result 14424 件
| JaLCDOI | 10.18926/AMO/52657 |
|---|---|
| FullText URL | 68_3_163.pdf |
| Author | Tate, Genshu| Kishimoto, Koji| Mitsuya, Toshiyuki| |
| Abstract | The aim of the present study is to address whether the molecular pathogenesis is identical among multiple basal cell carcinomas (BCCs) present in the same nevoid basal cell carcinoma syndrome (NBCCS) patient. Patient 1 is a 61-year-old (yo) Japanese female whose clinical characteristics and findings of a genetic analysis of PTCH1 have been previously described. Patient 2 is patient 1ʼs 64-yo sister who also suffered from NBCCS with a single base deletion at nucleotide 2613 in exon 16 (c.2613delC) in one PTCH1 allele. Thirteen and 3 independent specimens of BCC were applied for a molecular analysis of loss of heterozygosity (LOH) in PTCH1 in patients 1 and 2, respectively. Of particular note is that all BCC specimens examined showed a loss of the wild-type allele of exon 16 in PTCH1, thus indicating that LOH results in the biallelic disruption of PTCH1 in multiple BCCs that develop in an age- and location-independent manner in the same patient. These results indicate that the germline single base deletion of PTCH1 (c.2613 delC) is a first hit and the LOH of the wild-type allele is a second hit, implying that all 16 BCCs detected in these NBCCS sisters fit the standard two-hit model. |
| Keywords | biallelic disruption hedgehog nevoid basal cell carcinoma syndrome Patched 1 two-hit model |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-06 |
| Volume | volume68 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 163 |
| End Page | 170 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24942795 |
| Web of Science KeyUT | 000337655600006 |
| JaLCDOI | 10.18926/AMO/52656 |
|---|---|
| FullText URL | 68_3_157.pdf |
| Author | Oozawa, Susumu| Sano, Shunji| Nishibori, Masahiro| |
| Abstract | Atherosclerosis is often associated with chronic vascular inflammation. High-mobility group box 1 protein (HMGB1) plays various roles, not only as a transcriptional regulatory factor in the nucleus, but also as an inflammatory mediator. A previous study suggested that fibrinogen is an important factor associated with atherosclerosis progression. The present study was performed to examine the levels of plasma HMGB1 protein in atherosclerosis patients. We studied 24 patients with peripheral artery disease (PAD) with atherosclerosis, and 10 healthy controls. We found that the concentrations of HMGB1 were increased in the plasma of the patients with atherosclerosis, and there were significant correlations between the plasma HMGB1 and fibrinogen levels. Plasma HMGB1 may play a key role in the pathogenesis of clinical and experimental atherosclerosis. |
| Keywords | HMGB1 fibrinogen atherosclerosis peripheral artery disease |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-06 |
| Volume | volume68 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 157 |
| End Page | 162 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24942794 |
| Web of Science KeyUT | 000337655600005 |
| Related Url | http://doi.org/10.18926/AMO/52792 |
| JaLCDOI | 10.18926/AMO/52655 |
|---|---|
| FullText URL | 68_3_151.pdf |
| Author | Akavipat, Phuping| Hungsawanich, Nate| Jansin, Rungruedee| |
| Abstract | In neurosurgery in particular, the recommended placement of electrodes for monitoring depth of anesthesia during surgery sometimes conflicts with the surgical site or patient positioning. Therefore, we proposed this study to evaluate the agreement and correlation of bispectral index values recorded from the usual frontal area and the alternate, post-auricular areas in neurosurgery patients. Thirty-four patients scheduled for neurosurgery under general anesthesia were included. Bispectral index (BIS) sensors were placed at both the frontal and post-auricular areas. The anesthesia given was clinically adjusted according to the frontal (standard) BIS reading. The BIS values and impedance were recorded;Pearsonʼs correlation and Bland-Altman plots were analyzed. The bias ± 2SD for the electrode placement before, during, and post-anesthesia were 0±23.32, 1.5±10.69, and 2.1±13.52, while the limits of agreement were －23.3 to 23.3, －12.2 to 9.2, and －17.7 to 13.5, respectively. The correlation coefficient between frontal- and post-auricular-area electrodes was 0.74 with a p-value ＜0.001.The post-auricular placement of a BIS electrode is a practical alternative to frontal lobe placement. Nevertheless, proper electrode location is important to minimize error. |
| Keywords | Bland and Altman analysis electroencephalogram instrumentation equipment |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-06 |
| Volume | volume68 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 151 |
| End Page | 155 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24942793 |
| Web of Science KeyUT | 000337655600004 |
| JaLCDOI | 10.18926/AMO/52654 |
|---|---|
| FullText URL | 68_3_143.pdf |
| Author | Yamaguchi, Junichi| Imatoh, Takuya| Une, Hiroshi| |
