Author Yano, Shuya| Tazawa, Hiroshi| Hashimoto, Yuuri| Shirakawa, Yasuhiro| Kuroda, Shinji| Nishizaki, Masahiko| Kishimoto, Hiroyuki| Uno, Futoshi| Nagasaka, Takeshi| Urata, Yasuo| Kagawa, Shunsuke| Hoffman, Robert M.| Fujiwara, Toshiyoshi|
Published Date 2013-12-01
Publication Title Clinical Cancer Research
Volume volume19
Issue issue23
Content Type Journal Article
FullText URL cancers_11_2_177.pdf
Author Katsura, Yuki| Ohara, Toshiaki| Noma, Kazuhiro| Ninomiya, Takayuki| Kashima, Hajime| Kato, Takuya| Sato, Hiroaki| Komoto, Satoshi| Narusaka, Toru| Tomono, Yasuko| Xing, Boyi| Chen, Yuehua| Tazawa, Hiroshi| Kagawa, Shunsuke| Shirakawa, Yasuhiro| Kasai , Tomonari| Seno, Masaharu| Matsukawa, Akihiro| Fujiwara, Toshiyoshi|
Keywords cancer stem cells combination therapy iron stemness
Published Date 2019-02-03
Publication Title Cancers
Volume volume11
Issue issue2
Publisher MDPI
Start Page 177
ISSN 2072-6694
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2019 by the authors
File Version publisher
PubMed ID 30717462
DOI 10.3390/cancers11020177
Web of Science KeyUT 000460747200051
Related Url isVersionOf https://doi.org/10.3390/cancers11020177
Author Kojima, Toru| Hashimoto, Yuuri| Watanabe, Yuichi| Kagawa, Shunsuke| Uno, Futoshi| Kuroda, Shinji| Tazawa, Hiroshi| Kyo, Satoru| Mizuguchi, Hiroyuki| Urata, Yasuo| Tanaka, Noriaki| Fujiwara, Toshiyoshi|
Published Date 2009-10-01
Publication Title The Journal of Clinical Investigation
Volume volume119
Issue issue10
Content Type Journal Article
Author Kikuchi, Satoru| Kishimoto, Hiroyuki| Tazawa, Hiroshi| Hashimoto, Yuuri| Kuroda, Shinji| Nishizaki, Masahiko| Nagasaka, Takeshi| Shirakawa, Yasuhiro| Kagawa, Shunsuke| Urata, Yasuo| Robert M Hoffman| Fujiwara, Toshiyoshi|
Published Date 2014-12-19
Publication Title Molecular Therapy
Content Type Journal Article
FullText URL fulltext.pdf
Author Tazawa, Hiroshi| Hasei, Joe| Yano, Shuya| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi|
Keywords oncolytic adenovirus hTERT autophagy GFP p53
Published Date 2020-02-18
Publication Title Cancers
Volume volume12
Issue issue2
Publisher MDPI
ISSN 2072-6694
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 32085583
DOI 10.3390/cancers12020478
Web of Science KeyUT 000522477300224
Related Url isVersionOf https://doi.org/10.3390/cancers12020478
FullText URL fulltext.pdf
Author Ishikawa, Wataru| Kikuchi, Satoru| Ogawa, Toshihiro| Tabuchi, Motoyasu| Tazawa, Hiroshi| Kuroda, Shinji| Noma, Kazuhiro| Nishizaki, Masahiko| Kagawa, Shunsuke| Urata, Yasuo| Fujiwara, Toshiyoshi|
Keywords peritoneal metastasis adenovirus gastric cancer intraperitoneal chemotherapy paclitaxel oncolytic virus
Published Date 2020-09-25
Publication Title Molecular Therapy - Oncolytics
Volume volume18
Publisher Cell Press
Start Page 262
End Page 271
ISSN 2372-7705
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Author(s).
