Otsuka, Fumio - OU Author List - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

Poor vaccine responsiveness towards third-dose mRNA vaccine of COVID-19 in Japanese older people

FullText URL	fulltext20230508-03.pdf
Author	Hagiya, Hideharu\| Hikita, Takao\| Habu, Tomohiro\| Asada, Masaki\| Yorifuji, Takashi\| Toyooka, Shinichi\| Otsuka, Fumio\| Nakayama, Masanori\|
Note	© 2022 The British Infection Association. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at https://doi.org/10.1016/j.jinf.2022.07.007. \| This fulltext file will be available in Oct. 2023.\|
Published Date	2022-10
Publication Title	Journal of Infection
Volume	volume85
Issue	issue4
Publisher	Elsevier
Start Page	436
End Page	480
ISSN	0163-4453
NCID	AA00258231
Content Type	Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 The British Infection Association.
File Version	author
PubMed ID	35835411
DOI	10.1016/j.jinf.2022.07.007
Web of Science KeyUT	000883125700028
Related Url	isVersionOf https://doi.org/10.1016/j.jinf.2022.07.007

Tuberculous meningitis

FullText URL	fulltext.pdf
Author	Fukushima, Shinnosuke\| Ocho, Kazuki\| Fujita, Koji\| Hagiya, Hideharu\| Otsuka, Fumio\|
Keywords	basal meningitis cerebral infarction miliary tuberculosis tuberculous meningitis
Published Date	2023-01-16
Publication Title	Clinical Case Reports
Volume	volume11
Issue	issue1
Publisher	Wiley
Start Page	e06865
ISSN	2050-0904
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 The Authors.
File Version	publisher
PubMed ID	36694639
DOI	10.1002/ccr3.6865
Web of Science KeyUT	000921577100058
Related Url	isVersionOf https://doi.org/10.1002/ccr3.6865

Increased CCR4+ and Decreased Central Memory CD4+ T Lymphocytes in the Background Gastric Mucosa of Patients Developing Gastric Cancer After Helicobacter pylori Eradication: An Exploratory Study

FullText URL	fulltext.pdf
Author	Iwamuro, Masaya\| Takahashi, Takahide\| Hirabata, Araki\| Tanaka, Takehiro\| Otsuka, Fumio\| Okada, Horoyuki\|
Keywords	carcinogenesis lymphocytes helicobacter pylori gastric adenocarcinoma flow cytometry
Published Date	2022-11-20
Publication Title	Cureus Journal Of Medical Science
Volume	volume14
Issue	issue11
Publisher	Cureus Inc.
Start Page	e31713
ISSN	2168-8184
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 Iwamuro et al.
File Version	publisher
PubMed ID	36569708
DOI	10.7759/cureus.31713
Web of Science KeyUT	000918257500029
Related Url	isVersionOf https://doi.org/10.7759/cureus.31713

Prevalence of Inducible Macrolide, Lincosamide, and Streptogramin B (inducible MLSB) Resistance in Clindamycin-Susceptible Staphylococcus aureus at Okayama University Hospital

JaLCDOI	10.18926/AMO/64355
FullText URL	77_1_1.pdf
Author	Nahar, Lutfun\| Hagiya, Hideharu\| Nada, Takahiro\| Iio, Koji\| Gotoh, Kazuyoshi\| Matsushita, Osamu\| Otsuka, Fumio\|
Abstract	Inducible resistance to the macrolide, lincosamide, and streptogramin B (iMLSB) antibiotic family is a latent mechanism for antimicrobial resistance in Staphylococcus aureus. We here investigated the frequency and genotypic profiles of iMLSB resistance in clindamycin (CLDM)-susceptible S. aureus isolated in Okayama University Hospital from June 2020 to June 2021. We phenotypically screened the iMLSB resistance via D-zone test and performed PCR testing for the erythromycin ribosomal methylase (erm) genes: ermA and ermC. Among 432 CLDM-susceptible S. aureus isolates, 138 (31.9%) exhibited an iMLSB-resistance phenotype, with methicillinresistant S. aureus isolates (MRSA; 61 isolates: 58.6%) exhibiting higher positivity than methicillin-sensitive S. aureus isolates (MSSA; 77 isolates: 23.5%) (p<0.001). Male patients had a higher frequency of iMLSB resistance than females (OR [95%CI]: 1.8 [1.2-2.8]; p=0.007). Genotypically, ermA predominated in both MSSA (70.1%) and MRSA (86.9%) compared to ermC (14.3% in MSSA and 11.5% in MRSA). A single strain of MRSA possessed both ermA and ermC, while 12 (15.6%) MSSA isolates were negative for both ermA and ermC, suggesting the presence of other genetic mechanisms. Collectively, these results show that approximately 33% of CLDM-susceptible S. aureus isolates at our university hospital exhibited iMLSB resistance, predominantly caused by ermA in both MSSA and MRSA.
Keywords	antimicrobial resistance clindamycin erm D-zone test inducible MLSB
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2023-02
Volume	volume77
Issue	issue1
Publisher	Okayama University Medical School
Start Page	1
End Page	9
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	Copyright Ⓒ 2023 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	36849140
Web of Science KeyUT	000953663800001

