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  3. Kagawa, Shunsuke

Kagawa, Shunsuke

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Novel Therapeutic Algorism in Patients With Anterior Cutaneous Nerve Entrapment Syndrome
FullText URL fulltext.pdf
Author Kondo, Yoshitaka| Kanaya, Nobuhiko| Kobayashi, Ami| Arakawa, Kyosuke| Matsuoka, Yoshikazu| Mimata, Yudai| Kakiuchi, Yoshihiko| Shigeyasu, Kunitoshi| Kuroda, Shinji| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Keywords anterior cutaneous nerve entrapment syndrome (ACNES) neurectomy trigger point injections (TPIs)
Published Date 2025-03-17
Publication Title Neurology and Clinical Neuroscience
Publisher Wiley
ISSN 2049-4173
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 The Author(s).
File Version publisher
DOI 10.1111/ncn3.70008
Web of Science KeyUT 001446770700001
Related Url isVersionOf https://doi.org/10.1111/ncn3.70008
Cancer-related alopecia and wig acquisition: how age, sex, and treatment affect patient choices
FullText URL fulltext.pdf
Author Katayama, Hideki| Ichihara, Eiki| Morita, Ayako| Makimoto, Go| Kagawa, Shunsuke| Ishii, Ayano| Tabata, Masahiro| Maeda, Yoshinobu|
Keywords Cancer Alopecia Wig purchases Appearance care Patient support
Published Date 2025-03-15
Publication Title Supportive Care in Cancer
Volume volume33
Issue issue4
Publisher Springer Science and Business Media LLC
Start Page 283
ISSN 0941-4355
NCID AA10996793
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025
File Version publisher
PubMed ID 40088298
DOI 10.1007/s00520-025-09318-8
Web of Science KeyUT 001446435900003
Related Url isVersionOf https://doi.org/
Cancer-associated fibroblasts promote pro-tumor functions of neutrophils in pancreatic cancer via IL-8: potential suppression by pirfenidone
FullText URL fulltext.pdf
Author Yagi, Tomohiko| Kagawa, Shunsuke| Nogi, Shohei| Taniguchi, Atsuki| Yoshimoto, Masashi| Suemori, Kanto| Nagai, Yasuo| Fujita, Shuto| Kuroda, Shinji| Kikuchi, Satoru| Kakiuchi, Yoshihiko| Teraishi, Fuminori| Takagi, Kosei| Ohara, Toshiaki| Tazawa, Hiroshi| Fujiwara, Toshiyoshi|
Keywords Cancer-associated fibroblasts Neutrophil Anti-fibrotic agent Pirfenidone
Published Date 2025-02-04
Publication Title Cancer Immunology, Immunotherapy
Volume volume74
Issue issue3
Publisher Springer
Start Page 96
ISSN 0340-7004
NCID AA00598499
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025
File Version publisher
PubMed ID 39904796
DOI 10.1007/s00262-025-03946-z
Web of Science KeyUT 001413348800005
Related Url isVersionOf https://doi.org/10.1007/s00262-025-03946-z
Novel treatment strategy targeting interleukin-6 induced by cancer associated fibroblasts for peritoneal metastasis of gastric cancer
FullText URL fulltext.pdf
Author Mitsui, Ema| Kikuchi, Satoru| Okura, Tomohiro| Tazawa, Hiroshi| Une, Yuta| Nishiwaki, Noriyuki| Kuroda, Shinji| Noma, Kazuhiro| Kagawa, Shunsuke| Ohara, Toshiaki| Ohtsuka, Junko| Ohki, Rieko| Fujiwara, Toshiyoshi|
Keywords Peritoneal metastasis Gastric cancer Interleukin-6 Cancer-associated fibroblasts Interleukin-6 receptor antibody
Published Date 2025-01-25
Publication Title Scientific Reports
Volume volume15
Issue issue1
Publisher Nature Portfolio
Start Page 3267
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025
File Version publisher
PubMed ID 39863722
DOI 10.1038/s41598-025-88033-0
Web of Science KeyUT 001406498300020
Related Url isVersionOf https://doi.org/10.1038/s41598-025-88033-0
Effect of Oral Nutritional Supplements Composed of High Protein on Body Weight Loss After Gastrectomy
FullText URL fulltext.pdf
Author KIKUCHI, SATORU| TAKATA, NOBUO| KAKIUCHI, YOSHIHIKO| KURODA, SHINJI| KASHIMA, HAJIME| TANABE, SHUNSUKE| NOMA, KAZUHIRO| TAKAHASHI, AYAKO| KAGAWA, SHUNSUKE| FUJIWARA, TOSHIYOSHI|
Keywords Amino acid gastrectomy body weight loss nutritional intervention oral nutritional supplements
Published Date 2024-12-31
Publication Title In Vivo
Volume volume39
Issue issue1
Publisher Anticancer Research USA Inc.
