Title Alternative Experience with a nosocomial cluster of novel coronavirus infection and the cluster response algorithm
Author Fujita, Koji| Ocho, Kazuki| Kadowaki, Tomoka| Yorifuji, Takashi| Otsuka, Fumio|
Abstract  The novel coronavirus disease (COVID-19) pandemic that began in 2019 is yet to end, as of the summer of 2022. During the pandemic, community-acquired infections spread easily to healthcare-associated facilities, resulting in COVID-19 clusters among high-risk individuals that have been difficult to contain. Our regional base hospital also experienced a nosocomial cluster of COVID-19 in October 2020 that took 30 days to contain and affected 9 hospital staff and 14 patients. Six patients died due to COVID-19, and six died due to COVID-19-related complications. Two patients were discharged alive. Patient characteristics included ① advanced age (79.0±8.1 years), ② dementia (64.3%), ③ low Prognostic Nutrition Index (31.1 ±7.9), ④ zinc deficiency (50.2±13.1μg/dL), ⑤ vitamin C deficiency (1.6±1.9μg/mL), ⑥ elevated urea nitrogen-to-creatinine ratio (27.4±23.5), ⑦ anticancer and immunosuppressive drug use (78.6%), and ⑧ malignancy (75.6%). This cluster had a very high mortality rate, but the viral spread was contained in a short period. Algorithmizing the cluster response was crucial to controlling this cluster. We report on our actual cluster response algorithm, as well as our strategy and response procedure during the pandemic.
Keywords 新型コロナウイルス感染症(COVID-19) 院内クラスター(nosocomial cluster) 対応アルゴリズム(response algorithm)
Publication Title Journal of Okayama Medical Association
Published Date 2023-04-01
Volume volume135
Issue issue1
Start Page 22
End Page 33
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.135.22
language Japanese
Copyright Holders Copyright (c) 2023 岡山医学会
File Version publisher
DOI 10.4044/joma.135.22
FullText URL fulltext.pdf
Author Otsuka, Yuki| Hagiya, Hideharu| Takahashi, Misa| Fukushima, Shinnosuke| Maeda, Ruri| Sunada, Naruhiko| Yamada, Haruto| Kishida, Masayuki| Fujita, Koji| Otsuka, Fumio|
Published Date 2023-01-12
Publication Title Scientific Reports
Volume volume13
Issue issue1
Publisher Nature Research
Start Page 647
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2023
File Version publisher
PubMed ID 36635328
DOI 10.1038/s41598-022-27330-4
Web of Science KeyUT 000962604100025
Related Url isVersionOf https://doi.org/10.1038/s41598-022-27330-4
JaLCDOI 10.18926/AMO/65151
FullText URL 77_2_203.pdf
Author Fukushima, Shinnosuke| Hagiya, Hideharu| Iio, Koji| Honda, Hiroyuki| Ishida, Tomoharu| Nagaoka, Hirokazu| Hasegawa, Kou| Otsuka, Fumio|
Abstract Granulicatella species are rare, nutritionally variant streptococci that cause infective endocarditis. Their clinical and microbiological characteristics remain unknown. We reviewed five years of Granulicatella cases in our hospital database (Jan 2017-Jun 2022), finding 6 Granulicatella adiacens cases and 1 Granulicatella elegans case. Clinical backgrounds and bacteremia sources were diverse; 3 cases developed polymicrobial bacteremia. Antimicrobial testing showed non-susceptibility to penicillin G in 4 of 7 cases (57.1%), and high susceptibility to carbapenems and vancomycin in all cases. Determining optimal antibiotic therapy for Granulicatella infections is vital in this era of antimicrobial resistance.
