JaLCDOI 10.18926/AMO/63425
FullText URL 76_2_203.pdf
Author Masuda, Tomoya| Tazawa, Hiroshi| Hashimoto, Yuuri| Ieda, Takeshi| Kikuchi, Satoru| Kuroda, Shinji| Noma, Kazuhiro| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Abstract The epithelial-mesenchymal transition (EMT), a normal biological process by which epithelial cells acquire a mesenchymal phenotype, is associated with migration, metastasis, and chemoresistance in cancer cells, and with poor prognosis in patients with esophageal cancer. However, therapeutic strategies to inhibit EMT in tumor environments remain elusive. Here, we show the therapeutic potential of telomerase-specific replication- competent oncolytic adenovirus OBP-301 in human esophageal cancer TE4 and TE6 cells with an EMT phenotype. Transforming growth factor-β (TGF-β) administration induced the EMT phenotype with spindleshaped morphology, upregulation of mesenchymal markers and EMT transcription factors, migration, and chemoresistance in TE4 and TE6 cells. OBP-301 significantly inhibited the EMT phenotype via E1 accumulation. EMT cancer cells were susceptible to OBP-301 via massive autophagy induction. OBP-301 suppressed tumor growth and lymph node metastasis of TE4 cells co-inoculated with TGF-β-secreting fibroblasts. Our results suggest that OBP-301 inhibits the TGF-β-induced EMT phenotype in human esophageal cancer cells. OBP-301-mediated E1A overexpression is a promising antitumor strategy to inhibit EMT-mediated esophageal cancer progression.
Keywords esophageal cancer EMT TGF-β oncolytic adenovirus E1A
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-04
Volume volume76
Issue issue2
Publisher Okayama University Medical School
Start Page 203
End Page 215
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 35503449
Web of Science KeyUT 000792291900003
FullText URL fulltext20220131-2.pdf
Author Kanaya, Nobuhiko| Kuroda, Shinji| Kakiuchi, Yoshihiko| Takeda, Sho| Kikuchi, Satoru| Noma, Kazuhiro| Yoshida, Ryuichi| Umeda, Yuzo| Teraishi, Fuminori| Nishizaki, Masahiko| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Keywords Gastric cancer D2 lymphadenectomy Suprapancreatic lymphadenectomy Posterior hepatic plexus Distal gastrectomy
Note This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00423-022-02437-4|
Published Date 2022-1-12
Publication Title Langenbeck's Archives of Surgery
Volume volume407
Issue issue2
Publisher Springer Science and Business Media LLC
Start Page 871
End Page 877
ISSN 1435-2443
NCID AA11211080
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022
File Version author
PubMed ID 35022835
DOI 10.1007/s00423-022-02437-4
Web of Science KeyUT 000741939500003
Related Url isVersionOf https://doi.org/10.1007/s00423-022-02437-4
FullText URL fulltext.pdf
Author Fujiwara, Noriko| Watanabe, Mayu| Katayama, Akihiro| Noda, Yohei| Eguchi, Jun| Kataoka, Hitomi| Kagawa, Shunsuke| Wada, Jun|
Keywords C-peptide diabetes mellitus immune checkpoint inhibitor insulin secretion
Published Date 2021-09-07
Publication Title Clinical Case Reports
Volume volume9
Issue issue9
Publisher Wiley
Start Page e04574
ISSN 2050-0904
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 The Authors.
File Version publisher
PubMed ID 34522382
DOI 10.1002/ccr3.4574
Web of Science KeyUT 000700003300112
Related Url isVersionOf https://doi.org/10.1002/ccr3.4574
FullText URL fulltext20211015-3.pdf figure20211015-3.pdf Suppl_Information20211015-3.pdf
Author Kakiuchi, Yoshihiko| Kuroda, Shinji| Kanaya, Nobuhiko| Kumon, Kento| Tsumura, Tomoko| Hashimoto, Masashi| Yagi, Chiaki| Sugimoto, Ryoma| Hamada, Yuki| Kikuchi, Satoru| Nishizaki, Masahiko| Kagawa, Shunsuke| Tazawa, Hiroshi| Urata, Yasuo| Fujiwara, Toshiyoshi|
Keywords Extracellular vesicles Exosome Abscopal effect Oncolytic adenovirus Local treatment Systemic delivery Drug delivery system
Note © 2021 The American Society of Gene and Cell Therapy. This manuscript version is made available under the CC-BY-NC-ND 4.0 License.http://creativecommons.org/licenses/by-nc-nd/4.0/.This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.ymthe.2021.05.015] .|
Published Date 2021-05-21
Publication Title Molecular Therapy
Volume volume29
Issue issue10
Publisher The American Society of Gene and Cell Therapy
Start Page 2920
End Page 2930
ISSN 15250016
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 The American Society of Gene and Cell Therapy.
