FullText URL | fulltext.pdf |
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Author | Matsuoka-Uchiyama, Natsumi| Uchida, Haruhito A.| Okamoto, Shugo| Onishi, Yasuhiro| Katayama, Katsuyoshi| Tsuchida-Nishiwaki, Mariko| Takeuchi, Hidemi| Takemoto, Rika| Hada, Yoshiko| Umebayashi, Ryoko| Kurooka, Naoko| Tsuji, Kenji| Eguchi, Jun| Nakajima, Hirofumi| Shikata, Kenichi| Wada, Jun| |
Published Date | 2022-01-10 |
Publication Title | Journal Of Diabetes Research |
Volume | volume2022 |
Publisher | Hindawi Ltd. |
Start Page | 3157841 |
ISSN | 2314-6745 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022 Natsumi Matsuoka-Uchiyama et al. |
File Version | publisher |
PubMed ID | 35047644 |
DOI | 10.1155/2022/3157841 |
Web of Science KeyUT | 000774919000001 |
Related Url | isVersionOf https://doi.org/10.1155/2022/3157841 |
FullText URL | fulltext20220509-2.pdf |
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Author | Matsumoto, Yoshinori| Dimitriou, Ioannis D.| La Rose, Jose| Lim, Melissa| Camilleri, Susan| Law, Napoleon| Adissu, Hibret A.| Tong, Jiefei| Moran, Michael F.| Chruscinski, Andrzej| He, Fang| Asano, Yosuke| Katsuyama, Takayuki| Sada, Ken-ei| Wada, Jun| Rottapel, Robert| |
Published Date | 2022-4-1 |
Publication Title | Journal of Clinical Investigation |
Volume | volume132 |
Issue | issue7 |
Publisher | American Society for Clinical Investigation |
Start Page | e140869 |
ISSN | 1558-8238 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022, Matsumoto et al. |
File Version | publisher |
PubMed ID | 35274528 |
DOI | 10.1172/jci140869 |
Web of Science KeyUT | 000783678600007 |
Related Url | isVersionOf https://doi.org/10.1172/jci140869 |
FullText URL | fulltext.pdf |
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Author | Oda, Kaori| Miyamoto, Satoshi| Kodera, Ryo| Wada, Jun| Shikata, Kenichi| |
Keywords | Diabetic kidney disease Inflammasomes Suramin |
Published Date | 2022-10-29 |
Publication Title | Journal Of Diabetes Investigation |
Volume | volume14 |
Issue | issue2 |
Publisher | Wiley |
Start Page | 205 |
End Page | 220 |
ISSN | 2040-1116 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022 The Authors. |
File Version | publisher |
PubMed ID | 36308062 |
DOI | 10.1111/jdi.13930 |
Web of Science KeyUT | 000875614000001 |
Related Url | isVersionOf https://doi.org/10.1111/jdi.13930 |
JaLCDOI | 10.18926/AMO/54514 |
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FullText URL | 70_4_327.pdf |
Author | Watanabe, Mototsugu| Yamamoto, Hiromasa| Eikawa, Shingo| Shien, Kazuhiko| Shien, Tadahiko| Soh, Junichi| Hotta, Katsuyuki| Wada, Jun| Hinotsu, Shiro| Fujiwara, Toshiyoshi| Kiura, Katsuyuki| Doihara, Hiroyoshi| Miyoshi, Shinichiro| Udono, Heiichiro| Toyooka, Shinichi| |
Abstract | A study to evaluate the effect of metformin on the immune system was commenced in July 2014. Metformin is one of the most commonly prescribed drugs for type 2 diabetes, and previous studies have reported that metformin has an anti-tumor effect. The aim of this study is to evaluate the efficacy of metformin on the immune system in human cancer patients in vivo. The primary outcome parameter will be the rate change in the population of CD8+ T cells, which produce multiple cytokines. |
Keywords | metformin CD8+ T cells cancer immunology |
Amo Type | Clinical Study Protocols |
Publication Title | Acta Medica Okayama |
Published Date | 2016-08 |
Volume | volume70 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 327 |
End Page | 330 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 27549683 |
Web of Science KeyUT | 000384748600018 |
FullText URL | fulltext.pdf |
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Author | Fukushima, Kazuhiko| Kitamura, Shinji| Tsuji, Kenji| Sang, Yizhen| Wada, Jun| |
Keywords | sodium glucose co-transporter 2 inhibitor mammalian target of rapamycin (mTOR) autophagy obesity multi lamellar body |
Published Date | 2020-06-05 |
Publication Title | International Journal of Molecular Sciences |