Differences in Stress Perception of Medical Students Depending on In-Person Communication and Online Communication during the COVID-19 Pandemic: A Japanese Cross-Sectional Survey

FullText URL	fulltext.pdf
Author	Tokumasu, Kazuki\| Nishimura, Yoshito\| Sakamoto, Yoko\| Obika, Mikako\| Kataoka, Hitomi\| Otsuka, Fumio\|
Keywords	COVID-19 medical student medical education in-person communication online communication stress perception
Published Date	2023-01-15
Publication Title	International Journal of Environmental Research and Public Health
Volume	volume20
Issue	issue2
Publisher	MDPI
Start Page	1579
ISSN	1660-4601
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 by the authors.
File Version	publisher
PubMed ID	36674333
DOI	10.3390/ijerph20021579
Web of Science KeyUT	000915112800001
Related Url	isVersionOf https://doi.org/10.3390/ijerph20021579

Examining the association between vaccine reactogenicity and antibody titer dynamics after the third dose of BNT162b2 vaccine using a mixed-effects model

FullText URL	fulltext20230112-4.pdf figures20230112-4.pdf online-supplemental-figures20230112-4.pdf online-supplemental-Tables20230112-4.pdf
Author	Matsumoto, Naomi\| Hagiya, Hideharu\| Nakayama, Masanori\| Furukawa, Masanori\| Mitsuhashi, Toshiharu\| Takao, Soshi\| Otsuka, Fumio\| Yorifuji, Takashi\|
Keywords	SARS-CoV-2 Vaccine Antibody Reactogenicity Adverse reaction Mixed-effects model
Note	© 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.jiac.2022.09.012] . \| This full-text file will be available in Nov. 2023.\|
Published Date	2022-11-12
Publication Title	Journal of Infection and Chemotherapy
Volume	volume29
Issue	issue1
Publisher	Elsevier BV
Start Page	39
End Page	42
ISSN	1341-321X
NCID	AA11057978
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases
File Version	author
PubMed ID	36168999
DOI	10.1016/j.jiac.2022.09.012
Web of Science KeyUT	000894818300007
Related Url	isVersionOf https://doi.org/10.1016/j.jiac.2022.09.012

Characteristics of Sleep Disturbance in Patients with Long COVID: A Retrospective Observational Study in Japan

FullText URL	fulltext.pdf
Author	Sunada, Naruhiko\| Nakano, Yasuhiro\| Otsuka, Yuki\| Tokumasu, Kazuki\| Honda, Hiroyuki\| Sakurada, Yasue\| Matsuda, Yui\| Hasegawa, Toru\| Omura, Daisuke\| Ochi, Kanako\| Hagiya, Hideharu\| Ueda, Keigo\| Kataoka, Hitomi\| Otsuka, Fumio\|
Keywords	insomnia myalgic encephalomyelitis chronic fatigue long COVID Omicron variant post COVID-19 condition
Published Date	2022-12-09
Publication Title	Journal Of Clinical Medicine
Volume	volume11
Issue	issue24
Publisher	MDPI
Start Page	7332
ISSN	2077-0383
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 by the authors.
File Version	publisher
PubMed ID	36555948
DOI	10.3390/jcm11247332
Web of Science KeyUT	000901154300001
Related Url	isVersionOf https://doi.org/10.3390/jcm11247332

