result 940 件
| JaLCDOI | 10.18926/AMO/56869 |
|---|---|
| FullText URL | 73_3_255.pdf |
| Author | Seki, Daisuke| Takeshita, Nobuo| Seiryu, Masahiro| Deguchi, Toru| Takano-Yamamoto, Teruko| |
| Abstract | Orthodontists need to understand the orthodontic risks associated with systemic disorders. Axenfeld-Rieger syndrome (ARS) is a rare autosomal dominant disorder with genetic and morphological variability. The risks of orthodontic treatment in ARS patients have been unclear. Here we describe the correction of an anterior open bite in a 15-year-old Japanese female ARS patient by molar intrusion using sectional archwires with miniscrew implants. An undesirable development of external apical root resorption (EARR) was observed in all intrusive force-applied posterior teeth during the patient’s orthodontic treatment, suggesting that ARS patients have a higher risk of EARR than the general population. |
| Keywords | Axenfeld-Rieger syndrome external apical root resorption miniscrew implant anterior open bite |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-06 |
| Volume | volume73 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 255 |
| End Page | 262 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31235974 |
| JaLCDOI | 10.18926/AMO/56868 |
|---|---|
| FullText URL | 73_3_247.pdf |
| Author | Yoshio, Kotaro| Wakita, Akihisa| Mitsuhashi, Toshiharu| Kitayama, Takahiro| Hisazumi, Kento| Inoue, Daisaku| Tajiri, Nobuhisa| Shiode, Tsuyoki| Akaki, Shiro| Kanazawa, Susumu| |
| Abstract | We investigated the feasibility of simultaneous integrated boost (SIB) volumetric modulated arc therapy (VMAT) using elective nodal irradiation (ENI) for middle or lower esophageal cancer and compared it with three-dimensional conformal radiotherapy (3D-CRT). The study included 15 patients. The prescribed doses included a standard dose (50.4 Gy) and a high dose (60 Gy) for the planning target volume (PTV) of the involved lesions. The objective of the whole lung volume receiving ≥ 20 Gy (V20Gy) was < 30%, and the mean lung dose (MLD) was < 20 Gy. The volumes of the lung receiving 5 Gy (V5Gy) and the heart receiving 30-50 Gy (V30-50Gy) were kept as low as reasonably achievable. As a result, SIB-VMAT showed superior dose conformity for the PTV (p<0.001). Although the lung V5Gy was significantly increased (p<0.001), the V20Gy and MLD showed no significant increase. The heart V30-50Gy showed a > 20% reduction in the mean against 3D-CRTs. Our results demonstrate the feasibility of SIB-VMAT for the treatment of middle or lower esophageal cancer with ENI. Although attention should be paid to the low-dose area of the lungs, SIB-VMAT would be a promising treatment option with improved outcomes for esophageal cancer. |
| Keywords | esophageal cancer middle and lower thoracic volumetric modulated arc therapy, 3D-CRT elective nodal irradiation |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-06 |
| Volume | volume73 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 247 |
| End Page | 257 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31235973 |
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J Clin Oncol (1999) 17: 2915-2921.| Kato K, Muro K, Minashi K, Ohtsu A, Ishikura S, Boku N, Takiuchi H, Komatsu Y, Miyata Y and Fukuda H: Phase II study of chemoradiotherapy with 5-fluorouracil and cisplatin for Stage II-III esophageal squamous cell carcinoma: JCOG trial (JCOG 9906). Int J Radiat Oncol Biol Phys (2011) 81: 684-690.| Kato K, Nakajima TE, Ito Y, Katada C, Ishiyama H, Tokunaga SY, Tanaka M, Hironaka S, Hashimoto T, Ura T, Kodaira T and Yoshimura K: Phase II study of concurrent chemoradiotherapy at the dose of 50.4 Gy with elective nodal irradiation for Stage II-III esophageal carcinoma. Jpn J Clin Oncol (2013) 43: 608-615.| Onozawa M, Nihei K, Ishikura S, Minashi K, Yano T, Muto M, Ohtsu A and Ogino T: Elective nodal irradiation (ENI) in definitive chemoradiotherapy (CRT) for squamous cell carcinoma of the thoracic esophagus. Radiother Oncol (2009) 92: 266-269.| Cooper JS, Guo MD, Herskovic A, Macdonald JS, Martenson JA Jr, Al-Sarraf M, Byhardt R, Russell AH, Beitler JJ, Spencer S, Asbell SO, Graham MV and Leichman LL: Chemoradiotherapy of locally advanced esophageal cancer: long-term follow-up of a prospective randomized trial (RTOG 85-01). Radiation Therapy Oncology Group. JAMA (1999) 281: 1623-1627.