| Author | Kuroda, Shinji| Fujiwara, Toshiya| Shirakawa, Yasuhiro| Yamasaki, Yasumoto| Yano, Syuya| Uno, Futoshi| Tazawa, Hiroshi| Hashimoto, Yuuri| Watanabe, Yuichi| Noma, Kazuhiro| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2011-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume123 |
| Issue | issue2 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/52407 |
|---|---|
| FullText URL | 68_2_111.pdf |
| Author | Shirakawa, Yasuhiro| Noma, Kazuhiro| Maeda, Naoaki| Katsube, Ryoichi| Tanabe, Shunsuke| Ohara, Toshiaki| Sakurama, Kazufumi| Fujiwara, Toshiyoshi| |
| Abstract | Thoracoscopic esophagectomy in the prone position (TEPP) might enable solo-surgery in cases requiring resection of the esophagus and the surrounding lymph nodes due to the associated advantages of good exposure of the surgical field and ergonomic considerations for the surgeon. However, no one approach can be for all patients requiring extensive lymphadenectomy. We recently developed an assistant-based procedure to standardize exposure of the surgical field. Patients were divided into 1 of 2 groups:a pre-standardization group (n＝37) and a post-standardization group (n＝28). The thoracoscopic operative time was significantly shorter (p＝0.0037) in the post-standardization group (n＝28; 267±31min) than in the pre-standardization group (n＝37;301±53min). Further, learning curve analysis using the moving average method showed stabilization of the thoracoscopic operative time after the standardization. No significant differences were found in the number of mediastinal lymph nodes dissected or intraoperative blood loss between the 2 groups. There were also no significant differences in the complication rate. Assistant-based surgery and standardization of the procedure resulted in a well-exposed and safe surgical field. TEPP decreased the operative time, even in patients requiring extensive lymphadenectomy. |
| Keywords | thoracoscopic esophagectomy prone position standardization |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-04 |
| Volume | volume68 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 111 |
| End Page | 117 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24743786 |
| Web of Science KeyUT | 000334652700006 |
| Author | Satoh, Daisuke| Yagi, Takahito| Sadamori, Hiroshi| Matsuda, Hiroaki| Shinoura, Susumu| Umeda, Yuzo| Yoshida, Ryuichi| Utsumi, Takashi| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2011-12-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume123 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Satoh, Daisuke| Yagi, Takahito| Sadamori, Hiroshi| Umeda, Yuzo| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2011-12-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume123 |
| Issue | issue3 |
| Content Type | Journal Article |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Umeoka, Tatsuo| Kawashima, Takeshi| Kagawa, Shunsuke| Teraishi, Fuminori| Taki, Masaki| Nishizaki, Masahiko| Kyo, Satoru| Nagai, Katsuyuki| Urata, Yasuo| Tanaka, Noriaki| Fujiwara, Toshiyoshi| |
| Keywords | GFP adenovirus telomerase replication gene therapy |
| Note | Published with permission from the copyright holder. This is the author's copy, as published in Cancer Research, September 2004, Volume 64, Issue 17, Pages 6259-6265. Copyright © 2004 American Association for Cancer Research. All rights reserved.| |
| Published Date | 2004-09-01 |
| Publication Title | Cancer Research |
| Volume | volume64 |
| Issue | issue17 |
| Publisher | American Association for Cancer Research |
| Start Page | 6259 |
| End Page | 6265 |
| ISSN | 0008-5472 |
| NCID | AA00598557 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | American Association for Cancer Research |
| File Version | author |
| PubMed ID | 15342413 |
| DOI | 10.1158/0008-5472.can-04-1335 |
| Web of Science KeyUT | 000223603200048 |
| Official Url | http://cancerres.aacrjournals.org/content/64/17/6259| |
| Related Url | isVersionOf https://doi.org/10.1158/0008-5472.can-04-1335 |
| Author | Shinoura, Susumu| Yagi, Takahito| Sadamori, Hiroshi| Matsuda, Hiroaki| Umeda, Yuzo| Yoshida, Ryuichi| Satoh, Daisuke| Utsumi, Masashi| Yokomichi, Naosuke| Kuise, Takashi| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2012-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume124 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Nishizaki, Masahiko| Fujiwara, Yasuhiro| Chouda, Yasuhiro| Kanazawa, Takashi| Ninomiya, Motoki| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2012-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume124 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Sasaki, Tsuyoshi| Tazawa, Hiroshi| Hasei, Jo| Kunisada, Toshiyuki| Yoshida, Aki| Hashimoto, Yuuri| Yano, Shuya| Yoshida, Ryosuke| Uno, Futoshi| Kagawa, Shunsuke| Morimoto, Yuki| Urata, Yasuo| Fujiwara, Toshiyoshi| Ozaki, Toshifumi| |
|---|---|
