result 342 件
| FullText URL | fulltext20210831-5.pdf |
|---|---|
| Author | Taketa, Shin| Hattori, Momoko| Takami, Tsuneaki| Himi, Eiko| Sakamoto, Wataru| |
| Keywords | chloroplast GLK2 Hordeum vulgare photosynthesis spike thylakoid |
| Note | This is an Accepted Manuscript of an article published by Oxford University Press. This fulltext is available in Jan. 2022.| |
| Published Date | 2021-1-13 |
| Publication Title | Plant and Cell Physiology |
| Volume | volume62 |
| Issue | issue3 |
| Publisher | Oxford University Press (OUP) |
| Start Page | 447 |
| End Page | 457 |
| ISSN | 1471-9053 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 Japanese Society of Plant Physiologists |
| File Version | author |
| PubMed ID | 33439257 |
| DOI | 10.1093/pcp/pcab001 |
| Web of Science KeyUT | 000685215500009 |
| Related Url | isVersionOf https://doi.org/10.1093/pcp/pcab001 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hirooka, Asuka| Hamada, Mayuko| Fujiyama, Daiki| Takanami, Keiko| Kobayashi, Yasuhisa| Oti, Takumi| Katayama, Yukitoshi| Sakamoto, Tatsuya| Sakamoto, Hirotaka| |
| Published Date | 2021-06-25 |
| Publication Title | Scientific Reports |
| Volume | volume11 |
| Issue | issue1 |
| Publisher | Nature Research |
| Start Page | 13315 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2021 |
| File Version | publisher |
| PubMed ID | 34172791 |
| DOI | 10.1038/s41598-021-92528-x |
| Web of Science KeyUT | 000669451900012 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-021-92528-x |
| JaLCDOI | 10.18926/AMO/62236 |
|---|---|
| FullText URL | 75_3_391.pdf |
| Author | Fujiwara, Miyuki| Kimura, Shuhei| Morizane Hosokawa, Mio| Shiode, Yusuke| Doi, Shinichiro| Takahashi, Kosuke| Matoba, Ryo| Kanzaki, Yuki | Morizane, Yuki| |
| Abstract | A 58-year-old Japanese man underwent vitrectomy for rhegmatogenous retinal detachment (RRD) in 2002. Twelve years later, optical coherence tomography revealed the development of a lamellar macular hole; the visual acuity was 20/200. Two years later, because metamorphopsia and the foveal retina thinning were aggravated, epiretinal proliferation embedding was performed to restore the foveal structure by transplanting glial cells to the foveal cavity. The patient was followed-up for 4 years, and his macular morphology and visual acuity (20/66) improved. No complications occurred. This appears to be the first report of epiretinal proliferation embedding for a lamellar macular hole post-RRD repair. |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 391 |
| End Page | 395 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176945 |
| Web of Science KeyUT | 000667147700016 |
| NAID | 120007089821 |
| JaLCDOI | 10.18926/AMO/62232 |
|---|---|
| FullText URL | 75_3_363.pdf |
| Author | Tanioka, Nohito| Shimizu, Hiroko| Omori, Emiko| Takahashi, Toru| Yamaoka, Masakazu| Morimatsu, Hiroshi| |
| Abstract | Hepatic oxidative stress plays an important role in the pathogenesis of several acute liver diseases, and free heme is thought to contribute to endotoxemia-induced acute liver injury. The heme oxygenase 1 (HO-1) gene is upregulated and the δ-aminolevulinate synthase (ALAS1) gene is downregulated in the rat liver following lipopolysaccharide (LPS) treatment. BTB and CNC homology 1 (Bach1) is a heme-responsive transcription factor that normally represses HO-1 expression. In this study, we evaluated the changes in HO-1, ALAS1, and Bach1 expression and nuclear Bach1 expression in rat livers following intravenous LPS administration (10 mg/kg body weight). LPS significantly upregulated HO-1 mRNA and downregulated ALAS1 mRNA in the rat livers, suggesting that hepatic free heme concentrations are increased after LPS treatment. Bach1 mRNA was strongly induced after LPS injection. In contrast, nuclear Bach1 was significantly but transiently decreased after LPS treatment. Rats were also administered hemin (50 mg/kg body weight) intravenously to elevate heme concentrations, which decreased nuclear Bach1 levels. Our results suggest that elevated hepatic free heme may be associated with a decline of nuclear Bach1, and induction of Bach1 mRNA may compensate for the decreased nuclear Bach1 after LPS treatment in the rat liver. |
