FullText URL fulltext.pdf
Author Kondo, Hiroya| Tazawa, Hiroshi| Fujiwara, Tomohiro| Yoshida, Aki| Kure, Miho| Demiya, Koji| Kanaya, Nobuhiko| Hata, Toshiaki| Uotani, Koji| Hasei, Joe| Kunisada, Toshiyuki| Kagawa, Shunsuke| Yoshioka, Yusuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi|
Keywords Osteosarcoma Lung metastasis Tumor-associated macrophage CCL2 Extracellular vesicle
Note The version of record of this article, first published in Cancer Immunology, Immunotherapy, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00262-025-04051-x|
Published Date 2025-05-09
Publication Title Cancer Immunology, Immunotherapy
Volume volume74
Issue issue7
Publisher Springer
Start Page 193
ISSN 0340-7004
NCID AA00598499
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025
File Version publisher
PubMed ID 40343498
DOI 10.1007/s00262-025-04051-x
Web of Science KeyUT 001485530100002
Related Url isVersionOf https://doi.org/10.1007/s00262-025-04051-x
FullText URL fulltext.pdf
Author Chen, Yuehua| Ohara, Toshiaki| Hamada, Yusuke| Wang, Yuze| Tian, Miao| Noma, Kazuhiro| Tazawa, Hiroshi| Fujisawa, Masayoshi| Yoshimura, Teizo| Matsukawa, Akihiro|
Keywords Colorectal cancer Microsatellite stable Hypoxia-inducible factor Immune checkpoint inhibitors
Note The version of record of this article, first published in Cancer Immunology, Immunotherapy, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00262-025-04067-3|
Published Date 2025-05-09
Publication Title Cancer Immunology, Immunotherapy
Volume volume74
Issue issue7
Publisher Springer
Start Page 192
ISSN 0340-7004
NCID AA00598499
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025
File Version publisher
PubMed ID 40343532
DOI 10.1007/s00262-025-04067-3
Web of Science KeyUT 001485530100001
Related Url isVersionOf https://doi.org/10.1007/s00262-025-04067-3
FullText URL fulltext.pdf
Author Umeda, Hibiki| Shigeyasu, Kunitoshi| Takahashi, Toshiaki| Moriwake, Kazuya| Kondo, Yoshitaka| Yoshida, Kazuhiro| Takeda, Sho| Yano, Shuya| Matsumi, Yuki| Kishimoto, Hiroyuki| Fuji, Tomokazu| Yasui, Kazuya| Yamamoto, Hideki| Takagi, Kosei| Kayano, Masashi| Michiue, Hiroyuki| Nakamura, Keiichiro| Mori, Yoshiko| Teraishi, Fuminori| Tazawa, Hiroshi| Umeda, Yuzo| Kagawa, Shunsuke| Goel, Ajay| Fujiwara, Toshiyoshi|
Keywords RNA-editing Macrophage Chemoresistance Biomarker Colorectal cancer
Published Date 2025-04-16
Publication Title Molecular Cancer
Volume volume24
Issue issue1
Publisher BMC
Start Page 116
ISSN 1476-4598
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025.