Volume | volume21 |
Issue | issue11 |
Publisher | MDPI |
Start Page | 4054 |
ISSN | 1422-0067 |
NCID | AA12038549 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 by the authors |
File Version | publisher |
PubMed ID | 32517059 |
DOI | 10.3390/ijms21114054 |
Web of Science KeyUT | 000543400300316 |
Related Url | isVersionOf https://doi.org/10.3390/ijms21114054 |
FullText URL | fulltext20220708-4.pdf nep-supinfo.pdf |
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Author | Tsuji, Kenji| Kitamura, Shinji| Uchida, Haruhito A.| Wada, Jun| |
Keywords | Renal biopsy clinical nephrology ultrasound |
Note | This is the peer reviewed version of the following article: [Tsuji, K, Kitamura, S, Uchida, HA, Wada, J. Simulation for ultrasound-guided renal biopsy using boiled egg. Nephrology. 2022; 27( 9): 753- 757. doi:10.1111/nep.14079], which has been published in final form at [https://doi.org/10.1111/nep.14079]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. This fulltext is available in June 2023.| |
Published Date | 2022-06-28 |
Publication Title | Nephrology |
Volume | volume27 |
Issue | issue9 |
Publisher | Wiley |
Start Page | 753 |
End Page | 757 |
ISSN | 1320-5358 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022 Asian Pacific Society of Nephrology. |
File Version | author |
PubMed ID | 35762140 |
DOI | 10.1111/nep.14079 |
Web of Science KeyUT | 000816988200001 |
Related Url | isVersionOf https://doi.org/10.1111/nep.14079 |
FullText URL | fulltext.pdf |
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Author | Fukushima, Kazuhiko| Uchida, Haruhito A.| Fuchimoto, Yasuko| Mifune, Tomoyo| Watanabe, Mayu| Tsuji, Kenji| Tanabe, Katsuyuki| Kinomura, Masaru| Kitamura, Shinji| Miyamoto, Yosuke| Wada, Sae| Koyanagi, Taisaku| Sugiyama, Hitoshi| Kishimoto, Takumi| Wada, Jun| |
Keywords | lupus nephritis lupus pneumonitis silicosis SLE |
Published Date | 2022-02-18 |
Publication Title | Medicine |
Volume | volume101 |
Issue | issue7 |
Publisher | Lippincott Williams & Wilkins |
Start Page | e28872 |
ISSN | 0025-7974 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022 the Author(s). |
File Version | publisher |
PubMed ID | 35363197 |
DOI | 10.1097/MD.0000000000028872 |
Web of Science KeyUT | 000776738500059 |
Related Url | isVersionOf https://doi.org/10.1097/MD.0000000000028872 |
FullText URL | fulltext.pdf |
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Author | Tanaka, Keiko| Sugiyama, Hitoshi| Morinaga, Hiroshi| Kitagawa, Masashi| Kano, Yuzuki| Onishi, Yasuhiro| Mise, Koki| Tanabe, Katsuyuki| Uchida, Haruhito A.| Wada, Jun| |
Keywords | IgA nephropathy cytokines sCD40L IL-31 proteinuria inflammation interstitial fibrosis |
Published Date | 2023-03-03 |
Publication Title | Journal of Clinical Medicine |
Volume | volume12 |
Issue | issue5 |
Publisher | MDPI |
Start Page | 2023 |
ISSN | 2077-0383 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 by the authors. |
File Version | publisher |
PubMed ID | 36902810 |
DOI | 10.3390/jcm12052023 |
Web of Science KeyUT | 000947139700001 |
Related Url | isVersionOf https://doi.org/10.3390/jcm12052023 |
Author | Kurose, Yuko| Wada, Jun| Kanzaki, Motoko| Teshigawara, Sanae| Nakatsuka, Atsuko| Murakami, Kazutoshi| Inoue, Kentaro| Terami, Takahiro| Katayama, Akihiro| Watanabe, Mayu| Higuchi, Chigusa| Eguchi, Jun| Miyatake, Nobuyuki| Makino, Hirofumi| |
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Published Date | 2013-01-22 |
Publication Title | BMC Nephrology |
Volume | volume14 |
Content Type | Journal Article |
Author | Teshigawara, Sanae| Wada, Jun| Hida, Kazuyuki| Nakatsuka, Atsuko| Eguchi, Jun| Murakami, Kazutoshi| Kanzaki, Motoko| Inoue, Kentaro| Terami, Takahiro| Katayama, Akihiro| Iseda, Izumi| Matsushita, Yuichi| Miyatake, Nobuyuki| McDonald, John F.| Hotta, Kikuko| Makino, Hirofumi| |
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Published Date | 2012-07 |
Publication Title | Journal of Clinical Endocrinology & Metabolism |
