| Author | Shigeyasu, Kunitoshi| Tazawa, Hiroshi| Hashimoto, Yuuri| Mori, Yoshiko| Nishizaki, Masahiko| Kishimoto, Hiroyuki| Nagasaka, Takeshi| Kuroda, Shinji| Urata, Yasuo| Goel, Ajay| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2014-05-28 |
| Publication Title | Gut |
| Content Type | Journal Article |
| FullText URL | fulltext.pdf Graphical_Abstract.pptx Figure1-6.pdf Supp_Info.pdf |
|---|---|
| Author | Kanaya, Nobuhiko| Kuroda, Shinji| Kakiuchi, Yoshihiko| Kumon, Kento| Tsumura, Tomoko| Hashimoto, Masashi| Morihiro, Toshiaki| Kubota, Tetsushi| Aoyama, Katsuyuki| Kikuchi, Satoru| Nishizaki, Masahiko| Kagawa, Shunsuke| Tazawa, Hiroshi| Mizuguchi, Hiroyuki| Urata, Yasuo| Fujiwara, Toshiyoshi| |
| Keywords | immune checkpoint programmed death-1 oncolytic adenovirus combined immunotherapy immunogenic cell death tumor infiltrating lymphocytes CD8 abscopal effect |
| Published Date | 2020-01-10 |
| Publication Title | Molecular Therapy |
| Volume | volume28 |
| Issue | issue3 |
| Publisher | Cell Press |
| Start Page | 794 |
| End Page | 804 |
| ISSN | 15250016 |
| NCID | AA11475060 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 31991110 |
| DOI | 10.1016/j.ymthe.2020.01.003 |
| Web of Science KeyUT | 000518887200012 |
| Related Url | isVersionOf https://doi.org/10.1016/j.ymthe.2020.01.003 |
| FullText URL | Fulltext.pdf Tables.pdf Figure 1.tiff |
|---|---|
| Author | Kikuchi, Satoru| Kuroda, Shinji| Nishizaki, Masahiko| Kuwada, Kazuya| Takata, Nobuo| Kakiuchi, Yoshihiko| Yano, Shuya| Noma , Kazuhiro| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| Keywords | Billroth I reconstruction gastric cancer laparoscopic distal gastrectomy |
| Note | This is the peer reviewed version of the following article: Satoru Kikuchi et. al. Intracorporeal semi‐hand‐sewn Billroth I reconstruction in total laparoscopic distal gastrectomy. Asian Journal of Endoscopic Surgery (2020), which has been published in final form at https://doi.org/10.1111/ases.12887. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This fulltext is available on Oct. 2021.| |
| Published Date | 2020-10-27 |
| Publication Title | Asian Journal of Endoscopic Surgery |
| Volume | volume2021 |
| Issue | issue14 |
| Publisher | Wiley |
| Start Page | 640 |
| End Page | 643 |
| ISSN | 1758-5902 |
| NCID | AA12488501 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 33111451 |
| DOI | 10.1111/ases.12887 |
| Web of Science KeyUT | 000583948100001 |
| Related Url | isVersionOf https://doi.org/10.1111/ases.12887 |
| FullText URL | OncoImmunol_8_12_1671760.pdf |
|---|---|
| Author | Sakamoto, Shuichi| Kagawa, Shunsuke| Kuwada, Kazuya| Ito, Atene| Kajioka, Hiroki| Kakiuchi, Yoshihiko| Watanabe, Megumi| Kagawa, Tetsuya| Yoshida, Ryuichi| Kikuchi, Satoru| Kuroda, Shinji| Tazawa, Hiroshi| Fujiwara, Toshiyoshi| |
| Keywords | Gastric cancer tumor-associated macrophages tumor microenvironment peritoneal dissemination |
| Published Date | 2019-10-22 |
| Publication Title | OncoImmunology |
| Volume | volume8 |
| Issue | issue12 |
| Publisher | TAYLOR & FRANCIS |
| Start Page | e1671760 |
| ISSN | 2162402X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 The Author(s). |
| File Version | publisher |
| DOI | 10.1080/2162402X.2019.1671760 |
| Web of Science KeyUT | 000494085400001 |
| Related Url | isVersionOf https://doi.org/10.1080/2162402X.2019.1671760 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kakiuchi, Yoshihiko| Kikuchi, Satoru| Kuroda, Shinji| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| Keywords | Remnant gastric cancer Prognostic factor Tumor-infiltrating lymphocytes CD8(+) T cell Tumor immunity |