Start Page 426
End Page 432
ISSN 0258-851X
NCID AA10714348
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders ©2025 The Author(s).
File Version publisher
PubMed ID 39740898
DOI 10.21873/invivo.13845
Web of Science KeyUT 001391862100042
Related Url isVersionOf https://doi.org/10.21873/invivo.13845
A Case of a Transwoman with Colorectal Cancer after Flap Vaginoplasty
FullText URL fulltext.pdf
Author Watanabe, Shiho| Teraishi, Fuminori| Fujimoto, Sari| Watanabe, Toshiyuki| Takeda, Sho| Narita, Shuhei| Yamashita, Koya| Shigeyasu, Kunitoshi| Kagawa, Shunsuke| Namba, Yuzaburo| Kimata, Yoshihiro|
Keywords vaginoplasty gender-affirming surgery transwomen rectal cancer
Published Date 2023-07-27
Publication Title Journal of Plastic and Reconstructive Surgery
Volume volume2
Issue issue3
Publisher Japan Society of Plastic and Reconstructive Surgery
Start Page 98
End Page 101
ISSN 2436-259X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders Ⓒ 2023 The Japan Society of Plastic and Reconstructive Surgery
File Version publisher
DOI 10.53045/jprs.2022-0020
Web of Science KeyUT 001296376800004
Related Url isVersionOf https://doi.org/10.53045/jprs.2022-0020
Predictive marker for response to trifluridine/tipiracil plus bevacizumab in metastatic colorectal cancer patients
FullText URL fulltext.pdf
Author Takahashi, Toshiaki| Shigeyasu, Kunitoshi| Kondo, Yoshitaka| Takeda, Sho| Umeda, Hibiki| Moriwake, Kazuya| Kayano, Masashi| Sakurai, Yuya| Nakamura, Shunsuke| Takahashi, Masafumi| Nitta, Kaori| Yoshida, Kazuhiro| Matsumi, Yuki| Michiue, Hiroyuki| Yamamoto, Hideki| Kishimoto, Hiroyuki| Teraishi, Fuminori| Shoji, Ryohei| Kanaya, Nobuhiko| Kashima, Hajime| Kakiuchi, Yoshihiko| Kuroda, Shinji| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Keywords ADAR1 Colorectal cancer Biomarker Trifluridine/tipiracil
Note The version of record of this article, first published in BMC Cancer, is available online at Publisher’s website: http://dx.doi.org/10.1186/s12885-024-13370-8|
Published Date 2025-01-02
Publication Title BMC Cancer
Volume volume25
Issue issue1
Publisher BMC
Start Page 1
ISSN 1471-2407
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2024.