File Version publisher
PubMed ID 32728614
DOI 10.1016/j.omto.2020.06.021
Web of Science KeyUT 000575168700023
Related Url isVersionOf https://doi.org/10.1016/j.omto.2020.06.021
Author Hasei, Joe| Sasaki, Tsuyoshi| Tazawa, Hiroshi| Osaki, Shuhei| Yamakawa, Yasuaki| Kunisada, Toshiyuki| Yoshida, Aki| Hashimoto, Yuuri| Onishi, Teppei| Uno, Futoshi| Kagawa, Shunsuke| Urata, Yasuo| Ozaki, Toshifumi| Fujiwara, Toshiyoshi|
Published Date 2013-03
Publication Title Molecular Cancer Therapeutics
Volume volume12
Issue issue3
Content Type Journal Article
FullText URL fulltext.pdf
Author Tanimoto, Terutaka| Tazawa, Hiroshi| Ieda, Takeshi| Nouso, Hiroshi| Tani, Morimichi| Oyama, Takanori| Urata, Yasuo| Kagawa, Shunsuke| Noda, Takuo| Fujiwara, Toshiyoshi|
Keywords neuroblastoma MYCN hTERT adenovirus E2F1
Published Date 2020-09-25
Publication Title Molecular Therapy - Oncolytics
Volume volume18
Publisher Cell Press
Start Page 14
End Page 23
ISSN 2372-7705
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Author(s).
File Version publisher
PubMed ID 32637577
DOI 10.1016/j.omto.2020.05.015
Web of Science KeyUT 000575168700002
Related Url isVersionOf https://doi.org/10.1016/j.omto.2020.05.015
FullText URL fulltext.pdf
Author Ito, Atene| Kagawa, Shunsuke| Sakamoto, Shuichi| Kuwada, Kazuya| Kajioka, Hiroki| Yoshimoto, Masashi| Kikuchi, Satoru| Kuroda, Shinji| Yoshida, Ryuichi| Tazawa, Hiroshi| Fujiwara, Toshiyoshi|
Keywords Extracellular vesicles Gastric cancer Tumor-associated macrophages Tumor microenvironment
Published Date 2021-01-28
Publication Title BMC Cancer
Volume volume21
Issue issue1
Publisher BMC
Start Page 102
ISSN 1471-2407
NCID AA12034763
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2021
File Version publisher
PubMed ID 33509150
DOI 10.1186/s12885-021-07816-6
Web of Science KeyUT 000615987400002
Related Url isVersionOf https://doi.org/10.1186/s12885-021-07816-6
FullText URL fulltext.pdf
Author Yano, Shuya| Tazawa, Hiroshi| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| Hoffman, Robert M.|
Keywords cell cycle fluorescent proteins FUCCI imaging targeted cancer therapy quiescent cancer cells decoy chemotherapy
Published Date 2020-09-17
Publication Title Cancers
Volume volume12
Issue issue9
Publisher MDPI
Start Page 2655
ISSN 2072-6694
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 32957652
DOI 10.3390/cancers12092655
Web of Science KeyUT 000580315800001
Related Url isVersionOf https://doi.org/10.3390/cancers12092655
FullText URL fulltext.pdf
Author Katsube, Ryoichi| Noma, Kazuhiro| Ohara, Toshiaki| Nishiwaki, Noriyuki| Kobayashi, Teruki| Komoto, Satoshi| Sato, Hiroaki| Kashima, Hajime| Kato, Takuya| Kikuchi, Satoru| Tazawa, Hiroshi| Kagawa, Shunsuke| Shirakawa, Yasuhiro| Kobayashi, Hisataka| Fujiwara, Toshiyoshi|
Published Date 2021-01-18
Publication Title Scientific Reports
Volume volume11
Issue issue1
Publisher Nature Research
Start Page 1693
ISSN 2045-2322
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2021
File Version publisher
PubMed ID 33462372
DOI 10.1038/s41598-021-81465-4
Web of Science KeyUT 000612156600008