File Version publisher
PubMed ID 40241135
DOI 10.1186/s12943-025-02312-y
Web of Science KeyUT 001470204500003
Related Url isVersionOf https://doi.org/10.1186/s12943-025-02312-y
FullText URL fulltext.pdf
Author Yagi, Tomohiko| Kagawa, Shunsuke| Nogi, Shohei| Taniguchi, Atsuki| Yoshimoto, Masashi| Suemori, Kanto| Nagai, Yasuo| Fujita, Shuto| Kuroda, Shinji| Kikuchi, Satoru| Kakiuchi, Yoshihiko| Teraishi, Fuminori| Takagi, Kosei| Ohara, Toshiaki| Tazawa, Hiroshi| Fujiwara, Toshiyoshi|
Keywords Cancer-associated fibroblasts Neutrophil Anti-fibrotic agent Pirfenidone
Published Date 2025-02-04
Publication Title Cancer Immunology, Immunotherapy
Volume volume74
Issue issue3
Publisher Springer
Start Page 96
ISSN 0340-7004
NCID AA00598499
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025
File Version publisher
PubMed ID 39904796
DOI 10.1007/s00262-025-03946-z
Web of Science KeyUT 001413348800005
Related Url isVersionOf https://doi.org/10.1007/s00262-025-03946-z
FullText URL fulltext.pdf
Author Mitsui, Ema| Kikuchi, Satoru| Okura, Tomohiro| Tazawa, Hiroshi| Une, Yuta| Nishiwaki, Noriyuki| Kuroda, Shinji| Noma, Kazuhiro| Kagawa, Shunsuke| Ohara, Toshiaki| Ohtsuka, Junko| Ohki, Rieko| Fujiwara, Toshiyoshi|
Keywords Peritoneal metastasis Gastric cancer Interleukin-6 Cancer-associated fibroblasts Interleukin-6 receptor antibody
Published Date 2025-01-25
Publication Title Scientific Reports
Volume volume15
Issue issue1
Publisher Nature Portfolio
Start Page 3267
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025
File Version publisher
PubMed ID 39863722
DOI 10.1038/s41598-025-88033-0
Web of Science KeyUT 001406498300020
Related Url isVersionOf https://doi.org/10.1038/s41598-025-88033-0
FullText URL fulltext.pdf
Author Ohtani, Tomoko| Kuroda, Shinji| Kanaya, Nobuhiko| Kakiuchi, Yoshihiko| Kumon, Kento| Hashimoto, Masashi| Yagi, Chiaki| Sugimoto, Ryoma| Kikuchi, Satoru| Kagawa, Shunsuke| Tazawa, Hiroshi| Urata, Yasuo| Fujiwara, Toshiyoshi|
Keywords Oncolytic adenovirus p53 Dendritic cells Anti-tumor immunity Exosome
Note The version of record of this article, first published in Cancer Immunology, Immunotherapy, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00262-024-03849-5|
Published Date 2024-11-05
Publication Title Cancer Immunology, Immunotherapy
Volume volume74
Issue issue1
Publisher Springer Science and Business Media LLC
Start Page 12
ISSN 1432-0851
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2024
File Version publisher
PubMed ID 39499326
DOI 10.1007/s00262-024-03849-5
Web of Science KeyUT 001350703400001
Related Url isVersionOf https://doi.org/10.1007/s00262-024-03849-5
FullText URL fulltext20240701-01.pdf fig20240701-01.pdf
Author LI, YUNCHENG| TAZAWA, HIROSHI| NAGAI, YASUO| FUJITA, SHUTO| OKURA, TOMOHIRO| SHOJI, RYOHEI| YAMADA, MOTOHIKO| KIKUCHI, SATORU| KURODA, SHINJI| OHARA, TOSHIAKI| NOMA, KAZUHIRO| NISHIZAKI, MASAHIKO| KAGAWA, SHUNSUKE| FUJIWARA, TOSHIYOSHI|
Keywords Gastric cancer peritoneal metastasis senescent fibroblast IL-8 CXCR1/2
Note This is an Accepted Manuscript of an article published by International Institute of Anticancer Research.| This fulltext file will be available in Dec. 2024.|
Published Date 2024-05-31
Publication Title Anticancer Research
Volume volume44
Issue issue6
Publisher International Institute of Anticancer Research
Start Page 2497
End Page 2509
ISSN 0250-7005
NCID AA10625860
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 International Institute of Anticancer Research (Dr. George J. Delinasios)
File Version author
PubMed ID 38821603
DOI 10.21873/anticanres.17056
Web of Science KeyUT 001249685300009
Related Url isVersionOf https://doi.org/10.21873/anticanres.17056
FullText URL fulltext.pdf
Author Kawasaki, Kento| Noma, Kazuhiro| Kato, Takuya| Ohara, Toshiaki| Tanabe, Shunsuke| Takeda, Yasushige| Matsumoto, Hijiri| Nishimura, Seitaro| Kunitomo, Tomoyoshi| Akai, Masaaki| Kobayashi, Teruki| Nishiwaki, Noriyuki| Kashima, Hajime| Maeda, Naoaki| Kikuchi, Satoru| Tazawa, Hiroshi| Shirakawa, Yasuhiro| Fujiwara, Toshiyoshi|
Keywords Esophageal cancer Cancer-associated fibroblasts Programmed cell death 1 Program cell death ligand 1 Immune checkpoint inhibitors
Note The version of record of this article, first published in Cancer Immunology, Immunotherapy, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00262-023-03531-2|