| Keywords | heme oxygenase-1 BTB and CNC homology 1 heme, lipopolysaccharide liver injury |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 363 |
| End Page | 372 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176941 |
| Web of Science KeyUT | 000667147700012 |
| NAID | 120007089829 |
| JaLCDOI | 10.18926/AMO/62220 |
|---|---|
| FullText URL | 75_3_289.pdf |
| Author | Miyamoto, Masakazu| Osawa, Kazuhiro| Miyoshi, Toru| Mori, Atsushi| Yoshikawa, Masaki| Oka, Takefumi| Ichikawa, Keishi| Nakamura, Kazufumi| Ito, Hiroshi| |
| Abstract | Early treatment with an oral β-blocker is recommended in patients with a ST-segment–elevation myocardial infarction (STEMI). In this multicenter study, we evaluated the effects of a continuous administration of landiolol, an ultrashort-acting β-blocker, before primary percutaneous coronary intervention (PCI) on myocardial salvage and its safety in STEMI patients. A total of 47 Japanese patients with anterior or lateral STEMI undergoing a primary PCI within 12 h of symptom onset were randomized to receive intravenous landiolol (started at 3 μg/min/kg dose and continued to a total of 50 mg; n=23) or not (control; n=24). Patients with Killip class III or more were excluded. The primary outcome was the myocardial salvage index on cardiac magnetic resonance imaging (MRI) performed 5-7 days after the PCI. Cardiac MRI was performed in 35 patients (74%). The myocardial salvage index in the landiolol group was significantly greater than that in the control group (44.4±14.6% vs. 31.7±18.9%, respectively; p=0.04). There were no significant differences in adverse events at 24 h between the landiolol and control groups. A continuous administration of landiolol before a primary PCI may increase the degree of myocardial salvage without additional hemodynamic adverse effects within the first 24 h after STEMI. |
| Keywords | myocardial infarction landiolol magnetic resonance imaging STEMI PCI |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 289 |
| End Page | 297 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176932 |
| Web of Science KeyUT | 000667147700004 |
| NAID | 120007089835 |
| JaLCDOI | 10.18926/AMO/62219 |
|---|---|
| FullText URL | 75_3_279.pdf |
| Author | Nishinohara, Masa-aki| Nishimori, Hisakazu| Fujiwara, Hideaki| Asada, Noboru| Ennishi, Daisuke| Matsuoka, Ken-ichi| Fujii, Keiko| Fujii, Nobuharu| Maeda, Yoshinobu| |
| Abstract | A bloodstream infection (BSI) is the most common serious infectious complication of hematopoietic stem cell transplantation (HSCT). BSI promotes an inflammatory state, which exacerbates acute graft-versus-host disease (GVHD). We investigated whether a Gram-negative rod bloodstream infection (GNR-BSI), which develops early after allo-HSCT, affected the onset or exacerbated acute GVHD in 465 patients who underwent allo-HSCT from 1995 through 2015 at a single institution. Eighty-eight patients (19%) developed BSI during the study period. Among the cultures, 50 (57%) were Gram-positive cocci (GPC) and 31 (35%) were GNR. Of the 465 patients, 187 (40%) developed acute GVHD of grade II or higher within the first 100 days post-allogeneic HSCT: 124 (27%) had acute GVHD grade II, 47 (10%) had grade III, and 16 (3%) had grade IV. Multivariate analysis revealed that GNR-BSI was a significant risk factor for grade II-IV acute GVHD (grade II-IV: hazard ratio [HR] 1.75, 95% confidence interval [CI] 1.03-2.97; grade III-IV: HR 2.37, 95% CI 1.03-5.43). These results suggest that GNR-BSI may predict the onset and exacerbation of acute GVHD. |
| Keywords | blood stream infection graft-versus-host disease gram negative rods |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 279 |
| End Page | 287 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176931 |
| Web of Science KeyUT | 000667147700003 |