| Minsky BD, Pajak TF, Ginsberg RJ, Pisansky TM, Martenson J, Komaki R, Okawara G, Rosenthal SA and Kelsen DP: INT 0123 (Radiation Therapy Oncology Group 94-05) phase III trial of combined-modality therapy for esophageal cancer: high-dose versus standard-dose radiation therapy. J Clin Oncol (2002) 20: 1167-1174.| Welsh J, Settle SH, Amini A, Xiao L, Suzuki A, Hayashi Y, Hofstetter W, Komaki R, Liao Z and Ajani JA: Failure patterns in patients with esophageal cancer treated with definitive chemoradiation. Cancer (2012) 118:2632-2640.| Yu WW, Zhu ZF, Fu XL, Zhao KL, Mao JF, Wu KL, Yang HJ, Fan M, Zhao S and Welsh J: Simultaneous integrated boost intensity-modulated radiotherapy in esophageal carcinoma: early results of a phase II study. Strahlenther Onkol (2014) 190: 979-986.| Roeder F, Nicolay NH, Nguyen T, Saleh-Ebrahimi L, Askoxylakis V, Bostel T, Zwicker F, Debus J, Timke C and Huber PE: Intensity modulated radiotherapy (IMRT) with concurrent chemotherapy as definitive treatment of locally advanced esophageal cancer. Radiat Oncol (2014) 9: 191.| Chang CL, Tsai HC, Lin WC, Chang JH, Hsu HL, Chow JM, Yuan KS, Wu ATH and Wu SY: Dose escalation intensity-modulated radiotherapy-based concurrent chemoradiotherapy is effective for advanced-stage thoracic esophageal squamous cell carcinoma. Radiother Oncol (2017) 125: 73-79.| Alongi F, Fogliata A, Navarria P, Tozzi A, Mancosu P, Lobefalo F, Reggiori G, Clivio A, Cozzi L and Scorsetti M: Moderate hypofractionation and simultaneous integrated boost with volumetric modulated arc therapy (RapidArc) for prostate cancer. Report of feasibility and acute toxicity. Strahlenther Onkol (2012) 188: 990-996.| Peponi E, Glanzmann C, Kunz G, Renner C, Tomuschat K and Studer G: Simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) in nasopharyngeal cancer. Strahlenther Onkol (2010) 186: 135-142.| Vandecasteele K, De Neve W, De Gersem W, Delrue L, Paelinck L,Makar A, Fonteyne V, De Wagter C, Villeirs G and De Meerleer G: Intensity-modulated arc therapy with simultaneous integrated boost in the treatment of primary irresectable cervical cancer. Treatment planning, quality control, and clinical implementation. Strahlenther Onkol (2009) 185: 799-807.| Ogino I, Watanabe S, Sakamaki K, Ogino Y, Kunisaki C and Kimura K: Dosimetric predictors of radiation-induced pericardial effusion in esophageal cancer. Strahlenther Onkol (2017) 193: 552-560.| Wei X, Liu HH, Tucker SL, Wang S, Mohan R, Cox JD, Komaki R and Liao Z: Risk factors for pericardial effusion in inoperable esophageal cancer patients treated with definitive chemoradiation therapy. Int J Radiat Oncol Biol Phys (2008) 70: 707-714.| Grosshans D, Boehling NS, Palmer M, Spicer C, Erice R, Cox JD, Komaki R and Chang JY: Improving cardiac dosimetry: Alternative beam arrangements for intensity modulated radiation therapy planning in patients with carcinoma of the distal esophagus. Pract Radiat Oncol (2012) 2: 41-45.| Marks LB, Bentzen SM, Deasy JO, Kong FM, Bradley JD, Vogelius IS, El Naqa I, Hubbs JL, Lebesque JV, Timmerman RD, Martel MK and Jackson A: Radiation dose-volume effects in the lung. Int J Radiat Oncol Biol Phys (2010) 76(3 Suppl): S70-S76.| Paddick I: A simple scoring ratio to index the conformity of radiosurgical treatment plans. Technical note. J. Neurosurg (2000) 93 Suppl 3: 219-222. | Feuvret L, Noël G, Mazeron JJ and Bey P: Conformity index: a review. Int J Radiat Oncol Biol Phys (2006) 64: 333-342.| Fukada J, Shigematsu N, Takeuchi H, Ohashi T, Saikawa Y, Takaishi H, Hanada T, Shiraishi Y, Kitagawa Y and Fukuda K: Symptomatic pericardial effusion after chemoradiation therapy in esophageal cancer patients. Int J Radiat Oncol Biol Phys (2013) 87: 487-493.| Gayed IW, Liu HH, Yusuf SW, Komaki R, Wei X, Wang X, Chang JY, Swafford J, Broemeling L and Liao Z: The prevalence of myocardial ischemia after concurrent chemoradiation therapy as detected by gated myocardial perfusion imaging in patients with esophageal cancer. J Nucl Med (2006) 47: 1756-1762.