result 308 件
| JaLCDOI | 10.18926/interdisciplinary/61889 |
|---|---|
| Title Alternative | Information and communication technology equipment and services for remote monitoring and health management: Survey of services and their classification for use in home care nursing |
| FullText URL | interdisciplinary_1_47_63.pdf |
| Author | Sakamoto, Toshio| Hirata, Akina| Morita, Mizuki| |
| Abstract | This study aims to improve the quality of home nursing care for the elderly. The report presents web-based information about devices and services for remote monitoring and health management using information and communication technology and about how they can improve home care nursing station efficiency in Japan. The search terms "elderly people," "watch over," and "service," plus "sensor" were used to narrow the search. After repeating the search using a chained search for materials and links extracted from those search results, services for home care stations particularly addressing the remote monitoring of elderly people were selected and extracted. Early detection of abnormalities for support by home health nurse responsibilities for observing the general condition of the patient was chosen as the main evaluation index of usefulness. The contractor and service cost were secondary evaluation axes. Results show 9 information communication devices and services for real-time monitoring of the elderly persons’ vital signs in real time for 24 hr, 2 of which are highly useful for early detection of abnormalities and subsequent response. Results suggest that other services might be more useful, depending on how they are used, and that general-purpose services with minimum functions and low cost of introduction and maintenance can provide more opportunities for utilization. Providing these services on a BtoBtoC model and responding to patients’ medical needs can supplement home care nursing station work, increase human resource and time efficiencies, and give patients "the feeling that a nurse is always at their bedside,” even when far away. |
| Keywords | elderly people watch over sensor in home care support telenursing |
| Publication Title | Interdisciplinary Science |
| Published Date | 2021-03-31 |
| Volume | volume1 |
| Start Page | 47 |
| End Page | 63 |
| ISSN | 2436-3227 |
| language | Japanese |
| File Version | publisher |
| NAID | 120007029896 |
| JaLCDOI | 10.18926/AMO/61880 |
|---|---|
| FullText URL | 75_2_139.pdf |
| Author | Hamada, Kentaro| Kuroda, Masahiro| Yoshimura, Yuuki | Khasawneh, Abdullah| Barham, Majd| Tekiki, Nouha| Sugianto, Irfan| Bamgbose, Babatunde O.| Konishi, Kohei| Sugimoto, Kohei| Ishizaka, Hinata| Kurozumi, Akira| Matsushita, Toshi | Ohno, Seiichiro| Kanazawa, Susumu| Asaumi, Junichi| |
| Abstract | Diffusion-weighted imaging may be used to obtain the apparent diffusion coefficient (ADC), which aids the diagnosis of cerebral infarction and tumors. An ADC reflects elements of free diffusion. Diffusion kurtosis imaging (DKI) has attracted attention as a restricted diffusion imaging technique. The ADC subtraction method (ASM) was developed to visualize restricted diffusion with high resolution by using two ADC maps taken with different diffusion times. We conducted the present study to provide a bridge between the reported basic ASM research and clinical research. We developed new imaging software for clinical use and evaluated its performance herein. This software performs the imaging process automatically and continuously at the pixel level, using ImageJ software. The new software uses a macro or a plugin which is compatible with various operating systems via a Java Virtual Machine. We tested the new imaging software’s performance by using a Jurkat cell bio-phantom, and the statistical evaluation of the performance clarified that the ASM values of 99.98% of the pixels in the bio-phantom and physiological saline were calculated accurately (p<0.001). The new software may serve as a useful tool for future clinical applications and restricted diffusion imaging research. |
