| フルテキストURL | fulltext20240423-01.pdf fig20240423-01.pdf table20240423-01.pdf suppl20240423-01.pdf |
|---|---|
| 著者 | Hanzawa, Shunya| Kikuchi, Satoru| Kuroda, Shinji| Shoji, Ryohei| Kashima, Hajime| Matsumi, Yuki| Takahashi, Ayako| Kakiuchi, Yoshihiko| Takagi, Kosei| Tanabe, Shunsuke| Noma, Kazuhiro| Kagawa, Shunsuke| Shikata, Kenichi| Fujiwara, Toshiyoshi| |
| 備考 | This is an Accepted Manuscript of an article published by Taylor & Francis in Nutrition and Cancer on 15 Apr 2024, available at: https://doi.org/10.1080/01635581.2024.2340782.| This fulltext file will be available in Apr. 2025.| |
| 発行日 | 2024-04-15 |
| 出版物タイトル | Nutrition and Cancer |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Informa UK Limited |
| 開始ページ | 476 |
| 終了ページ | 485 |
| ISSN | 0163-5581 |
| NCID | AA00325612 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| PubMed ID | 38619145 |
| DOI | 10.1080/01635581.2024.2340782 |
| Web of Science KeyUT | 001202947500001 |
| 関連URL | isVersionOf https://doi.org/10.1080/01635581.2024.2340782 |
| JaLCDOI | 10.18926/AMO/66924 |
|---|---|
| フルテキストURL | 78_2_151.pdf |
| 著者 | Komatsubara, Tadashi| Tazawa, Hiroshi| Hasei, Joe| Omori, Toshinori| Sugiu, Kazuhisa| Mochizuki, Yusuke| Demiya, Koji| Yoshida, Aki| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi| |
| 抄録 | Soft-tissue sarcoma (STS) is a heterogeneous group of rare tumors originating predominantly from the embryonic mesoderm. Despite the development of combined modalities including radiotherapy, STSs are often refractory to antitumor modalities, and novel strategies that improve the prognosis of STS patients are needed. We previously demonstrated the therapeutic potential of two telomerase-specific replication-competent oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in human STS cells. Here, we demonstrate in vitro and in vivo antitumor effects of OBP-702 in combination with ionizing radiation against human STS cells (HT1080, NMS-2, SYO-1). OBP-702 synergistically promoted the antitumor effect of ionizing radiation in the STS cells by suppressing the expression of B-cell lymphoma-X large (BCL-xL) and enhancing ionizing radiation-induced apoptosis. The in vivo experiments demonstrated that this combination therapy significantly suppressed STS tumors’ growth. Our results suggest that OBP-702 is a promising antitumor reagent for promoting the radiosensitivity of STS tumors. |
| キーワード | soft-tissue sarcoma radiotherapy oncolytic adenovirus p53 BCL-xL |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-04 |
| 巻 | 78巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 151 |
| 終了ページ | 161 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38688833 |
| Web of Science KeyUT | 001229151800007 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Kuroda, Shinji| Ishida, Michihiro| Choda, Yasuhiro| Muraoka, Atsushi| Hato, Shinji| Kagawa, Tetsuya| Tanaka, Norimitsu| Mitsuhashi, Toshiharu| Kakiuchi, Yoshihiko| Kikuchi, Satoru| Nishizaki, Masahiko| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| キーワード | anti-reflux surgery double-flap technique gastric cancer Kamikawa procedure proximal gastrectomy |
| 発行日 | 2024-02-22 |
| 出版物タイトル | Annals of Gastroenterological Surgery |
| 巻 | 8巻 |
| 号 | 3号 |
| 出版者 | Wiley |
| 開始ページ | 374 |
| 終了ページ | 382 |
| ISSN | 2475-0328 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 The Authors. |
| 論文のバージョン | publisher |
| PubMed ID | 38707222 |
| DOI | 10.1002/ags3.12783 |
| Web of Science KeyUT | 001174392500001 |
| 関連URL | isVersionOf https://doi.org/10.1002/ags3.12783 |
| フルテキストURL | fulltext20240219-05.pdf |
|---|---|
| 著者 | Hashimoto, Masashi| Kuroda, Shinji| Kanaya, Nobuhiko| Kadowaki, Daisuke| Yoshida, Yusuke| Sakamoto, Masaki| Hamada, Yuki| Sugimoto, Ryoma| Yagi, Chiaki| Ohtani, Tomoko| Kumon, Kento| Kakiuchi, Yoshihiko| Yasui, Kazuya| Kikuchi, Satoru| Yoshida, Ryuichi| Tazawa, Hiroshi| Kagawa, Shunsuke| Yagi, Takahito| Urata, Yasuo| Fujiwara, Toshiyoshi| |