File Version publisher
PubMed ID 39748254
DOI 10.1186/s12885-024-13370-8
Web of Science KeyUT 001389189700001
Related Url isVersionOf https://doi.org/10.1186/s12885-024-13370-8
Optimization of workflow processes for sustainable paternal involvement: case study of an academic “daddy surgeon” in Japan
FullText URL fulltext.pdf
Author Kanaya, Nobuhiko| Kuroda, Shinji| Kondo, Yoshitaka| Takehara, Yuko| Kakiuchi, Yoshihiko| Minagi, Hitoshi| Sakamoto, Masaki| Kagawa, Shunsuke| Kataoka, Hitomi| Fujiwara, Toshiyoshi|
Keywords Optimization of workflow processes Sustainable paternity participation “Daddy surgeon”
Note The version of record of this article, first published in Surgery Today, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00595-024-02959-y|
Published Date 2024-12-07
Publication Title Surgery Today
Publisher Springer Science and Business Media LLC
ISSN 0941-1291
NCID AA10824685
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2024
File Version publisher
PubMed ID 39644389
DOI 10.1007/s00595-024-02959-y
Web of Science KeyUT 001371519800001
Related Url isVersionOf https://doi.org/10.1007/s00595-024-02959-y
Dendritic cell maturation is induced by p53-armed oncolytic adenovirus via tumor-derived exosomes enhancing systemic antitumor immunity
FullText URL fulltext.pdf
Author Ohtani, Tomoko| Kuroda, Shinji| Kanaya, Nobuhiko| Kakiuchi, Yoshihiko| Kumon, Kento| Hashimoto, Masashi| Yagi, Chiaki| Sugimoto, Ryoma| Kikuchi, Satoru| Kagawa, Shunsuke| Tazawa, Hiroshi| Urata, Yasuo| Fujiwara, Toshiyoshi|
Keywords Oncolytic adenovirus p53 Dendritic cells Anti-tumor immunity Exosome
Note The version of record of this article, first published in Cancer Immunology, Immunotherapy, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00262-024-03849-5|
Published Date 2024-11-05
Publication Title Cancer Immunology, Immunotherapy
Volume volume74
Issue issue1
Publisher Springer Science and Business Media LLC
Start Page 12
ISSN 1432-0851
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2024
File Version publisher
PubMed ID 39499326
DOI 10.1007/s00262-024-03849-5
Web of Science KeyUT 001350703400001
Related Url isVersionOf https://doi.org/10.1007/s00262-024-03849-5
Primary ileal myeloid sarcoma presenting with bowel obstruction: a case report
FullText URL fulltext.pdf
Author Minagi, Hitoshi| Kanaya, Nobuhiko| Kondo, Yoshitaka| Kakiuchi, Yoshihiko| Kuroda, Shinji| Shoji, Ryohei| Kashima, Hajime| Matsumi, Yuki| Kikuchi, Satoru| Shigeyasu, Kunitoshi| Teraishi, Fuminori| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Keywords Myeloid sarcoma Chloroma Granulocytic sarcoma Bowel obstruction Abdominal pain
Note The version of record of this article, first published in Surgical Case Reports, is available online at Publisher’s website: http://dx.doi.org/10.1186/s40792-024-02030-5|
Published Date 2024-10-04
Publication Title Surgical Case Reports
Volume volume10
Issue issue1
Publisher Springer
Start Page 229
ISSN 2198-7793
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2024.