Keywords antimicrobial resistance bacteremia Granulicatella species nutritionally variant streptococci
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2023-04
Volume volume77
Issue issue2
Publisher Okayama University Medical School
Start Page 203
End Page 207
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37094959
Web of Science KeyUT 000982563800002
FullText URL fulltext.pdf
Author Matsuda, Yui| Tokumasu, Kazuki| Otsuka, Yuki| Sunada, Naruhiko| Honda, Hiroyuki| Sakurada, Yasue| Nakano, Yasuhiro| Hasegawa, Toru| Obika, Mikako| Ueda, Keigo| Otsuka, Fumio|
Keywords dysgeusia dysosmia fatigue hypozincemia long COVID
Published Date 2023-03-06
Publication Title Journal of Clinical Medicine
Volume volume12
Issue issue5
Publisher MDPI
Start Page 2062
ISSN 2077-0383
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 by the authors.
File Version publisher
PubMed ID 36902849
DOI 10.3390/jcm12052062
Web of Science KeyUT 000947564300001
Related Url isVersionOf https://doi.org/10.3390/jcm12052062
FullText URL fulltext.pdf
Author Sakurada, Yasue| Otsuka, Yuki| Tokumasu, Kazuki| Sunada, Naruhiko| Honda, Hiroyuki| Nakano, Yasuhiro| Matsuda, Yui| Hasegawa, Toru| Ochi, Kanako| Hagiya, Hideharu| Ueda, Keigo| Kataoka, Hitomi| Otsuka, Fumio|
Keywords Delta variant schoolchildren teenagers Omicron variant post-COVID-19 condition
Published Date 2023-01-29
Publication Title Medicina
Volume volume59
Issue issue2
Publisher MDPI
Start Page 261
ISSN 1010-660X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 by the authors.
File Version publisher
PubMed ID 36837463
DOI 10.3390/medicina59020261
Web of Science KeyUT 000940850700001
Related Url isVersionOf https://doi.org/10.3390/medicina59020261
FullText URL fulltext20230508-03.pdf
Author Hagiya, Hideharu| Hikita, Takao| Habu, Tomohiro| Asada, Masaki| Yorifuji, Takashi| Toyooka, Shinichi| Otsuka, Fumio| Nakayama, Masanori|
Note © 2022 The British Infection Association. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at https://doi.org/10.1016/j.jinf.2022.07.007. | This fulltext file will be available in Oct. 2023.|
Published Date 2022-10
Publication Title Journal of Infection
Volume volume85
Issue issue4
Publisher Elsevier
Start Page 436
End Page 480
ISSN 0163-4453
NCID AA00258231
Content Type Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The British Infection Association.
File Version author
PubMed ID 35835411
DOI 10.1016/j.jinf.2022.07.007
Web of Science KeyUT 000883125700028
Related Url isVersionOf https://doi.org/10.1016/j.jinf.2022.07.007
FullText URL fulltext.pdf
Author Fukushima, Shinnosuke| Ocho, Kazuki| Fujita, Koji| Hagiya, Hideharu| Otsuka, Fumio|
Keywords basal meningitis cerebral infarction miliary tuberculosis tuberculous meningitis
Published Date 2023-01-16
Publication Title Clinical Case Reports
Volume volume11
Issue issue1
Publisher Wiley
Start Page e06865
ISSN 2050-0904
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 The Authors.
File Version publisher
PubMed ID 36694639
DOI 10.1002/ccr3.6865
Web of Science KeyUT 000921577100058
Related Url isVersionOf https://doi.org/10.1002/ccr3.6865
FullText URL fulltext.pdf
Author Iwamuro, Masaya| Takahashi, Takahide| Hirabata, Araki| Tanaka, Takehiro| Otsuka, Fumio| Okada, Horoyuki|
Keywords carcinogenesis lymphocytes helicobacter pylori gastric adenocarcinoma flow cytometry
Published Date 2022-11-20
Publication Title Cureus Journal Of Medical Science
Volume volume14
Issue issue11
Publisher Cureus Inc.
Start Page e31713
ISSN 2168-8184
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 Iwamuro et al.