| Keywords | apparent diffusion coefficient ADC subtraction method restricted diffusion ImageJ plugin |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-04 |
| Volume | volume75 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 139 |
| End Page | 145 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33953420 |
| NAID | 120007029903 |
| FullText URL | fulltext20210506_1.pdf |
|---|---|
| Author | Ninomiya, Kiichiro| Teraoka, Shunsuke| Zenke, Yoshitaka| Kenmotsu, Hirotsugu| Nakamura, Yukiko| Okuma, Yusuke| Tamiya, Akihiro| Nosaki, Kaname| Morise, Masahiro| Aokage, Keiju| Oya, Yuko| Kozuki, Toshiyuki| Sakamoto, Tomohiro| Tanaka, Kentaro| Tanaka, Hisashi| Tanizaki, Junko| Miura, Satoru| Mizutani, Hideaki| Miyauchi, Eisaku| Yamaguchi, Ou| Ebi, Noriyuki| Goto, Yasushi| Sasaki, Takaaki| Daga, Haruko| Morita, Satoshi| Yamanaka, Takeharu| Amano, Shinsuke| Hasegawa, Kazuo| Imamura, Chiyo K.| Suzuki, Kenichi| Nakajima, Kazuko| Nishimoto, Hitomi| Oizumi, Satoshi| Hida, Toyoaki| Hotta, Katsuyuki| Takiguchi, Yuichi| |
| Keywords | Non–small cell lung cancer Epidermal growth factor receptor Systematic review Guidelines |
| Published Date | 2021-01-31 |
| Publication Title | JTO Clinical and Research Reports |
| Volume | volume2 |
| Issue | issue1 |
| Publisher | Elsevier |
| Start Page | 100107 |
| ISSN | 26663643 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Authors. |
| File Version | publisher |
| NAID | 120007032762 |
| DOI | 10.1016/j.jtocrr.2020.100107 |
| Related Url | isVersionOf https://doi.org/10.1016/j.jtocrr.2020.100107 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ito, Atene| Kagawa, Shunsuke| Sakamoto, Shuichi| Kuwada, Kazuya| Kajioka, Hiroki| Yoshimoto, Masashi| Kikuchi, Satoru| Kuroda, Shinji| Yoshida, Ryuichi| Tazawa, Hiroshi| Fujiwara, Toshiyoshi| |
| Keywords | Extracellular vesicles Gastric cancer Tumor-associated macrophages Tumor microenvironment |
| Published Date | 2021-01-28 |
| Publication Title | BMC Cancer |
| Volume | volume21 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 102 |
| ISSN | 1471-2407 |
| NCID | AA12034763 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s). 2021 |
| File Version | publisher |
| PubMed ID | 33509150 |
| DOI | 10.1186/s12885-021-07816-6 |
| Web of Science KeyUT | 000615987400002 |
| Related Url | isVersionOf https://doi.org/10.1186/s12885-021-07816-6 |
| JaLCDOI | 10.18926/AMO/61428 |
|---|---|
| FullText URL | 75_1_9.pdf |
| Author | Gobara, Hideo| Yamamoto, Akira| Komakic, Toshiyuki| Kitayama, Toshiaki| Sakurai, Jun| Iguchi, Toshihiro| Matsui, Yusuke| Uka, Mayu| Tomita, Koji| Hiraki, Takao| Kanazawa, Susumu| |
| Abstract | To assess the feasibility of needle tract ablation in liver tissue in ex vivo and in vivo animal models using a cryo-probe and electrosurgical device. The experimental device is made by inserting a cryoprobe through an intro-ducer sheath for insulation, with 2-cm of probe tip projecting out. A beagle liver was punctured by the device, and electric current was applied at 30-W with the electrosurgical knife touching the non-insulated device base. The discolored area of cut surface along the device was evaluated in 5 application-time groups (5 , 10 , 15 , 20, or 25 seconds). An ex vivo experiment was performed to determine an ablation algorithm with an appropriate application time by comparison with radiofrequency ablation (RFA) results. Thereafter, an in vivo experiment was performed to verify the algorithm’s feasibility. In the ex vivo model, the cut surface demonstrated different amounts of discolored area according to the application time. The total discolored area in the 20-seconds group was similar to that by RFA. In the in vivo model, the liver did not bleed, the total discolored area was similar to that ex vivo, and coagulation necrosis was confirmed by photomicrograph. Needle tract ablation can be per-formed using the experimental device and electrosurgical device. |
| Keywords | needle tract ablation cryoablation electrosurgical device animal liver |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-02 |