Related Url isVersionOf https://doi.org/10.1038/s41598-021-81465-4
Author Shigeyasu, Kunitoshi| Tazawa, Hiroshi| Hashimoto, Yuuri| Mori, Yoshiko| Nishizaki, Masahiko| Kishimoto, Hiroyuki| Nagasaka, Takeshi| Kuroda, Shinji| Urata, Yasuo| Goel, Ajay| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Published Date 2014-05-28
Publication Title Gut
Content Type Journal Article
FullText URL fulltext.pdf Graphical_Abstract.pptx Figure1-6.pdf Supp_Info.pdf
Author Kanaya, Nobuhiko| Kuroda, Shinji| Kakiuchi, Yoshihiko| Kumon, Kento| Tsumura, Tomoko| Hashimoto, Masashi| Morihiro, Toshiaki| Kubota, Tetsushi| Aoyama, Katsuyuki| Kikuchi, Satoru| Nishizaki, Masahiko| Kagawa, Shunsuke| Tazawa, Hiroshi| Mizuguchi, Hiroyuki| Urata, Yasuo| Fujiwara, Toshiyoshi|
Keywords immune checkpoint programmed death-1 oncolytic adenovirus combined immunotherapy immunogenic cell death tumor infiltrating lymphocytes CD8 abscopal effect
Published Date 2020-01-10
Publication Title Molecular Therapy
Volume volume28
Issue issue3
Publisher Cell Press
Start Page 794
End Page 804
ISSN 15250016
NCID AA11475060
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 31991110
DOI 10.1016/j.ymthe.2020.01.003
Web of Science KeyUT 000518887200012
Related Url isVersionOf https://doi.org/10.1016/j.ymthe.2020.01.003
FullText URL OncoImmunol_8_12_1671760.pdf
Author Sakamoto, Shuichi| Kagawa, Shunsuke| Kuwada, Kazuya| Ito, Atene| Kajioka, Hiroki| Kakiuchi, Yoshihiko| Watanabe, Megumi| Kagawa, Tetsuya| Yoshida, Ryuichi| Kikuchi, Satoru| Kuroda, Shinji| Tazawa, Hiroshi| Fujiwara, Toshiyoshi|
Keywords Gastric cancer tumor-associated macrophages tumor microenvironment peritoneal dissemination
Published Date 2019-10-22
Publication Title OncoImmunology
Volume volume8
Issue issue12
Publisher TAYLOR & FRANCIS
Start Page e1671760
ISSN 2162402X
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2019 The Author(s).
File Version publisher
DOI 10.1080/2162402X.2019.1671760
Web of Science KeyUT 000494085400001
Related Url isVersionOf https://doi.org/10.1080/2162402X.2019.1671760
Author Kakiuchi, Yoshihiko| Kuroda, Shinji| Kanaya, Nobuhiko| Kumon, Kento| Tsumura, Tomoko| Hashimoto, Masashi| Yagi, Chiaki| Sugimoto, Ryoma| Hamada, Yuki| Kikuchi, Satoru| Nishizaki, Masahiko| Kagawa, Shunsuke| Tazawa, Hiroshi| Urata, Yasuo| Fujiwara, Toshiyoshi|
Keywords Extracellular vesicles Exosome Abscopal effect Oncolytic adenovirus Local treatment Systemic delivery Drug delivery system
Note © 2021 The American Society of Gene and Cell Therapy. This manuscript version is made available under the CC-BY-NC-ND 4.0 License.http://creativecommons.org/licenses/by-nc-nd/4.0/.This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.ymthe.2021.05.015] .<br> This fulltext is available in May. 2022.|
Published Date 2021-05-21
Publication Title Molecular Therapy
Volume volume29
Issue issue10
Publisher The American Society of Gene and Cell Therapy
Start Page 2920
End Page 2930
ISSN 15250016
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2021 The American Society of Gene and Cell Therapy.