| Speirs CK, DeWees TA, Rehman S, Molotievschi A, Velez MA, Mullen D, Fergus S, Trovo M, Bradley JD and Robinson CG: Heart Dose Is an Independent Dosimetric Predictor of Overall Survival in Locally Advanced Non-Small Cell Lung Cancer. J Thorac Oncol (2017) 12: 293-301.| Nutting CM, Bedford JL, Cosgrove VP, Tait DM, Dearnaley DP and Webb S: A comparison of conformal and intensity-modulated techniques for oesophageal radiotherapy. Radiother Oncol (2001) 61: 157-163.| Yom SS, Liao Z, Liu HH, Tucker SL, Hu CS, Wei X, Wang X, Wang S, Mohan R, Cox JD and Komaki R: Initial evaluation of treatment-related pneumonitis in advanced-stage non-small-cell lung cancer patients treated with concurrent chemotherapy and intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys (2007) 68: 94-102.| Shaikh T, Churilla TM, Monpara P, Scott WJ, Cohen SJ and Meyer JE: Risk of radiation pneumonitis in patients receiving taxane-based trimodality therapy for locally advanced esophageal cancer. Pract Radiat Oncol (2016) 6: 388-394.| Shirakawa Y, Noma K, Maeda N, Tanabe S, Kuroda S, Kagawa S, Katsui K, Katayama N, Kanazawa S and Fujiwara T: Outcome of Radiation Monotherapy for High-risk Patients with Stage I Esophageal Cancer. Acta Med Okayama (2017) 71: 127-133.| |
| JaLCDOI | 10.18926/AMO/56862 |
|---|---|
| FullText URL | 73_3_205.pdf |
| Author | Mukai, Yuko| Sakurai, Toru| Watanabe, Toshiyuki| Sako, Tomoko| Sugimoto, Morito| Kimata, Yoshihiro| Mori, Yoshiko| Nagasaka, Takeshi| Namba, Yuzaburo| |
| Abstract | Intestinal vaginoplasty has several advantageous features, such as scarless surgery, low incidence of contraction of the reconstructed vagina, maintenance of vaginal depth, spontaneous mucus production, and a low rate of complications. Therefore, this technique is becoming popular in many countries. Following the global trend, the demand for intestinal vaginoplasty for transsexuals is also increasing in Japan. However, there are few reports on intestinal vaginoplasty in Japan. In this study, we examined the safety and effectiveness of rectosigmoid colon vaginoplasty in the Japanese population. We retrospectively surveyed 18 male-to-female transsexuals who underwent laparoscopic rectosigmoid colon vaginoplasty at the Okayama University Hospital Gender Center between October 2012 and December 2017. One patient had developed an anastomotic leak and 2 patients experienced vaginal prolapse, which needed revision surgery. Both adverse outcomes were comparable with those from previous studies. The anastomotic leak was managed adequately with conservative treatment. To avoid vaginal prolapse, it is important to decide the length of the rectosigmoid segment so that a pull on it does not cause it to become lax, while excessive stress on the feeder vessels is avoided. Based on our study, we concluded that rectosigmoid vaginoplasty was a reliable technique in the Japanese population. |
| Keywords | vaginoplasty male-to-female transsexuals rectosigmoid colon |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-06 |
| Volume | volume73 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 205 |
| End Page | 211 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31235967 |
| FullText URL | K0005921_abstract_review.pdf.pdf K0005921_summary.pdf.pdf K0005921_fulltext.pdf.pdf |
|---|---|
| Author | Watanabe, Sho| |
| Published Date | 2019-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5921号 |
| Granted Date | 2019-03-25 |
| Thesis Type | Doctor of Philosophy in Dental Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005873_abstract_review.pdf K0005873_summary.pdf K0005873_fulltext.pdf |
|---|---|
| Author | Watanabe, Megumi| |
| Published Date | 2019-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5873号 |
| Granted Date | 2019-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | J_ClinMicrobiol_52_3_1020.pdf |
|---|---|
| Author | Ghosh, Priyanka| Naha, Arindam| Basak, Surajit| Ghosh, Santanu| Ramamurthy, T.| Koley, Hemanta| K Nandy, Ranjan| Shinoda, Sumio| Watanabe, Haruo| Mukhopadhyay, Asish K.| |
| Keywords | Cholera Vibrio cholerae tcpA El Tor |
| Note | This is an Accepted Manuscript of an article published by American Society for Microbiology| |
| Published Date | 2014-03 |
| Publication Title | Journal of Clinical Microbiology |
| Volume | volume52 |
| Issue | issue3 |
| Publisher | American Society for Microbiology |
