| Author | Ieda, Takeshi| Tazawa, Hiroshi| Okabayashi, Hiroki| Yano, Shuya| Shigeyasu, Kunitoshi| Kuroda, Shinji| Ohara, Toshiaki| Noma, Kazuhiro| Kishimoto, Hiroyuki| Nishizaki, Masahiko| Kagawa, Shunsuke| Shirakawa, Yasuhiro| Saitou, Takashi| Imamura, Takeshi| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2019-11-8 |
| Publication Title | Scientific Reports |
| Volume | volume9 |
| Publisher | Nature Publishing Group |
| Start Page | 16378 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2019 |
| File Version | publisher |
| PubMed ID | 31705021 |
| DOI | 10.1038/s41598-019-52816-z |
| Web of Science KeyUT | 000495372900001 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-019-52816-z |
| FullText URL | SR9_1_4633.pdf |
|---|---|
| Author | Morihiro, Toshiaki| Kuroda, Shinji| Kanaya, Nobuhiko| Kakiuchi, Yoshihiko| Kubota, Tetsushi| Aoyama, Katsuyuki| Tanaka, Takehiro| Kikuch, Satoru| Nagasaka, Takeshi| Nishizaki, Masahiko| Kagawa, Shunsuke| Tazawa, Hiroshi| Fujiwara, Toshiyoshi| |
| Published Date | 2019-3-15 |
| Publication Title | Scientific Reports |
| Volume | volume9 |
| Publisher | Nature Publishing Group |
| Start Page | 4633 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2019 |
| File Version | publisher |
| PubMed ID | 30874607 |
| DOI | 10.1038/s41598-019-41177-2 |
| Web of Science KeyUT | 000461303000015 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-019-41177-2 |
| FullText URL | AGS3_1_96.pdf SI.pdf |
|---|---|
| Author | Kuroda, Shinji| Choda, Yasuhiro| Otsuka, Shinya| Ueyama, Satoshi| Tanaka, Norimitsu| Muraoka, Atsushi| Hato, Shinji| Kimura, Toshikazu| Tanakaya, Kohji| Kikuchi, Satoru| Tanabe, Shunsuke| Noma, Kazuhiro| Nishizaki, Masahiko| Kagawa, Shunsuke| Shirakawa, Yasuhiro| Kamikawa, Yasuaki| Fujiwara, Toshiyoshi| |
| Keywords | Kamikawa procedure antireflux surgery double‐flap technique esophagogastrostomy proximal gastrectomy |
| Published Date | 2018-10-11 |
| Publication Title | Annals of Gastroenterological Surgery |
| Volume | volume3 |
| Issue | issue1 |
| Publisher | Woley |
| Start Page | 96 |
| End Page | 103 |
| ISSN | 2475-0328 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2018 The Authors |
| File Version | publisher |
| PubMed ID | 30697614 |
| DOI | 10.1002/ags3.12216 |
| Web of Science KeyUT | 000456643500012 |
| Related Url | isVersionOf https://doi.org/10.1002/ags3.12216 |
| FullText URL | cancers_11_2_177.pdf |
|---|---|
| Author | Katsura, Yuki| Ohara, Toshiaki| Noma, Kazuhiro| Ninomiya, Takayuki| Kashima, Hajime| Kato, Takuya| Sato, Hiroaki| Komoto, Satoshi| Narusaka, Toru| Tomono, Yasuko| Xing, Boyi| Chen, Yuehua| Tazawa, Hiroshi| Kagawa, Shunsuke| Shirakawa, Yasuhiro| Kasai , Tomonari| Seno, Masaharu| Matsukawa, Akihiro| Fujiwara, Toshiyoshi| |
| Keywords | cancer stem cells combination therapy iron stemness |
| Published Date | 2019-02-03 |
| Publication Title | Cancers |
| Volume | volume11 |
| Issue | issue2 |
| Publisher | MDPI |
| Start Page | 177 |
| ISSN | 2072-6694 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 by the authors |
| File Version | publisher |
| PubMed ID | 30717462 |
| DOI | 10.3390/cancers11020177 |
| Web of Science KeyUT | 000460747200051 |
| Related Url | isVersionOf https://doi.org/10.3390/cancers11020177 |
| FullText URL | OncoImmunol_8_12_1671760.pdf |
|---|---|
| Author | Sakamoto, Shuichi| Kagawa, Shunsuke| Kuwada, Kazuya| Ito, Atene| Kajioka, Hiroki| Kakiuchi, Yoshihiko| Watanabe, Megumi| Kagawa, Tetsuya| Yoshida, Ryuichi| Kikuchi, Satoru| Kuroda, Shinji| Tazawa, Hiroshi| Fujiwara, Toshiyoshi| |
| Keywords | Gastric cancer tumor-associated macrophages tumor microenvironment peritoneal dissemination |
| Published Date | 2019-10-22 |
| Publication Title | OncoImmunology |
| Volume | volume8 |
| Issue | issue12 |
| Publisher | TAYLOR & FRANCIS |
| Start Page | e1671760 |
| ISSN | 2162402X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 The Author(s). |
| File Version | publisher |
| DOI | 10.1080/2162402X.2019.1671760 |
| Web of Science KeyUT | 000494085400001 |