| NAID | 120007089834 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Mizuki, Yutaka| Sakamoto, Shinji| Okahisa, Yuko| Yada, Yuji| Hashimoto, Nozomu| Takaki, Manabu| Yamada, Norihito| |
| Keywords | DISC1 kalirin ARHGEF11 Akt/GSK3 beta Wnt beta-catenin |
| Published Date | 2020-12-14 |
| Publication Title | International Journal of Neuropsychopharmacology |
| Volume | volume24 |
| Issue | issue5 |
| Publisher | Oxford Univ Press |
| Start Page | 367 |
| End Page | 382 |
| ISSN | 1461-1457 |
| NCID | AA11545519 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2020. |
| File Version | publisher |
| PubMed ID | 33315097 |
| DOI | 10.1093/ijnp/pyaa097 |
| NAID | 120007045004 |
| Web of Science KeyUT | 000656192700001 |
| Related Url | isVersionOf https://doi.org/10.1093/ijnp/pyaa097 |
| FullText URL | K0006368_fulltext.pdf K0006368_abstract_review.pdf K0006368_summary.pdf |
|---|---|
| Author | Sakamoto, Yumi| |
| Published Date | 2021-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6368号 |
| Granted Date | 2021-03-25 |
| Thesis Type | Doctor of Philosophy in Dental Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | (C)2020 The Authors. Published by Elsevier Inc. |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nasu, Atsuko| Gion, Yuka| Nishimura, Yoshito| Nishikori, Asami| Sakamoto, Misa| Egusa, Yuria| Fujita, Azusa| Yoshino, Tadashi| Sato, Yasuharu| |
| Keywords | SOX4 p16 adult T-cell leukemia/lymphoma peripheral T-cell lymphoma not otherwise specified |
| Published Date | 2021-04-24 |
| Publication Title | Diagnostics |
| Volume | volume11 |
| Issue | issue5 |
| Publisher | MDPI |
| Start Page | 766 |
| ISSN | 2075-4418 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 by the authors. |
| File Version | publisher |
| PubMed ID | 33923245 |
| DOI | 10.3390/diagnostics11050766 |
| NAID | 120007042395 |
| Web of Science KeyUT | 000653793000001 |
| Related Url | isVersionOf https://doi.org/10.3390/diagnostics11050766 |
| Author | Sakamoto, Keiji| Tomonari, Misaki| Ariya, Uyanga| Nakagiri, Erika| Matsumoto, Tetsuya| Akaji, Yasuaki| Otoda, Takashi| Hirobe, Muneto| Nachin, Baatarbileg| |
|---|---|
| Keywords | Disturbance Forest floor Salvage logging Seed source Succession |
| Note | metadata only access. The Version of Record is available online at: http://dx.doi.org/10.1007/s11355-021-00457-8| |
| Published Date | 2021-04-17 |
| Publication Title | Landscape and Ecological Engineering |
| Volume | volume17 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 267 |
| End Page | 279 |
| ISSN | 1860-1871 |
| NCID | AA12090017 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | none |
| DOI | 10.1007/s11355-021-00457-8 |
| Web of Science KeyUT | 000640827800001 |
| Related Url | isVersionOf https://doi.org/10.1007/s11355-021-00457-8 |
| Title Alternative | The 2019 Incentive Award of the Okayama Medical Association in Neuroscience (2019 Niimi Prize) |
|---|---|
| FullText URL | 133_4.pdf |
| Author | Kawai, Hiroki| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2021-04-01 |
| Volume | volume133 |
| Issue | issue1 |
| Start Page | 4 |
| End Page | 6 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.133.4 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2021 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.133.4 |
| NAID | 130008034810 |
| FullText URL | fulltext20210518-4.pdf |
|---|---|
| Author | Tada, Naoya| Uemori, Takeshi| Sakamoto, Junji| |
| Note | This is an Accepted Manuscript of an article published by ASME International. This fulltext is available in October 2021.| |
| Published Date | 2020-10-5 |
| Publication Title | Journal of Pressure Vessel Technology |
| Volume | volume143 |
| Issue | issue2 |
| Publisher | ASME International |
| Start Page | 021502 |
| ISSN | 0094-9930 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | (c) ASME, 2021 |
| File Version | author |
| DOI | 10.1115/1.4048063 |
| Web of Science KeyUT | 000626089100013 |
| Related Url | isVersionOf https://doi.org/10.1115/1.4048063 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Uta, Daisuke| Oti, Takumi| Sakamoto, Tatsuya| Sakamoto, Hirotaka| |