| 備考 | The version of record of this article, first published in British Journal of Cancer, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41416-024-02583-0| |
| 発行日 | 2024-02-05 |
| 出版物タイトル | British Journal of Cancer |
| 巻 | 130巻 |
| 号 | 7号 |
| 出版者 | Springer Science and Business Media LLC |
| 開始ページ | 1187 |
| 終了ページ | 1195 |
| ISSN | 0007-0920 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2024 |
| 論文のバージョン | publisher |
| PubMed ID | 38316993 |
| DOI | 10.1038/s41416-024-02583-0 |
| Web of Science KeyUT | 001156904400001 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41416-024-02583-0 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Tamura, Shuta| Tazawa, Hiroshi| Hori, Naoto| Li, Yuncheng| Yamada, Motohiko| Kikuchi, Satoru| Kuroda, Shinji| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| 発行日 | 2023-11-16 |
| 出版物タイトル | PLoS ONE |
| 巻 | 18巻 |
| 号 | 11号 |
| 出版者 | Public Library of Science |
| 開始ページ | e0294491 |
| ISSN | 1932-6203 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2023 Tamura et al. |
| 論文のバージョン | publisher |
| PubMed ID | 37972012 |
| DOI | 10.1371/journal.pone.0294491 |
| Web of Science KeyUT | 001119675000083 |
| 関連URL | isVersionOf https://doi.org/10.1371/journal.pone.0294491 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Kakiuchi, Yoshihiko| Kuroda, Shinji| Kikuchi, Satoru| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| キーワード | Gastric cancer (GC) elderly stage IA comorbidity Charlson comorbidity index (CCI) |
| 発行日 | 2022-10 |
| 出版物タイトル | Journal of Gastrointestinal Oncology |
| 巻 | 13巻 |
| 号 | 5号 |
| 出版者 | AME Publishing Company |
| 開始ページ | 2178 |
| 終了ページ | 2185 |
| ISSN | 2078-6891 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © Journal of Gastrointestinal Oncology. |
| 論文のバージョン | publisher |
| PubMed ID | 36388703 |
| DOI | 10.21037/jgo-22-527 |
| Web of Science KeyUT | 000864732300001 |
| 関連URL | isVersionOf https://doi.org/10.21037/jgo-22-527 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Iwamuro, Masaya| Tanaka, Takehiro| Kagawa, Shunsuke| Inoo, Shoko| Otsuka, Motoyuki| |
| キーワード | immune checkpoint inhibitor chemotherapy-induced diarrhea immune-related adverse event colitis colonoscopy collagenous colitis |
| 発行日 | 2023-05-25 |
| 出版物タイトル | Cureus |
| 巻 | 15巻 |
| 号 | 5号 |
| 出版者 | Springer |
| 開始ページ | e39466 |
| ISSN | 2168-8184 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2023 Iwamuro et al. |
| 論文のバージョン | publisher |
| PubMed ID | 37378156 |
| DOI | 10.7759/cureus.39466 |
| Web of Science KeyUT | 001023091300016 |
| 関連URL | isVersionOf https://doi.org/10.7759/cureus.39466 |
| フルテキストURL | fulltext20230720-02.pdf fig20230720-02.pdf suppl_table20230720-02.pdf suppl_fig20230720-02.pdf |
|---|---|
| 著者 | Yoshimoto, Masashi| Kagawa, Shunsuke| Kajioka, Hiroki| Taniguchi, Atsuki| Kuroda, Shinji| Kikuchi, Satoru| Kakiuchi, Yoshihiko| Yagi, Tomohiko| Nogi, Shohei| Teraishi, Fuminori| Shigeyasu, Kunitoshi| Yoshida, Ryuichi| Umeda, Yuzo| Noma, Kazuhiro| Tazawa, Hiroshi| Fujiwara, Toshiyoshi| |
| キーワード | Aspirin Ticagrelor P-selectin Platelet Time-lapse imaging |
| 備考 | © 2023 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Jul. 2024.| |
| 発行日 | 2023-07-28 |
| 出版物タイトル | Cancer Letters |
| 巻 | 567巻 |
| 出版者 | Elsevier BV |
| 開始ページ | 216260 |
| ISSN | 0304-3835 |
| NCID | AA00598513 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2023 Elsevier B.V. |
| 論文のバージョン | author |
| PubMed ID | 37295551 |
| DOI | 10.1016/j.canlet.2023.216260 |
| Web of Science KeyUT | 001020524700001 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.canlet.2023.216260 |
| JaLCDOI | 10.18926/AMO/65152 |
|---|---|
| フルテキストURL | 77_2_209.pdf |