Isolated unilateral absence of adult pulmonary artery

FullText URL	fulltext.pdf
Author	Yamamoto, Koichiro\| Nakano, Yasuhiro\| Otsuka, Fumio\|
Keywords	collateral artery congenital heart disease hemoptysis
Published Date	2022-11-27
Publication Title	Clinical Case Reports
Volume	volume10
Issue	issue11
Publisher	Wiley
Start Page	e06652
ISSN	2050-0904
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 The Authors.
File Version	publisher
PubMed ID	36447660
DOI	10.1002/ccr3.6652
Web of Science KeyUT	000891440900026
Related Url	isVersionOf https://doi.org/10.1002/ccr3.6652

Key signs indicating mesenteric panniculitis

FullText URL	fulltext.pdf
Author	Yamamoto, Koichiro\| Honda, Hiroyuki\| Ogawa, Hiroko\| Otsuka, Fumio\|
Keywords	fat ring sign mesenteric panniculitis sclerosing mesenteritis and tumoral pseudocapsule sign
Published Date	2022-12
Publication Title	Clinical Case Reports
Volume	volume10
Issue	issue12
Publisher	Wiley
Start Page	e06654
ISSN	2050-0904
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 The Authors.
File Version	publisher
PubMed ID	36514474
DOI	10.1002/ccr3.6654
Web of Science KeyUT	000893849100001
Related Url	isVersionOf https://doi.org/10.1002/ccr3.6654

Detection of Enterobacter cloacae complex strain with a blaNDM-1-harboring plasmid from an elderly resident at a long-term care facility in Okayama, Japan

FullText URL	fulltext20221116-2.pdf
Author	Gotoh, Kazuyoshi\| Hagiya, Hideharu\| Iio, Koji\| Yamada, Haruto\| Matsushita, Osamu\| Otsuka, Fumio\|
Keywords	Antimicrobial resistance Carbapenemase-producing Enterobacterales Carbapenem-resistant Enterobacterales New Delhi metallo-β-lactamase (NDM) Enterobacter cloacae complex
Note	© 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.jiac.2022.08.019] .\| This full-text will be available in Oct. 2023.\|
Published Date	2022-12
Publication Title	Journal of Infection and Chemotherapy
Volume	volume28
Issue	issue12
Publisher	Elsevier BV
Start Page	1697
End Page	1699
ISSN	1341-321X
NCID	AA11057978
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.
File Version	author
PubMed ID	36049614
DOI	10.1016/j.jiac.2022.08.019
Web of Science KeyUT	000874559900019
Related Url	isVersionOf https://doi.org/10.1016/j.jiac.2022.08.019

Trends in the incidence of syphilis in the middle‐aged and older adults in Japan: A nationwide observational study, 2009–2019

FullText URL	fulltext20221116-1.pdf
Author	Takahashi, Misa\| Hagiya, Hideharu\| Koyama, Toshihiro\| Otsuka, Fumio\|
Keywords	aging sexual health sexually transmitted infection spirochete syphilis
Note	This is the peer reviewed version of the following article: [Takahashi, M, Hagiya, H, Koyama, T, Otsuka, F. Trends in the incidence of syphilis in the middle-aged and older adults in Japan: A nationwide observational study, 2009–2019. Geriatr. Gerontol. Int. 2022; 22: 1019–1024. https://doi.org/10.1111/ggi.14500], which has been published in final form at [https://doi.org/10.1111/ggi.14500]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.\| This full-text will be available in Nov. 2023.\|
Published Date	2022-11-01
Publication Title	Geriatrics and Gerontology International
Volume	volume22
Issue	issue12
Publisher	Wiley
Start Page	1019
End Page	1024
ISSN	1444-1586
NCID	AA1155729X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 Japan Geriatrics Society.
File Version	author
PubMed ID	36320169
DOI	10.1111/ggi.14500
Web of Science KeyUT	000877369900001
Related Url	isVersionOf https://doi.org/10.1111/ggi.14500

Transitional Changes in Fatigue-Related Symptoms Due to Long COVID: A Single-Center Retrospective Observational Study in Japan