Volume | volume97 |
Issue | issue7 |
Content Type | Journal Article |
FullText URL | fulltext.pdf |
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Author | Sang, Yizhen| Tsuji, Kenji| Inoue-Torii, Akiko| Fukushima, Kazuhiko| Kitamura, Shinji| Wada, Jun| |
Keywords | semaphorin3A podocyte proteinuria apoptosis c-Jun N-terminal kinase |
Published Date | 2020-06-08 |
Publication Title | International Journal of Molecular Sciences |
Volume | volume21 |
Issue | issue11 |
Publisher | MDPI |
Start Page | 4099 |
ISSN | 1422-0067 |
NCID | AA12038549 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 by the authors. |
File Version | publisher |
PubMed ID | 32521824 |
DOI | 10.3390/ijms21114099 |
Web of Science KeyUT | 000543400300361 |
Related Url | isVersionOf https://doi.org/10.3390/ijms21114099 |
JaLCDOI | 10.18926/AMO/63717 |
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FullText URL | 76_3_235.pdf |
Author | Tenta, Masafumi| Eguchi, Jun| Wada, Jun| |
Abstract | The combination of sarcopenia and obesity (sarcopenic obesity) is associated with the development of metabolic syndrome and cardiovascular events. The molecular pathways that develop sarcopenic obesity have studied intensively. Transmembrane protein 97 (TMEM97) is 176 amino acids conserved integral membrane protein with four transmembrane domains that is expressed in several types of cancer. Its physiological significance in adipose tissue and skeletal muscle has been unclear. We studied TMEM97-transgenic mice and mice lacking TMEM97, and our findings indicate that TMEM97 expression is regulated in adipose tissue and skeletal muscle from obesity. TMEM97 represses adipogenesis and promotes myogenesis in vitro. Fat-specific TMEM97 transgenic mice showed systemic insulin resistance. Mice overexpressing TMEM97 in skeletal muscle exhibited systemic insulin resistance. Mice lacking TMEM97 were protected against diet-induced obesity and insulin resistance. These phenotypes are associated with the effects of TMEM97 on inflammation genes in adipose tissue and skeletal muscle. Our findings indicates that there is a link between TMEM97 and chronic inflammation in obesity. |
Keywords | adipose tissue skeletal muscle obesity |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2022-06 |
Volume | volume76 |
Issue | issue3 |
Publisher | Okayama University Medical School |
Start Page | 235 |
End Page | 245 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 35790353 |
Web of Science KeyUT | 000823568300002 |
FullText URL | fulltext.pdf |
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Author | Kurooka, Naoko| Eguchi, Jun| Wada, Jun| |
Keywords | Dibaetes GPIHBP1 Lipoprotein lipase |
Published Date | 2023-07-13 |
Publication Title | Journal of Diabetes Investigation |
Volume | volume14 |
Issue | issue10 |
Publisher | Wiley |
Start Page | 1148 |
End Page | 1156 |
ISSN | 2040-1116 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 The Authors. |
File Version | publisher |
PubMed ID | 37448184 |
DOI | 10.1111/jdi.14056 |
Web of Science KeyUT | 001024517600001 |
Related Url | isVersionOf https://doi.org/10.1111/jdi.14056 |
FullText URL | fulltext.pdf |
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Author | Sang, Yizhen| Tsuji, Kenji| Nakanoh, Hiroyuki| Fukushima, Kazuhiko| Kitamura, Shinji| Wada, Jun| |
Keywords | semaphorin 3A neuropilin-1 podocyte diabetic nephropathy acute kidney injury chronic kidney injury lupus nephritis fibrosis apoptosis inflammation |
Published Date | 2023-09-25 |
Publication Title | Diagnostics |
Volume | volume13 |
Issue | issue19 |
Publisher | MDPI |
Start Page | 3038 |
ISSN | 2075-4418 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 by the authors. |
File Version | publisher |
PubMed ID | 37835781 |
DOI | 10.3390/diagnostics13193038 |
Web of Science KeyUT | 001083705600001 |
Related Url | isVersionOf https://doi.org/10.3390/diagnostics13193038 |
JaLCDOI | 10.18926/AMO/57953 |