File Version publisher
PubMed ID 36569708
DOI 10.7759/cureus.31713
Web of Science KeyUT 000918257500029
Related Url isVersionOf https://doi.org/10.7759/cureus.31713
JaLCDOI 10.18926/AMO/64355
FullText URL 77_1_1.pdf
Author Nahar, Lutfun| Hagiya, Hideharu| Nada, Takahiro| Iio, Koji| Gotoh, Kazuyoshi| Matsushita, Osamu| Otsuka, Fumio|
Abstract Inducible resistance to the macrolide, lincosamide, and streptogramin B (iMLSB) antibiotic family is a latent mechanism for antimicrobial resistance in Staphylococcus aureus. We here investigated the frequency and genotypic profiles of iMLSB resistance in clindamycin (CLDM)-susceptible S. aureus isolated in Okayama University Hospital from June 2020 to June 2021. We phenotypically screened the iMLSB resistance via D-zone test and performed PCR testing for the erythromycin ribosomal methylase (erm) genes: ermA and ermC. Among 432 CLDM-susceptible S. aureus isolates, 138 (31.9%) exhibited an iMLSB-resistance phenotype, with methicillinresistant S. aureus isolates (MRSA; 61 isolates: 58.6%) exhibiting higher positivity than methicillin-sensitive S. aureus isolates (MSSA; 77 isolates: 23.5%) (p<0.001). Male patients had a higher frequency of iMLSB resistance than females (OR [95%CI]: 1.8 [1.2-2.8]; p=0.007). Genotypically, ermA predominated in both MSSA (70.1%) and MRSA (86.9%) compared to ermC (14.3% in MSSA and 11.5% in MRSA). A single strain of MRSA possessed both ermA and ermC, while 12 (15.6%) MSSA isolates were negative for both ermA and ermC, suggesting the presence of other genetic mechanisms. Collectively, these results show that approximately 33% of CLDM-susceptible S. aureus isolates at our university hospital exhibited iMLSB resistance, predominantly caused by ermA in both MSSA and MRSA.
Keywords antimicrobial resistance clindamycin erm D-zone test inducible MLSB
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-02
Volume volume77
Issue issue1
Publisher Okayama University Medical School
Start Page 1
End Page 9
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36849140
Web of Science KeyUT 000953663800001
FullText URL fulltext.pdf
Author Tokumasu, Kazuki| Nishimura, Yoshito| Sakamoto, Yoko| Obika, Mikako| Kataoka, Hitomi| Otsuka, Fumio|
Keywords COVID-19 medical student medical education in-person communication online communication stress perception
Published Date 2023-01-15
Publication Title International Journal of Environmental Research and Public Health
Volume volume20
Issue issue2
Publisher MDPI
Start Page 1579
ISSN 1660-4601
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 by the authors.
File Version publisher
PubMed ID 36674333
DOI 10.3390/ijerph20021579
Web of Science KeyUT 000915112800001
Related Url isVersionOf https://doi.org/10.3390/ijerph20021579
FullText URL fulltext20230112-4.pdf figures20230112-4.pdf online-supplemental-figures20230112-4.pdf online-supplemental-Tables20230112-4.pdf
Author Matsumoto, Naomi| Hagiya, Hideharu| Nakayama, Masanori| Furukawa, Masanori| Mitsuhashi, Toshiharu| Takao, Soshi| Otsuka, Fumio| Yorifuji, Takashi|
Keywords SARS-CoV-2 Vaccine Antibody Reactogenicity Adverse reaction Mixed-effects model
Note © 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.jiac.2022.09.012] . | This full-text file will be available in Nov. 2023.|
Published Date 2022-11-12
Publication Title Journal of Infection and Chemotherapy
Volume volume29
Issue issue1
Publisher Elsevier BV
Start Page 39
End Page 42
ISSN 1341-321X
NCID AA11057978
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases
File Version author
PubMed ID 36168999
DOI 10.1016/j.jiac.2022.09.012
Web of Science KeyUT 000894818300007