Published Date 2023-09-05
Publication Title Cancer Immunology, Immunotherapy
Volume volume72
Issue issue11
Publisher Springer Science and Business Media LLC
Start Page 3787
End Page 3802
ISSN 0340-7004
NCID AA00598499
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2023
File Version publisher
PubMed ID 37668710
DOI 10.1007/s00262-023-03531-2
Web of Science KeyUT 001062743200002
Related Url isVersionOf https://doi.org/10.1007/s00262-023-03531-2
FullText URL fulltext.pdf
Author Uotani, Koji| Tazawa, Hiroshi| Hasei, Joe| Fujiwara, Tomohiro| Yoshida, Aki| Yamakawa, Yasuaki| Omori, Toshinori| Sugiu, Kazuhisa| Komatsubara, Tadashi| Kondo, Hiroya| Morita, Takuya| Kiyono, Masahiro| Yokoo, Suguru| Hata, Toshiaki| Kunisada, Toshiyuki| Takeda, Ken| Urata, Yasuo| Fujiwara, Toshiyoshi| Ozaki, Toshifumi|
Published Date 2024-02-20
Publication Title PLoS ONE
Volume volume19
Issue issue2
Publisher Public Library of Science
Start Page e0298292
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 Uotani et al.
File Version publisher
PubMed ID 38377118
DOI 10.1371/journal.pone.0298292
Web of Science KeyUT 001176939600021
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0298292
JaLCDOI 10.18926/AMO/66924
FullText URL 78_2_151.pdf
Author Komatsubara, Tadashi| Tazawa, Hiroshi| Hasei, Joe| Omori, Toshinori| Sugiu, Kazuhisa| Mochizuki, Yusuke| Demiya, Koji| Yoshida, Aki| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi|
Abstract Soft-tissue sarcoma (STS) is a heterogeneous group of rare tumors originating predominantly from the embryonic mesoderm. Despite the development of combined modalities including radiotherapy, STSs are often refractory to antitumor modalities, and novel strategies that improve the prognosis of STS patients are needed. We previously demonstrated the therapeutic potential of two telomerase-specific replication-competent oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in human STS cells. Here, we demonstrate in vitro and in vivo antitumor effects of OBP-702 in combination with ionizing radiation against human STS cells (HT1080, NMS-2, SYO-1). OBP-702 synergistically promoted the antitumor effect of ionizing radiation in the STS cells by suppressing the expression of B-cell lymphoma-X large (BCL-xL) and enhancing ionizing radiation-induced apoptosis. The in vivo experiments demonstrated that this combination therapy significantly suppressed STS tumors’ growth. Our results suggest that OBP-702 is a promising antitumor reagent for promoting the radiosensitivity of STS tumors.
Keywords soft-tissue sarcoma radiotherapy oncolytic adenovirus p53 BCL-xL
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2024-04
Volume volume78
Issue issue2
Publisher Okayama University Medical School
Start Page 151
End Page 161
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38688833
Web of Science KeyUT 001229151800007
FullText URL fulltext20240219-05.pdf
Author Hashimoto, Masashi| Kuroda, Shinji| Kanaya, Nobuhiko| Kadowaki, Daisuke| Yoshida, Yusuke| Sakamoto, Masaki| Hamada, Yuki| Sugimoto, Ryoma| Yagi, Chiaki| Ohtani, Tomoko| Kumon, Kento| Kakiuchi, Yoshihiko| Yasui, Kazuya| Kikuchi, Satoru| Yoshida, Ryuichi| Tazawa, Hiroshi| Kagawa, Shunsuke| Yagi, Takahito| Urata, Yasuo| Fujiwara, Toshiyoshi|
Note The version of record of this article, first published in British Journal of Cancer, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41416-024-02583-0|
Published Date 2024-02-05
Publication Title British Journal of Cancer
Volume volume130
Issue issue7
Publisher Springer Science and Business Media LLC
Start Page 1187
End Page 1195
ISSN 0007-0920
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2024
File Version publisher
PubMed ID 38316993
DOI 10.1038/s41416-024-02583-0
Web of Science KeyUT 001156904400001
Related Url isVersionOf https://doi.org/10.1038/s41416-024-02583-0
FullText URL fulltext.pdf
Author Tamura, Shuta| Tazawa, Hiroshi| Hori, Naoto| Li, Yuncheng| Yamada, Motohiko| Kikuchi, Satoru| Kuroda, Shinji| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Published Date 2023-11-16
Publication Title PLoS ONE
Volume volume18
Issue issue11
Publisher Public Library of Science
Start Page e0294491
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Tamura et al.