| Abstract | The purpose of this study was to clarify, through a prospective study, the relationship between leptin and adiponectin levels, and subsequent weight change. The study subjects were 2,485 male office workers aged 35-64 employed by a company in Fukuoka Prefecture, Japan. Of these men, 1,936 (77.9%) received health check-ups both in 2005-2007 and 3 years later, in 2008-2010. Of the subjects who received both health check-ups, 352 were excluded duo to cancer, cardiac infarction, stroke or diabetes mellitus, leaving a total of 1,584. We divided them into tertiles according to baseline leptin and adiponectin levels, and compared the subsequent change in body mass index (BMI) over 3 years. The subjects with the lowest leptin levels showed a significantly greater increase in BMI (difference in change in BMI＝0.178kg/m2, 95% CI:0.025-0.331kg/m2) over 3 years when those with the highest leptin levels were regarded as the reference even after adjusting for age, baseline BMI, smoking status, drinking status and exercise. The subjects with the highest adiponectin levels showed a greater increase in BMI (difference in change in BMI＝0.099kg/m2, 95% CI:－0.034-0.231kg/m2) over 3 years when those with the lowest adiponectin levels were regarded as the reference, but this association was not statistically significant after adjusting for age, baseline BMI, smoking status, drinking status and exercise. Our findings suggest that higher leptin levels may suppress weight gain in Japanese male workers. |
| Keywords | leptin adiponectin weight change Japanese male workers prospective study |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-06 |
| Volume | volume68 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 143 |
| End Page | 149 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24942792 |
| Web of Science KeyUT | 000337655600003 |
| JaLCDOI | 10.18926/AMO/52653 |
|---|---|
| FullText URL | 68_3_137.pdf |
| Author | Akamatsu, Megumi| Nakatsuka, Mikiya| |
| Abstract | Untouched toe is a condition in which a toe does not touch the ground while standing. It is frequently observed in women even under physiological conditions. Deformities or symptoms of the toes are not observed in these women. The clinical significance of untouched toe has not been fully elucidated. Two hundred young healthy women were recruited into the present study after informed consent. We evaluated the prevalence of untouched toe by measuring various indexes of the toe using a foot-sole-measuring equipment. We also conducted a self-administered questionnaire regarding general malaise. Untouched toe was observed in 114 of these 200 women (57.0%). The fifth toe was more frequently affected than the other toes. There were no significant differences in size of foot except the area and proportion touching the ground between women with untouched toe and those without untouched toe. The prevalence of general malaise was significantly higher in women with at least one untouched toe (57.0%) compared with those without untouched toe (43.0%) (p＜0.05). Twelve symptoms―irritability, headache, tired eyes, hazy vision, congested or runny nose, irregular menstruation or menstrual pain, shoulder stiffness, neck stiffness, low back pain, cold hands, swollen feet, and cold feet―were more frequently observed in women with at least one untouched toe compared with those without untouched toes. Untouched toe was associated with various symptoms of general malaise. However, the pathological mechanism by which untouched toe causes these symptoms has not been determined. Further analysis of gait and exercise habits in women with untouched toe is necessary. |
| Keywords | cold feet general malaise shoulder stiffness untouched toe young women |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-06 |
| Volume | volume68 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 137 |
| End Page | 142 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24942791 |
| Web of Science KeyUT | 000337655600002 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/52635 |
| JaLCDOI | 10.18926/AMO/52652 |
|---|---|
| FullText URL | 68_3_129.pdf |
| Author | Minoura, Akira| Wang, Da-Hong| Sato, Yoshie| Zou, Yu| Sakano, Noriko| Kubo, Masayuki| Takemoto, Kei| Masatomi, Chie| Ogino, Keiki| |
| Abstract | We examined the relationships between dietary carbohydrate, protein, fat, and the ratio of n6/n3 fatty acid intakes with the predicted 10-year coronary heart disease (CHD) risk in a general Japanese population. We used the Framingham risk score to determine the 10-year CHD risk of the subjects, who were employees of 6 companies in a single prefecture in Japan. After excluding the subjects who reported any history of angina pectoris, myocardial infarction, diabetes, or cancer, and those with missing data resulting in the inability of estimation of 10-year CHD risk and food intakes, the final data analysis was carried out for 809 subjects. The logistic regression models revealed a significantly increased odds ratio of 10-year CHD risk in the subjects with the highest tertile of carbohydrate intake (% energy) (odds ratio 3.64, 95% CI, 2.07-6.40);after adjustment for other variables, the odds ratio for the 10-year CHD risk was also higher in the subjects with the highest tertile of carbohydrate intake (odds ratio 1.72, 95% CI, 0.70-4.25). We also found that fat intake and the ratio of n6/n3 fatty acids were inversely associated with the predicted 10-year CHD risk (p for trend＜0.01). The present findings added evidence of a positive association of dietary carbohydrate and inverse associations of total fat and n6/n3 fatty acid ratio with the predicted 10-year CHD risk in a general Japanese population. |