| Volume | volume75 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 9 |
| End Page | 14 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33649608 |
| JaLCDOI | 10.18926/AMO/61424 |
|---|---|
| FullText URL | 75_1_1.pdf |
| Author | Hamahara, Jun| Honda, Hiroyuki| Yamamoto, Koichiro| Tokumasu, Kazuki| Hanayama, Yoshihisa| Hagiya, Hideharu| Obika, Mikako| Ueda, Keigo| Kishida, Masayuki| Otsuka, Fumio| |
| Abstract | To determine the clinical characteristics of low androgen status in adult males with diabetes, we retrospectively analyzed the medical records of patients with type 2 diabetes mellitus in whom serum free testosterone (FT) levels were examined for 1 year. Among the 46 patients (56 ± 1.5 years old), decreases in serum FT levels to < 8.5 pg/ml (indicating the occurrence of late-onset hypogonadism [LOH]) were detected in 18 (39%). The per-centages of patients with low FT levels were high in the ≥ 50 years age group (83%), the HbA1c < 7% group (67%), and the 25 ≤ BMI < 30 kg/m2 group (56%). The serum FT levels tended to decrease age-dependently. The level of HbA1c was significantly correlated with the Heinemann Aging Male Symptoms (AMS) score (R = 0.47). The low-FT group had decreased levels of hemoglobin. Of note, the serum FSH level (R = −0.32) was negatively correlated with the serum FT level, whereas the serum TSH level (R = 0.36) was positively correlated with the serum FT level. Collectively, these results revealed that many diabetic males may have low FT levels and that the AMS score is related to the HbA1c level. A slightly anemic condition, thyroid dysfunction, and obesity (class 1) might be involved in LOH in middle-aged diabetic males. |
| Keywords | androgen diabetes mellitus late-onset hypogonadism testosterone thyroid function |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-02 |
| Volume | volume75 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 1 |
| End Page | 8 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33649607 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Otubo, Akito| Kawakami, Natsuko| Maejima, Sho| Ueda, Yasumasa| Morris, John F.| Sakamoto, Tatsuya| Sakamoto, Hirotaka| |
| Keywords | corticotrophin‐releasing factor Japanese macaque monkey (Macaca fuscata) median eminence paraventricular nucleus of the hypothalamus vasopressin |
| Published Date | 2020-05-23 |
| Publication Title | Journal of Neuroendocrinology |
| Volume | volume32 |
| Issue | issue8 |
| Publisher | Wiley |
| Start Page | e12875 |
| ISSN | 0953-8194 |
| NCID | AA10755083 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Authors. |
| File Version | publisher |
| PubMed ID | 32715549 |
| DOI | 10.1111/jne.12875 |
| Web of Science KeyUT | 000552300500001 |
| Related Url | isVersionOf https://doi.org/10.1111/jne.12875 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nishioka, Keiji| Kato, Yusuke| Ozawa, Shin-ichiro| Takahashi, Yuichiro| Sakamoto, Wataru| |
| Keywords | Chloroplast Phos-tag Protein phosphorylation Thylakoid membrane STN7 STN8 |
| Published Date | 2021-01 |
| Publication Title | Photosynthesis Research |
| Volume | volume147 |
| Issue | issue1 |
| Publisher | Springer |
| Start Page | 107 |
| End Page | 124 |
| ISSN | 0166-8595 |
| NCID | AA00362200 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Authors. |
| File Version | publisher |
| PubMed ID | 33269435 |
| DOI | 10.1007/s11120-020-00803-1 |
| Web of Science KeyUT | 000595363200001 |
| Related Url | isVersionOf https://doi.org/10.1007/s11120-020-00803-1 |
| FullText URL | fulltext.pdf Figures.pdf Suppl_Material_Methods.pdf Suppl_Figures.pdf Legend_suppl_figures.pdf Suppl_Table.pdf |
|---|---|
| Author | Kajioka, Hiroki| Kagawa, Shunsuke| Ito, Atene| Yoshimoto, Masashi| Sakamoto, Shuichi| Kikuchi, Satoru| Kuroda, Shinji| Yoshida, Ryuichi| Umeda, Yuzo| Noma, Kazuhiro| Tazawa, Hiroshi| Fujiwara, Toshiyoshi| |
| Keywords | HMGB1 Epithelial to mesenchymal transition Phorbol 12-myristate 13-acetate Ischemia-reperfusion model |
| Note | This fulltext is available in January, 2022.| |
| Published Date | 2021-01-28 |
| Publication Title | Cancer Letters |
