FullText URL fulltext.pdf
Author Matsuoka-Uchiyama, Natsumi| Uchida, Haruhito A.| Okamoto, Shugo| Onishi, Yasuhiro| Katayama, Katsuyoshi| Tsuchida-Nishiwaki, Mariko| Takeuchi, Hidemi| Takemoto, Rika| Hada, Yoshiko| Umebayashi, Ryoko| Kurooka, Naoko| Tsuji, Kenji| Eguchi, Jun| Nakajima, Hirofumi| Shikata, Kenichi| Wada, Jun|
Published Date 2022-01-10
Publication Title Journal Of Diabetes Research
Volume volume2022
Publisher Hindawi Ltd.
Start Page 3157841
ISSN 2314-6745
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 Natsumi Matsuoka-Uchiyama et al.
File Version publisher
PubMed ID 35047644
DOI 10.1155/2022/3157841
Web of Science KeyUT 000774919000001
Related Url isVersionOf https://doi.org/10.1155/2022/3157841
FullText URL fulltext20220509-2.pdf
Author Matsumoto, Yoshinori| Dimitriou, Ioannis D.| La Rose, Jose| Lim, Melissa| Camilleri, Susan| Law, Napoleon| Adissu, Hibret A.| Tong, Jiefei| Moran, Michael F.| Chruscinski, Andrzej| He, Fang| Asano, Yosuke| Katsuyama, Takayuki| Sada, Ken-ei| Wada, Jun| Rottapel, Robert|
Published Date 2022-4-1
Publication Title Journal of Clinical Investigation
Volume volume132
Issue issue7
Publisher American Society for Clinical Investigation
Start Page e140869
ISSN 1558-8238
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022, Matsumoto et al.
File Version publisher
PubMed ID 35274528
DOI 10.1172/jci140869
Web of Science KeyUT 000783678600007
Related Url isVersionOf https://doi.org/10.1172/jci140869
FullText URL fulltext.pdf
Author Oda, Kaori| Miyamoto, Satoshi| Kodera, Ryo| Wada, Jun| Shikata, Kenichi|
Keywords Diabetic kidney disease Inflammasomes Suramin
Published Date 2022-10-29
Publication Title Journal Of Diabetes Investigation
Volume volume14
Issue issue2
Publisher Wiley
Start Page 205
End Page 220
ISSN 2040-1116
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Authors.
File Version publisher
PubMed ID 36308062
DOI 10.1111/jdi.13930
Web of Science KeyUT 000875614000001
Related Url isVersionOf https://doi.org/10.1111/jdi.13930
JaLCDOI 10.18926/AMO/54514
FullText URL 70_4_327.pdf
Author Watanabe, Mototsugu| Yamamoto, Hiromasa| Eikawa, Shingo| Shien, Kazuhiko| Shien, Tadahiko| Soh, Junichi| Hotta, Katsuyuki| Wada, Jun| Hinotsu, Shiro| Fujiwara, Toshiyoshi| Kiura, Katsuyuki| Doihara, Hiroyoshi| Miyoshi, Shinichiro| Udono, Heiichiro| Toyooka, Shinichi|
Abstract A study to evaluate the effect of metformin on the immune system was commenced in July 2014. Metformin is one of the most commonly prescribed drugs for type 2 diabetes, and previous studies have reported that metformin has an anti-tumor effect. The aim of this study is to evaluate the efficacy of metformin on the immune system in human cancer patients in vivo. The primary outcome parameter will be the rate change in the population of CD8+ T cells, which produce multiple cytokines.
