ID | 65037 |
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Tanaka, Keiko
Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences
Sugiyama, Hitoshi
Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences
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Morinaga, Hiroshi
Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences
Kitagawa, Masashi
Department of Nephrology, National Hospital Organization Okayama Medical Center
Kano, Yuzuki
Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences
Onishi, Yasuhiro
Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences
Mise, Koki
Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences
Tanabe, Katsuyuki
Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences
Uchida, Haruhito A.
Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences
Wada, Jun
Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences
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Abstract | Background: IgA nephropathy (IgAN) is a major cause of chronic glomerulonephritis worldwide. T cell dysregulation has been reported to contribute to the pathogenesis of IgAN. Methods We measured a broad range of Th1, Th2 and Th17 cytokines in the serum of IgAN patients. We searched for significant cytokines, which were associated with clinical parameters and histological scores in IgAN patients. Results: Among 15 cytokines, the levels of soluble CD40L (sCD40L) and IL-31 were higher in IgAN patients and were significantly associated with a higher estimated glomerular filtration rate (eGFR), a lower urinary protein to creatinine ratio (UPCR), and milder tubulointerstitial lesions (i.e., the early phase of IgAN). Multivariate analysis revealed that serum sCD40L was an independent determinant of a lower UPCR after adjustment for age, eGFR, and mean blood pressure (MBP). CD40, a receptor of sCD40L, has been reported to be upregulated on mesangial cells in IgAN. The sCD40L/CD40 interaction may directly induce inflammation in mesangial areas and may therefore be involved in the development of IgAN. Conclusions: The present study demonstrated the significance of serum sCD40L and IL-31 in the early phase of IgAN. Serum sCD40L may be a marker of the beginning of inflammation in IgAN.
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Keywords | IgA nephropathy
cytokines
sCD40L
IL-31
proteinuria
inflammation
interstitial fibrosis
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Published Date | 2023-03-03
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Publication Title |
Journal of Clinical Medicine
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Volume | volume12
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Issue | issue5
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Publisher | MDPI
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Start Page | 2023
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ISSN | 2077-0383
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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Copyright Holders | © 2023 by the authors.
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File Version | publisher
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Related Url | isVersionOf https://doi.org/10.3390/jcm12052023
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License | https://creativecommons.org/licenses/by/4.0/
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Citation | Tanaka, K.; Sugiyama, H.; Morinaga, H.; Kitagawa, M.; Kano, Y.; Onishi, Y.; Mise, K.; Tanabe, K.; Uchida, H.A.;Wada, J. Serum sCD40L and IL-31 in Association with Early Phase of IgA Nephropathy. J. Clin. Med. 2023, 12, 2023. https://doi.org/10.3390/jcm12052023
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