| Published Date | 2022-11-30 |
| Publication Title | World Journal Of Surgical Oncology |
| Volume | volume20 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 374 |
| ISSN | 1477-7819 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022. |
| File Version | publisher |
| PubMed ID | 36451224 |
| DOI | 10.1186/s12957-022-02853-2 |
| Web of Science KeyUT | 000892980100002 |
| Related Url | isVersionOf https://doi.org/10.1186/s12957-022-02853-2 |
| FullText URL | fulltext20211015-3.pdf figure20211015-3.pdf Suppl_Information20211015-3.pdf |
|---|---|
| Author | Kakiuchi, Yoshihiko| Kuroda, Shinji| Kanaya, Nobuhiko| Kumon, Kento| Tsumura, Tomoko| Hashimoto, Masashi| Yagi, Chiaki| Sugimoto, Ryoma| Hamada, Yuki| Kikuchi, Satoru| Nishizaki, Masahiko| Kagawa, Shunsuke| Tazawa, Hiroshi| Urata, Yasuo| Fujiwara, Toshiyoshi| |
| Keywords | Extracellular vesicles Exosome Abscopal effect Oncolytic adenovirus Local treatment Systemic delivery Drug delivery system |
| Note | © 2021 The American Society of Gene and Cell Therapy. This manuscript version is made available under the CC-BY-NC-ND 4.0 License.http://creativecommons.org/licenses/by-nc-nd/4.0/.This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.ymthe.2021.05.015] .| |
| Published Date | 2021-05-21 |
| Publication Title | Molecular Therapy |
| Volume | volume29 |
| Issue | issue10 |
| Publisher | The American Society of Gene and Cell Therapy |
| Start Page | 2920 |
| End Page | 2930 |
| ISSN | 15250016 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 The American Society of Gene and Cell Therapy. |
| File Version | author |
| PubMed ID | 34023506 |
| DOI | 10.1016/j.ymthe.2021.05.015 |
| Web of Science KeyUT | 000708324600008 |
| Related Url | isVersionOf https://doi.org/10.1016/j.ymthe.2021.05.015 |
| JaLCDOI | 10.18926/AMO/65152 |
|---|---|
| FullText URL | 77_2_209.pdf |
| Author | Sakamoto, Masaki| Teraishi, Fuminori| Shigeyasu Kunitoshi| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| Abstract | A 70-year-old male with anal pain and fever was diagnosed with rectal cancer perforation and abscess in the right gluteus maximus (GM) muscle. He underwent a transverse colon colostomy followed by preoperative capecitabine+oxaliplatin. Some local control was achieved but a residual abscess was observed in the right GM muscle. To secure circumferential resection margin by tumor reduction, he received chemoradiotherapy as total neoadjuvant therapy (TNT) and underwent laparoscopic abdominoperineal resection, D3 lymph node dissection, combined coccyx resection, and partial resection of the right GM muscle. The skin defect and pelvic dead space were filled with a right lateral vastus lateral great muscle flap. Histopathologically, the resected specimen showed no tumor cells in the primary tumor or lymph nodes, indicating a pathological complete response (pCR). This case suggests that TNT might improve the R0 resection and pCR rates and overall survival. |
| Keywords | locally advanced rectal cancer total neoadjuvant therapy lateral vastus lateral great muscle flap |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-04 |
| Volume | volume77 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 209 |
| End Page | 213 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37094960 |
| Web of Science KeyUT | 000982563800003 |
| JaLCDOI | 10.18926/AMO/61906 |
|---|---|
| FullText URL | 75_2_231.pdf |