File Version author
PubMed ID 34023506
DOI 10.1016/j.ymthe.2021.05.015
Web of Science KeyUT 000708324600008
Related Url isVersionOf https://doi.org/10.1016/j.ymthe.2021.05.015
FullText URL fulltext20210831-3.pdf
Author Shirakawa, Yasuhiro| Tazawa, Hiroshi| Tanabe, Shunsuke| Kanaya, Nobuhiko| Noma, Kazuhiro| Koujima, Takeshi| Kashima, Hajime| Kato, Takuya| Kuroda, Shinji| Kikuchi, Satoru| Kagawa, Shunsuke| Katsui, Kuniaki| Kanazawa, Susumu| Urata, Yasuo| Fujiwara, Toshiyoshi|
Keywords Telomerase adenovirus radiotherapy esophageal cancer immunotherapy
Note © 2021 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.ejca.2021.04.043] .|
Published Date 2021-8
Publication Title European Journal of Cancer
Volume volume153
Publisher Elsevier BV
Start Page 98
End Page 108
ISSN 0959-8049
NCID AA1075407X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 Elsevier Ltd.
File Version author
PubMed ID 34153720
DOI 10.1016/j.ejca.2021.04.043
Web of Science KeyUT 000686051300013
Related Url isVersionOf https://doi.org/10.1016/j.ejca.2021.04.043
FullText URL fulltext20210628-1.pdf Figure_20210628-1.pdf Supple_Figure_20210628-1.pdf Supple_Table_20210628-1.pdf
Author Sugiu, Kazuhisa| Tazawa, Hiroshi| Hasei, Joe| Yamakawa, Yasuaki| Omori, Toshinori| Komatsubara, Tadashi| Mochizuki, Yusuke| Kondo, Hiroya| Osaki, Shuhei| Fujiwara, Tomohiro| Yoshida, Aki| Kunisada, Toshiyuki| Ueda, Koji| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi|
Keywords Osteosarcoma Chemoresistance MDR1 Oncolytic adenovirus p53
Note This is a post-peer-review, pre-copyedit version of an article published in Cancer Chemotherapy and Pharmacology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00280-021-04310-5|
Published Date 2021-6-10
Publication Title Cancer Chemotherapy and Pharmacology
Volume volume88
Issue issue3
Publisher Springer Science and Business Media LLC
Start Page 513
End Page 524
ISSN 0344-5704
NCID AA00598397
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 34114067
DOI 10.1007/s00280-021-04310-5
Web of Science KeyUT 000659839700002
Related Url isVersionOf https://doi.org/10.1007/s00280-021-04310-5
FullText URL fulltext20210608-1.pdf highlights20210608-1.pdf figure20210608-1.pdf table20210608-1.pdf supplement20210608-1.pdf
Author Kuroda, Shinji| Kikuchi, Satoru| Kakiuchi, Yoshihiko| Watanabe, Megumi| Kuwada, Kazuya| Tsumura, Tomoko| Nishizaki, Masahiko| Kagawa, Shunsuke| Hinotsu, Shiro| Fujiwara, Toshiyoshi|
Note This is an Accepted Manuscript of an article published by Elsevier BV. © 2021 IJS Publishing Group Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.ijsu.2021.105946] . |
Published Date 2021-5
Publication Title International Journal of Surgery
Volume volume89
Publisher Elsevier BV
Start Page 105946
ISSN 1743-9191
NCID AA12063080
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 IJS Publishing Group Ltd.
