volume volume67
Issue issue5
Publisher Okayama University Medical School
Start Page 319
End Page 324
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 24145732
Web of Science KeyUT 000325836100006
Title Alternative Drug interaction (29. drug interaction of steroids)
FullText URL 126_59.pdf
Author Hayashi, Youko| Nawa, Hideki| Kitamura, Yoshihisa| Sendo, Toshiaki|
Publication Title 岡山医学会雑誌
Published Date 2014-04-01
Volume volume126
Issue issue1
Start Page 59
End Page 63
ISSN 0030-1558
Related Url http://www.okayama-u.ac.jp/user/oma/
language 日本語
Copyright Holders Copyright (c) 2014 岡山医学会
File Version publisher
DOI 10.4044/joma.126.59
Title Alternative Drug interaction (30. combination with therapeutic drugs for chronic pain)
FullText URL 126_159.pdf
Author Ogawa, Atsushi| Kitamura, Yoshihisa| Sendo, Toshiaki|
Publication Title 岡山医学会雑誌
Published Date 2014-08-01
Volume volume126
Issue issue2
Start Page 159
End Page 163
ISSN 0030-1558
language 日本語
Copyright Holders Copyright (c) 2014 岡山医学会
File Version publisher
DOI 10.4044/joma.126.159
NAID 130004685269
Title Alternative Drug interaction (31. drug interaction in hormonal breast cancer therapy)
FullText URL 126_245.pdf
Author Masaoka, Yasuyuki| Kitamura, Yoshihisa| Sendo, Toshiaki|
Publication Title 岡山医学会雑誌
Published Date 2014-12-01
Volume volume126
Issue issue3
Start Page 245
End Page 248
ISSN 0030-1558
language 日本語
Copyright Holders Copyright (c) 2014 岡山医学会
File Version publisher
DOI 10.4044/joma.126.245
NAID 130004903247
Title Alternative Drug interaction (32. Drug interaction in novel oral anticoagulants)
FullText URL 127_59.pdf
Author Ida, Hiromi| Kitamura, Yoshihisa| Sendo, Toshiaki|
Publication Title 岡山医学会雑誌
Published Date 2015-04-01
Volume volume127
Issue issue1
Start Page 59
End Page 61
ISSN 0030-1558
Related Url http://www.okayama-u.ac.jp/user/oma/
language 日本語
Copyright Holders Copyright (c) 2015 岡山医学会
File Version publisher
DOI 10.4044/joma.127.59
NAID 130005068338
Title Alternative Drug interaction (33. Combination with antimicrobial agents)
FullText URL 127_151.pdf
Author Tasaka, Ken| Shiraishi, Naoko| Kitamura, Yoshihisa| Sendo, Toshiaki|
Publication Title 岡山医学会雑誌
Published Date 2015-08-03
Volume volume127
Issue issue2
Start Page 151
End Page 154
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.127.151
language 日本語
Copyright Holders Copyright (c) 2015 岡山医学会
File Version publisher
DOI 10.4044/joma.127.151
NAID 130005096260
Title Alternative Drug interaction (34. Drug interactions of food and medicine)
FullText URL 127_245.pdf
Author Hino, Hayato| Kitamura, Yoshihisa| Sendo, Toshiaki|
Publication Title 岡山医学会雑誌
Published Date 2015-12-01
Volume volume127
Issue issue3
Start Page 245
End Page 249
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.127.245
language 日本語
Copyright Holders Copyright (c) 2015 岡山医学会
File Version publisher
DOI 10.4044/joma.127.245
NAID 130005116813
Title Alternative Drug interaction (35. Opioid-analgesic drug interactions)
FullText URL 128_53.pdf
Author Sada, Hikaru| Kajizono, Makoto| Kitamura, Yoshihisa| Sendo, Toshiaki|
Publication Title 岡山医学会雑誌
Published Date 2016-04-01
Volume volume128
Issue issue1
Start Page 53
End Page 59
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.128.53
language 日本語
Copyright Holders Copyright (c) 2016 岡山医学会
File Version publisher
DOI 10.4044/joma.128.53
NAID 130005149610
Title Alternative Drug interaction (36. Combination with oral molecular target drugs in lung cancer)
FullText URL 128_141.pdf
Author Higashionna, Tsukasa| Esumi, Satoru| Kitamura, Yoshihisa| Sendo, Toshiaki|
Publication Title Journal of Okayama Medical Association
Published Date 2016-08-01
Volume volume128
Issue issue2
Start Page 141
End Page 146
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.128.141
language 日本語
Copyright Holders Copyright (c) 2016 岡山医学会
File Version publisher
DOI 10.4044/joma.128.141
NAID 130005262644
Author Miyamoto, Masashi| Esumi, Satoru| Kitamura, Yoshihisa| Sendo, Toshiaki|
Published Date 2016-12-01
Publication Title Journal of Okayama Medical Association