File Version author
PubMed ID 34023506
DOI 10.1016/j.ymthe.2021.05.015
Related Url isVersionOf https://doi.org/10.1016/j.ymthe.2021.05.015
Author Yoshida, Ryosuke| Tazawa, Hiroshi| Hashimoto, Yuuri| Yano, Shuya| Onishi, Teppei| Sasaki, Tsuyoshi| Shirakawa, Yasuhiro| Kishimoto, Hiroyuki| Uno, Futoshi| Nishizaki, Masahiko| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Published Date 2012-11
Publication Title Cancer Immunology, Immunotherapy
Volume volume61
Issue issue11
Content Type Journal Article
JaLCDOI 10.18926/AMO/52006
FullText URL 67_6_333.pdf
Author Tazawa, Hiroshi| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Abstract Autophagy is a catabolic process that produces energy through lysosomal degradation of intracellular organelles. Autophagy functions as a cytoprotective factor under physiological conditions such as nutrient deprivation, hypoxia, and interruption of growth factors. On the other hand, infection with pathogenic viruses and bacteria also induces autophagy in infected cells. Oncolytic virotherapy with replication-competent viruses is thus a promising strategy to induce tumor-specific cell death. Oncolytic adenoviruses induce autophagy and subsequently contribute to cell death rather than cell survival in tumor cells. We previously developed a telomerase-specific replication-competent oncolytic adenovirus, OBP-301, which induces cell lysis in tumor cells with telomerase activities. OBP-301-mediated cytopathic activity is significantly associated with induction of autophagy biomarkers. In this review, we focus on the tumor-suppressive role and molecular basis of autophagic machinery induced by oncolytic adenoviruses. Addition of tumor-specific promoters and modification of the fiber knob of adenoviruses supports the oncolytic adenovirus-mediated autophagic cell death. Autophagy is cooperatively regulated by the E1-dependent activation pathway, E4-dependent inhibitory pathway, and microRNA-dependent fine-tuning. Thus, future exploration of the functional role and molecular mechanisms underlying oncolytic adenovirus-induced autophagy would provide novel insights and improve the therapeutic potential of oncolytic adenoviruses.
Keywords oncolytic adenovirus autophagy E2F1 microRNA
Amo Type Review
Published Date 2013-12
Publication Title Acta Medica Okayama
Volume volume67
Issue issue6
Publisher Okayama University Medical School
Start Page 333
End Page 342
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 24356717
Web of Science KeyUT 000328915700001
FullText URL fulltext.pdf
Author Koujima, Takeshi| Tazawa, Hiroshi| Ieda, Takeshi| Araki, Hiroyuki| Fushimi, Takuro| Shoji, Ryohei| Kuroda, Shinji| Kikuchi, Satoru| Yoshida, Ryuichi| Umeda, Yuzo| Teraishi, Fuminori| Urata, Yasuo| Mizuguchi, Hiroyuki| Fujiwara, Toshiyoshi|
Published Date 2020-06-26
Publication Title Molecular Therapy - Oncolytics
Volume volume17
Publisher Cell Press
Start Page 107
End Page 117
ISSN 2372-7705
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Author(s).
File Version publisher
PubMed ID 32322667
DOI 10.1016/j.omto.2020.03.016
Web of Science KeyUT 000544101600010
Related Url isVersionOf https://doi.org/10.1016/j.omto.2020.03.016
FullText URL fulltext.pdf
Author Omori, Toshinori| Tazawa, Hiroshi| Yamakawa, Yasuaki| Osaki, Shuhei| Hasei, Joe| Sugiu, Kazuhisa| Komatsubara, Tadashi| Fujiwara, Tomohiro| Yoshida, Aki| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi|
Keywords Gastric yolk sac Tumor-like carcinoma Adenocarcinoma; Alpha-fetoprotein
Published Date 2021-04-22
Publication Title PLoS ONE
Volume volume16
Issue issue4
Publisher Public Library Science
Start Page e0250643
ISSN 1932-6203
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2021 Omori et al.
File Version publisher
PubMed ID 33886686
NAID 120007045007
DOI 10.1371/journal.pone.0250643
Web of Science KeyUT 000644138300019
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0250643
Author Sugiu, Kazuhisa| Tazawa, Hiroshi| Hasei, Joe| Yamakawa, Yasuaki| Omori, Toshinori| Komatsubara, Tadashi| Mochizuki, Yusuke| Kondo, Hiroya| Osaki, Shuhei| Fujiwara, Tomohiro| Yoshida, Aki| Kunisada, Toshiyuki| Ueda, Koji| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi|
Keywords Osteosarcoma Chemoresistance MDR1 Oncolytic adenovirus p53
Note This is a post-peer-review, pre-copyedit version of an article published in Cancer Chemotherapy and Pharmacology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00280-021-04310-5<br> This fulltext is available in June 2022.|
Published Date 2021-6-10
Publication Title Cancer Chemotherapy and Pharmacology
Publisher Springer Science and Business Media LLC
ISSN 0344-5704
NCID AA00598397
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 34114067
DOI 10.1007/s00280-021-04310-5
Web of Science KeyUT 000659839700002
Related Url isVersionOf https://doi.org/10.1007/s00280-021-04310-5