| 著者 | Sakamoto, Masaki| Teraishi, Fuminori| Shigeyasu Kunitoshi| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| 抄録 | A 70-year-old male with anal pain and fever was diagnosed with rectal cancer perforation and abscess in the right gluteus maximus (GM) muscle. He underwent a transverse colon colostomy followed by preoperative capecitabine+oxaliplatin. Some local control was achieved but a residual abscess was observed in the right GM muscle. To secure circumferential resection margin by tumor reduction, he received chemoradiotherapy as total neoadjuvant therapy (TNT) and underwent laparoscopic abdominoperineal resection, D3 lymph node dissection, combined coccyx resection, and partial resection of the right GM muscle. The skin defect and pelvic dead space were filled with a right lateral vastus lateral great muscle flap. Histopathologically, the resected specimen showed no tumor cells in the primary tumor or lymph nodes, indicating a pathological complete response (pCR). This case suggests that TNT might improve the R0 resection and pCR rates and overall survival. |
| キーワード | locally advanced rectal cancer total neoadjuvant therapy lateral vastus lateral great muscle flap |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-04 |
| 巻 | 77巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 209 |
| 終了ページ | 213 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 37094960 |
| Web of Science KeyUT | 000982563800003 |
| JaLCDOI | 10.18926/AMO/64368 |
|---|---|
| フルテキストURL | 77_1_91.pdf |
| 著者 | Takahashi, Toshiaki| Kakiuchi, Yoshihiko| Kikuch, Satoru| Kuroda, Shinji| Takeda, Sho| Shigeyasu, Kunitoshi| Kondo, Yoshitaka| Teraishi, Fuminori| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| 抄録 | An annular pancreas is a rare anomaly of the pancreas, defined as pancreatic tissue that totally or partly encircles the duodenum, usually the descending portion. A 76-year-old man who was diagnosed with gastric cancer cT3N0M0 Stage IIB underwent laparoscopic distal gastrectomy with D2 lymph node dissection. Intraoperatively, the dorsal half of the duodenal bulb was seen to be half surrounded by the pancreas, and a non-typical annular pancreas was diagnosed. Because of the risk to the pancreas, it was considered impossible to perform anastomosis by a linear stapler as in the usual laparoscopic procedure. Therefore, we performed laparoscopically assisted distal gastrectomy and Billroth-I reconstruction using a circular stapler, and the surgery was completed without difficulties. His postoperative course was good despite the development of a pancreatic fistula, which was an International Study Group for Pancreas Fistula biochemical leak. Some APs can be diagnosed preoperatively, but the rarer subtypes such as ours are more difficult to visualize on imaging. In gastrectomy, it is both oncologically important and technically challenging to perform lymph node dissection around the pancreas. In this case with an especially proximal pancreas, a circular stapler was considered better suited for gastroduodenal anastomosis and required a broader field than that afforded by laparoscopy. A case of non-typical annular pancreas diagnosed during laparoscopic gastric surgery is described. |
| キーワード | annular pancreas gastric cancer laparoscopic distal gastrectomye |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-02 |
| 巻 | 77巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 91 |
| 終了ページ | 95 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36849152 |
| Web of Science KeyUT | 000952978000002 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Kakiuchi, Yoshihiko| Kikuchi, Satoru| Kuroda, Shinji| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| キーワード | Remnant gastric cancer Prognostic factor Tumor-infiltrating lymphocytes CD8(+) T cell Tumor immunity |
| 発行日 | 2022-11-30 |
| 出版物タイトル | World Journal Of Surgical Oncology |
| 巻 | 20巻 |
| 号 | 1号 |
| 出版者 | BMC |
| 開始ページ | 374 |
| ISSN | 1477-7819 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2022. |