| Volume | volume497 |
| Publisher | Elsevier |
| Start Page | 1 |
| End Page | 3 |
| ISSN | 0304-3835 |
| NCID | AA00598513 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 33065249 |
| DOI | 10.1016/j.canlet.2020.10.015 |
| Web of Science KeyUT | 000596072900001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.canlet.2020.10.015 |
| JaLCDOI | 10.18926/AMO/61216 |
|---|---|
| FullText URL | 74_6_551.pdf |
| Author | Tanaka, Masato| Fujiwara, Yoshihiro| Uotani, Koji| Kadiri, Venkatesh| Yamauchi, Taro| |
| Abstract | A minimally invasive posterolateral approach designed to avoid the lateral misplacement of midcervical pedicle screws was reported, but there is no technical report that describes this technique without C-arm fluoroscopy. We report the results of a 2.5 years follow-up of a 62-year-old female patient with C4 metastatic breast cancer. The patient suffered from severe neck pain and impending quadriplegia for 2 months after radiation therapy. We performed C-arm-free minimally invasive cervical pedicle screw fixation (MICEPS). The patient was suc-cessfully treated with surgery, and her neck pain was well controlled. She had neither neurological deficits nor neck pain at the final (2.5-year) follow-up. C-arm-free MICEPS is a useful technique; in addition, the sur-geons and staff have no risk of radiation exposure, there is a reduced need for postoperative imaging, and a decreased revision rate can be expected with C-arm-free MICEPS. |
| Keywords | cervical spine navigation surgery minimally invasive surgery cervical pedicle screw C-arm free |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-12 |
| Volume | volume74 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 551 |
| End Page | 556 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33361877 |
| Web of Science KeyUT | 000601203600013 |
| NAID | 120006948943 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Miyata, Takashi| Hagiwara, Daisuke| Hodai, Yuichi| Miwata, Tsutomu| Kawaguchi, Yohei| Kurimoto, Junki| Ozaki, Hajime| Mitsumoto, Kazuki| Takagi, Hiroshi| Suga, Hidetaka| Kobayashi, Tomoko| Sugiyama, Mariko| Onoue, Takeshi| Ito, Yoshihiro| Iwama, Shintaro| Banno, Ryoichi| Matsumoto, Mami| Kawakami, Natsuko| Ohno, Nobuhiko| Sakamoto, Hirotaka| Arima, Hiroshi| |
| Published Date | 2020-10-23 |
| Publication Title | iScience |
| Volume | volume23 |
| Issue | issue10 |
| Publisher | Cell Press |
| Start Page | 101648 |
| ISSN | 2589-0042 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Authors. |
| File Version | publisher |
| PubMed ID | 33103081 |
| DOI | 10.1016/j.isci.2020.101648 |
| Web of Science KeyUT | 000581985500098 |
| Related Url | isVersionOf https://doi.org/10.1016/j.isci.2020.101648 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Oti, Takumi| Satoh, Keita| Uta, Daisuke| Nagafuchi, Junta| Tateishi, Sayaka| Ueda, Ryota| Takanami, Keiko| Young, Larry J.| Galione, Antony| Morris, John F.| Sakamoto, Tatsuya| Sakamoto, Hirotaka| |
| Keywords | oxytocin localized volume transmission spinal cord male sexual activity gastrin-releasing peptide spinal ejaculation generator |
| Note | © 2020 Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 License.http://creativecommons.org/licenses/by-nc-nd/4.0/.This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.cub.2020.09.089] .| |
| Published Date | 2020-10-29 |
| Publication Title | Current Biology |
| Volume | volume31 |
| Issue | issue1 |
| Publisher | Elsevier |
| Start Page | 103 |
| End Page | 114.e5 |
| ISSN | 0960-9822 |
| NCID | AA1081652X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| PubMed ID | 33125871 |
| DOI | 10.1016/j.cub.2020.09.089 |
| Related Url | isVersionOf https://doi.org/10.1016/j.cub.2020.09.089 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Katayama, Yukitoshi| Saito, Kazuhiro| Sakamoto, Tatsuya| |
| Keywords | stressors thirst angiotensin II corticosteroids amphibious fish |
| Published Date | 2020-09-14 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume21 |
| Issue | issue18 |
| Publisher | MDPI |
| Start Page | 6748 |