| Start Page | 1020 |
| End Page | 1021 |
| ISSN | 00951137 |
| NCID | AA00695531 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 24371245 |
| DOI | 10.1128/JCM.03042-13 |
| Web of Science KeyUT | 000332164200053 |
| Related Url | isVersionOf https://doi.org/10.1128/JCM.03042-13 |
| JaLCDOI | 10.18926/AMO/56649 |
|---|---|
| FullText URL | 73_2_135.pdf |
| Author | Maeba, Takahiro| Yonezawa, Tomoko| Ono, Mitsuaki| Tomono, Yasuko| Heljasvaara, Ritva| Pihlajaniemi, Taina| Inagawa, Kiichi| Oohashi, Toshitaka| |
| Abstract | The basement membrane (BM) is composed of various extracellular molecules and regulates tissue regeneration and maintenance. Here, we demonstrate that collagen XVIII was spatiotemporally expressed in the BM during skin wound healing in a mouse excisional wound-splinting model. Re-epithelialization was detected at days 3 and 6 post-wounding. The ultrastructure of epidermal BM was discontinuous at day 3, whereas on day 6 a continuous BM was observed in the region proximal to the wound edge. Immunohistochemistry demonstrated that collagen XVIII was deposited in the BM zone beneath newly forming epidermis in day 3 and 6 wounds. Laminin-332, known to be the earliest BM component appearing in wounds, was colocalized with collagen XVIII in the epidermal BM zone at days 3 and 6. The deposition of α1(IV) collagen and nidogen-1 in the epidermal BM zone occurred later than that of collagen XVIII. We also observed the short isoform of collagen XVIII in the epidermal BM zone at day 3 post-wounding. Collectively, our results suggested that collagen XVIII plays a role in the formation of the dermal-epidermal junction during re-epithelialization, and that it is the short isoform that is involved in the early phase of re-epithelialization. |
| Keywords | collagen XVIII basement membrane wound healing re-epithelialization skin |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-04 |
| Volume | volume73 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 135 |
| End Page | 146 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31015748 |
| JaLCDOI | 10.18926/AMO/56646 |
|---|---|
| FullText URL | 73_2_109.pdf |
| Author | Abe, Makoto| Iwamuro, Masaya| Kawahara, Yoshiro| Kanzaki, Hiromitsu| Kawano, Seiji| Tanaka, Takehiro| Tsumura, Munechika| Makino, Takuma| Noda, Yohei| Marunaka, Hidenori| Nishizaki, Kazunori| Okada, Hiroyuki| |
| Abstract | The efficacy and safety of endoscopic submucosal dissection (ESD) for superficial cancer of the pharynx are still unclear. To identify clinicopathological features of superficial pharyngeal cancer, and the efficacy and safety of ESD, we retrospectively assessed 70 pharyngeal cancers in 59 patients who underwent ESD. Of these patients, 61.0% and 50.8% had a history of esophageal cancer and head and neck cancer, respectively. The median tumor size was 15 mm, and 75.7% of the lesions were located at the piriform sinus. The en bloc resection rate was 94.9%. Treatment-related adverse events occurred in 8 cases, but there was no treatment-related death. The lateral margin was positive for neoplasm in 3 lesions (4.3%) and inconclusive in 27 lesions (38.6%), but no local recurrence was observed. Cervical lymph node metastasis was observed in 6 patients, and was successfully treated by cervical lymph node dissection. The three-year overall survival rate was 91.5% (95%CI: 76.6-97.3%) and the cause-specific survival rate was 97.6% (95%CI: 84.9-99.7%). In conclusion, ESD for superficial pharyngeal cancer was safe and effective. “Resect and watch” is probably a feasible and rational strategy for treatment of patients with superficial pharyngeal cancer. |
| Keywords | endoscopic submucosal dissection superficial cancer pharynx endoscopic resection |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-04 |
| Volume | volume73 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 109 |
| End Page | 115 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31015745 |
| Title Alternative | A survey of nurses’ and physicians’ safety awareness in CT/MRI examinations |
|---|---|
| FullText URL | 130_161.pdf |
| Author | Watanabe, Manae| Matsuura, Ryutaro| Namba, Shihoko| |