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FullText URL | 74_1_53.pdf |
Author | Kubota, Risa| Araki, Motoo| Wada, Koichiro| Kawamura, Kasumi| Maruyama, Yuki| Mitsui, Yosuke| Sadahira, Takuya| Ariyoshi, Yuichi| Iwata, Takehiro| Nishimura, Shingo| Takamoto, Atsushi| Sako, Tomoko| Edamura, Kohei| Kobayashi, Yasuyuki| Kano, Yuzuki| Kitagawa, Masashi| Tanabe, Katsuyuki| Sugiyama, Hitoshi| Wada, Jun| Watanabe, Masami| Watanabe, Toyohiko| Nasu, Yasutomo| |
Abstract | We investigated the feasibility of robotic renal autotransplantation (RAT) in a porcine model to reduce invasiveness of RAT. Five pigs underwent robotic RAT using the da Vinci® robotic system. A robotic left nephrectomy was performed in all cases. Robotic RAT was performed on the left side in all but one case. Four ports were used. In 3 cases, the kidney was taken out through the GelPort® and irrigated on ice with Ringer’s solution. In 2 cases, a complete intracorporeal robotic RAT was performed. An end-to-side anastomosis was performed between the renal vein and the external iliac vein and between the renal artery and the external iliac artery. Ureteroneocystostomy was also performed in 2 cases. All cases were performed robotically without open conversion. The median (IQR) console time was 3.1 (0.7) h, and the operative time was 3.8 (1.1) h. The estimated blood loss was 30 (0) ml. The warm ischemia time was 4.0 (0.2) min, and the cold ischemia time was 97 (17) min. Intracorporeal transarterial hypothermic renal perfusion was feasible in the 2 complete intracorporeal robotic RAT cases by using a perfusion catheter through a laparoscopic port. Robotic RAT has the potential to be a new minimally invasive substitute for conventional open surgery. |
Keywords | renal autotransplantation robotic porcine model transplantation |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2020-02 |
Volume | volume74 |
Issue | issue1 |
Publisher | Okayama University Medical School |
Start Page | 53 |
End Page | 58 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 32099249 |
Web of Science KeyUT | 000516606200008 |
NAID | 120006795620 |
FullText URL | fulltext.pdf |
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Author | Hayashi, Keigo| Sada, Ken-Ei| Asano, Yosuke| Hiramatsu Asano, Sumie| Yamamura, Yuriko| Ohashi, Keiji| Morishita, Michiko| Watanabe, Haruki| Narazaki, Mariko| Matsumoto, Yoshinori| Wada, Jun| |
Keywords | Nephrology Rheumatology |
Published Date | 2020-10-30 |
Publication Title | Scientific Reports |
Volume | volume10 |
Issue | issue1 |
Publisher | Nature Research |
Start Page | 18715 |
ISSN | 2045-2322 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2020 |
File Version | publisher |
PubMed ID | 33127957 |
DOI | 10.1038/s41598-020-75655-9 |
Web of Science KeyUT | 000591916900014 |
Related Url | isVersionOf https://doi.org/10.1038/s41598-020-75655-9 |
JaLCDOI | 10.18926/AMO/59949 |
---|---|
FullText URL | 74_3_191.pdf |
Author | Ohashi, Keiji| Sada, Ken-Ei| Asano, Yosuke| Hayashi, Keigo| Yamamura, Yuriko| Asano, Sumie Hiramatsu| Miyawaki, Yoshia| Morishita, Michiko| Katsuyama, Eri| Watanabe, Haruki| Tatebe, Noriko| Narazaki, Mariko| Matsumoto, Yoshinori| Sunahori-Watanabe, Katsue| Kawabata, Tomoko| Yajima, Nobuyuki| Wada, Jun| |
Abstract | Chronic damage accumulation affects not only mortality but also quality of life in patients with systemic lupus erythematosus (SLE). Risk factors for chronic damage were explored in SLE through different onset eras. Two hundred forty-five patients at Okayama University Hospital and Showa University Hospital were divided into three groups based on the onset era: a past-onset group (onset before 1995; n=83), middle-onset group (1996-2009; n=88), and recent-onset group (after 2010; n=74). The mean Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) score as an index of chronic damage was 1.93, 1.24, and 0.53 in the past-, middle-, and recent-onset groups, respectively. In the pastonset group, the total SDI score was significantly associated with glucocorticoid monotherapy by linear regression analysis (β-coefficient [β]=0.63; 95% confidence interval [CI], 0.21-1.05) and C-reactive protein levels (β=0.67; 95% CI, 0.27-1.07). In the middle-onset group, the total SDI score was significantly associated with the SLE Disease Activity Index at registration (β=0.09; 95% CI, 0.03-0.12). Reducing the accumulation of chronic damage in SLE patients might be possible with the concomitant use of immunosuppressants and tight control of disease activity. |