Related Url isVersionOf https://doi.org/10.1016/j.jiac.2022.09.012
FullText URL fulltext.pdf
Author Sunada, Naruhiko| Nakano, Yasuhiro| Otsuka, Yuki| Tokumasu, Kazuki| Honda, Hiroyuki| Sakurada, Yasue| Matsuda, Yui| Hasegawa, Toru| Omura, Daisuke| Ochi, Kanako| Hagiya, Hideharu| Ueda, Keigo| Kataoka, Hitomi| Otsuka, Fumio|
Keywords insomnia myalgic encephalomyelitis chronic fatigue long COVID Omicron variant post COVID-19 condition
Published Date 2022-12-09
Publication Title Journal Of Clinical Medicine
Volume volume11
Issue issue24
Publisher MDPI
Start Page 7332
ISSN 2077-0383
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 36555948
DOI 10.3390/jcm11247332
Web of Science KeyUT 000901154300001
Related Url isVersionOf https://doi.org/10.3390/jcm11247332
FullText URL fulltext.pdf
Author Yamamoto, Koichiro| Nakano, Yasuhiro| Otsuka, Fumio|
Keywords collateral artery congenital heart disease hemoptysis
Published Date 2022-11-27
Publication Title Clinical Case Reports
Volume volume10
Issue issue11
Publisher Wiley
Start Page e06652
ISSN 2050-0904
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Authors.
File Version publisher
PubMed ID 36447660
DOI 10.1002/ccr3.6652
Web of Science KeyUT 000891440900026
Related Url isVersionOf https://doi.org/10.1002/ccr3.6652
FullText URL fulltext.pdf
Author Yamamoto, Koichiro| Honda, Hiroyuki| Ogawa, Hiroko| Otsuka, Fumio|
Keywords fat ring sign mesenteric panniculitis sclerosing mesenteritis and tumoral pseudocapsule sign
Published Date 2022-12
Publication Title Clinical Case Reports
Volume volume10
Issue issue12
Publisher Wiley
Start Page e06654
ISSN 2050-0904
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Authors.
File Version publisher
PubMed ID 36514474
DOI 10.1002/ccr3.6654
Web of Science KeyUT 000893849100001
Related Url isVersionOf https://doi.org/10.1002/ccr3.6654
FullText URL fulltext20221116-2.pdf
Author Gotoh, Kazuyoshi| Hagiya, Hideharu| Iio, Koji| Yamada, Haruto| Matsushita, Osamu| Otsuka, Fumio|
Keywords Antimicrobial resistance Carbapenemase-producing Enterobacterales Carbapenem-resistant Enterobacterales New Delhi metallo-β-lactamase (NDM) Enterobacter cloacae complex
Note © 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.jiac.2022.08.019] .| This full-text will be available in Oct. 2023.|
Published Date 2022-12
Publication Title Journal of Infection and Chemotherapy
Volume volume28
Issue issue12
Publisher Elsevier BV
Start Page 1697
End Page 1699
ISSN 1341-321X
NCID AA11057978
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.
File Version author
PubMed ID 36049614
DOI 10.1016/j.jiac.2022.08.019
Web of Science KeyUT 000874559900019
Related Url isVersionOf https://doi.org/10.1016/j.jiac.2022.08.019
FullText URL fulltext20221116-1.pdf
Author Takahashi, Misa| Hagiya, Hideharu| Koyama, Toshihiro| Otsuka, Fumio|
Keywords aging sexual health sexually transmitted infection spirochete syphilis
Note This is the peer reviewed version of the following article: [Takahashi, M, Hagiya, H, Koyama, T, Otsuka, F. Trends in the incidence of syphilis in the middle-aged and older adults in Japan: A nationwide observational study, 2009–2019. Geriatr. Gerontol. Int. 2022; 22: 1019–1024. https://doi.org/10.1111/ggi.14500], which has been published in final form at [https://doi.org/10.1111/ggi.14500]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This full-text will be available in Nov. 2023.|
Published Date 2022-11-01
Publication Title Geriatrics and Gerontology International
Volume volume22
Issue issue12
Publisher Wiley
Start Page 1019
End Page 1024
ISSN 1444-1586
NCID AA1155729X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 Japan Geriatrics Society.