| Abstract | To perform computed tomography （CT）/magnetic resonance imaging （MRI） scans safely and reliably, adherence to a pre-scan checklist is crucial. However, physicians and nurses may differ in their recognition of the usefulness of this checklist. We conducted the present study to investigate possible differences between physicians’ and nurses’ awareness of CT/MRI scan safety in terms of their adherence to the pre-scan checklist. We prepared an independently developed self-administered 23-item questionnaire about attributes of subjects, CT/ MRI scan safety recognition and current situation for CT/MRI examinations. The survey was distributed to 468 participants who combined nurses and physicians at Okayama University Hospitalin Okayama, Japan. We analysis the responses of the 224 participants （117 nurses and 107 physicians）who returned the survey with on missing data （a 65.1% completion rate）. The overall safety recognition scores were significantly higher for the nurses than for the physicians （p＜0.001）. In addition, the physicians did not sufficiently know or implement the guidelines in the CT/MRI scan safety manual used at our hospital. Nurses and physicians demonstrated marked differences in their awareness and knowledge of safety regarding CT/MRI scans. Measures for improving safety recognition should thus be designed for individual healthcare occupations. |
| Keywords | CT/MRI検査（CT/MRI examinations） 安全認識（safety recognition） 職種の差異（difference between occupations） CT/MRI検査マニュアル（CT/MRI examinations manual） |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2018-12-03 |
| Volume | volume130 |
| Issue | issue3 |
| Start Page | 161 |
| End Page | 166 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.130.161 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2018 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.130.161 |
| NAID | 130007542844 |
| JaLCDOI | 10.18926/AMO/56464 |
|---|---|
| FullText URL | 73_1_85.pdf |
| Author | Abe, Yoshiyuki| Fujibayashi, Kazutoshi| Nishizaki, Yuji| Yanagisawa, Naotake| Nojiri, Shuko| Nakano, Soichiro| Tada, Kurisu| Yamaji, Ken| Tamura, Naoto| |
| Abstract | Pneumocystis pneumonia (PCP) due to Pneumocystis jirovecii infection is the leading cause of fatal opportunistic infections in immunocompromised patients. We will determine whether a daily sulfamethoxazole-trimethoprim (SMX/TMP) dose of 200/40 mg was non-inferior to 400/80 mg for PCP prevention in patients with systemic rheumatic disease under immunosuppressive therapy. This is a randomized, open-label, multicenter controlled trial. The primary outcome is the rate of PCP prevention at 52 weeks. The secondary outcome is the discontinuation rate of SMX/TMP. The trial will evaluate the optimal dose of SMX/TMP for PCP prevention in patients with systemic rheumatic disease under immunosuppressive therapy. |
| Keywords | pneumocystis pneumonia prophylaxis systemic rheumatic disease sulfamethoxazole-trimethoprim conventional-dose versus half-dose |
| Amo Type | Clinical Study Protocol |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-02 |
| Volume | volume73 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 85 |
| End Page | 89 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30820060 |
| JaLCDOI | 10.18926/AMO/56456 |
|---|---|
| FullText URL | 73_1_29.pdf |
| Author | Matsumoto, Atsushi| Nakamura, Takehiro| Shinomiya, Aya| Kawakita, Kenya| Kawanishi, Masahiko| Miyake, Keisuke| Kuroda, Yasuhiro| Keep, Richard F.| Tamiya, Takashi| |
| Abstract | Cerebral vasospasm (CVS) is a major contributor to the high morbidity and mortality of aneurysmal subarachnoid hemorrhage (aSAH) patients. We measured histidine-rich glycoprotein (HRG), a new biomarker of aSAH, in cerebrospinal fluid (CSF) to investigate whether HRG might be an early predictor of CVS. A total of seven controls and 14 aSAH patients (8 males, 6 females aged 53.4±15.4 years) were enrolled, and serial CSF and serum samples were taken. We allocated these samples to three phases (T1-T3) and measured HRG, interleukin (IL)-6, fibrinopeptide A (FpA), and 8-hydroxy-2’-deoxyguanosine (8OHdG) in the CSF, and the HRG in serum. We also examined the release of HRG in rat blood incubated in artificial CSF. In contrast to the other biomarkers examined, the change in the CSF HRG concentration was significantly different between the nonspasm and spasm groups (p<0.01). The rat blood/CSF model revealed a time course similar to that of the human CSF samples in the non-spasm group. HRG thus appears to have the potential to become an early predictor of CVS. In addition, the interaction of HRG with IL-6, FpA, and 8OHdG may form the pathology of CVS. |