Keywords metformin CD8+ T cells cancer immunology
Amo Type Clinical Study Protocols
Publication Title Acta Medica Okayama
Published Date 2016-08
Volume volume70
Issue issue4
Publisher Okayama University Medical School
Start Page 327
End Page 330
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27549683
Web of Science KeyUT 000384748600018
FullText URL fulltext.pdf
Author Fukushima, Kazuhiko| Kitamura, Shinji| Tsuji, Kenji| Sang, Yizhen| Wada, Jun|
Keywords sodium glucose co-transporter 2 inhibitor mammalian target of rapamycin (mTOR) autophagy obesity multi lamellar body
Published Date 2020-06-05
Publication Title International Journal of Molecular Sciences
Volume volume21
Issue issue11
Publisher MDPI
Start Page 4054
ISSN 1422-0067
NCID AA12038549
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors
File Version publisher
PubMed ID 32517059
DOI 10.3390/ijms21114054
Web of Science KeyUT 000543400300316
Related Url isVersionOf https://doi.org/10.3390/ijms21114054
FullText URL fulltext20220708-4.pdf nep-supinfo.pdf
Author Tsuji, Kenji| Kitamura, Shinji| Uchida, Haruhito A.| Wada, Jun|
Keywords Renal biopsy clinical nephrology ultrasound
Note This is the peer reviewed version of the following article: [Tsuji, K, Kitamura, S, Uchida, HA, Wada, J. Simulation for ultrasound-guided renal biopsy using boiled egg. Nephrology. 2022; 27( 9): 753- 757. doi:10.1111/nep.14079], which has been published in final form at [https://doi.org/10.1111/nep.14079]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
This fulltext is available in June 2023.|
Published Date 2022-06-28
Publication Title Nephrology
Volume volume27
Issue issue9
Publisher Wiley
Start Page 753
End Page 757
ISSN 1320-5358
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 Asian Pacific Society of Nephrology.
File Version author
PubMed ID 35762140
DOI 10.1111/nep.14079
Web of Science KeyUT 000816988200001
Related Url isVersionOf https://doi.org/10.1111/nep.14079
FullText URL fulltext.pdf
Author Fukushima, Kazuhiko| Uchida, Haruhito A.| Fuchimoto, Yasuko| Mifune, Tomoyo| Watanabe, Mayu| Tsuji, Kenji| Tanabe, Katsuyuki| Kinomura, Masaru| Kitamura, Shinji| Miyamoto, Yosuke| Wada, Sae| Koyanagi, Taisaku| Sugiyama, Hitoshi| Kishimoto, Takumi| Wada, Jun|
Keywords lupus nephritis lupus pneumonitis silicosis SLE
Published Date 2022-02-18
Publication Title Medicine
Volume volume101
Issue issue7
Publisher Lippincott Williams & Wilkins
Start Page e28872
ISSN 0025-7974
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 the Author(s).
File Version publisher
PubMed ID 35363197
DOI 10.1097/MD.0000000000028872
Web of Science KeyUT 000776738500059
Related Url isVersionOf https://doi.org/10.1097/MD.0000000000028872
FullText URL fulltext.pdf
Author Tanaka, Keiko| Sugiyama, Hitoshi| Morinaga, Hiroshi| Kitagawa, Masashi| Kano, Yuzuki| Onishi, Yasuhiro| Mise, Koki| Tanabe, Katsuyuki| Uchida, Haruhito A.| Wada, Jun|
Keywords IgA nephropathy cytokines sCD40L IL-31 proteinuria inflammation interstitial fibrosis
Published Date 2023-03-03
Publication Title Journal of Clinical Medicine
Volume volume12
Issue issue5
Publisher MDPI
Start Page 2023
ISSN 2077-0383
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 by the authors.