| Keywords | in vivo extracellular recording in vivo whole-cell patch-clamp recording optogenetics spinal cord lamina X spinal ejaculation generator gastrin-releasing peptide neurons oxytocin |
| Published Date | 2021-03-26 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume22 |
| Issue | issue7 |
| Publisher | MDPI |
| Start Page | 3400 |
| ISSN | 1422-0067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 by the authors. |
| File Version | publisher |
| PubMed ID | 33810239 |
| DOI | 10.3390/ijms22073400 |
| NAID | 120007029875 |
| Web of Science KeyUT | 000638607100001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms22073400 |
| JaLCDOI | 10.18926/AMO/61901 |
|---|---|
| FullText URL | 75_2_199.pdf |
| Author | Matsuda, Tatsuo| Umeda, Yuzo| Yoshida, Kazuhiro| Matsuda, Tadakazu| Uno, Masatoshi| Abe, Masaya| Asada, Noboru| Maeda, Yoshinobu| Yagi, Takahito| Fujiwara, Toshiyoshi| |
| Abstract | We present the first case of laparoscopic left lateral segmentectomy for hepatocellular carcinoma (HCC) in a patient with hemophilia A, acquired hepatitis C, and high-titer factor VIII inhibitor, which was confirmed by preoperative diagnosis. He underwent laparoscopic left lateral segmentectomy with the administration of recombinant activated factor VII. Surgery could be performed with reduced intraoperative hemorrhage. He experienced postoperative intra-abdominal wall hemorrhage, which was successfully managed with red cell concentrates transfusion and administration of recombinant activated factor VII. Laparoscopic hepatectomy can be applied for hemophilia patients with high titer inhibitors. |
| Keywords | hemophilia A hepatectomy inhibitor laparoscopy hepatocellular carcinoma |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-04 |
| Volume | volume75 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 199 |
| End Page | 204 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33953426 |
| NAID | 120007029886 |
| JaLCDOI | 10.18926/interdisciplinary/61889 |
|---|---|
| Title Alternative | Information and communication technology equipment and services for remote monitoring and health management: Survey of services and their classification for use in home care nursing |
| FullText URL | interdisciplinary_1_47_63.pdf |
| Author | Sakamoto, Toshio| Hirata, Akina| Morita, Mizuki| |
| Abstract | This study aims to improve the quality of home nursing care for the elderly. The report presents web-based information about devices and services for remote monitoring and health management using information and communication technology and about how they can improve home care nursing station efficiency in Japan. The search terms "elderly people," "watch over," and "service," plus "sensor" were used to narrow the search. After repeating the search using a chained search for materials and links extracted from those search results, services for home care stations particularly addressing the remote monitoring of elderly people were selected and extracted. Early detection of abnormalities for support by home health nurse responsibilities for observing the general condition of the patient was chosen as the main evaluation index of usefulness. The contractor and service cost were secondary evaluation axes. Results show 9 information communication devices and services for real-time monitoring of the elderly persons’ vital signs in real time for 24 hr, 2 of which are highly useful for early detection of abnormalities and subsequent response. Results suggest that other services might be more useful, depending on how they are used, and that general-purpose services with minimum functions and low cost of introduction and maintenance can provide more opportunities for utilization. Providing these services on a BtoBtoC model and responding to patients’ medical needs can supplement home care nursing station work, increase human resource and time efficiencies, and give patients "the feeling that a nurse is always at their bedside,” even when far away. |