File Version publisher
PubMed ID 39365540
DOI 10.1186/s40792-024-02030-5
Web of Science KeyUT 001326038200001
Related Url isVersionOf https://doi.org/10.1186/s40792-024-02030-5
Senescent Fibroblasts Potentiate Peritoneal Metastasis of Diffuse-type Gastric Cancer Cells via IL-8–mediated Crosstalk
FullText URL fulltext20240701-01.pdf fig20240701-01.pdf
Author LI, YUNCHENG| TAZAWA, HIROSHI| NAGAI, YASUO| FUJITA, SHUTO| OKURA, TOMOHIRO| SHOJI, RYOHEI| YAMADA, MOTOHIKO| KIKUCHI, SATORU| KURODA, SHINJI| OHARA, TOSHIAKI| NOMA, KAZUHIRO| NISHIZAKI, MASAHIKO| KAGAWA, SHUNSUKE| FUJIWARA, TOSHIYOSHI|
Keywords Gastric cancer peritoneal metastasis senescent fibroblast IL-8 CXCR1/2
Note This is an Accepted Manuscript of an article published by International Institute of Anticancer Research.| This fulltext file will be available in Dec. 2024.|
Published Date 2024-05-31
Publication Title Anticancer Research
Volume volume44
Issue issue6
Publisher International Institute of Anticancer Research
Start Page 2497
End Page 2509
ISSN 0250-7005
NCID AA10625860
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 International Institute of Anticancer Research (Dr. George J. Delinasios)
File Version author
PubMed ID 38821603
DOI 10.21873/anticanres.17056
Web of Science KeyUT 001249685300009
Related Url isVersionOf https://doi.org/10.21873/anticanres.17056
Perioperative and Postoperative Continuous Nutritional Counseling Improves Quality of Life of Gastric Cancer Patient Undergoing Gastrectomy
FullText URL fulltext20240423-01.pdf fig20240423-01.pdf table20240423-01.pdf suppl20240423-01.pdf
Author Hanzawa, Shunya| Kikuchi, Satoru| Kuroda, Shinji| Shoji, Ryohei| Kashima, Hajime| Matsumi, Yuki| Takahashi, Ayako| Kakiuchi, Yoshihiko| Takagi, Kosei| Tanabe, Shunsuke| Noma, Kazuhiro| Kagawa, Shunsuke| Shikata, Kenichi| Fujiwara, Toshiyoshi|
Note This is an Accepted Manuscript of an article published by Taylor & Francis in Nutrition and Cancer on 15 Apr 2024, available at: https://doi.org/10.1080/01635581.2024.2340782.| This fulltext file will be available in Apr. 2025.|
Published Date 2024-04-15
Publication Title Nutrition and Cancer
Volume volume76
Issue issue6
Publisher Informa UK Limited
Start Page 476
End Page 485
ISSN 0163-5581
NCID AA00325612
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 38619145
DOI 10.1080/01635581.2024.2340782
Web of Science KeyUT 001202947500001
Related Url isVersionOf https://doi.org/10.1080/01635581.2024.2340782
p53-Armed Oncolytic Virotherapy Improves Radiosensitivity in Soft-Tissue Sarcoma by Suppressing BCL-xL Expression
JaLCDOI 10.18926/AMO/66924
FullText URL 78_2_151.pdf
Author Komatsubara, Tadashi| Tazawa, Hiroshi| Hasei, Joe| Omori, Toshinori| Sugiu, Kazuhisa| Mochizuki, Yusuke| Demiya, Koji| Yoshida, Aki| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi|
Abstract Soft-tissue sarcoma (STS) is a heterogeneous group of rare tumors originating predominantly from the embryonic mesoderm. Despite the development of combined modalities including radiotherapy, STSs are often refractory to antitumor modalities, and novel strategies that improve the prognosis of STS patients are needed. We previously demonstrated the therapeutic potential of two telomerase-specific replication-competent oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in human STS cells. Here, we demonstrate in vitro and in vivo antitumor effects of OBP-702 in combination with ionizing radiation against human STS cells (HT1080, NMS-2, SYO-1). OBP-702 synergistically promoted the antitumor effect of ionizing radiation in the STS cells by suppressing the expression of B-cell lymphoma-X large (BCL-xL) and enhancing ionizing radiation-induced apoptosis. The in vivo experiments demonstrated that this combination therapy significantly suppressed STS tumors’ growth. Our results suggest that OBP-702 is a promising antitumor reagent for promoting the radiosensitivity of STS tumors.