File Version publisher
PubMed ID 36902810
DOI 10.3390/jcm12052023
Web of Science KeyUT 000947139700001
Related Url isVersionOf https://doi.org/10.3390/jcm12052023
Author Kurose, Yuko| Wada, Jun| Kanzaki, Motoko| Teshigawara, Sanae| Nakatsuka, Atsuko| Murakami, Kazutoshi| Inoue, Kentaro| Terami, Takahiro| Katayama, Akihiro| Watanabe, Mayu| Higuchi, Chigusa| Eguchi, Jun| Miyatake, Nobuyuki| Makino, Hirofumi|
Published Date 2013-01-22
Publication Title BMC Nephrology
Volume volume14
Content Type Journal Article
Author Teshigawara, Sanae| Wada, Jun| Hida, Kazuyuki| Nakatsuka, Atsuko| Eguchi, Jun| Murakami, Kazutoshi| Kanzaki, Motoko| Inoue, Kentaro| Terami, Takahiro| Katayama, Akihiro| Iseda, Izumi| Matsushita, Yuichi| Miyatake, Nobuyuki| McDonald, John F.| Hotta, Kikuko| Makino, Hirofumi|
Published Date 2012-07
Publication Title Journal of Clinical Endocrinology & Metabolism
Volume volume97
Issue issue7
Content Type Journal Article
FullText URL fulltext.pdf
Author Sang, Yizhen| Tsuji, Kenji| Inoue-Torii, Akiko| Fukushima, Kazuhiko| Kitamura, Shinji| Wada, Jun|
Keywords semaphorin3A podocyte proteinuria apoptosis c-Jun N-terminal kinase
Published Date 2020-06-08
Publication Title International Journal of Molecular Sciences
Volume volume21
Issue issue11
Publisher MDPI
Start Page 4099
ISSN 1422-0067
NCID AA12038549
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 32521824
DOI 10.3390/ijms21114099
Web of Science KeyUT 000543400300361
Related Url isVersionOf https://doi.org/10.3390/ijms21114099
JaLCDOI 10.18926/AMO/63717
FullText URL 76_3_235.pdf
Author Tenta, Masafumi| Eguchi, Jun| Wada, Jun|
Abstract The combination of sarcopenia and obesity (sarcopenic obesity) is associated with the development of metabolic syndrome and cardiovascular events. The molecular pathways that develop sarcopenic obesity have studied intensively. Transmembrane protein 97 (TMEM97) is 176 amino acids conserved integral membrane protein with four transmembrane domains that is expressed in several types of cancer. Its physiological significance in adipose tissue and skeletal muscle has been unclear. We studied TMEM97-transgenic mice and mice lacking TMEM97, and our findings indicate that TMEM97 expression is regulated in adipose tissue and skeletal muscle from obesity. TMEM97 represses adipogenesis and promotes myogenesis in vitro. Fat-specific TMEM97 transgenic mice showed systemic insulin resistance. Mice overexpressing TMEM97 in skeletal muscle exhibited systemic insulin resistance. Mice lacking TMEM97 were protected against diet-induced obesity and insulin resistance. These phenotypes are associated with the effects of TMEM97 on inflammation genes in adipose tissue and skeletal muscle. Our findings indicates that there is a link between TMEM97 and chronic inflammation in obesity.
Keywords adipose tissue skeletal muscle obesity
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-06
Volume volume76
Issue issue3
Publisher Okayama University Medical School
Start Page 235
End Page 245
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 35790353
Web of Science KeyUT 000823568300002
FullText URL fulltext.pdf
Author Kurooka, Naoko| Eguchi, Jun| Wada, Jun|
Keywords Dibaetes GPIHBP1 Lipoprotein lipase
Published Date 2023-07-13
Publication Title Journal of Diabetes Investigation
Volume volume14
Issue issue10
Publisher Wiley
Start Page 1148
End Page 1156
ISSN 2040-1116
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 The Authors.
File Version publisher
PubMed ID 37448184
DOI 10.1111/jdi.14056
Web of Science KeyUT 001024517600001
Related Url isVersionOf https://doi.org/10.1111/jdi.14056
FullText URL fulltext.pdf
Author Sang, Yizhen| Tsuji, Kenji| Nakanoh, Hiroyuki| Fukushima, Kazuhiko| Kitamura, Shinji| Wada, Jun|
Keywords semaphorin 3A neuropilin-1 podocyte diabetic nephropathy acute kidney injury chronic kidney injury lupus nephritis fibrosis apoptosis inflammation
Published Date 2023-09-25
Publication Title Diagnostics
Volume volume13
Issue issue19
Publisher MDPI
Start Page 3038
ISSN 2075-4418
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 by the authors.