| Related Url | isVersionOf https://doi.org/10.1080/2162402X.2019.1671760 |
| JaLCDOI | 10.18926/AMO/54981 |
|---|---|
| FullText URL | 71_2_127.pdf |
| Author | Shirakawa, Yasuhiro| Noma, Kazuhiro| Maeda, Naoaki| Tanabe, Shunsuke| Kuroda, Shinji| Kagawa, Shunsuke| Katsui, Kuniaki| Katayama, Norihisa| Kanazawa, Susumu| Fujiwara, Toshiyoshi| |
| Abstract | Currently, chemoradiation is the most widely used nonsurgical treatment for esophageal cancer. However, some patients, particularly the very elderly or those with severe vital organ dysfunction, face difficulty with the chemotherapy component. We therefore examined the outcome of radiation therapy (RT) alone for patients with esophageal cancer at our facility. Between January 2005 and December 2014, 84 patients underwent RT at our hospital, and 78 of these patients received concomitant chemotherapy. The remaining 6 patients underwent RT alone; these patients were considered to be high-risk and to have no lymph node metastasis (stage I). Five of them received irradiation up to a curative dose: 4 showed a complete response (CR) and 1 showed a partial response (PR). Of the patients exhibiting CR, 3 are currently living recurrence-free, whereas 1 patient underwent endoscopic submucosal dissection (ESD) as salvage therapy for local recurrence, with no subsequent recurrence. High-risk stage I esophageal cancer patients can be treated radically with RT alone under certain conditions. In the future, to broaden the indications for RT monotherapy to include some degree of advanced cancers, a novel concurrent therapy should be identified. |
| Keywords | esophageal cancer radiation therapy high-risk patient |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2017-04 |
| Volume | volume71 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 127 |
| End Page | 133 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28420894 |
| JaLCDOI | 10.18926/AMO/54601 |
|---|---|
| FullText URL | 70_5_401.pdf |
| Author | Kuroda, Shinji| Kikuchi, Satoru| Nishizaki, Masahiko| Kagawa, Shunsuke| Hinotsu, Shiro| Fujiwara, Toshiyoshi| |
| Abstract | Although intermittent pneumatic compression (IPC) has become common as perioperative prophylaxis for venous thromboembolism (VTE) consisting of pulmonary thromboembolism (PE) and deep vein thrombosis (DVT), the prophylactic effect against VTE, especially lethal PE, is not yet satisfactory. Therefore, pharmacologic prophylaxis, such as with enoxaparin, is desirable. While the efficacy and safety of enoxaparin have been proven in several clinical trials, concern about bleeding with longterm (at least 7 days) use have potentially decreased its widespread adoption. We have launched a phase II study to evaluate the efficacy and safety of short-term (3 days) enoxaparin, in which a total of 70 gastric cancer patients undergoing gastrectomy will be recruited, and the primary endpoint is the incidence of DVT. This study could contribute to making pharmacologic prophylaxis for VTE more common. |
| Keywords | venous thromboembolism enoxaparin short-term use gastric cancer surgery |
| Amo Type | Clinical Study Protocols |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-10 |
| Volume | volume70 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 401 |
| End Page | 404 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27777435 |
| Web of Science KeyUT | 000388098700012 |
| JaLCDOI | 10.18926/AMO/54421 |
|---|---|
| FullText URL | 70_3_213.pdf |
| Author | Kikuchi, Satoru| Kagawa, Shunsuke| Ohara, Toshiaki| Kubota, Tetsushi| Kuwada, Kazuya| Kagawa, Tetsuya| Kuroda, Shinji| Shirakawa, Yasuhiro| Nishizaki, Masahiko| Fujiwara, Toshiyoshi| |