| 論文のバージョン | publisher |
| PubMed ID | 36451224 |
| DOI | 10.1186/s12957-022-02853-2 |
| Web of Science KeyUT | 000892980100002 |
| 関連URL | isVersionOf https://doi.org/10.1186/s12957-022-02853-2 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Sato, Hiroaki| Noma, Kazuhiro| Ohara, Toshiaki| Kawasaki, Kento| Akai, Masaaki| Kobayashi, Teruki| Nishiwaki, Noriyuki| Narusaka, Toru| Komoto, Satoshi| Kashima, Hajime| Katsura, Yuki| Kato, Takuya| Kikuchi, Satoru| Tazawa, Hiroshi| Kagawa, Shunsuke| Shirakawa, Yasuhiro| Kobayashi, Hisataka| Fujiwara, Toshiyoshi| |
| 発行日 | 2022-11-23 |
| 出版物タイトル | Scientific Reports |
| 巻 | 12巻 |
| 号 | 1号 |
| 出版者 | Nature Portfolio |
| 開始ページ | 20152 |
| ISSN | 2045-2322 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2022 |
| 論文のバージョン | publisher |
| PubMed ID | 36418422 |
| DOI | 10.1038/s41598-022-24313-3 |
| Web of Science KeyUT | 000887936300054 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41598-022-24313-3 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Araki, Hiroyuki| Tazawa, Hiroshi| Kanaya, Nobuhiko| Kajiwara, Yoshinori| Yamada, Motohiko| Hashimoto, Masashi| Kikuchi, Satoru| Kuroda, Shinji| Yoshida, Ryuichi| Umeda, Yuzo| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| 発行日 | 2022-12-15 |
| 出版物タイトル | Molecular Therapy - Oncolytics |
| 巻 | 27巻 |
| 出版者 | Cell Press |
| 開始ページ | 3 |
| 終了ページ | 13 |
| ISSN | 2372-7705 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 The Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 36212775 |
| DOI | 10.1016/j.omto.2022.09.003 |
| Web of Science KeyUT | 000870232500001 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.omto.2022.09.003 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Komatsu, Yasuhiro| Shigeyasu, Kunitoshi| Yano, Shuya| Takeda, Sho| Takahashi, Kazutaka| Hata, Nanako| Umeda, Hibiki| Yoshida, Kazuhiro| Mori, Yoshiko| Yasui, Kazuya| Yoshida, Ryuichi| Kondo, Yoshitaka| Kishimoto, Hiroyuki| Teraishi, Fuminori| Umeda, Yuzo| Kagawa, Shunsuke| Michiue, Hiroyuki| Tazawa, Hiroshi| Goel, Ajay| Fujiwara, Toshiyoshi| |
| 発行日 | 2022-08-08 |
| 出版物タイトル | Scientific Reports |
| 巻 | 12巻 |
| 号 | 1号 |
| 出版者 | Nature Portfolio |
| 開始ページ | 13540 |
| ISSN | 2045-2322 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © TheAuthor(s)2022 |
| 論文のバージョン | publisher |
| PubMed ID | 35941214 |
| DOI | 10.1038/s41598-022-17773-0 |
| Web of Science KeyUT | 000837764800013 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41598-022-17773-0 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Teraishi, Fuminori| Shigeyasu, Kunitoshi| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| 発行日 | 2022-05-01 |
| 出版物タイトル | Journal Of Surgical Case Reports |
| 巻 | 2022巻 |
| 号 | 5号 |
| 出版者 | Oxford University Press |
| 開始ページ | rjac101 |
| ISSN | 2042-8812 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2022. |
| 論文のバージョン | publisher |
| PubMed ID | 35620231 |
| DOI | 10.1093/jscr/rjac101 |
| Web of Science KeyUT | 000799968300004 |
| 関連URL | isVersionOf https://doi.org/10.1093/jscr/rjac101 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Ogawa, Toshihiro| Kikuchi, Satoru| Tabuchi, Motoyasu| Mitsui, Ema| Une, Yuta| Tazawa, Hiroshi| Kuroda, Shinji| Noma, Kazuhiro| Ohara, Toshiaki| Kagawa, Shunsuke| Urata, Yasuo| Fujiwara, Toshiyoshi| |
| 発行日 | 2022-06-16 |
| 出版物タイトル | Molecular Therapy-Oncolytics |
| 巻 | 25巻 |
| 出版者 | Cell Press |
| 開始ページ | 249 |
| 終了ページ | 261 |
| ISSN | 2372-7705 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 The Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 35615263 |
| DOI | 10.1016/j.omto.2022.04.009 |
| Web of Science KeyUT | 000800437000008 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.omto.2022.04.009 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Tazawa, Hiroshi| Shigeyasu, Kunitoshi| Noma, Kazuhiro| Kagawa, Shunsuke| Sakurai, Fuminori| Mizuguchi, Hiroyuki| Kobayashi, Hisataka| Imamura, Takeshi| Fujiwara, Toshiyoshi| |