File Version publisher
PubMed ID 37835781
DOI 10.3390/diagnostics13193038
Web of Science KeyUT 001083705600001
Related Url isVersionOf https://doi.org/10.3390/diagnostics13193038
JaLCDOI 10.18926/AMO/57953
FullText URL 74_1_53.pdf
Author Kubota, Risa| Araki, Motoo| Wada, Koichiro| Kawamura, Kasumi| Maruyama, Yuki| Mitsui, Yosuke| Sadahira, Takuya| Ariyoshi, Yuichi| Iwata, Takehiro| Nishimura, Shingo| Takamoto, Atsushi| Sako, Tomoko| Edamura, Kohei| Kobayashi, Yasuyuki| Kano, Yuzuki| Kitagawa, Masashi| Tanabe, Katsuyuki| Sugiyama, Hitoshi| Wada, Jun| Watanabe, Masami| Watanabe, Toyohiko| Nasu, Yasutomo|
Abstract We investigated the feasibility of robotic renal autotransplantation (RAT) in a porcine model to reduce invasiveness of RAT. Five pigs underwent robotic RAT using the da Vinci® robotic system. A robotic left nephrectomy was performed in all cases. Robotic RAT was performed on the left side in all but one case. Four ports were used. In 3 cases, the kidney was taken out through the GelPort® and irrigated on ice with Ringer’s solution. In 2 cases, a complete intracorporeal robotic RAT was performed. An end-to-side anastomosis was performed between the renal vein and the external iliac vein and between the renal artery and the external iliac artery. Ureteroneocystostomy was also performed in 2 cases. All cases were performed robotically without open conversion. The median (IQR) console time was 3.1 (0.7) h, and the operative time was 3.8 (1.1) h. The estimated blood loss was 30 (0) ml. The warm ischemia time was 4.0 (0.2) min, and the cold ischemia time was 97 (17) min. Intracorporeal transarterial hypothermic renal perfusion was feasible in the 2 complete intracorporeal robotic RAT cases by using a perfusion catheter through a laparoscopic port. Robotic RAT has the potential to be a new minimally invasive substitute for conventional open surgery.
Keywords renal autotransplantation robotic porcine model transplantation
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-02
Volume volume74
Issue issue1
Publisher Okayama University Medical School
Start Page 53
End Page 58
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32099249
Web of Science KeyUT 000516606200008
NAID 120006795620
FullText URL fulltext.pdf
Author Hayashi, Keigo| Sada, Ken-Ei| Asano, Yosuke| Hiramatsu Asano, Sumie| Yamamura, Yuriko| Ohashi, Keiji| Morishita, Michiko| Watanabe, Haruki| Narazaki, Mariko| Matsumoto, Yoshinori| Wada, Jun|
Keywords Nephrology Rheumatology
Published Date 2020-10-30
Publication Title Scientific Reports
Volume volume10
Issue issue1
Publisher Nature Research
Start Page 18715
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2020
File Version publisher
PubMed ID 33127957
DOI 10.1038/s41598-020-75655-9
Web of Science KeyUT 000591916900014
Related Url isVersionOf https://doi.org/10.1038/s41598-020-75655-9
JaLCDOI 10.18926/AMO/59949
FullText URL 74_3_191.pdf
Author Ohashi, Keiji| Sada, Ken-Ei| Asano, Yosuke| Hayashi, Keigo| Yamamura, Yuriko| Asano, Sumie Hiramatsu| Miyawaki, Yoshia| Morishita, Michiko| Katsuyama, Eri| Watanabe, Haruki| Tatebe, Noriko| Narazaki, Mariko| Matsumoto, Yoshinori| Sunahori-Watanabe, Katsue| Kawabata, Tomoko| Yajima, Nobuyuki| Wada, Jun|
Abstract Chronic damage accumulation affects not only mortality but also quality of life in patients with systemic lupus erythematosus (SLE). Risk factors for chronic damage were explored in SLE through different onset eras. Two hundred forty-five patients at Okayama University Hospital and Showa University Hospital were divided into three groups based on the onset era: a past-onset group (onset before 1995; n=83), middle-onset group (1996-2009; n=88), and recent-onset group (after 2010; n=74). The mean Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) score as an index of chronic damage was 1.93, 1.24, and 0.53 in the past-, middle-, and recent-onset groups, respectively. In the pastonset group, the total SDI score was significantly associated with glucocorticoid monotherapy by linear regression analysis (β-coefficient [β]=0.63; 95% confidence interval [CI], 0.21-1.05) and C-reactive protein levels (β=0.67; 95% CI, 0.27-1.07). In the middle-onset group, the total SDI score was significantly associated with the SLE Disease Activity Index at registration (β=0.09; 95% CI, 0.03-0.12). Reducing the accumulation of chronic damage in SLE patients might be possible with the concomitant use of immunosuppressants and tight control of disease activity.