| ISSN | 1422-0067 |
| NCID | AA12038549 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 by the authors. |
| File Version | publisher |
| PubMed ID | 32938015 |
| DOI | 10.3390/ijms21186748 |
| Web of Science KeyUT | 000580799600001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms21186748 |
| Author | Sakamoto, Syunya| |
|---|---|
| Published Date | 2013-05-03 |
| Publication Title | Multimedia and Ubiquitous Engineering |
| Content Type | Book |
| JaLCDOI | 10.18926/AMO/60808 |
|---|---|
| FullText URL | 74_5_455.pdf |
| Author | Yamanouchi, Kosho| Kuba, Sayaka| Matsumoto, Megumi| Yano, Hiroshi| Morita, Michi| Sakimura, Chika| Otsubo, Ryota| Kanetaka, Kengo| Nagayasu, Takeshi| Eguchi, Susumu| |
| Abstract | Taxanes are key drugs for patients with breast cancer. A major adverse effect associated with the administration of the taxane docetaxel is chemotherapy-induced peripheral neuropathy (CIPN). We are conducting a singlecenter, single-arm, open-label historical control trial to evaluate the ability of compression therapy using stockings or sleeves to prevent CIPN due to docetaxel treatment. The primary endpoint is the incidence of all-grade CIPN according to patients’ records until 3 weeks after the fourth docetaxel administration. This study’s results will clarify whether compression therapy using stockings or sleeves can prevent CIPN in breast cancer patients. |
| Keywords | breast cancer docetaxel neuropathy compression |
| Amo Type | Clinical Study Protocol |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-10 |
| Volume | volume74 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 455 |
| End Page | 459 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33106704 |
| Web of Science KeyUT | 000581970100013 |
| NAID | 120006892934 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kawakami, Natsuko| Otubo, Akito| Maejima, Sho| Talukder, Ashraf H.| Satoh, Keita| Oti, Takumi| Takanami, Keiko| Ueda, Yasumasa| Itoi, Keiichi| Morris, John F.| Sakamoto, Tatsuya| Sakamoto, Hirotaka| |
| Keywords | copeptin hypothalamo‐pituitary–adrenal system immunohistochemistry paraventricular nucleus of the hypothalamus processing vasopressin RRID: AB_2722604 RRID: AB_2061966 RRID: AB_2314234 RRID: AB_10013361 RRID: AB_2313960 RRID: AB_2722605 RRID: AB_90782 |
| Published Date | 2020-09-06 |
| Publication Title | Journal of Comparative Neurology |
| Volume | volume529 |
| Issue | issue7 |
| Publisher | Wiley |
| Start Page | 1372 |
| End Page | 1390 |
| ISSN | 0021-9967 |
| NCID | AA00695917 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Authors. |
| File Version | publisher |
| PubMed ID | 32892351 |
| DOI | 10.1002/cne.25026 |
| Web of Science KeyUT | 000571267600001 |
| Related Url | isVersionOf https://doi.org/10.1002/cne.25026 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tsutsui, Naoaki| Kobayashi, Yasuhisa| Izumikawa, Kouichi| Sakamoto, Tatsuya| |
| Keywords | peptide hormone Marsupenaeus japonicus ovary reproduction transcriptome vitellogenesis |
| Published Date | 2020-08-19 |
| Publication Title | Frontiers in Endocrinology |
| Volume | volume11 |
| Publisher | Frontiers Media |
| Start Page | 541 |
| ISSN | 1664-2392 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 Tsutsui, Kobayashi, Izumikawa and Sakamoto. |
| File Version | publisher |
| DOI | 10.3389/fendo.2020.00541 |
| Web of Science KeyUT | 000566191000001 |
| Related Url | isVersionOf https://doi.org/10.3389/fendo.2020.00541 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sakamoto, Yumi| Okui, Tatsuo| Yoneda, Toshiyuki| Ryumon, Shoji| Nakamura, Tomoya| Kawai, Hotaka| Kunisada, Yuki| Ibaragi, Soichiro| Masui, Masanori| Ono, Kisho| Obata, Kyoichi| Shimo, Tsuyoshi| Sasaki, Akira| |
| Keywords | Oral squamous cell cancer HMGB1 Bone destruction Osteoclasts |
| Published Date | 2020-10-20 |
| Publication Title | Biochemical and Biophysical Research Communications |
| Volume | volume531 |
| Issue | issue3 |
| Publisher | Elsevier |
| Start Page | 422 |
| End Page | 430 |
| ISSN | 0006-291X |