File Version author
PubMed ID 33892160
DOI 10.1016/j.ijsu.2021.105946
Web of Science KeyUT 000651625600016
Related Url isVersionOf https://doi.org/10.1016/j.ijsu.2021.105946
FullText URL fulltext20210607-4.pdf table1-20210607-4.pdf table2-20210607-4.pdf figure-20210607-4.pdf
Author Kikuchi, Satoru| Kagawa, Tetsuya| Kuroda, Shinji| Nishizaki, Masahiko| Takata, Nobuo| Kuwada, Kazuya| Shoji, Ryohei| Kakiuchi, Yoshihiko| Mitsuhashi, Toshiharu| Umeda, Yuzo| Noma, Kazuhiro| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Keywords Endoscopic surgical skill quantification system Qualified surgeon Laparoscopic distal gastrectomy Gastric cancer Cumulative sum analysis
Note This is a post-peer-review, pre-copyedit version of an article published in [Surgery Today]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00595-021-02309-2|
Published Date 2021-5-29
Publication Title Surgery Today
Volume volume51
Publisher Springer Science and Business Media LLC
Start Page 1978
End Page 1984
ISSN 0941-1291
NCID AA10824685
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Springer Nature Singapore Pte Ltd. 2021
File Version author
PubMed ID 34050804
DOI 10.1007/s00595-021-02309-2
Web of Science KeyUT 000655944300001
Related Url isVersionOf https://doi.org/10.1007/s00595-021-02309-2
FullText URL fulltext.pdf
Author Omori, Toshinori| Tazawa, Hiroshi| Yamakawa, Yasuaki| Osaki, Shuhei| Hasei, Joe| Sugiu, Kazuhisa| Komatsubara, Tadashi| Fujiwara, Tomohiro| Yoshida, Aki| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi|
Keywords Gastric yolk sac Tumor-like carcinoma Adenocarcinoma; Alpha-fetoprotein
Published Date 2021-04-22
Publication Title PLoS ONE
Volume volume16
Issue issue4
Publisher Public Library Science
Start Page e0250643
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 Omori et al.
File Version publisher
PubMed ID 33886686
NAID 120007045007
DOI 10.1371/journal.pone.0250643
Web of Science KeyUT 000644138300019
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0250643
FullText URL fulltext20210608.pdf
Author Umeda, Hibiki| Kikuchi, Satoru| Kuroda, Shinji| Yano, Shuya| Tanaka, Takehiro| Noma, Kazuhiro| Nishizaki, Masahiko| Kagawa, Shunsuke| Umeda, Yuzo| Fujiwara, Toshiyoshi|
Keywords Gastric yolk sac Tumor-like carcinoma Adenocarcinoma Alpha-fetoprotein
Published Date 2021-05-06
Publication Title Surgical Case Reports
Volume volume7
Issue issue1
Publisher Springer
Start Page 111
ISSN 2198-7793
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2021.
File Version publisher
PubMed ID 33956241
NAID 120007045008
DOI 10.1186/s40792-021-01199-3
Web of Science KeyUT 000656467700001
Related Url isVersionOf https://doi.org/10.1186/s40792-021-01199-3
JaLCDOI 10.18926/AMO/61906
FullText URL 75_2_231.pdf
Author Endo, Motochika| Yano, Shuya| Asano, Hiroaki| Takeda, Sho| Hamada, Yuki| Kondo, Yoshitaka| Kuroda, Shinji| Shigeyasu, Kunitoshi| Kikuchi, Satoru| Tanaka, Takehiro| Teraishi, Fuminori| Nishizaki, Masahiko| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Abstract Targeted therapies for malignant melanoma have improved patients’ prognoses. A primary gastrointestinal malignant melanoma is very rare, with no standard treatment strategy. We treated a 78-year-old Japanese female with advanced primary gastrointestinal melanoma of the descending colon and gallbladder. We administered a multidisciplinary treatment: surgical resection of the descending colon and gallbladder tumors, resection of the metastatic lymph nodes behind the pancreas head, and immune checkpoint antibody-blockade therapy (nivolumab) for ~4 years. PET/CT demonstrated no recurrent lesion for > 3 years. Multidisciplinary therapies (e.g., surgery, chemotherapy, radiotherapy, target therapy, and immune checkpoint antibody-blockade therapy) can successfully treat primary gastrointestinal malignant melanoma.