File Version author
PubMed ID 36320169
DOI 10.1111/ggi.14500
Web of Science KeyUT 000877369900001
Related Url isVersionOf https://doi.org/10.1111/ggi.14500
FullText URL fulltext.pdf
Author Nakano, Yasuhiro| Otsuka, Yuki| Honda, Hiroyuki| Sunada, Naruhiko| Tokumasu, Kazuki| Sakurada, Yasue| Matsuda, Yui| Hasegawa, Toru| Ochi, Kanako| Hagiya, Hideharu| Kataoka, Hitomi| Ueda, Keigo| Otsuka, Fumio|
Keywords dysgeusia dysosmia myalgic encephalomyelitis/chronic fatigue syndrome Omicron variant and post COVID-19 condition
Published Date 2022-10-05
Publication Title Medicina-Lithuania
Volume volume58
Issue issue10
Publisher MDPI
Start Page 1393
ISSN 1010-660X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 36295554
DOI 10.3390/medicina58101393
Web of Science KeyUT 000875069800001
Related Url isVersionOf https://doi.org/10.3390/medicina58101393
FullText URL fulltext20221102-2.pdf
Author Hagiya, Hideharu| Onishi, Yuji| Shinohara, Natsumi| Tokuyasu, Mayumi| Imanishi, Aki| Fukushima, Shinnosuke| Nahar, Lutfun| Iio, Koji| Otsuka, Fumio|
Keywords Aging society Antimicrobial resistance Carbapenem-resistant Enterobacteriaceae Extended-spectrum beta-lactamase Infection prevention and control
Note © 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.jiac.2022.07.014] . |
Published Date 2022-11
Publication Title Journal of Infection and Chemotherapy
Volume volume28
Issue issue11
Publisher Elsevier BV
Start Page 1578
End Page 1581
ISSN 1341-321X
NCID AA11057978
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.
File Version author
PubMed ID 35921967
DOI 10.1016/j.jiac.2022.07.014
Web of Science KeyUT 000863109600009
Related Url isVersionOf https://doi.org/10.1016/j.jiac.2022.07.014
FullText URL fulltext.pdf
Author Miyoshi, Tomoko| Ida, Hiromi| Nishimura, Yoshito| Ako, Soichiro| Otsuka, Fumio|
Keywords stress burnout yoga mindfulness stress in healthcare workers self-compassion the COVID-19 pandemic
Published Date 2022-09-30
Publication Title International Journal Of Environmental Research and Public Health
Volume volume19
Issue issue19
Publisher MDPI
Start Page 12523
ISSN 1660-4601
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 36231820
DOI 10.3390/ijerph191912523
Web of Science KeyUT 000868048000001
Related Url isVersionOf https://doi.org/10.3390/ijerph191912523
FullText URL fulltext.pdf
Author Hagiya, Hideharu| Takase, Ryosuke| Honda, Hiroyuki| Nakano, Yasuhiro| Otsuka, Yuki| Kataoka, Hitomi| Uno, Mika| Ueda, Keigo| Takahashi, Misa| Ogawa, Hiroko| Hanayama, Yoshihisa| Otsuka, Fumio|
Keywords Traffic safety Older people Aging Motor vehicle accidents Frailty Dementia Polypharmacy Sarcopenia
Published Date 2022-10-11
Publication Title BMC Geriatrics
Volume volume22
Issue issue1
Publisher BMC
Start Page 792
ISSN 1471-2318
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022.
File Version publisher
PubMed ID 36221051
DOI 10.1186/s12877-022-03490-w
Web of Science KeyUT 000866114200002
Related Url isVersionOf https://doi.org/10.1186/s12877-022-03490-w