| Abstract | A 69-year-old man underwent endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) at the lesser curvature in the angle of stomach. Histological examination revealed tub1, pM, ly0, v0, pLM(-), pVM(-), and the resection was considered curative. The scar after ESD was followed by esophagogastroduodenoscopy (EGD) and biopsy. Twenty months later, EGD showed an ulcerative lesion in the vicinity of the ESD scar, and histological examination of the biopsy specimen showed adenocarcinoma. A distal gastrectomy with lymph node dissection was then performed. Postoperative pathology showed tub1, pM, pN0, ly0, v0, and Stage 1A. Skip lesions were seen in the specimen resected by ESD, and the histological review confirmed so-called “dysplasia-like atypia” (DLA) between the lesions. It has been reported recently that in DLA, the dysplasia-like change involves only the bases of the pits, without upper pit or surface epithelium involvement, and it is said that the rate of DLA is higher in gastric cancer patients. We speculated that a precancerous lesion close to the resected cancer developed into a local recurrence. |
| Keywords | dysplasia-like atypia early gastric cancer endoscopic submucosal dissection local recurrence |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-06 |
| Volume | volume70 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 213 |
| End Page | 216 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27339211 |
| Web of Science KeyUT | 000379406100009 |
| JaLCDOI | 10.18926/AMO/53524 |
|---|---|
| FullText URL | 69_3_173.pdf |
| Author | Shirakawa, Yasuhiro| Noma, Kazuhiro| Ohara, Toshiaki| Kashima, Hajime| Maeda, Naoaki| Tanabe, Shunsuke| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| Abstract | A chyle leak can occur as a complication after neck or chest surgery. Such a leak prolongs the hospital stay and is sometimes life-threatening. The treatment options are conservative management, interventional radiologic embolization, and surgery. Thoracoscopic ligation of the thoracic duct has emerged as a promising and definitive treatment. The case of a 65-year-old Japanese male patient with a rare congenital right aortic arch (typeⅢB1 of Edwardʼs classification) and a severe chyle leak that occurred after a total pharyngolaryngo-esophagectomy (TPLE) is described. The chyle leak was successfully managed by thoracoscopic ligation of the thoracic duct via a left-side approach with the patient in the prone position. |
| Keywords | chyle leak thoracic duct thoracoscopy prone position |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2015-06 |
| Volume | volume69 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 173 |
| End Page | 176 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26101193 |
| Web of Science KeyUT | 000356903000006 |
| Author | Kikuchi, Satoru| Kishimoto, Hiroyuki| Tazawa, Hiroshi| Hashimoto, Yuuri| Kuroda, Shinji| Nishizaki, Masahiko| Nagasaka, Takeshi| Shirakawa, Yasuhiro| Kagawa, Shunsuke| Urata, Yasuo| Robert M Hoffman| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2014-12-19 |
| Publication Title | Molecular Therapy |
| Content Type | Journal Article |
| Author | Shigeyasu, Kunitoshi| Tazawa, Hiroshi| Hashimoto, Yuuri| Mori, Yoshiko| Nishizaki, Masahiko| Kishimoto, Hiroyuki| Nagasaka, Takeshi| Kuroda, Shinji| Urata, Yasuo| Goel, Ajay| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2014-05-28 |
| Publication Title | Gut |
| Content Type | Journal Article |
| Author | Yano, Shuya| Tazawa, Hiroshi| Hashimoto, Yuuri| Shirakawa, Yasuhiro| Kuroda, Shinji| Nishizaki, Masahiko| Kishimoto, Hiroyuki| Uno, Futoshi| Nagasaka, Takeshi| Urata, Yasuo| Kagawa, Shunsuke| Hoffman, Robert M.| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2013-12-01 |
| Publication Title | Clinical Cancer Research |
| Volume | volume19 |
| Issue | issue23 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/52006 |
|---|---|
| FullText URL | 67_6_333.pdf |