File Version publisher
PubMed ID 37972012
DOI 10.1371/journal.pone.0294491
Web of Science KeyUT 001119675000083
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0294491
FullText URL fulltext20230720-02.pdf fig20230720-02.pdf suppl_table20230720-02.pdf suppl_fig20230720-02.pdf
Author Yoshimoto, Masashi| Kagawa, Shunsuke| Kajioka, Hiroki| Taniguchi, Atsuki| Kuroda, Shinji| Kikuchi, Satoru| Kakiuchi, Yoshihiko| Yagi, Tomohiko| Nogi, Shohei| Teraishi, Fuminori| Shigeyasu, Kunitoshi| Yoshida, Ryuichi| Umeda, Yuzo| Noma, Kazuhiro| Tazawa, Hiroshi| Fujiwara, Toshiyoshi|
Keywords Aspirin Ticagrelor P-selectin Platelet Time-lapse imaging
Note © 2023 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Jul. 2024.|
Published Date 2023-07-28
Publication Title Cancer Letters
Volume volume567
Publisher Elsevier BV
Start Page 216260
ISSN 0304-3835
NCID AA00598513
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Elsevier B.V.
File Version author
PubMed ID 37295551
DOI 10.1016/j.canlet.2023.216260
Web of Science KeyUT 001020524700001
Related Url isVersionOf https://doi.org/10.1016/j.canlet.2023.216260
FullText URL fulltext.pdf
Author Hata, Nanako| Shigeyasu, Kunitoshi| Umeda, Yuzo| Yano, Shuya| Takeda, Sho| Yoshida, Kazuhiro| Fuji, Tomokazu| Yoshida, Ryuichi| Yasui, Kazuya| Umeda, Hibiki| Takahashi, Toshiaki| Kondo, Yoshitaka| Kishimoto, Hiroyuki| Mori, Yoshiko| Teraishi, Fuminori| Yamamoto, Hideki| Michiue, Hiroyuki| Nakamura, Keiichiro| Tazawa, Hiroshi| Fujiwara, Toshiyoshi|
Note The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-023-29397-z|
Published Date 2023-02-06
Publication Title Scientific Reports
Volume volume13
Issue issue1
Publisher Nature Portfolio
Start Page 2078
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2023
File Version publisher
PubMed ID 36747029
DOI 10.1038/s41598-023-29397-z
Web of Science KeyUT 000989985700018
Related Url isVersionOf https://doi.org/10.1038/s41598-023-29397-z
FullText URL fulltext.pdf
Author Komoto, Satoshi| Noma, Kazuhiro| Kato, Takuya| Kobayashi, Teruki| Nishiwaki, Noriyuki| Narusaka, Toru| Sato, Hiroaki| Katsura, Yuki| Kashima, Hajime| Kikuchi, Satoru| Ohara, Toshiaki| Tazawa, Hiroshi| Fujiwara, Toshiyoshi|
Keywords cancer-associated fibroblast chemotherapy radiotherapy esophageal cancer tumor microenvironment
Published Date 2023-05-30
Publication Title Cancers
Volume volume15
Issue issue11
Publisher MDPI
Start Page 2971
ISSN 2072-6694
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 by the authors.