Keywords | systemic lupus erythematosus chronic damage glucocorticoids, disease activity disease duration |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2020-06 |
Volume | volume74 |
Issue | issue3 |
Publisher | Okayama University Medical School |
Start Page | 191 |
End Page | 198 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 32577016 |
Web of Science KeyUT | 000543363400002 |
NAID | 120006862791 |
FullText URL | SR9_1_3054.pdf |
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Author | Hiramatsu, Sumie| Watanabe, Katsue S.| Zeggar, Sonia| Asano, Yosuke| Miyawaki, Yoshia| Yamamura, Yuriko| Katsuyama, Eri| Katsuyama, Takayuki| Watanabe, Haruki| Takano-Narazaki, Mariko| Matsumoto, Yoshinori| Kawabata, Tomoko| Sada, Ken-Ei| Wada, Jun| |
Published Date | 2019-2-28 |
Publication Title | Scientific Reports |
Volume | volume9 |
Publisher | Nature Publishing Group |
Start Page | 3054 |
ISSN | 2045-2322 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2019 |
File Version | publisher |
PubMed ID | 30816218 |
DOI | 10.1038/s41598-019-38809-y |
Web of Science KeyUT | 000459891700064 |
Related Url | isVersionOf https://doi.org/10.1038/s41598-019-38809-y |
JaLCDOI | 10.18926/AMO/66927 |
---|---|
FullText URL | 78_2_185.pdf |
Author | Takahashi, Hiroko| Eguchi, Jun| Watanabe, Mayu| Nakayama, Masanori| Wada, Jun| |
Abstract | The global pandemic of coronavirus infection 2019 (COVID-19) was an unprecedented public health emergency. Several clinical studies reported that heart disease, lung disease, diabetes, hypertension, dyslipidemia, and obesity are critical risk factors for increased severity of and hospitalization for COVID-19. This is largely because patients with these underlying medical conditions can show poor immune responses to the COVID-19 vaccinations. Diabetes is one of the underlying conditions most highly associated with COVID-19 susceptibility and is considered a predictor of poor prognosis of COVID-19. We therefore investigated factors that influence the anti-SARS-CoV-2 spike IgG antibody titer after three doses of vaccination in patients with type 2 diabetes. We found that obesity was associated with low anti-SARS-CoV-2 spike IgG antibody titers following three-dose vaccination in type 2 diabetics. Obese patients with type 2 diabetes may have attenuated vaccine efficacy and require additional vaccination; continuous infection control should be considered in such patients. |
Keywords | obesity type 2 diabetes COVID-19 vaccination |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2024-04 |
Volume | volume78 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 185 |
End Page | 191 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
FullText URL | fulltext.pdf |
---|---|
Author | Yamamura, Yuriko| Matsumoto, Yoshinori| Tadokoro, Koh| Ohta, Yasuyuki| Sato, Kota| Yamashita, Toru| Yamamura, Masahiro| Sada, Ken-Ei| Abe, Koji| Wada, Jun| |
Keywords | Noninvasive pressure support ventilation Statin-associated necrotizing myopathy BIPAP |
Published Date | 2020-06-03 |
Publication Title | BMC Pulmonary Medicine |
Volume | volume20 |
Issue | issue1 |
Publisher | BMC |
Start Page | 156 |
ISSN | 1471-2466 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s). 2020 |
File Version | publisher |
PubMed ID | 32493279 |
DOI | 10.1186/s12890-020-01195-7 |
Web of Science KeyUT | 000540247100001 |
Related Url | isVersionOf https://doi.org/10.1186/s12890-020-01195-7 |