| Author | Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2010-12-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume122 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Kojima, Toru| Hashimoto, Yuuri| Kagawa, Shunsuke| Tanaka, Noriaki| Urata, Yasuo| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2010-12-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume122 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Nagasaka, Takeshi| Tanaka, Noriaki| Sun, Dong-Sheng| Naomoto, Yoshio| Mastubara, Nagahide| Yagi, Takahito| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2010-08-02 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume122 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Teraishi, Fuminori| Kagawa, Shunsuke| Watanabe, Takanori| Tango, Yasuhisa| Kawashima, Takeshi| Umeoka, Tatsuo| Nisizaki, Masahiko| Tanaka, Noriaki| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2005-08-01 |
| Publication Title | FEBS Letters |
| Volume | volume579 |
| Issue | issue19 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/31570 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Matsuoka, Junji| Sakagami, Kenichi| Fujiwara, Toshiyoshi| Onoda, Tadashi| Idani, Hitoshi| Gochi, Akira| Orita, Kunzo| |
| Abstract | A sustained release system for interleukin-2 (IL-2), and IL-2 mini-pellet (IL-2 mp), was developed by fusing IL-2 into a needle shaped collagen. Serum concentration of IL-2 after a single subcutaneous injection of the IL-2 mp into C57BL/6 mice remained elevated longer than after an injection of aqueous IL-2. IL-2 in the serum became undetectable by 6h after a subcutaneous injection of 1 x 10(6) unit of IL-2 in phosphate-buffered saline (PBS). In contrast, after a single subcutaneous injection of IL-2 mp containing the same amount of IL-2, the concentration of IL-2 increased to its maximum at 6h after injection, then began to decrease gradually. IL-2 was detected even on the third day after a single subcutaneous injection of one IL-2 mp. Augmentation of NK activity and generation of IL-2 activated killer cells were observed in the spleen from day 1--day 3 after a single subcutaneous injection of IL-2 mp into C57BL/6 mice. This activation was not observed following a single subcutaneous injection of the same amount of IL-2 in PBS. Adoptive immunotherapy by a single subcutaneous injection of IL-2 mp followed by intravenous injections of in vitro cultured IL-2 activated killer cells showed better results in decreasing the number of metastases of Lewis lung carcinoma in C57BL/6 mice than immunotherapy using IL-2 solution.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Keywords | IL-2 drug delivery system immunotherapy mouse |
| Amo Type | Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 1993-04 |
| Volume | volume47 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 79 |
| End Page | 84 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 8506753 |
| Web of Science KeyUT | A1993LA45200002 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Umeoka, Tatsuo| Kawashima, Takeshi| Kagawa, Shunsuke| Teraishi, Fuminori| Taki, Masaki| Nishizaki, Masahiko| Kyo, Satoru| Nagai, Katsuyuki| Urata, Yasuo| Tanaka, Noriaki| Fujiwara, Toshiyoshi| |
| Keywords | GFP adenovirus telomerase replication gene therapy |
| Note | Published with permission from the copyright holder. This is the author's copy, as published in Cancer Research, September 2004, Volume 64, Issue 17, Pages 6259-6265. Copyright © 2004 American Association for Cancer Research. All rights reserved.| |
| Published Date | 2004-09-01 |
| Publication Title | Cancer Research |
| Volume | volume64 |
| Issue | issue17 |
| Publisher | American Association for Cancer Research |
| Start Page | 6259 |
| End Page | 6265 |
| ISSN | 0008-5472 |
| NCID | AA00598557 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | American Association for Cancer Research |
| File Version | author |
| PubMed ID | 15342413 |
| DOI | 10.1158/0008-5472.can-04-1335 |
| Web of Science KeyUT | 000223603200048 |
| Official Url | http://cancerres.aacrjournals.org/content/64/17/6259| |
| Related Url | isVersionOf https://doi.org/10.1158/0008-5472.can-04-1335 |
| Author | Fujiwara, Toshiyoshi| Tanaka, Noriaki| |
|---|---|
| Published Date | 2008-12-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume120 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Endo, Yoshikatsu| Sakai, Ryo| Ouchi, Masaaki| Onimatsu, Hideki| Hioki, Masayoshi| Kagawa, Shunsuke| Uno, Futoshi| Watanabe, Yuichi| Urata, Yasuo| Tanaka, Noriaki| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2008-12-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume120 |
| Issue | issue3 |
| Content Type | Journal Article |
| Title Alternative | Two cases of acute pulmonary embolism after esophageal cancer operation |
|---|---|
| FullText URL | 118_41.pdf |
| Author | Kanazawa, Takashi| Watababe, Nobuyuki| Naomoto, Yoshio| Kobayashi, Masahiko| Shirakawa, Yasuhiro| Yamatsuji, Tomoki| Kobayashi, Naoya| Fujiwara, Tohsiyoshi| Matsubara, Nagahide| Iwagaki, Hiromi| Matsuoka, Junji| Tanaka, Noriaki| |