| Keywords | biomarker histidine-rich glycoprotein predictor subarachnoid hemorrhage vasospasm |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-02 |
| Volume | volume73 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 29 |
| End Page | 39 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30820052 |
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| JaLCDOI | 10.18926/AMO/56455 |
|---|---|
| FullText URL | 73_1_21.pdf |
| Author | Oiwa, Yuko| Watanabe, Toyohiko| Sadahira, Takuya| Ishii, Ayano| Sako, Tomoko| Inoue, Miyabi| Wada, Koichiro| Kobayashi, Yasuyuki| Araki, Motoo| Nasu, Yasutomo| |
| Abstract | We measured basal clitoral blood flow by Doppler sonography to determine whether tension-free vaginal mesh(TVM) affects the clitoral blood flow and sexual function in women with pelvic organ prolapse (POP). We performed a prospective study of 22 patients who underwent TVM for POP. Clitoral blood flow was measured by Doppler ultrasound. The resistance index (RI), pulsatility index (PI), peak systolic velocity (PSV), and end-diastolic velocity (EDV) of the clitoral arteries were measured preoperatively and at 1, 3, and 6 months postoperatively. Female sexual function was also investigated with the Female Sexual Function Index (FSFI). The mean PI and RI were increased at 1 month and significantly decreased at 6 months postoperatively (p<0.05). In contrast, the mean PSV and EDV decreased at 1 month postoperatively and increased at 6 months postoperatively. These four parameters recovered to baseline levels at 6 months following surgery. Total FSFI scores improved significantly from 10.2±7.9 at baseline to 18.2±8.9 at 6 months postoperatively. Color Doppler ultrasonography is potentially useful in measuring clitoral blood flow in patients treated with TVM for POP. Prospective long-term studies are needed to evaluate the utility of this modality as a diagnostic and prognostic tool for female sexual dysfunction. |
| Keywords | clitoris pelvic organ prolapse Doppler ultrasound |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-02 |
| Volume | volume73 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 21 |
| End Page | 27 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30820051 |
| JaLCDOI | 10.18926/AMO/56380 |
|---|---|
| FullText URL | 72_6_605.pdf |
| Author | Mitsui, Yosuke| Sadahira, Takuya| Maruyama, Yuki| Wada, Koichiro| Tanimoto, Ryuta| Sugimoto, Morito| Araki, Motoo| Watanabe, Masami| Yanai, Hiroyuki| Watanabe, Toyohiko| Nasu, Yasutomo| |
| Abstract | Metastatic prostate cancer (PCa) cases that cannot be detected on repeat prostate biopsy are extremely rare. Our patient was a 51-year-old Japanese man diagnosed as metastatic PCa by histopathological examination of lesions obtained bone biopsy and lymph node dissection. The primary tumor was not detected after repeated prostate biopsy. Metastatic PCa was diagnosed based on immunohistochemical staining: PSA, AR, P504S, and NKX3.1 of bone and lymph node with metastasis. We speculate that the primary PCa was “burned-out,” demonstrating remote metastases with no apparent primary tumor in the prostate. Burned-out PCa may be difficult to diagnose and treat due to its rarity. |
| Keywords | prostate cancer metastasis unknown primary tumor repeat biopsy CRPC |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-12 |
| Volume | volume72 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 605 |
| End Page | 609 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30573917 |
| NAID | 120006545165 |
| JaLCDOI | 10.18926/AMO/56371 |
|---|---|
| FullText URL | 72_6_547.pdf |
| Author | Watanabe, Akihisa| Ono, Qana| Nishigami, Tomohiko| Hirooka, Takahiko| Machida, Hirohisa| |