| Author | Endo, Motochika| Yano, Shuya| Asano, Hiroaki| Takeda, Sho| Hamada, Yuki| Kondo, Yoshitaka| Kuroda, Shinji| Shigeyasu, Kunitoshi| Kikuchi, Satoru| Tanaka, Takehiro| Teraishi, Fuminori| Nishizaki, Masahiko| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| Abstract | Targeted therapies for malignant melanoma have improved patients’ prognoses. A primary gastrointestinal malignant melanoma is very rare, with no standard treatment strategy. We treated a 78-year-old Japanese female with advanced primary gastrointestinal melanoma of the descending colon and gallbladder. We administered a multidisciplinary treatment: surgical resection of the descending colon and gallbladder tumors, resection of the metastatic lymph nodes behind the pancreas head, and immune checkpoint antibody-blockade therapy (nivolumab) for ~4 years. PET/CT demonstrated no recurrent lesion for > 3 years. Multidisciplinary therapies (e.g., surgery, chemotherapy, radiotherapy, target therapy, and immune checkpoint antibody-blockade therapy) can successfully treat primary gastrointestinal malignant melanoma. |
| Keywords | primary gastrointestinal melanoma laparoscopic surgery immune checkpoint antibody-blockade inhibitor |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-04 |
| Volume | volume75 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 231 |
| End Page | 238 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33953431 |
| NAID | 120007029881 |
| FullText URL | fulltext20240219-05.pdf |
|---|---|
| Author | Hashimoto, Masashi| Kuroda, Shinji| Kanaya, Nobuhiko| Kadowaki, Daisuke| Yoshida, Yusuke| Sakamoto, Masaki| Hamada, Yuki| Sugimoto, Ryoma| Yagi, Chiaki| Ohtani, Tomoko| Kumon, Kento| Kakiuchi, Yoshihiko| Yasui, Kazuya| Kikuchi, Satoru| Yoshida, Ryuichi| Tazawa, Hiroshi| Kagawa, Shunsuke| Yagi, Takahito| Urata, Yasuo| Fujiwara, Toshiyoshi| |
| Note | The version of record of this article, first published in British Journal of Cancer, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41416-024-02583-0| |
| Published Date | 2024-02-05 |
| Publication Title | British Journal of Cancer |
| Volume | volume130 |
| Issue | issue7 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 1187 |
| End Page | 1195 |
| ISSN | 0007-0920 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024 |
| File Version | publisher |
| PubMed ID | 38316993 |
| DOI | 10.1038/s41416-024-02583-0 |
| Web of Science KeyUT | 001156904400001 |
| Related Url | isVersionOf https://doi.org/10.1038/s41416-024-02583-0 |
| FullText URL | fulltext20210608.pdf |
|---|---|
| Author | Umeda, Hibiki| Kikuchi, Satoru| Kuroda, Shinji| Yano, Shuya| Tanaka, Takehiro| Noma, Kazuhiro| Nishizaki, Masahiko| Kagawa, Shunsuke| Umeda, Yuzo| Fujiwara, Toshiyoshi| |
| Keywords | Gastric yolk sac Tumor-like carcinoma Adenocarcinoma Alpha-fetoprotein |
| Published Date | 2021-05-06 |
| Publication Title | Surgical Case Reports |
| Volume | volume7 |
| Issue | issue1 |
| Publisher | Springer |
| Start Page | 111 |
| ISSN | 2198-7793 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2021. |
| File Version | publisher |
| PubMed ID | 33956241 |
| NAID | 120007045008 |
| DOI | 10.1186/s40792-021-01199-3 |
| Web of Science KeyUT | 000656467700001 |
| Related Url | isVersionOf https://doi.org/10.1186/s40792-021-01199-3 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Fujiwara, Noriko| Watanabe, Mayu| Katayama, Akihiro| Noda, Yohei| Eguchi, Jun| Kataoka, Hitomi| Kagawa, Shunsuke| Wada, Jun| |
| Keywords | C-peptide diabetes mellitus immune checkpoint inhibitor insulin secretion |
| Published Date | 2021-09-07 |
| Publication Title | Clinical Case Reports |
| Volume | volume9 |
| Issue | issue9 |
| Publisher | Wiley |
| Start Page | e04574 |