File Version publisher
PubMed ID 37296933
DOI 10.3390/cancers15112971
Web of Science KeyUT 001006082400001
Related Url isVersionOf https://doi.org/10.3390/cancers15112971
FullText URL fulltext20221215-1.pdf figures20221215-1.pdf Supple_Figures20221215-1.pdf Supple_Table20221215-1.pdf
Author Kajiwara, Yoshinori| Tazawa, Hiroshi| Yamada, Motohiko| Kanaya, Nobuhiko| Fushimi, Takuro| Kikuchi, Satoru| Kuroda, Shinji| Ohara, Toshiaki| Noma, Kazuhiro| Yoshida, Ryuichi| Umeda, Yuzo| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Keywords Pancreatic cancer Chemoresistance MDSC GM-CSF Oncolytic virus
Note This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00262-022-03334-x| This full-text of the article will be available in Nov. 2023.|
Published Date 2022-11-27
Publication Title Cancer Immunology, Immunotherapy
Volume volume72
Issue issue5
Publisher Springer Science and Business Media LLC
Start Page 1285
End Page 1300
ISSN 0340-7004
NCID AA00598499
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022
File Version author
PubMed ID 36436021
DOI 10.1007/s00262-022-03334-x
Web of Science KeyUT 000889040300003
Related Url isVersionOf https://doi.org/10.1007/s00262-022-03334-x
FullText URL fulltext.pdf
Author Sato, Hiroaki| Noma, Kazuhiro| Ohara, Toshiaki| Kawasaki, Kento| Akai, Masaaki| Kobayashi, Teruki| Nishiwaki, Noriyuki| Narusaka, Toru| Komoto, Satoshi| Kashima, Hajime| Katsura, Yuki| Kato, Takuya| Kikuchi, Satoru| Tazawa, Hiroshi| Kagawa, Shunsuke| Shirakawa, Yasuhiro| Kobayashi, Hisataka| Fujiwara, Toshiyoshi|
Published Date 2022-11-23
Publication Title Scientific Reports
Volume volume12
Issue issue1
Publisher Nature Portfolio
Start Page 20152
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022
File Version publisher
PubMed ID 36418422
DOI 10.1038/s41598-022-24313-3
Web of Science KeyUT 000887936300054
Related Url isVersionOf https://doi.org/10.1038/s41598-022-24313-3
FullText URL fulltext.pdf
Author Araki, Hiroyuki| Tazawa, Hiroshi| Kanaya, Nobuhiko| Kajiwara, Yoshinori| Yamada, Motohiko| Hashimoto, Masashi| Kikuchi, Satoru| Kuroda, Shinji| Yoshida, Ryuichi| Umeda, Yuzo| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Published Date 2022-12-15
Publication Title Molecular Therapy - Oncolytics
Volume volume27
Publisher Cell Press
Start Page 3
End Page 13
ISSN 2372-7705
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Author(s).
File Version publisher
PubMed ID 36212775
DOI 10.1016/j.omto.2022.09.003
Web of Science KeyUT 000870232500001
Related Url isVersionOf https://doi.org/10.1016/j.omto.2022.09.003
FullText URL fulltext.pdf
Author Komatsu, Yasuhiro| Shigeyasu, Kunitoshi| Yano, Shuya| Takeda, Sho| Takahashi, Kazutaka| Hata, Nanako| Umeda, Hibiki| Yoshida, Kazuhiro| Mori, Yoshiko| Yasui, Kazuya| Yoshida, Ryuichi| Kondo, Yoshitaka| Kishimoto, Hiroyuki| Teraishi, Fuminori| Umeda, Yuzo| Kagawa, Shunsuke| Michiue, Hiroyuki| Tazawa, Hiroshi| Goel, Ajay| Fujiwara, Toshiyoshi|
Published Date 2022-08-08
Publication Title Scientific Reports
Volume volume12
Issue issue1
Publisher Nature Portfolio
Start Page 13540
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © TheAuthor(s)2022
File Version publisher
PubMed ID 35941214
DOI 10.1038/s41598-022-17773-0
Web of Science KeyUT 000837764800013
Related Url isVersionOf https://doi.org/10.1038/s41598-022-17773-0
FullText URL fulltext.pdf
Author Ogawa, Toshihiro| Kikuchi, Satoru| Tabuchi, Motoyasu| Mitsui, Ema| Une, Yuta| Tazawa, Hiroshi| Kuroda, Shinji| Noma, Kazuhiro| Ohara, Toshiaki| Kagawa, Shunsuke| Urata, Yasuo| Fujiwara, Toshiyoshi|
Published Date 2022-06-16
Publication Title Molecular Therapy-Oncolytics
Volume volume25
Publisher Cell Press
Start Page 249
End Page 261
ISSN 2372-7705
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Author(s).
File Version publisher
PubMed ID 35615263
DOI 10.1016/j.omto.2022.04.009
Web of Science KeyUT 000800437000008
Related Url isVersionOf https://doi.org/10.1016/j.omto.2022.04.009