| Keywords | elderly people watch over sensor in home care support telenursing |
| Publication Title | Interdisciplinary Science |
| Published Date | 2021-03-31 |
| Volume | volume1 |
| Start Page | 47 |
| End Page | 63 |
| ISSN | 2436-3227 |
| language | Japanese |
| File Version | publisher |
| NAID | 120007029896 |
| JaLCDOI | 10.18926/AMO/61880 |
|---|---|
| FullText URL | 75_2_139.pdf |
| Author | Hamada, Kentaro| Kuroda, Masahiro| Yoshimura, Yuuki | Khasawneh, Abdullah| Barham, Majd| Tekiki, Nouha| Sugianto, Irfan| Bamgbose, Babatunde O.| Konishi, Kohei| Sugimoto, Kohei| Ishizaka, Hinata| Kurozumi, Akira| Matsushita, Toshi | Ohno, Seiichiro| Kanazawa, Susumu| Asaumi, Junichi| |
| Abstract | Diffusion-weighted imaging may be used to obtain the apparent diffusion coefficient (ADC), which aids the diagnosis of cerebral infarction and tumors. An ADC reflects elements of free diffusion. Diffusion kurtosis imaging (DKI) has attracted attention as a restricted diffusion imaging technique. The ADC subtraction method (ASM) was developed to visualize restricted diffusion with high resolution by using two ADC maps taken with different diffusion times. We conducted the present study to provide a bridge between the reported basic ASM research and clinical research. We developed new imaging software for clinical use and evaluated its performance herein. This software performs the imaging process automatically and continuously at the pixel level, using ImageJ software. The new software uses a macro or a plugin which is compatible with various operating systems via a Java Virtual Machine. We tested the new imaging software’s performance by using a Jurkat cell bio-phantom, and the statistical evaluation of the performance clarified that the ASM values of 99.98% of the pixels in the bio-phantom and physiological saline were calculated accurately (p<0.001). The new software may serve as a useful tool for future clinical applications and restricted diffusion imaging research. |
| Keywords | apparent diffusion coefficient ADC subtraction method restricted diffusion ImageJ plugin |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-04 |
| Volume | volume75 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 139 |
| End Page | 145 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33953420 |
| NAID | 120007029903 |
| FullText URL | fulltext20210506_1.pdf |
|---|---|
| Author | Ninomiya, Kiichiro| Teraoka, Shunsuke| Zenke, Yoshitaka| Kenmotsu, Hirotsugu| Nakamura, Yukiko| Okuma, Yusuke| Tamiya, Akihiro| Nosaki, Kaname| Morise, Masahiro| Aokage, Keiju| Oya, Yuko| Kozuki, Toshiyuki| Sakamoto, Tomohiro| Tanaka, Kentaro| Tanaka, Hisashi| Tanizaki, Junko| Miura, Satoru| Mizutani, Hideaki| Miyauchi, Eisaku| Yamaguchi, Ou| Ebi, Noriyuki| Goto, Yasushi| Sasaki, Takaaki| Daga, Haruko| Morita, Satoshi| Yamanaka, Takeharu| Amano, Shinsuke| Hasegawa, Kazuo| Imamura, Chiyo K.| Suzuki, Kenichi| Nakajima, Kazuko| Nishimoto, Hitomi| Oizumi, Satoshi| Hida, Toyoaki| Hotta, Katsuyuki| Takiguchi, Yuichi| |
| Keywords | Non–small cell lung cancer Epidermal growth factor receptor Systematic review Guidelines |
| Published Date | 2021-01-31 |
| Publication Title | JTO Clinical and Research Reports |
| Volume | volume2 |
| Issue | issue1 |
| Publisher | Elsevier |
| Start Page | 100107 |
| ISSN | 26663643 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Authors. |
| File Version | publisher |
| DOI | 10.1016/j.jtocrr.2020.100107 |
| NAID | 120007032762 |
| Related Url | isVersionOf https://doi.org/10.1016/j.jtocrr.2020.100107 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ito, Atene| Kagawa, Shunsuke| Sakamoto, Shuichi| Kuwada, Kazuya| Kajioka, Hiroki| Yoshimoto, Masashi| Kikuchi, Satoru| Kuroda, Shinji| Yoshida, Ryuichi| Tazawa, Hiroshi| Fujiwara, Toshiyoshi| |
| Keywords | Extracellular vesicles Gastric cancer Tumor-associated macrophages Tumor microenvironment |
| Published Date | 2021-01-28 |
| Publication Title | BMC Cancer |
| Volume | volume21 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 102 |