FullText URL	fulltext.pdf
Author	Nakano, Yasuhiro\| Otsuka, Yuki\| Honda, Hiroyuki\| Sunada, Naruhiko\| Tokumasu, Kazuki\| Sakurada, Yasue\| Matsuda, Yui\| Hasegawa, Toru\| Ochi, Kanako\| Hagiya, Hideharu\| Kataoka, Hitomi\| Ueda, Keigo\| Otsuka, Fumio\|
Keywords	dysgeusia dysosmia myalgic encephalomyelitis/chronic fatigue syndrome Omicron variant and post COVID-19 condition
Published Date	2022-10-05
Publication Title	Medicina-Lithuania
Volume	volume58
Issue	issue10
Publisher	MDPI
Start Page	1393
ISSN	1010-660X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 by the authors.
File Version	publisher
PubMed ID	36295554
DOI	10.3390/medicina58101393
Web of Science KeyUT	000875069800001
Related Url	isVersionOf https://doi.org/10.3390/medicina58101393

High frequency of extended-spectrum beta-lactamase-producing Enterobacteriaceae carriers at a Japanese long-term care hospital

FullText URL	fulltext20221102-2.pdf
Author	Hagiya, Hideharu\| Onishi, Yuji\| Shinohara, Natsumi\| Tokuyasu, Mayumi\| Imanishi, Aki\| Fukushima, Shinnosuke\| Nahar, Lutfun\| Iio, Koji\| Otsuka, Fumio\|
Keywords	Aging society Antimicrobial resistance Carbapenem-resistant Enterobacteriaceae Extended-spectrum beta-lactamase Infection prevention and control
Note	© 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.jiac.2022.07.014] . \|
Published Date	2022-11
Publication Title	Journal of Infection and Chemotherapy
Volume	volume28
Issue	issue11
Publisher	Elsevier BV
Start Page	1578
End Page	1581
ISSN	1341-321X
NCID	AA11057978
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.
File Version	author
PubMed ID	35921967
DOI	10.1016/j.jiac.2022.07.014
Web of Science KeyUT	000863109600009
Related Url	isVersionOf https://doi.org/10.1016/j.jiac.2022.07.014

Effects of Yoga and Mindfulness Programs on Self-Compassion in Medical Professionals during the COVID-19 Pandemic: An Intervention Study

FullText URL	fulltext.pdf
Author	Miyoshi, Tomoko\| Ida, Hiromi\| Nishimura, Yoshito\| Ako, Soichiro\| Otsuka, Fumio\|
Keywords	stress burnout yoga mindfulness stress in healthcare workers self-compassion the COVID-19 pandemic
Published Date	2022-09-30
Publication Title	International Journal Of Environmental Research and Public Health
Volume	volume19
Issue	issue19
Publisher	MDPI
Start Page	12523
ISSN	1660-4601
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 by the authors.
File Version	publisher
PubMed ID	36231820
DOI	10.3390/ijerph191912523
Web of Science KeyUT	000868048000001
Related Url	isVersionOf https://doi.org/10.3390/ijerph191912523

Prevalence of medical factors related to aging among older car drivers: a multicenter, cross-sectional, descriptive study

FullText URL	fulltext.pdf
Author	Hagiya, Hideharu\| Takase, Ryosuke\| Honda, Hiroyuki\| Nakano, Yasuhiro\| Otsuka, Yuki\| Kataoka, Hitomi\| Uno, Mika\| Ueda, Keigo\| Takahashi, Misa\| Ogawa, Hiroko\| Hanayama, Yoshihisa\| Otsuka, Fumio\|
Keywords	Traffic safety Older people Aging Motor vehicle accidents Frailty Dementia Polypharmacy Sarcopenia
Published Date	2022-10-11
Publication Title	BMC Geriatrics
Volume	volume22
Issue	issue1
Publisher	BMC
Start Page	792
ISSN	1471-2318
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2022.
File Version	publisher
PubMed ID	36221051
DOI	10.1186/s12877-022-03490-w
Web of Science KeyUT	000866114200002
Related Url	isVersionOf https://doi.org/10.1186/s12877-022-03490-w

Secondary autoimmune hypothalamitis with severe memory impairment 7 years after the onset of diabetes insipidus due to lymphocytic hypophysitis: a case report