| ISSN | 2050-0904 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 The Authors. |
| File Version | publisher |
| PubMed ID | 34522382 |
| DOI | 10.1002/ccr3.4574 |
| Web of Science KeyUT | 000700003300112 |
| Related Url | isVersionOf https://doi.org/10.1002/ccr3.4574 |
| Author | Yoshida, Ryosuke| Tazawa, Hiroshi| Hashimoto, Yuuri| Yano, Shuya| Onishi, Teppei| Sasaki, Tsuyoshi| Shirakawa, Yasuhiro| Kishimoto, Hiroyuki| Uno, Futoshi| Nishizaki, Masahiko| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2012-11 |
| Publication Title | Cancer Immunology, Immunotherapy |
| Volume | volume61 |
| Issue | issue11 |
| Content Type | Journal Article |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ogawa, Toshihiro| Kikuchi, Satoru| Tabuchi, Motoyasu| Mitsui, Ema| Une, Yuta| Tazawa, Hiroshi| Kuroda, Shinji| Noma, Kazuhiro| Ohara, Toshiaki| Kagawa, Shunsuke| Urata, Yasuo| Fujiwara, Toshiyoshi| |
| Published Date | 2022-06-16 |
| Publication Title | Molecular Therapy-Oncolytics |
| Volume | volume25 |
| Publisher | Cell Press |
| Start Page | 249 |
| End Page | 261 |
| ISSN | 2372-7705 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Author(s). |
| File Version | publisher |
| PubMed ID | 35615263 |
| DOI | 10.1016/j.omto.2022.04.009 |
| Web of Science KeyUT | 000800437000008 |
| Related Url | isVersionOf https://doi.org/10.1016/j.omto.2022.04.009 |
| FullText URL | AGS3_1_96.pdf SI.pdf |
|---|---|
| Author | Kuroda, Shinji| Choda, Yasuhiro| Otsuka, Shinya| Ueyama, Satoshi| Tanaka, Norimitsu| Muraoka, Atsushi| Hato, Shinji| Kimura, Toshikazu| Tanakaya, Kohji| Kikuchi, Satoru| Tanabe, Shunsuke| Noma, Kazuhiro| Nishizaki, Masahiko| Kagawa, Shunsuke| Shirakawa, Yasuhiro| Kamikawa, Yasuaki| Fujiwara, Toshiyoshi| |
| Keywords | Kamikawa procedure antireflux surgery double‐flap technique esophagogastrostomy proximal gastrectomy |
| Published Date | 2018-10-11 |
| Publication Title | Annals of Gastroenterological Surgery |
| Volume | volume3 |
| Issue | issue1 |
| Publisher | Woley |
| Start Page | 96 |
| End Page | 103 |
| ISSN | 2475-0328 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2018 The Authors |
| File Version | publisher |
| PubMed ID | 30697614 |
| DOI | 10.1002/ags3.12216 |
| Web of Science KeyUT | 000456643500012 |
| Related Url | isVersionOf https://doi.org/10.1002/ags3.12216 |
| JaLCDOI | 10.18926/AMO/52006 |
|---|---|
| FullText URL | 67_6_333.pdf |
| Author | Tazawa, Hiroshi| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| Abstract | Autophagy is a catabolic process that produces energy through lysosomal degradation of intracellular organelles. Autophagy functions as a cytoprotective factor under physiological conditions such as nutrient deprivation, hypoxia, and interruption of growth factors. On the other hand, infection with pathogenic viruses and bacteria also induces autophagy in infected cells. Oncolytic virotherapy with replication-competent viruses is thus a promising strategy to induce tumor-specific cell death. Oncolytic adenoviruses induce autophagy and subsequently contribute to cell death rather than cell survival in tumor cells. We previously developed a telomerase-specific replication-competent oncolytic adenovirus, OBP-301, which induces cell lysis in tumor cells with telomerase activities. OBP-301-mediated cytopathic activity is significantly associated with induction of autophagy biomarkers. In this review, we focus on the tumor-suppressive role and molecular basis of autophagic machinery induced by oncolytic adenoviruses. Addition of tumor-specific promoters and modification of the fiber knob of adenoviruses supports the oncolytic adenovirus-mediated autophagic cell death. Autophagy is cooperatively regulated by the E1-dependent activation pathway, E4-dependent inhibitory pathway, and microRNA-dependent fine-tuning. Thus, future exploration of the functional role and molecular mechanisms underlying oncolytic adenovirus-induced autophagy would provide novel insights and improve the therapeutic potential of oncolytic adenoviruses. |