| Abstract | Distinct anatomic variants of the scapula such as the critical shoulder angle (CSA) were found to be associated with rotator cuff tears (RCTs), but it is unclear whether the CSA is a risk factor in Japanese. Here we sought to determine whether the CSA is associated with RCTs in a Japanese population, and whether the CSA is a more useful parameter than the conventionally used parameters. Our RCT group and non-RCT group each consisted of 54 consecutive cases. We compared the groups’ values of CSA, the acromion index (AI), and the lateral acromion angle (LAA) obtained by X-ray imaging. Receiver operating characteristic (ROC) analyses were performed to determine cutoff values and the area under the curve (AUC), and to assess the odds ratio. The means of the CSA and the AI in the RCT group were significantly larger (36.3° vs. 33.7°, 0.74 vs 0.68), but the LAA did not show a significant between-group difference. The AUCs for the CSA and AI were 0.678 and 0.658, the cutoff values were 35.0° and 0.72, and the odds ratios were 3.1 and 2.5, respectively. In conclusion, the CSA was a strong risk factor compared to the AI and LAA for rotator cuff tears. |
| Keywords | rotator cuff tear risk factor critical shoulder angle acromion index lateral acromion angle |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-12 |
| Volume | volume72 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 547 |
| End Page | 551 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30573908 |
| NAID | 120006545156 |
| FullText URL | mjou_061_085_098.pdf |
|---|---|
| Author | Watanabe, Taisuke| |
| Abstract | We verify some cases of a conjecture by C. Hayashi on the structure of the profile of a finite connected quandle. |
| Keywords | connected quandle finite quandle |
| Published Date | 2019-01 |
| Publication Title | Mathematical Journal of Okayama University |
| Volume | volume61 |
| Issue | issue1 |
| Publisher | Department of Mathematics, Faculty of Science, Okayama University |
| Start Page | 85 |
| End Page | 98 |
| ISSN | 0030-1566 |
| NCID | AA00723502 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright©2019 by the Editorial Board of Mathematical Journal of Okayama University |
| JaLCDOI | 10.18926/AMO/56067 |
|---|---|
| FullText URL | 72_3_223.pdf |
| Author | Ida, Jun| Kotani, Kazuhiko| Miyoshi, Toru| Nakamura, Kazufumi| Kohno, Kunihisa| Asonuma, Hirohiko| Sakuragi, Satoru| Doi, Masayuki| Miki, Takashi| Koyama, Yasushi| Ito, Hiroshi| |
| Abstract | Lipoprotein(a), or Lp(a), is a low-density lipoprotein-like particle largely independent of known risk factors for, and predictive of, cardiovascular disease (CVD). We investigated the association between baseline Lp(a) levels and the progression of coronary artery calcification (CAC) in patients with hypercholesterolemia undergoing statin therapy. This study was a sub-analysis of a multicenter prospective study that evaluated the annual progression of CAC under intensive and standard pitavastatin treatment with or without eicosapentaenoic acid in patients with an Agatston score of 1 to 999, and hypercholesterolemia treated with statins. We classified the patients into 3 groups according to CAC progression. A total of 147 patients (mean age, 67 years; men, 54%) were analyzed. The proportion of patients with Lp(a) > 30 mg/dL significantly increased as CAC progressed (non-progression; 5.4%, 0 |
| Keywords | lipoprotein(a) coronary artery calcification statins hypercholesterolemia |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-06 |
| Volume | volume72 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 223 |
| End Page | 230 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 29925999 |
| Title Alternative | A case of a mesenteric desmoid tumor preoperatively distinguished from imaging findings |
|---|---|
| FullText URL | 130_13.pdf |
| Author | Kawai, Takashi| Watanabe, Takanori| Nobuhisa, Tetuji| Matumoto, Yusuke| Kai, Kyohei| Sato, Shiso| |