Keywords soft-tissue sarcoma radiotherapy oncolytic adenovirus p53 BCL-xL
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2024-04
Volume volume78
Issue issue2
Publisher Okayama University Medical School
Start Page 151
End Page 161
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38688833
Web of Science KeyUT 001229151800007
A multi-center, prospective, clinical study to evaluate the anti-reflux efficacy of laparoscopic double-flap technique (lD-FLAP Study)
FullText URL fulltext.pdf
Author Kuroda, Shinji| Ishida, Michihiro| Choda, Yasuhiro| Muraoka, Atsushi| Hato, Shinji| Kagawa, Tetsuya| Tanaka, Norimitsu| Mitsuhashi, Toshiharu| Kakiuchi, Yoshihiko| Kikuchi, Satoru| Nishizaki, Masahiko| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Keywords anti-reflux surgery double-flap technique gastric cancer Kamikawa procedure proximal gastrectomy
Published Date 2024-02-22
Publication Title Annals of Gastroenterological Surgery
Volume volume8
Issue issue3
Publisher Wiley
Start Page 374
End Page 382
ISSN 2475-0328
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 The Authors.
File Version publisher
PubMed ID 38707222
DOI 10.1002/ags3.12783
Web of Science KeyUT 001174392500001
Related Url isVersionOf https://doi.org/10.1002/ags3.12783
Long-term activation of anti-tumor immunity in pancreatic cancer by a p53-expressing telomerase-specific oncolytic adenovirus
FullText URL fulltext20240219-05.pdf
Author Hashimoto, Masashi| Kuroda, Shinji| Kanaya, Nobuhiko| Kadowaki, Daisuke| Yoshida, Yusuke| Sakamoto, Masaki| Hamada, Yuki| Sugimoto, Ryoma| Yagi, Chiaki| Ohtani, Tomoko| Kumon, Kento| Kakiuchi, Yoshihiko| Yasui, Kazuya| Kikuchi, Satoru| Yoshida, Ryuichi| Tazawa, Hiroshi| Kagawa, Shunsuke| Yagi, Takahito| Urata, Yasuo| Fujiwara, Toshiyoshi|
Note The version of record of this article, first published in British Journal of Cancer, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41416-024-02583-0|
Published Date 2024-02-05
Publication Title British Journal of Cancer
Volume volume130
Issue issue7
Publisher Springer Science and Business Media LLC
Start Page 1187
End Page 1195
ISSN 0007-0920
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2024
File Version publisher
PubMed ID 38316993
DOI 10.1038/s41416-024-02583-0
Web of Science KeyUT 001156904400001
Related Url isVersionOf https://doi.org/10.1038/s41416-024-02583-0
p53-armed oncolytic adenovirus induces autophagy and apoptosis in KRAS and BRAF-mutant colorectal cancer cells
FullText URL fulltext.pdf
Author Tamura, Shuta| Tazawa, Hiroshi| Hori, Naoto| Li, Yuncheng| Yamada, Motohiko| Kikuchi, Satoru| Kuroda, Shinji| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Published Date 2023-11-16
Publication Title PLoS ONE
Volume volume18
Issue issue11
Publisher Public Library of Science
Start Page e0294491
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Tamura et al.
File Version publisher
PubMed ID 37972012
DOI 10.1371/journal.pone.0294491
Web of Science KeyUT 001119675000083
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0294491
Prognostic risk factors for postoperative long-term outcomes in elderly stage IA gastric cancer patients
FullText URL fulltext.pdf
Author Kakiuchi, Yoshihiko| Kuroda, Shinji| Kikuchi, Satoru| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Keywords Gastric cancer (GC) elderly stage IA comorbidity Charlson comorbidity index (CCI)
Published Date 2022-10
Publication Title Journal of Gastrointestinal Oncology
Volume volume13
Issue issue5
Publisher AME Publishing Company
Start Page 2178
End Page 2185
ISSN 2078-6891
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Journal of Gastrointestinal Oncology.