| NCID | AA00564395 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Authors |
| File Version | publisher |
| PubMed ID | 32800556 |
| DOI | 10.1016/j.bbrc.2020.07.120 |
| Web of Science KeyUT | 000571663900011 |
| Related Url | isVersionOf https://doi.org/10.1016/j.bbrc.2020.07.120 |
| JaLCDOI | 10.18926/AMO/60367 |
|---|---|
| FullText URL | 74_4_293.pdf |
| Author | Yoshioka, Takashi| Omae, Kenji| Kawada, Tatsushi| Inoue, Yosuke| Sugimoto, Morito| Oeda, Tadashi| Uehara, Shinya| Araki, Motoo| Fukuhara, Shunichi| |
| Abstract | In this retrospective single-center cohort study, we investigated the impact of preoperative use of an alpha-1 adrenergic receptor (AR) blocker on the outcome of single-session extracorporeal shock wave lithotripsy (SWL) in 193 male patients who underwent SWL for a single ureteral calculus between 2006 and 2016. We reviewed their medical records to obtain the data on the preoperative use of alpha-1 AR blockers. The primary outcome was treatment success after single-session SWL. We performed a multivariable logistic regression analysis adjusting for clinically important confounders to examine the association between preoperative use of alpha-1 AR blockers and the treatment success of SWL. Among the 193 patients, 15 (7.8%) were taking an alpha-1 AR blocker preoperatively. A multivariable analysis showed that preoperative use of an alpha-1 AR blocker was a significant negative predictor for treatment success of SWL (adjusted odds ratio 0.17; 95% confidence intervals, 0.04-0.74). Our findings suggest that the preoperative use of an alpha-1 AR blocker was a negative predictor of treatment success of SWL in male patients with a single ureteral calculus. Clinicians should pay more attention to the preoperative drug use in determining an appropriate stone therapy modality. |
| Keywords | urolithiasis extracorporeal shockwave therapy adrenergic alpha-1 receptor antagonists |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-08 |
| Volume | volume74 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 293 |
| End Page | 299 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32843760 |
| Web of Science KeyUT | 000562508700004 |
| NAID | 120006880206 |
| JaLCDOI | 10.18926/AMO/60364 |
|---|---|
| FullText URL | 74_4_275.pdf |
| Author | Muro, Taiko| Nakamura, Shinichiro| Takaki, Akinobu| Onishi, Hideki| Wada, Nozomu| Yasunaka, Tetsuya| Uchida, Daisuke| Oyama, Atsushi| Adachi, Takuya| Shiraha, Hidenori| Okada, Hiroyuki| |
| Abstract | Radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) is a promising method for controlling tumors, although it does not entirely eliminate recurrence. Oxidative stress is associated with the progression of hepatocarcinogenesis, while also acting as an anticancer response. The objective of the present study was to investigate the factors influencing post-RFA outcomes. We recruited 235 newly diagnosed HCC patients who received RFA for single tumors. The patients with recurrence were sub-grouped into early and segmental recurrence groups. The characteristics of the sub-grouped patients were evaluated, including by measuring oxidative stress marker reactive oxygen metabolites and antioxidant marker OXY-adsorbent tests. The factors associated with poor survival were a high Child-Pugh score and early recurrence within 2 years in the same segment. The patients who experienced recurrence within 2 years in the same segment showed a larger tumor diameter than did others. According to a multivariate analysis, the OXY values were also significantly low in these patients. In conclusion, maintaining the antioxidant reservoir function with a high OXY value might be necessary to prevent early recurrence within the RFA-treated segment. |
| Keywords | oxidative stress hepatocellular carcinoma recurrence, radiofrequency ablation |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-08 |
| Volume | volume74 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 275 |
| End Page | 283 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32843758 |
| Web of Science KeyUT | 000562508700002 |
| NAID | 120006880203 |