| Abstract | A 73-year-old woman was admitted for closer investigation into an abdominal tumor. Abdominal ultra-sonography, CT, and magnetic resonance imaging showed a discrete abdominal tumor. Especially on MRI, the tumor appeared as a relatively ill-defined whorled soft-tissue thickening within the mesenteric fat, causing angulation or speculation of adjacent bowel mesentery. Surgery was performed under a presumptive diagnosis of a mesojejunum desmoid. The tumor was invading the transverse mesocolon and mesojejunum as well as the third portion of the duodenum and the middle colic artery, and it was close to but apart from the superior mesenteric artery. The tumor was resected, including removal of part of the duodenum and transverse colon. The specimen contained a white solid tumor measuring 14×12×8cm. Pathologic examination showed differentiated fibroblasts and copious collagen fibers. The tumor was negative for CD34, c-kit, S-100, and α-SMA, but positive for β-catenin. On the basis of these findings, we established a diagnosis of mesenteric desmoid tumor of the small intestine. The patient has been followed postoperatively for 2 years, no sign of recurrence, to date. |
| Keywords | 小腸間膜 (mesentery of the small intestine) デスモイド (desomoid) 腸間膜腫瘍 (mesenteric tumor) |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2018-04-02 |
| Volume | volume130 |
| Issue | issue1 |
| Start Page | 13 |
| End Page | 18 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.130.13 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2018 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.130.13 |
| NAID | 130006730865 |
| FullText URL | K0005653_abstract_review.pdf K0005653_summary.pdf K0005653_ fulltext.pdf |
|---|---|
| Author | Watanabe, Haruki| |
| Published Date | 2018-03-23 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5653号 |
| Granted Date | 2018-03-23 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| JaLCDOI | 10.18926/AMO/55667 |
|---|---|
| FullText URL | 72_1_77.pdf |
| Author | Watanabe, Kenya| Fukuzawa, Takuma| Mitsui, Katsuhiro| |
| Abstract | Schwannoma is the most common tumor of the peripheral nerve sheath. However, there have been few reports on schwannoma of the posterior tibial nerve causing tarsal tunnel syndrome. We report on a 60-year-old man with tarsal tunnel syndrome caused by a schwannoma of the posterior tibial nerve, which was first diagnosed as a ganglion cyst. After enucleation of this tumor, the patient was asymptomatic and had no related sequelae except for minor numbness in the plantar aspects of his digits. Although schwannoma of the posterior tibial nerve is rare, it should be considered even if a ganglion is clinically suspected. |
| Keywords | tarsal tunnel syndrome schwannoma posterior tibial nerve |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-02 |
| Volume | volume72 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 77 |
| End Page | 80 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 29463943 |
| JaLCDOI | 10.18926/AMO/55665 |
|---|---|
| FullText URL | 72_1_67.pdf |
| Author | Watanabe, Akihisa| Ono, Qana| Nishigami, Tomohiko| Hirooka, Takahiko| Machida, Hirohisa| |
| Abstract | It has been unclear whether the risk factors for rotator cuff tears are the same at all ages or differ between young and older populations. In this study, we examined the risk factors for rotator cuff tears using classification and regression tree analysis as methods of nonlinear regression analysis. There were 65 patients in the rotator cuff tears group and 45 patients in the intact rotator cuff group. Classification and regression tree analysis was performed to predict rotator cuff tears. The target factor was rotator cuff tears; explanatory variables were age, sex, trauma, and critical shoulder angle≥35°. In the results of classification and regression tree analysis, the tree was divided at age 64. For patients aged≥64, the tree was divided at trauma. For patients aged<64, the tree was divided at critical shoulder angle≥35°. The odds ratio for critical shoulder angle≥35° was significant for all ages (5.89), and for patients aged<64 (10.3) while trauma was only a significant factor for patients aged≥64 (5.13). Age, trauma, and critical shoulder angle≥35° were related to rotator cuff tears in this study. However, these risk factors showed different trends according to age group, not a linear relationship. |
| Keywords | rotator cuff tears risk factor critical shoulder angle trauma classification and regression tree analysis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-02 |
| Volume | volume72 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 67 |
| End Page | 72 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 29463941 |