| キーワード | adenovirus EMT survivin telomerase vimentin |
| 発行日 | 2022-04-09 |
| 出版物タイトル | Cancer Science |
| 出版者 | Wiley |
| ISSN | 1347-9032 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 The Authors. |
| 論文のバージョン | publisher |
| PubMed ID | 35398956 |
| DOI | 10.1111/cas.15369 |
| Web of Science KeyUT | 000783300600001 |
| 関連URL | isVersionOf https://doi.org/10.1111/cas.15369 |
| JaLCDOI | 10.18926/AMO/63425 |
|---|---|
| フルテキストURL | 76_2_203.pdf |
| 著者 | Masuda, Tomoya| Tazawa, Hiroshi| Hashimoto, Yuuri| Ieda, Takeshi| Kikuchi, Satoru| Kuroda, Shinji| Noma, Kazuhiro| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| 抄録 | The epithelial-mesenchymal transition (EMT), a normal biological process by which epithelial cells acquire a mesenchymal phenotype, is associated with migration, metastasis, and chemoresistance in cancer cells, and with poor prognosis in patients with esophageal cancer. However, therapeutic strategies to inhibit EMT in tumor environments remain elusive. Here, we show the therapeutic potential of telomerase-specific replication- competent oncolytic adenovirus OBP-301 in human esophageal cancer TE4 and TE6 cells with an EMT phenotype. Transforming growth factor-β (TGF-β) administration induced the EMT phenotype with spindleshaped morphology, upregulation of mesenchymal markers and EMT transcription factors, migration, and chemoresistance in TE4 and TE6 cells. OBP-301 significantly inhibited the EMT phenotype via E1 accumulation. EMT cancer cells were susceptible to OBP-301 via massive autophagy induction. OBP-301 suppressed tumor growth and lymph node metastasis of TE4 cells co-inoculated with TGF-β-secreting fibroblasts. Our results suggest that OBP-301 inhibits the TGF-β-induced EMT phenotype in human esophageal cancer cells. OBP-301-mediated E1A overexpression is a promising antitumor strategy to inhibit EMT-mediated esophageal cancer progression. |
| キーワード | esophageal cancer EMT TGF-β oncolytic adenovirus E1A |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-04 |
| 巻 | 76巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 203 |
| 終了ページ | 215 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35503449 |
| Web of Science KeyUT | 000792291900003 |
| フルテキストURL | fulltext20220131-2.pdf |
|---|---|
| 著者 | Kanaya, Nobuhiko| Kuroda, Shinji| Kakiuchi, Yoshihiko| Takeda, Sho| Kikuchi, Satoru| Noma, Kazuhiro| Yoshida, Ryuichi| Umeda, Yuzo| Teraishi, Fuminori| Nishizaki, Masahiko| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| キーワード | Gastric cancer D2 lymphadenectomy Suprapancreatic lymphadenectomy Posterior hepatic plexus Distal gastrectomy |
| 備考 | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00423-022-02437-4| |
| 発行日 | 2022-1-12 |
| 出版物タイトル | Langenbeck's Archives of Surgery |
| 巻 | 407巻 |
| 号 | 2号 |
| 出版者 | Springer Science and Business Media LLC |
| 開始ページ | 871 |
| 終了ページ | 877 |
| ISSN | 1435-2443 |
| NCID | AA11211080 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022 |
| 論文のバージョン | author |
| PubMed ID | 35022835 |
| DOI | 10.1007/s00423-022-02437-4 |
| Web of Science KeyUT | 000741939500003 |
| 関連URL | isVersionOf https://doi.org/10.1007/s00423-022-02437-4 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Fujiwara, Noriko| Watanabe, Mayu| Katayama, Akihiro| Noda, Yohei| Eguchi, Jun| Kataoka, Hitomi| Kagawa, Shunsuke| Wada, Jun| |
| キーワード | C-peptide diabetes mellitus immune checkpoint inhibitor insulin secretion |
| 発行日 | 2021-09-07 |
| 出版物タイトル | Clinical Case Reports |
| 巻 | 9巻 |
| 号 | 9号 |
| 出版者 | Wiley |
| 開始ページ | e04574 |
| ISSN | 2050-0904 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2021 The Authors. |
| 論文のバージョン | publisher |
| PubMed ID | 34522382 |
| DOI | 10.1002/ccr3.4574 |
| Web of Science KeyUT | 000700003300112 |
| 関連URL | isVersionOf https://doi.org/10.1002/ccr3.4574 |