Keywords systemic lupus erythematosus chronic damage glucocorticoids, disease activity disease duration
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-06
Volume volume74
Issue issue3
Publisher Okayama University Medical School
Start Page 191
End Page 198
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32577016
Web of Science KeyUT 000543363400002
NAID 120006862791
FullText URL SR9_1_3054.pdf
Author Hiramatsu, Sumie| Watanabe, Katsue S.| Zeggar, Sonia| Asano, Yosuke| Miyawaki, Yoshia| Yamamura, Yuriko| Katsuyama, Eri| Katsuyama, Takayuki| Watanabe, Haruki| Takano-Narazaki, Mariko| Matsumoto, Yoshinori| Kawabata, Tomoko| Sada, Ken-Ei| Wada, Jun|
Published Date 2019-2-28
Publication Title Scientific Reports
Volume volume9
Publisher Nature Publishing Group
Start Page 3054
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2019
File Version publisher
PubMed ID 30816218
DOI 10.1038/s41598-019-38809-y
Web of Science KeyUT 000459891700064
Related Url isVersionOf https://doi.org/10.1038/s41598-019-38809-y
JaLCDOI 10.18926/AMO/66927
FullText URL 78_2_185.pdf
Author Takahashi, Hiroko| Eguchi, Jun| Watanabe, Mayu| Nakayama, Masanori| Wada, Jun|
Abstract The global pandemic of coronavirus infection 2019 (COVID-19) was an unprecedented public health emergency. Several clinical studies reported that heart disease, lung disease, diabetes, hypertension, dyslipidemia, and obesity are critical risk factors for increased severity of and hospitalization for COVID-19. This is largely because patients with these underlying medical conditions can show poor immune responses to the COVID-19 vaccinations. Diabetes is one of the underlying conditions most highly associated with COVID-19 susceptibility and is considered a predictor of poor prognosis of COVID-19. We therefore investigated factors that influence the anti-SARS-CoV-2 spike IgG antibody titer after three doses of vaccination in patients with type 2 diabetes. We found that obesity was associated with low anti-SARS-CoV-2 spike IgG antibody titers following three-dose vaccination in type 2 diabetics. Obese patients with type 2 diabetes may have attenuated vaccine efficacy and require additional vaccination; continuous infection control should be considered in such patients.
Keywords obesity type 2 diabetes COVID-19 vaccination
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2024-04
Volume volume78
Issue issue2
Publisher Okayama University Medical School
Start Page 185
End Page 191
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
FullText URL fulltext.pdf
Author Yamamura, Yuriko| Matsumoto, Yoshinori| Tadokoro, Koh| Ohta, Yasuyuki| Sato, Kota| Yamashita, Toru| Yamamura, Masahiro| Sada, Ken-Ei| Abe, Koji| Wada, Jun|
Keywords Noninvasive pressure support ventilation Statin-associated necrotizing myopathy BIPAP
Published Date 2020-06-03
Publication Title BMC Pulmonary Medicine
Volume volume20
Issue issue1
Publisher BMC
Start Page 156
ISSN 1471-2466
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2020
File Version publisher
PubMed ID 32493279
DOI 10.1186/s12890-020-01195-7
Web of Science KeyUT 000540247100001
Related Url isVersionOf https://doi.org/10.1186/s12890-020-01195-7