| Keywords | oncolytic adenovirus autophagy E2F1 microRNA |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-12 |
| Volume | volume67 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 333 |
| End Page | 342 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24356717 |
| Web of Science KeyUT | 000328915700001 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Omori, Toshinori| Tazawa, Hiroshi| Yamakawa, Yasuaki| Osaki, Shuhei| Hasei, Joe| Sugiu, Kazuhisa| Komatsubara, Tadashi| Fujiwara, Tomohiro| Yoshida, Aki| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi| |
| Keywords | Gastric yolk sac Tumor-like carcinoma Adenocarcinoma; Alpha-fetoprotein |
| Published Date | 2021-04-22 |
| Publication Title | PLoS ONE |
| Volume | volume16 |
| Issue | issue4 |
| Publisher | Public Library Science |
| Start Page | e0250643 |
| ISSN | 1932-6203 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 Omori et al. |
| File Version | publisher |
| PubMed ID | 33886686 |
| NAID | 120007045007 |
| DOI | 10.1371/journal.pone.0250643 |
| Web of Science KeyUT | 000644138300019 |
| Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0250643 |
| FullText URL | fulltext20210628-1.pdf Figure_20210628-1.pdf Supple_Figure_20210628-1.pdf Supple_Table_20210628-1.pdf |
|---|---|
| Author | Sugiu, Kazuhisa| Tazawa, Hiroshi| Hasei, Joe| Yamakawa, Yasuaki| Omori, Toshinori| Komatsubara, Tadashi| Mochizuki, Yusuke| Kondo, Hiroya| Osaki, Shuhei| Fujiwara, Tomohiro| Yoshida, Aki| Kunisada, Toshiyuki| Ueda, Koji| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi| |
| Keywords | Osteosarcoma Chemoresistance MDR1 Oncolytic adenovirus p53 |
| Note | This is a post-peer-review, pre-copyedit version of an article published in Cancer Chemotherapy and Pharmacology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00280-021-04310-5| |
| Published Date | 2021-6-10 |
| Publication Title | Cancer Chemotherapy and Pharmacology |
| Volume | volume88 |
| Issue | issue3 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 513 |
| End Page | 524 |
| ISSN | 0344-5704 |
| NCID | AA00598397 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 34114067 |
| DOI | 10.1007/s00280-021-04310-5 |
| Web of Science KeyUT | 000659839700002 |
| Related Url | isVersionOf https://doi.org/10.1007/s00280-021-04310-5 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Araki, Hiroyuki| Tazawa, Hiroshi| Kanaya, Nobuhiko| Kajiwara, Yoshinori| Yamada, Motohiko| Hashimoto, Masashi| Kikuchi, Satoru| Kuroda, Shinji| Yoshida, Ryuichi| Umeda, Yuzo| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| Published Date | 2022-12-15 |
| Publication Title | Molecular Therapy - Oncolytics |
| Volume | volume27 |
| Publisher | Cell Press |
| Start Page | 3 |
| End Page | 13 |
| ISSN | 2372-7705 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Author(s). |
| File Version | publisher |
| PubMed ID | 36212775 |
| DOI | 10.1016/j.omto.2022.09.003 |
| Web of Science KeyUT | 000870232500001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.omto.2022.09.003 |
| JaLCDOI | 10.18926/AMO/54981 |
|---|---|
| FullText URL | 71_2_127.pdf |
