ID | 65661 |
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Kondo, Takumi
Division of Transfusion, Okayama University Hospital
Sumii, Yuichi
Division of Transfusion, Okayama University Hospital
Urata, Tomohiro
Division of Transfusion, Okayama University Hospital
Kimura, Maiko
Division of Transfusion, Okayama University Hospital
Matsuda, Masayuki
Division of Transfusion, Okayama University Hospital
Ikegawa, Shuntaro
Division of Transfusion, Okayama University Hospital
Washio, Kana
Department of Pediatrics/Pediatric Hematology and Oncology, Okayama University Hospital
Fujiwara, Hideaki
Department of Hematology and Oncology, Okayama University Hospital
Asada, Noboru
Department of Hematology and Oncology, Okayama University Hospital
Kaken ID
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Ennishi, Daisuke
Department of Hematology and Oncology, Okayama University Hospital
Nishimori, Hisakazu
Department of Hematology and Oncology, Okayama University Hospital
Kaken ID
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Matsuoka, Ken‐ichi
Department of Hematology and Oncology, Okayama University Hospital
Otsuka, Fumio
Division of Clinical Laboratory, Okayama University Hospital
ORCID
Kaken ID
publons
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Maeda, Yoshinobu
Department of Hematology and Oncology, Okayama University Hospital
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Abstract | Background: Granulocyte transfusion therapy is a rational therapeutic option for patients with prolonged, severe neutropenia. Although high molecular weight hydroxyethyl starch (hHES) facilitates the separation of red blood cells during granulocyte collection, renal dysfunction has been noted as a potential side effect. HES130/0.4 (Voluven®) is a medium molecular weight HES (mHES) with superior safety profiles compared to hHES. Although HES130/0.4 is reportedly effective in the collection of granulocytes, we lack studies comparing the efficiency of granulocyte collection using HES130/0.4 and hHES.
Study Design and Methods: We retrospectively collected the data from 60 consecutive apheresis procedures performed on 40 healthy donors at the Okayama University Hospital between July 2013 and December 2021. All procedures were performed using the Spectra Optia system. Based on the HES130/0.4 concentration in the separation chamber, granulocyte collection methods using HES130/0.4 were classified into m0.46, m0.44, m0.37, and m0.8 groups. We used HES130/0.4 and hHES groups to compare the various sample collection methods. Results: The median granulocyte collection efficiency (CE) was approximately 24.0% and 28.1% in the m0.8 and hHES groups, respectively, which were significantly higher than those in the m0.46, m0.44, and m0.37 groups. One month following granulocyte collection with HES130/0.4, no significant changes were observed in serum creatinine levels compared to those before the donation. Conclusion: Therefore, we propose a granulocyte collection approach employing HES130/0.4, which is comparable to the use of hHES in terms of the granulocyte CE. A high concentration of HES130/0.4 in the separation chamber was considered crucial for granulocyte collection. |
Keywords | blood center operations
cellular therapy
therapeutic apheresis
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Note | This is the peer reviewed version of the following article: [Kondo T, Fujii K, Fujii N, Sumii Y, Urata T, Kimura M, et al. Efficient granulocyte collection method using high concentrations of medium molecular weight hydroxyethyl starch. Transfusion. 2023; 63(7): 1344–1353. https://doi.org/10.1111/trf.17450], which has been published in final form at [https://doi.org/10.1111/trf.17450]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
This fulltext file will be available in Jun. 2024.
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Published Date | 2023-06-09
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Publication Title |
Transfusion
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Volume | volume63
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Issue | issue7
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Publisher | Wiley
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Start Page | 1344
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End Page | 1353
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ISSN | 0041-1132
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NCID | AA00868753
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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Copyright Holders | © 2023 AABB.
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File Version | author
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Related Url | isVersionOf https://doi.org/10.1111/trf.17450
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Citation | Kondo T, Fujii K, Fujii N, Sumii Y, Urata T, Kimura M, et al. Efficient granulocyte collection method using high concentrations of medium molecular weight hydroxyethyl starch. Transfusion. 2023; 63(7): 1344–1353. https://doi.org/10.1111/trf.17450
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