File Version publisher
PubMed ID 36388703
DOI 10.21037/jgo-22-527
Web of Science KeyUT 000864732300001
Related Url isVersionOf https://doi.org/10.21037/jgo-22-527
Collagenous Colitis in a Patient With Gastric Cancer Who Underwent Chemotherapy
FullText URL fulltext.pdf
Author Iwamuro, Masaya| Tanaka, Takehiro| Kagawa, Shunsuke| Inoo, Shoko| Otsuka, Motoyuki|
Keywords immune checkpoint inhibitor chemotherapy-induced diarrhea immune-related adverse event colitis colonoscopy collagenous colitis
Published Date 2023-05-25
Publication Title Cureus
Volume volume15
Issue issue5
Publisher Springer
Start Page e39466
ISSN 2168-8184
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Iwamuro et al.
File Version publisher
PubMed ID 37378156
DOI 10.7759/cureus.39466
Web of Science KeyUT 001023091300016
Related Url isVersionOf https://doi.org/10.7759/cureus.39466
Dual antiplatelet therapy inhibits neutrophil extracellular traps to reduce liver micrometastases of intrahepatic cholangiocarcinoma
FullText URL fulltext20230720-02.pdf fig20230720-02.pdf suppl_table20230720-02.pdf suppl_fig20230720-02.pdf
Author Yoshimoto, Masashi| Kagawa, Shunsuke| Kajioka, Hiroki| Taniguchi, Atsuki| Kuroda, Shinji| Kikuchi, Satoru| Kakiuchi, Yoshihiko| Yagi, Tomohiko| Nogi, Shohei| Teraishi, Fuminori| Shigeyasu, Kunitoshi| Yoshida, Ryuichi| Umeda, Yuzo| Noma, Kazuhiro| Tazawa, Hiroshi| Fujiwara, Toshiyoshi|
Keywords Aspirin Ticagrelor P-selectin Platelet Time-lapse imaging
Note © 2023 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Jul. 2024.|
Published Date 2023-07-28
Publication Title Cancer Letters
Volume volume567
Publisher Elsevier BV
Start Page 216260
ISSN 0304-3835
NCID AA00598513
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Elsevier B.V.
File Version author
PubMed ID 37295551
DOI 10.1016/j.canlet.2023.216260
Web of Science KeyUT 001020524700001
Related Url isVersionOf https://doi.org/10.1016/j.canlet.2023.216260
Locally Advanced Rectal Cancer Invading the Gluteus Maximus Muscle Completely Responded to Total Neoadjuvant Therapy
JaLCDOI 10.18926/AMO/65152
FullText URL 77_2_209.pdf
Author Sakamoto, Masaki| Teraishi, Fuminori| Shigeyasu Kunitoshi| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Abstract A 70-year-old male with anal pain and fever was diagnosed with rectal cancer perforation and abscess in the right gluteus maximus (GM) muscle. He underwent a transverse colon colostomy followed by preoperative capecitabine+oxaliplatin. Some local control was achieved but a residual abscess was observed in the right GM muscle. To secure circumferential resection margin by tumor reduction, he received chemoradiotherapy as total neoadjuvant therapy (TNT) and underwent laparoscopic abdominoperineal resection, D3 lymph node dissection, combined coccyx resection, and partial resection of the right GM muscle. The skin defect and pelvic dead space were filled with a right lateral vastus lateral great muscle flap. Histopathologically, the resected specimen showed no tumor cells in the primary tumor or lymph nodes, indicating a pathological complete response (pCR). This case suggests that TNT might improve the R0 resection and pCR rates and overall survival.
Keywords locally advanced rectal cancer total neoadjuvant therapy lateral vastus lateral great muscle flap
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2023-04
Volume volume77
Issue issue2
Publisher Okayama University Medical School
Start Page 209
End Page 213
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37094960
Web of Science KeyUT 000982563800003
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