| Abstract | We encountered two cases of pulmonary embolism (PE)/venous thrombs (DVT) after surgery for esophageal cancer. The first case was a 58-year-old male. He underwent a subtotal esophagectomy and reconstruction using the stomach via the subcutaneus route. His postoperative course was stable; however, 13 days after the operation､ he had an elevated fever and pulmonary thrombi were observed on CT-scan screening. Scintigraphy confirmed the thrombi. An inferior vena cava filter (IVCF) was inserted and anti-coagulation therapy using heparin was started. His fever subsided, and 35 days after the operation, the thrombi disappeared. He was discharged thereafter and is being followed up using warfarin. The second case was a 74-year-old male. He also underwent subtotal esophagectomy and reconstruction using the stomach via the subcutaneus route. A central line was inserted via right femoral vein; however, the artery was injured and pressurization to the vessel was needed. His post-operative course was stable and symptom-free; however, ultrasound screening detected DVT in his right femoral vein. IVCF was mserted and anti-coagulation therapy was begun, thrombi disappeared 8 days after the therapy. |
| Keywords | 食道癌 (esophageal cancer) 肺塞栓症 (pulmonary embolism) 深部静脈血栓症 (deep venous thrombs) |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2006-05-01 |
| Volume | volume118 |
| Issue | issue1 |
| Start Page | 41 |
| End Page | 45 |
| ISSN | 0030-1558 |
| language | Japanese |
| Copyright Holders | Copyright© 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma1947.118.1_41 |
| NAID | 10017417131 |
| FullText URL | 118_9.pdf |
|---|---|
| Author | 梅岡 達生| 川嶋 健| 香川 俊輔| 寺石 文則| 滝 正樹| 京 哲| 永井 勝幸| 浦田 泰生| 田中 紀章| 藤原 俊義| |
| Keywords | GFP アデノウイルス テロメラーゼ 増幅 遺伝子治療 |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2006-05-01 |
| Volume | volume118 |
| Issue | issue1 |
| Start Page | 9 |
| End Page | 15 |
| ISSN | 0030-1558 |
| language | Japanese |
| Copyright Holders | Copyright© 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma1947.118.1_9 |
| NAID | 10017417061 |
| Title Alternative | Adenoviral p53 gene therapy for lung cancer |
|---|---|
| FullText URL | 119_229.pdf |
| Author | Fujiwara, Toshiyoshi| Tanaka, Noriaki| |
| Abstract | To determine the feasibility, safety, humoral immune response, and biological activity of multiple intratumoral injections of Ad5CMV-p53, and to characterize the pharmacokinetics of Ad5CMV-p53 in patients with advanced non-small cell lung cancer (NSCLC). Fifteen patients with histologically confirmed NSCLC and p53 mutations were enrolled into this phase I trial. Nine patients received escalating dose levels of Ad5CMV-p53 (1 × 109 to 1 × 1011 plaque-forming units[PFU]) as monotherapy once every 4 weeks. Six patients were treated on a 28-day schedule with Ad5CMV-p53 in combination with intravenous administration of cisplatin (80 mg/m2). Patients were monitored for toxicity, vector distribution, antibody formation, and tumor response. Fifteen patients received a total of 63 intratumoral injections of Ad5CMV-p53 without dose-limiting toxicity. The most common treatment-related toxicity was a transient fever. Specific p53 transgene expression was detected using reverse-transcriptase polymerase chain reaction in biopsied tumor tissues throughout the period of treatment despite of the presence of neutralizing anti-adenovirus antibody. Distribution studies revealed that the vector was detected in the gargle and plasma, but rarely in the urine. Thirteen of 15 patients were assessable for efficacy; one patient had a partial response (squamous cell carcinoma at the carina), 10 patients had stable disease, with three lasting ≥9 months, and 2 patients had progressive disease. Multiple courses of intratumoral Ad5CMV-p53 injection alone or in combination with intravenous administration of cisplatin were feasible and well tolerated in advanced NSCLC patients, and appeared to provide clinical benefit. |
| Keywords | p53 遺伝子 アデノウイルスベクター (adenovirus vector) 肺癌 (lung cancer) 臨床試験 (clinical trial) |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2008-01-04 |
| Volume | volume119 |
| Issue | issue3 |
| Start Page | 229 |
| End Page | 234 |
| ISSN | 00301558 |
| language | Japanese |
| Copyright Holders | 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.119.229 |
| NAID | 10020282723 |
| Title Alternative | In vivo imaging of lymph node metastasis with telomerase-specific replication-selective adenovirus |
|---|---|
| FullText URL | 120_01_013_021.pdf |
| Author | Kishimoto, Hiroyuki| Kojima, Toru| Watanabe, Yuichi| Kagawa, Shunsuke| Fujiwara, Toshiya| Uno, Futoshi| Teraishi, Fuminori| Kyo, Satoru| Mizuguchi, Hiroyuki| Hashimoto, Yuuri| Urata, Yasuo| Tanaka, Noriaki| Fujiwara, Toshiyoshi| |
| Keywords | GFP アデノウイルス ヒトテロメラーゼ逆転写酵素 |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2008-05-01 |
| Volume | volume120 |
| Issue | issue1 |
| Start Page | 13 |
| End Page | 21 |
| ISSN | 00301558 |
| language | Japanese |
| Copyright Holders | 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.120.13 |
| NAID | 10024170197 |
| FullText URL | K000876.pdf |
|---|---|
| Author | Fujiwara, Toshiyoshi| |
| Published Date | 1990-09-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第876号 |
| Granted Date | 1990-09-30 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | Japanese |