Keywords primary gastrointestinal melanoma laparoscopic surgery immune checkpoint antibody-blockade inhibitor
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2021-04
Volume volume75
Issue issue2
Publisher Okayama University Medical School
Start Page 231
End Page 238
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33953431
NAID 120007029881
FullText URL fulltext.pdf
Author Ito, Atene| Kagawa, Shunsuke| Sakamoto, Shuichi| Kuwada, Kazuya| Kajioka, Hiroki| Yoshimoto, Masashi| Kikuchi, Satoru| Kuroda, Shinji| Yoshida, Ryuichi| Tazawa, Hiroshi| Fujiwara, Toshiyoshi|
Keywords Extracellular vesicles Gastric cancer Tumor-associated macrophages Tumor microenvironment
Published Date 2021-01-28
Publication Title BMC Cancer
Volume volume21
Issue issue1
Publisher BMC
Start Page 102
ISSN 1471-2407
NCID AA12034763
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2021
File Version publisher
PubMed ID 33509150
DOI 10.1186/s12885-021-07816-6
Web of Science KeyUT 000615987400002
Related Url isVersionOf https://doi.org/10.1186/s12885-021-07816-6
FullText URL fulltext.pdf
Author Katsube, Ryoichi| Noma, Kazuhiro| Ohara, Toshiaki| Nishiwaki, Noriyuki| Kobayashi, Teruki| Komoto, Satoshi| Sato, Hiroaki| Kashima, Hajime| Kato, Takuya| Kikuchi, Satoru| Tazawa, Hiroshi| Kagawa, Shunsuke| Shirakawa, Yasuhiro| Kobayashi, Hisataka| Fujiwara, Toshiyoshi|
Published Date 2021-01-18
Publication Title Scientific Reports
Volume volume11
Issue issue1
Publisher Nature Research
Start Page 1693
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2021
File Version publisher
PubMed ID 33462372
DOI 10.1038/s41598-021-81465-4
Web of Science KeyUT 000612156600008
Related Url isVersionOf https://doi.org/10.1038/s41598-021-81465-4
FullText URL fulltext.pdf
Author Yano, Shuya| Tazawa, Hiroshi| Kishimoto, Hiroyuki| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| Hoffman, Robert M.|
Keywords cancer cell cycle fluorescent proteins FUCCI imaging adenovirus oncolytic virotherapy cancer stem cell mouse model orthotopic
Published Date 2021-01-17
Publication Title International Journal of Molecular Sciences
Volume volume22
Issue issue2
Publisher MDPI
Start Page 879
ISSN 1422-0067
NCID AA12038549
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 by the authors.
File Version publisher
PubMed ID 33477279
DOI 10.3390/ijms22020879
Web of Science KeyUT 000611296000001
Related Url isVersionOf https://doi.org/10.3390/ijms22020879
FullText URL fulltext.pdf Figures.pdf Suppl_Material_Methods.pdf Suppl_Figures.pdf Legend_suppl_figures.pdf Suppl_Table.pdf
Author Kajioka, Hiroki| Kagawa, Shunsuke| Ito, Atene| Yoshimoto, Masashi| Sakamoto, Shuichi| Kikuchi, Satoru| Kuroda, Shinji| Yoshida, Ryuichi| Umeda, Yuzo| Noma, Kazuhiro| Tazawa, Hiroshi| Fujiwara, Toshiyoshi|
Keywords HMGB1 Epithelial to mesenchymal transition Phorbol 12-myristate 13-acetate Ischemia-reperfusion model
Note This fulltext is available in January, 2022.|
Published Date 2021-01-28
Publication Title Cancer Letters
Volume volume497
Publisher Elsevier
Start Page 1
End Page 3
ISSN 0304-3835
NCID AA00598513
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 33065249
DOI 10.1016/j.canlet.2020.10.015
Web of Science KeyUT 000596072900001
Related Url isVersionOf https://doi.org/10.1016/j.canlet.2020.10.015
FullText URL fulltext.pdf
Author Tsumura, Tomoko| Kuroda, Shinji| Nishizaki, Masahiko| Kikuchi, Satoru| Kakiuchi, Yoshihiko| Takata, Nobuo| Ito, Atene| Watanabe, Megumi| Kuwada, Kazuya| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Published Date 2020-11-12
Publication Title PLoS ONE
Volume volume15
Issue issue11
Publisher Public Library of Science
Start Page e0242223
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 Tsumura et al.