| Author | Tazawa, Hiroshi| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| Abstract | Autophagy is a catabolic process that produces energy through lysosomal degradation of intracellular organelles. Autophagy functions as a cytoprotective factor under physiological conditions such as nutrient deprivation, hypoxia, and interruption of growth factors. On the other hand, infection with pathogenic viruses and bacteria also induces autophagy in infected cells. Oncolytic virotherapy with replication-competent viruses is thus a promising strategy to induce tumor-specific cell death. Oncolytic adenoviruses induce autophagy and subsequently contribute to cell death rather than cell survival in tumor cells. We previously developed a telomerase-specific replication-competent oncolytic adenovirus, OBP-301, which induces cell lysis in tumor cells with telomerase activities. OBP-301-mediated cytopathic activity is significantly associated with induction of autophagy biomarkers. In this review, we focus on the tumor-suppressive role and molecular basis of autophagic machinery induced by oncolytic adenoviruses. Addition of tumor-specific promoters and modification of the fiber knob of adenoviruses supports the oncolytic adenovirus-mediated autophagic cell death. Autophagy is cooperatively regulated by the E1-dependent activation pathway, E4-dependent inhibitory pathway, and microRNA-dependent fine-tuning. Thus, future exploration of the functional role and molecular mechanisms underlying oncolytic adenovirus-induced autophagy would provide novel insights and improve the therapeutic potential of oncolytic adenoviruses. |
| Keywords | oncolytic adenovirus autophagy E2F1 microRNA |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-12 |
| Volume | volume67 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 333 |
| End Page | 342 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24356717 |
| Web of Science KeyUT | 000328915700001 |
| Author | Tazawa, Hiroshi| Yano, Syuya| Yoshida, Ryosuke| Yamasaki, Yasumoto| Sasaki, Tsuyoshi| Hashimoto, Yuuri| Kuroda, Shinji| Ouchi, Masaaki| Onishi, Teppei| Uno, Futoshi| Kagawa, Syunsuke| Urata, Yasuo| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2013-12-02 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume125 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Hasei, Joe| Sasaki, Tsuyoshi| Tazawa, Hiroshi| Osaki, Shuhei| Yamakawa, Yasuaki| Kunisada, Toshiyuki| Yoshida, Aki| Hashimoto, Yuuri| Onishi, Teppei| Uno, Futoshi| Kagawa, Shunsuke| Urata, Yasuo| Ozaki, Toshifumi| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2013-03 |
| Publication Title | Molecular Cancer Therapeutics |
| Volume | volume12 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Hashimoto, Yuuri| Tazawa, Hiroshi| Teraishi, Fuminori| Kojima, Toru| Watanabe, Yuichi| Uno, Futoshi| Yano, Shuya| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2012-06-15 |
| Publication Title | PLoS ONE |
| Volume | volume7 |
| Issue | issue6 |
| Content Type | Journal Article |
| Author | Yoshida, Ryosuke| Tazawa, Hiroshi| Hashimoto, Yuuri| Yano, Shuya| Onishi, Teppei| Sasaki, Tsuyoshi| Shirakawa, Yasuhiro| Kishimoto, Hiroyuki| Uno, Futoshi| Nishizaki, Masahiko| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2012-11 |
| Publication Title | Cancer Immunology, Immunotherapy |
| Volume | volume61 |
| Issue | issue11 |
| Content Type | Journal Article |
| Author | Kojima, Toru| Watanabe, Yuichi| Hashimoto, Yuuri| Kuroda, Shinji| Yamasaki, Yasumoto| Yano, Shuya| Tazawa, Hiroshi| Uno, Futoshi| Kagawa, Shunsuke| Tanaka, Noriaki| Urata, Yasuo| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2013-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume125 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Kojima, Toru| Hashimoto, Yuuri| Watanabe, Yuichi| Kagawa, Shunsuke| Uno, Futoshi| Kuroda, Shinji| Tazawa, Hiroshi| Kyo, Satoru| Mizuguchi, Hiroyuki| Urata, Yasuo| Tanaka, Noriaki| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2009-10-01 |
| Publication Title | The Journal of Clinical Investigation |
| Volume | volume119 |
| Issue | issue10 |
| Content Type | Journal Article |
| Author | Sasaki, Tsuyoshi| Tazawa, Hiroshi| Hasei, Jo| Kunisada, Toshiyuki| Yoshida, Aki| Hashimoto, Yuuri| Yano, Shuya| Yoshida, Ryosuke| Uno, Futoshi| Kagawa, Shunsuke| Morimoto, Yuki| Urata, Yasuo| Fujiwara, Toshiyoshi| Ozaki, Toshifumi| |
|---|---|
| Published Date | 2012-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume124 |
| Issue | issue2 |
| Content Type | Journal Article |