Volume volume128
Issue issue3
Content Type Article
Title Alternative Drug interaction (38. Combination with novel hypnotic drugs : ramelteon and suvorexant)
FullText URL 129_53.pdf
Author Kubo, Kazuko| Esumi, Satoru| Kitamura, Yoshihisa| Sendo, Toshiaki|
Publication Title Journal of Okayama Medical Association
Published Date 2017-04-03
Volume volume129
Issue issue1
Start Page 53
End Page 57
ISSN 0030-1558
language 日本語
Copyright Holders Copyright (c) 2017 岡山医学会
File Version publisher
DOI 10.4044/joma.129.53
NAID 130005632075
Title Alternative Drug interaction (39. Drug interaction in prostate cancer therapy)
FullText URL 129_131.pdf
Author Kanzaki, Hirotaka| Tanaka, Yuta| Maruo, Akinori| Nishihara, Shigeki | Kitamura, Yoshihisa| Sendo, Toshiaki|
Publication Title Journal of Okayama Medical Association
Published Date 2017-08-01
Volume volume129
Issue issue2
Start Page 131
End Page 136
ISSN 0030-1558
Related Url https://doi.org/10.4044/joma.129.131
language 日本語
Copyright Holders Copyright (c) 2017 岡山医学会
File Version publisher
DOI 10.4044/joma.129.131
NAID 130006039378
Title Alternative Drug interaction(46. Blending change and interaction of an injection drug)
Author Morishita, Yosuke| Esumi, Satoru| Nishihara, Shigeki| Kitamura, Yoshihisa| Sendo, Toshiaki|
Publication Title Journal of Okayama Medical Association
Published Date 2019-12-02
Volume volume131
Issue issue3
Start Page 161
End Page 164
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.131.161
language 日本語
Copyright Holders Copyright (c) 2019 岡山医学会
File Version publisher
DOI 10.4044/joma.131.161
NAID 130007782628
Title Alternative Drug interaction (47. Combination with general anesthetics)
Author Igawa, Yusuke| Esumi, Satoru| Kitamura, Yoshihisa| Sendo, Toshiaki|
Publication Title Journal of Okayama Medical Association
Published Date 2020-04-01
Volume volume132
Issue issue1
Start Page 29
End Page 33
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.132.29
language 日本語
Copyright Holders Copyright (c) 2020 岡山医学会
File Version publisher
DOI 10.4044/joma.132.29
NAID 130007840319
JaLCDOI 10.18926/AMO/40129
FullText URL 64_4_219.pdf
Author Doi, Maho| Miyazaki, Ikuko| Nagamachi, Tomoko| Shinomiya, Kazuaki| Matsunaga, Hisashi| Sendo, Toshiaki| Kawasaki, Hiromu| Asanuma, Masato| Gomita, Yutaka| Kitamura, Yoshihisa|
Abstract We examined the influence of chronic adrenocorticotropic hormone (ACTH) treatment on the number of Ki-67-positive cells in the dentate gyrus of the hippocampus in rats. ACTH treatment for 14 days decreased the number of such cells. The administration of imipramine or lithium alone for 14 days had no effect in saline-treated rats. The effect of ACTH was blocked by the administration of imipramine. Furthermore, the coadministration of imipramine and lithium for 14 days significantly increased the number of Ki-67-positive cells in both the saline and ACTH-treated rats. The coadministration of imipramine and lithium normalized the cell proliferation in the dentate gyrus of the hippocampus in rats treated with ACTH.
Keywords ACTH imipramine lithium proliferation Ki-67
Amo Type Original Article
Published Date 2010-08
Publication Title Acta Medica Okayama
Volume volume64
Issue issue4
Publisher Okayama University Medical School
Start Page 219
End Page 223
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 20802538
Web of Science KeyUT 000281384400002
Author Kitagawa, Kohei| Matsunaga, Hisashi| Sendo, Toshiaki|
Published Date 2012-04-01
Publication Title 岡山医学会雑誌
Volume volume124
Issue issue1
Content Type Journal Article
Author Hayashi, Keiichiro| Ueshima, Satoshi| Ouchida, Mamoru| Mashimo, Tomoji| Nishiki, Teiichi| Sendo, Toshiaki| Serikawa, Tadao| Matsui, Hideki| Ohmori, Iori|
Published Date 2011-05
Publication Title Epilepsia
Volume volume52
Issue issue5
Content Type Journal Article
Author Nishimiya, Yusuke| Konuma, Toshimitsu| Tasaka, Ken| Sendo, Toshiaki|
Published Date 2012-08-01
Publication Title 岡山医学会雑誌
Volume volume124
Issue issue2
Content Type Journal Article