File Version publisher
PubMed ID 33180871
DOI 10.1371/journal.pone.0242223
Web of Science KeyUT 000593948000022
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0242223
FullText URL fulltext.pdf figures.pdf SuppleFigures.pdf
Author Mochizuki, Yusuke| Tazawa, Hiroshi| Demiya, Koji| Kure, Miho| Kondo, Hiroya| Komatsubara, Tadashi| Sugiu, Kazuhisa| Hasei, Joe| Yoshida, Aki| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi|
Keywords Oncolytic adenovirus hTERT Immunogenic cell death ATP CD8
Note This is a post-peer-review, pre-copyedit version of an article published in Cancer Immunology, Immunotherapy. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00262-020-02774-7.|
Published Date 2020-11-05
Publication Title Cancer Immunology, Immunotherapy
Volume volume70
Publisher Springer
Start Page 1405
End Page 1417
ISSN 0340-7004
NCID AA00598499
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 33151368
DOI 10.1007/s00262-020-02774-7
Web of Science KeyUT 000586350500002
Related Url isVersionOf https://doi.org/10.1007/s00262-020-02774-7
FullText URL Fulltext.pdf Tables.pdf Figure 1.tiff
Author Kikuchi, Satoru| Kuroda, Shinji| Nishizaki, Masahiko| Kuwada, Kazuya| Takata, Nobuo| Kakiuchi, Yoshihiko| Yano, Shuya| Noma , Kazuhiro| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Keywords Billroth I reconstruction gastric cancer laparoscopic distal gastrectomy
Note This is the peer reviewed version of the following article: Satoru Kikuchi et. al. Intracorporeal semi‐hand‐sewn Billroth I reconstruction in total laparoscopic distal gastrectomy. Asian Journal of Endoscopic Surgery (2020), which has been published in final form at https://doi.org/10.1111/ases.12887. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
This fulltext is available on Oct. 2021.|
Published Date 2020-10-27
Publication Title Asian Journal of Endoscopic Surgery
Volume volume2021
Issue issue14
Publisher Wiley
Start Page 640
End Page 643
ISSN 1758-5902
NCID AA12488501
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 33111451
DOI 10.1111/ases.12887
Web of Science KeyUT 000583948100001
Related Url isVersionOf https://doi.org/10.1111/ases.12887
FullText URL fulltext.pdf
Author Yano, Shuya| Tazawa, Hiroshi| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| Hoffman, Robert M.|
Keywords cell cycle fluorescent proteins FUCCI imaging targeted cancer therapy quiescent cancer cells decoy chemotherapy
Published Date 2020-09-17
Publication Title Cancers
Volume volume12
Issue issue9
Publisher MDPI
Start Page 2655
ISSN 2072-6694
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 32957652
DOI 10.3390/cancers12092655
Web of Science KeyUT 000580315800001
Related Url isVersionOf https://doi.org/10.3390/cancers12092655
FullText URL fulltext.pdf
Author Tanimoto, Terutaka| Tazawa, Hiroshi| Ieda, Takeshi| Nouso, Hiroshi| Tani, Morimichi| Oyama, Takanori| Urata, Yasuo| Kagawa, Shunsuke| Noda, Takuo| Fujiwara, Toshiyoshi|
Keywords neuroblastoma MYCN hTERT adenovirus E2F1
Published Date 2020-09-25
Publication Title Molecular Therapy - Oncolytics
Volume volume18
Publisher Cell Press
Start Page 14
End Page 23
ISSN 2372-7705
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Author(s).
File Version publisher
PubMed ID 32637577
DOI 10.1016/j.omto.2020.05.015
Web of Science KeyUT 000575168700002
Related Url isVersionOf https://doi.org/10.1016/j.omto.2020.05.015