| Keywords | fat intake carbohydrate intake ratio of n6/n3 fatty acids 10-year coronary heart disease risk Japanese |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-06 |
| Volume | volume68 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 129 |
| End Page | 135 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24942790 |
| Web of Science KeyUT | 000337655600001 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/52516 |
| FullText URL | O0004420_abstract_review.pdf O0004420_fulltext.pdf |
|---|---|
| Author | Yoshida, Kohei| |
| Published Date | 2014-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 乙第4420号 |
| Granted Date | 2014-03-25 |
| Thesis Type | Doctor of Philosophy in Science |
| Grantor | 岡山大学 |
| language | Japanese English |
| FullText URL | K0005003_abstract_review.pdf K0005003_fulltext.pdf |
|---|---|
| Author | Hayashida, Kaori| |
| Published Date | 2014-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5003号 |
| Granted Date | 2014-03-25 |
| Thesis Type | Doctor of Philosophy in Health Sciences |
| Grantor | 岡山大学 |
| language | Japanese English |
| FullText URL | K0005001_abstract_review.pdf K0005001_fulltext.pdf |
|---|---|
| Author | Akamatsu, Megumi| |
| Published Date | 2014-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5001号 |
| Granted Date | 2014-03-25 |
| Thesis Type | Doctor of Philosophy in Nursing Science |
| Grantor | 岡山大学 |
| language | Japanese English |
| FullText URL | K0005000_abstract_review.pdf K0005000_fulltext.pdf |
|---|---|
| Author | Sawai, Takashi| |
| Published Date | 2014-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5000号 |
| Granted Date | 2014-03-25 |
| Thesis Type | Doctor of Philosophy |
| Grantor | 岡山大学 |
| language | Japanese English |
| FullText URL | K0004997_abstract_review.pdf K0004997_fulltext.pdf |
|---|---|
| Author | Paweena Jariyathitipong| |
| Published Date | 2014-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4997号 |
| Granted Date | 2014-03-25 |
| Thesis Type | Doctor of Philosophy in Environmental Science |
| Grantor | 岡山大学 |
| language | Japanese English |
| FullText URL | K0004995_abstract_review.pdf K0004995_fulltext.pdf |
|---|---|
| Author | 包 紅梅| |
| Published Date | 2014-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4995号 |
| Granted Date | 2014-03-25 |
| Thesis Type | Doctor of Philosophy |
| Grantor | 岡山大学 |
| language | Japanese English |
| FullText URL | K0004990_abstract_review.pdf K0004990_fulltext.pdf |
|---|---|
| Author | Suzaki, Yu| |
| Published Date | 2014-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4990号 |
| Granted Date | 2014-03-25 |
| Thesis Type | Doctor of Philosophy in Environmental Science |
| Grantor | 岡山大学 |
| language | Japanese English |
| FullText URL | K0004988_abstract_review.pdf K0004988_fulltext.pdf |
|---|---|
| Author | Hoang Ngoc Minh Chau| |
| Published Date | 2014-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4988号 |
| Granted Date | 2014-03-25 |
| Thesis Type | Doctor of Philosophy in Environmental Science |
| Grantor | 岡山大学 |
| language | Japanese English |
| FullText URL | K0004986_abstract_review.pdf K0004986_fulltext.pdf |
|---|---|
| Author | Shaban El khabiry| |
| Published Date | 2014-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4986号 |
| Granted Date | 2014-03-25 |
| Thesis Type | Doctor of Philosophy in Engineering |
| Grantor | 岡山大学 |
| language | Japanese English |
| FullText URL | K0004983_abstract_review.pdf K0004983_fulltext.pdf |
|---|---|
| Author | Lakha Salaipeth| |
| Published Date | 2014-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4983号 |
| Granted Date | 2014-03-25 |
| Thesis Type | Doctor of Philosophy in Agriculture |
| Grantor | 岡山大学 |
| language | Japanese English |
| Author | 韓 紅燕| |
|---|---|
| Published Date | 2014-03-25 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| FullText URL | K0004981_abstract_review.pdf K0004981_fulltext.pdf |
|---|---|
| Author | 暁 敏| |
| Published Date | 2014-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4981号 |
| Granted Date | 2014-03-25 |
| Thesis Type | Doctor of Philosophy in Agriculture |
| Grantor | 岡山大学 |
| language | Japanese English |
| FullText URL | K0004978_abstract_review.pdf K0004978_fulltext.pdf |
|---|---|
| Author | Yoshioka, Shin| |
| Published Date | 2014-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4978号 |
| Granted Date | 2014-03-25 |
| Thesis Type | Doctor of Philosophy in Agriculture |
| Grantor | 岡山大学 |
| language | Japanese English |
| FullText URL | K0004977_abstract_review.pdf K0004977_fulltext.pdf |
|---|---|
| Author | Kamrun Nahar| |
| Published Date | 2014-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4977号 |
| Granted Date | 2014-03-25 |
| Thesis Type | Doctor of Philosophy in Agriculture |
| Grantor | 岡山大学 |
| language | Japanese English |