| Author | Shirakawa, Yasuhiro| Noma, Kazuhiro| Maeda, Naoaki| Tanabe, Shunsuke| Kuroda, Shinji| Kagawa, Shunsuke| Katsui, Kuniaki| Katayama, Norihisa| Kanazawa, Susumu| Fujiwara, Toshiyoshi| |
| Abstract | Currently, chemoradiation is the most widely used nonsurgical treatment for esophageal cancer. However, some patients, particularly the very elderly or those with severe vital organ dysfunction, face difficulty with the chemotherapy component. We therefore examined the outcome of radiation therapy (RT) alone for patients with esophageal cancer at our facility. Between January 2005 and December 2014, 84 patients underwent RT at our hospital, and 78 of these patients received concomitant chemotherapy. The remaining 6 patients underwent RT alone; these patients were considered to be high-risk and to have no lymph node metastasis (stage I). Five of them received irradiation up to a curative dose: 4 showed a complete response (CR) and 1 showed a partial response (PR). Of the patients exhibiting CR, 3 are currently living recurrence-free, whereas 1 patient underwent endoscopic submucosal dissection (ESD) as salvage therapy for local recurrence, with no subsequent recurrence. High-risk stage I esophageal cancer patients can be treated radically with RT alone under certain conditions. In the future, to broaden the indications for RT monotherapy to include some degree of advanced cancers, a novel concurrent therapy should be identified. |
| Keywords | esophageal cancer radiation therapy high-risk patient |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2017-04 |
| Volume | volume71 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 127 |
| End Page | 133 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28420894 |
| JaLCDOI | 10.18926/AMO/63425 |
|---|---|
| FullText URL | 76_2_203.pdf |
| Author | Masuda, Tomoya| Tazawa, Hiroshi| Hashimoto, Yuuri| Ieda, Takeshi| Kikuchi, Satoru| Kuroda, Shinji| Noma, Kazuhiro| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| Abstract | The epithelial-mesenchymal transition (EMT), a normal biological process by which epithelial cells acquire a mesenchymal phenotype, is associated with migration, metastasis, and chemoresistance in cancer cells, and with poor prognosis in patients with esophageal cancer. However, therapeutic strategies to inhibit EMT in tumor environments remain elusive. Here, we show the therapeutic potential of telomerase-specific replication- competent oncolytic adenovirus OBP-301 in human esophageal cancer TE4 and TE6 cells with an EMT phenotype. Transforming growth factor-β (TGF-β) administration induced the EMT phenotype with spindleshaped morphology, upregulation of mesenchymal markers and EMT transcription factors, migration, and chemoresistance in TE4 and TE6 cells. OBP-301 significantly inhibited the EMT phenotype via E1 accumulation. EMT cancer cells were susceptible to OBP-301 via massive autophagy induction. OBP-301 suppressed tumor growth and lymph node metastasis of TE4 cells co-inoculated with TGF-β-secreting fibroblasts. Our results suggest that OBP-301 inhibits the TGF-β-induced EMT phenotype in human esophageal cancer cells. OBP-301-mediated E1A overexpression is a promising antitumor strategy to inhibit EMT-mediated esophageal cancer progression. |
| Keywords | esophageal cancer EMT TGF-β oncolytic adenovirus E1A |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-04 |
| Volume | volume76 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 203 |
| End Page | 215 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35503449 |
| Web of Science KeyUT | 000792291900003 |