| Published Date | 2012-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume124 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Tanabe, Shunsuke| Shirakawa, Yasuhiro| Maeda, Naoaki| Ohara, Toshiaki| Noma, Kazuhiro| Sakurama, Kazufumi| Yanai, Hiroyuki| Yamatsuji, Tomoki| Naomoto, Yoshio| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2012-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume124 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Kojima, Toru| Hashimoto, Yuuri| Watanabe, Yuichi| Kagawa, Shunsuke| Uno, Futoshi| Kuroda, Shinji| Tazawa, Hiroshi| Kyo, Satoru| Mizuguchi, Hiroyuki| Urata, Yasuo| Tanaka, Noriaki| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2009-10-01 |
| Publication Title | The Journal of Clinical Investigation |
| Volume | volume119 |
| Issue | issue10 |
| Content Type | Journal Article |
| Author | Huang, P| Kaku, H| Chen, J| Kashiwakura, Y| Saika, T| Nasu, Y| Urata, Y| Fujiwara, T| Watanabe, M| Kumon, H| |
|---|---|
| Published Date | 2010-07 |
| Publication Title | Cancer Gene Therapy |
| Volume | volume17 |
| Issue | issue7 |
| Content Type | Journal Article |
| Author | Noguchi, Hirofumi| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2012-12-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume124 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Kojima, Toru| Watanabe, Yuichi| Hashimoto, Yuuri| Kuroda, Shinji| Yamasaki, Yasumoto| Yano, Shuya| Tazawa, Hiroshi| Uno, Futoshi| Kagawa, Shunsuke| Tanaka, Noriaki| Urata, Yasuo| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2013-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume125 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Uno, Futoshi| Fujiwara, Yasuhiro| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2013-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume125 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Inada, Ryo| Nagasaka, Takeshi| Takehara, Kiyoto| Sugihara, Masahiro| Mori, Yoshiko| Umeda, Yuzo| Kubota, Nobuhito| Morikawa, Tatsuya| Kondo, Yoshitaka| Uno, Futoshi| Sadamori, Yu| Yagi, Takahito| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2013-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume125 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Inada, Ryo| Nagasaka, Takeshi| Mori, Yoshiko| Umeda, Yuzo| Kubota, Nobuhito| Morikawa, Tatsuya| Kondo, Yoshitaka| Uno, Futoshi| Sadamori, Yu| Yagi, Takahito| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2013-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume125 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Shinoura, Susumu| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2013-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume125 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Yoshida, Ryosuke| Tazawa, Hiroshi| Hashimoto, Yuuri| Yano, Shuya| Onishi, Teppei| Sasaki, Tsuyoshi| Shirakawa, Yasuhiro| Kishimoto, Hiroyuki| Uno, Futoshi| Nishizaki, Masahiko| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2012-11 |
| Publication Title | Cancer Immunology, Immunotherapy |
| Volume | volume61 |
| Issue | issue11 |
| Content Type | Journal Article |
| Author | Hashimoto, Yuuri| Tazawa, Hiroshi| Teraishi, Fuminori| Kojima, Toru| Watanabe, Yuichi| Uno, Futoshi| Yano, Shuya| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2012-06-15 |
| Publication Title | PLoS ONE |
| Volume | volume7 |
| Issue | issue6 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/52006 |
|---|---|
| FullText URL | 67_6_333.pdf |
| Author | Tazawa, Hiroshi| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| Abstract | Autophagy is a catabolic process that produces energy through lysosomal degradation of intracellular organelles. Autophagy functions as a cytoprotective factor under physiological conditions such as nutrient deprivation, hypoxia, and interruption of growth factors. On the other hand, infection with pathogenic viruses and bacteria also induces autophagy in infected cells. Oncolytic virotherapy with replication-competent viruses is thus a promising strategy to induce tumor-specific cell death. Oncolytic adenoviruses induce autophagy and subsequently contribute to cell death rather than cell survival in tumor cells. We previously developed a telomerase-specific replication-competent oncolytic adenovirus, OBP-301, which induces cell lysis in tumor cells with telomerase activities. OBP-301-mediated cytopathic activity is significantly associated with induction of autophagy biomarkers. In this review, we focus on the tumor-suppressive role and molecular basis of autophagic machinery induced by oncolytic adenoviruses. Addition of tumor-specific promoters and modification of the fiber knob of adenoviruses supports the oncolytic adenovirus-mediated autophagic cell death. Autophagy is cooperatively regulated by the E1-dependent activation pathway, E4-dependent inhibitory pathway, and microRNA-dependent fine-tuning. Thus, future exploration of the functional role and molecular mechanisms underlying oncolytic adenovirus-induced autophagy would provide novel insights and improve the therapeutic potential of oncolytic adenoviruses. |
| Keywords | oncolytic adenovirus autophagy E2F1 microRNA |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-12 |
| Volume | volume67 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 333 |
| End Page | 342 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24356717 |
| Web of Science KeyUT | 000328915700001 |