| ISSN | 1471-2407 |
| NCID | AA12034763 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s). 2021 |
| File Version | publisher |
| PubMed ID | 33509150 |
| DOI | 10.1186/s12885-021-07816-6 |
| Web of Science KeyUT | 000615987400002 |
| Related Url | isVersionOf https://doi.org/10.1186/s12885-021-07816-6 |
| JaLCDOI | 10.18926/AMO/61428 |
|---|---|
| FullText URL | 75_1_9.pdf |
| Author | Gobara, Hideo| Yamamoto, Akira| Komakic, Toshiyuki| Kitayama, Toshiaki| Sakurai, Jun| Iguchi, Toshihiro| Matsui, Yusuke| Uka, Mayu| Tomita, Koji| Hiraki, Takao| Kanazawa, Susumu| |
| Abstract | To assess the feasibility of needle tract ablation in liver tissue in ex vivo and in vivo animal models using a cryo-probe and electrosurgical device. The experimental device is made by inserting a cryoprobe through an intro-ducer sheath for insulation, with 2-cm of probe tip projecting out. A beagle liver was punctured by the device, and electric current was applied at 30-W with the electrosurgical knife touching the non-insulated device base. The discolored area of cut surface along the device was evaluated in 5 application-time groups (5 , 10 , 15 , 20, or 25 seconds). An ex vivo experiment was performed to determine an ablation algorithm with an appropriate application time by comparison with radiofrequency ablation (RFA) results. Thereafter, an in vivo experiment was performed to verify the algorithm’s feasibility. In the ex vivo model, the cut surface demonstrated different amounts of discolored area according to the application time. The total discolored area in the 20-seconds group was similar to that by RFA. In the in vivo model, the liver did not bleed, the total discolored area was similar to that ex vivo, and coagulation necrosis was confirmed by photomicrograph. Needle tract ablation can be per-formed using the experimental device and electrosurgical device. |
| Keywords | needle tract ablation cryoablation electrosurgical device animal liver |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-02 |
| Volume | volume75 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 9 |
| End Page | 14 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33649608 |
| JaLCDOI | 10.18926/AMO/61424 |
|---|---|
| FullText URL | 75_1_1.pdf |
| Author | Hamahara, Jun| Honda, Hiroyuki| Yamamoto, Koichiro| Tokumasu, Kazuki| Hanayama, Yoshihisa| Hagiya, Hideharu| Obika, Mikako| Ueda, Keigo| Kishida, Masayuki| Otsuka, Fumio| |
| Abstract | To determine the clinical characteristics of low androgen status in adult males with diabetes, we retrospectively analyzed the medical records of patients with type 2 diabetes mellitus in whom serum free testosterone (FT) levels were examined for 1 year. Among the 46 patients (56 ± 1.5 years old), decreases in serum FT levels to < 8.5 pg/ml (indicating the occurrence of late-onset hypogonadism [LOH]) were detected in 18 (39%). The per-centages of patients with low FT levels were high in the ≥ 50 years age group (83%), the HbA1c < 7% group (67%), and the 25 ≤ BMI < 30 kg/m2 group (56%). The serum FT levels tended to decrease age-dependently. The level of HbA1c was significantly correlated with the Heinemann Aging Male Symptoms (AMS) score (R = 0.47). The low-FT group had decreased levels of hemoglobin. Of note, the serum FSH level (R = −0.32) was negatively correlated with the serum FT level, whereas the serum TSH level (R = 0.36) was positively correlated with the serum FT level. Collectively, these results revealed that many diabetic males may have low FT levels and that the AMS score is related to the HbA1c level. A slightly anemic condition, thyroid dysfunction, and obesity (class 1) might be involved in LOH in middle-aged diabetic males. |
| Keywords | androgen diabetes mellitus late-onset hypogonadism testosterone thyroid function |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-02 |
| Volume | volume75 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 1 |
| End Page | 8 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33649607 |