FullText URL	fulltext.pdf
Author	Asada, Takahiro\| Takenoshita, Shintaro\| Senda, Mayuko\| Yamamoto, Koichiro\| Sasaki, Ryo\| Otsuka, Fumio\| Terada, Seishi\| Yamada, Norihito\|
Keywords	Lymphocytic hypophysitis Autoimmune hypophysitis Autoimmune hypothalamitis Cognitive dysfunction Memory impairment
Published Date	2022-09-29
Publication Title	BMC Neurology
Volume	volume22
Issue	issue1
Publisher	BMC
Start Page	371
ISSN	1471-2377
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2022.
File Version	publisher
PubMed ID	36175850
DOI	10.1186/s12883-022-02891-z
Web of Science KeyUT	000861890200002
Related Url	isVersionOf https://doi.org/10.1186/s12883-022-02891-z

Idiopathic Plasmacytic Lymphadenopathy Forms an Independent Subtype of Idiopathic Multicentric Castleman Disease

FullText URL	fulltext.pdf
Author	Nishikori, Asami\| Nishimura, Midori Filiz\| Nishimura, Yoshito\| Otsuka, Fumio\| Maehama, Kanna\| Ohsawa, Kumiko\| Momose, Shuji\| Nakamura, Naoya\| Sato, Yasuharu\|
Keywords	Castleman disease idiopathic multicentric Castleman disease idiopathic plasmacytic lymphadenopathy plasma cell morphology
Published Date	2022-09-07
Publication Title	International Journal Of Molecular Sciences
Volume	volume23
Issue	issue18
Publisher	MDPI
Start Page	10301
ISSN	1422-0067
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 by the authors.
File Version	publisher
PubMed ID	36142213
DOI	10.3390/ijms231810301
Web of Science KeyUT	000856382100001
Related Url	isVersionOf https://doi.org/10.3390/ijms231810301

Site-specific differences in T lymphocyte composition of the gastric mucosa after Helicobacter pylori eradication

FullText URL	fulltext.pdf
Author	Iwamuro, Masaya\| Takahashi, Takahide\| Watanabe, Natsuki\| Abe, Makoto\| Sakae, Hiroyuki\| Kono, Yoshiyasu\| Kanzaki, Hiromitsu\| Tanaka, Takehiro\| Kawano, Seiji\| Otsuka, Fumio\| Kawahara, Yoshiro\| Yanai, Hiroyuki\| Okada, Hiroyuki\|
Keywords	eradication flow cytometry Helicobacter pylori T lymphocytes
Published Date	2022-08-26
Publication Title	Medicine
Volume	volume101
Issue	issue34
Publisher	Lippincott Williams & Wilkins
Start Page	e30241
ISSN	0025-7974
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 the Author(s).
File Version	publisher
PubMed ID	36042652
DOI	10.1097/MD.0000000000030241
Web of Science KeyUT	000847532100050
Related Url	isVersionOf https://doi.org/10.1097/MD.0000000000030241

Impact of the cervical cancer awareness months on public interest in Japan: A Google Trends analysis, 2012-2021

FullText URL	fulltext.pdf
Author	Hagiya, Hideharu\| Koyama, Toshihiro\| Otsuka, Fumio\|
Published Date	2022-09-13
Publication Title	Scientific Reports
Volume	volume12
Issue	issue1
Publisher	Nature Portfolio
Start Page	15391
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2022
File Version	publisher
PubMed ID	36100649
DOI	10.1038/s41598-022-19798-x
Web of Science KeyUT	000855580800036
Related Url	isVersionOf https://doi.org/10.1038/s41598-022-19798-x

Mutual Effects of Orexin and Bone Morphogenetic Proteins on Gonadotropin Expression by Mouse Gonadotrope Cells

FullText URL	fulltext.pdf
Author	Soejima, Yoshiaki\| Iwata, Nahoko\| Nakayama, Nanako\| Hirata, Shinichi\| Nakano, Yasuhiro\| Yamamoto, Koichiro\| Suyama, Atsuhito\| Oguni, Kohei\| Nada, Takahiro\| Fujisawa, Satoshi\| Otsuka, Fumio\|
Keywords	bone morphogenetic protein (BMP) clock gonadotropin orexin pituitary
Published Date	2022-08-29
Publication Title	International Journal Of Molecular Sciences
Volume	volume23
Issue	issue17
Publisher	MDPI
Start Page	9782
ISSN	1422-0067
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 by the authors.
File Version	publisher
PubMed ID	36077179
DOI	10.3390/ijms23179782
Web of Science KeyUT	000851102000001
Related Url	isVersionOf https://doi.org/10.3390/ijms23179782