Tazawa, Hiroshi - OU Author List - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

Senescent Fibroblasts Potentiate Peritoneal Metastasis of Diffuse-type Gastric Cancer Cells via IL-8–mediated Crosstalk

Author	LI, YUNCHENG\| TAZAWA, HIROSHI\| NAGAI, YASUO\| FUJITA, SHUTO\| OKURA, TOMOHIRO\| SHOJI, RYOHEI\| YAMADA, MOTOHIKO\| KIKUCHI, SATORU\| KURODA, SHINJI\| OHARA, TOSHIAKI\| NOMA, KAZUHIRO\| NISHIZAKI, MASAHIKO\| KAGAWA, SHUNSUKE\| FUJIWARA, TOSHIYOSHI\|
Keywords	Gastric cancer peritoneal metastasis senescent fibroblast IL-8 CXCR1/2
Note	This is an Accepted Manuscript of an article published by International Institute of Anticancer Research.\| This fulltext file will be available in Dec. 2024.\|
Published Date	2024-05-31
Publication Title	Anticancer Research
Volume	volume44
Issue	issue6
Publisher	International Institute of Anticancer Research
Start Page	2497
End Page	2509
ISSN	0250-7005
NCID	AA10625860
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 International Institute of Anticancer Research (Dr. George J. Delinasios)
File Version	author
PubMed ID	38821603
DOI	10.21873/anticanres.17056
Web of Science KeyUT	001249685300009
Related Url	isVersionOf https://doi.org/10.21873/anticanres.17056

PD-L1-expressing cancer-associated fibroblasts induce tumor immunosuppression and contribute to poor clinical outcome in esophageal cancer

FullText URL	fulltext.pdf
Author	Kawasaki, Kento\| Noma, Kazuhiro\| Kato, Takuya\| Ohara, Toshiaki\| Tanabe, Shunsuke\| Takeda, Yasushige\| Matsumoto, Hijiri\| Nishimura, Seitaro\| Kunitomo, Tomoyoshi\| Akai, Masaaki\| Kobayashi, Teruki\| Nishiwaki, Noriyuki\| Kashima, Hajime\| Maeda, Naoaki\| Kikuchi, Satoru\| Tazawa, Hiroshi\| Shirakawa, Yasuhiro\| Fujiwara, Toshiyoshi\|
Keywords	Esophageal cancer Cancer-associated fibroblasts Programmed cell death 1 Program cell death ligand 1 Immune checkpoint inhibitors
Note	The version of record of this article, first published in Cancer Immunology, Immunotherapy, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00262-023-03531-2\|
Published Date	2023-09-05
Publication Title	Cancer Immunology, Immunotherapy
Volume	volume72
Issue	issue11
Publisher	Springer Science and Business Media LLC
Start Page	3787
End Page	3802
ISSN	0340-7004
NCID	AA00598499
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2023
File Version	publisher
PubMed ID	37668710
DOI	10.1007/s00262-023-03531-2
Web of Science KeyUT	001062743200002
Related Url	isVersionOf https://doi.org/10.1007/s00262-023-03531-2

Fluorescence-guided assessment of bone and soft-tissue sarcomas for predicting the efficacy of telomerase-specific oncolytic adenovirus

FullText URL	fulltext.pdf
Author	Uotani, Koji\| Tazawa, Hiroshi\| Hasei, Joe\| Fujiwara, Tomohiro\| Yoshida, Aki\| Yamakawa, Yasuaki\| Omori, Toshinori\| Sugiu, Kazuhisa\| Komatsubara, Tadashi\| Kondo, Hiroya\| Morita, Takuya\| Kiyono, Masahiro\| Yokoo, Suguru\| Hata, Toshiaki\| Kunisada, Toshiyuki\| Takeda, Ken\| Urata, Yasuo\| Fujiwara, Toshiyoshi\| Ozaki, Toshifumi\|
Published Date	2024-02-20
Publication Title	PLoS ONE
Volume	volume19
Issue	issue2
Publisher	Public Library of Science
Start Page	e0298292
ISSN	1932-6203
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 Uotani et al.
File Version	publisher
PubMed ID	38377118
DOI	10.1371/journal.pone.0298292
Web of Science KeyUT	001176939600021
Related Url	isVersionOf https://doi.org/10.1371/journal.pone.0298292

p53-Armed Oncolytic Virotherapy Improves Radiosensitivity in Soft-Tissue Sarcoma by Suppressing BCL-xL Expression

JaLCDOI	10.18926/AMO/66924
FullText URL	78_2_151.pdf
Author	Komatsubara, Tadashi\| Tazawa, Hiroshi\| Hasei, Joe\| Omori, Toshinori\| Sugiu, Kazuhisa\| Mochizuki, Yusuke\| Demiya, Koji\| Yoshida, Aki\| Fujiwara, Tomohiro\| Kunisada, Toshiyuki\| Urata, Yasuo\| Kagawa, Shunsuke\| Ozaki, Toshifumi\| Fujiwara, Toshiyoshi\|
Abstract	Soft-tissue sarcoma (STS) is a heterogeneous group of rare tumors originating predominantly from the embryonic mesoderm. Despite the development of combined modalities including radiotherapy, STSs are often refractory to antitumor modalities, and novel strategies that improve the prognosis of STS patients are needed. We previously demonstrated the therapeutic potential of two telomerase-specific replication-competent oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in human STS cells. Here, we demonstrate in vitro and in vivo antitumor effects of OBP-702 in combination with ionizing radiation against human STS cells (HT1080, NMS-2, SYO-1). OBP-702 synergistically promoted the antitumor effect of ionizing radiation in the STS cells by suppressing the expression of B-cell lymphoma-X large (BCL-xL) and enhancing ionizing radiation-induced apoptosis. The in vivo experiments demonstrated that this combination therapy significantly suppressed STS tumors’ growth. Our results suggest that OBP-702 is a promising antitumor reagent for promoting the radiosensitivity of STS tumors.
Keywords	soft-tissue sarcoma radiotherapy oncolytic adenovirus p53 BCL-xL
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2024-04
Volume	volume78
Issue	issue2
Publisher	Okayama University Medical School
Start Page	151
End Page	161
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	Copyright Ⓒ 2024 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	38688833
Web of Science KeyUT	001229151800007

Long-term activation of anti-tumor immunity in pancreatic cancer by a p53-expressing telomerase-specific oncolytic adenovirus

FullText URL	fulltext20240219-05.pdf
Author	Hashimoto, Masashi\| Kuroda, Shinji\| Kanaya, Nobuhiko\| Kadowaki, Daisuke\| Yoshida, Yusuke\| Sakamoto, Masaki\| Hamada, Yuki\| Sugimoto, Ryoma\| Yagi, Chiaki\| Ohtani, Tomoko\| Kumon, Kento\| Kakiuchi, Yoshihiko\| Yasui, Kazuya\| Kikuchi, Satoru\| Yoshida, Ryuichi\| Tazawa, Hiroshi\| Kagawa, Shunsuke\| Yagi, Takahito\| Urata, Yasuo\| Fujiwara, Toshiyoshi\|
Note	The version of record of this article, first published in British Journal of Cancer, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41416-024-02583-0\|
Published Date	2024-02-05
Publication Title	British Journal of Cancer
Volume	volume130
Issue	issue7
Publisher	Springer Science and Business Media LLC
Start Page	1187
End Page	1195
ISSN	0007-0920
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2024
File Version	publisher
PubMed ID	38316993
DOI	10.1038/s41416-024-02583-0
Web of Science KeyUT	001156904400001
Related Url	isVersionOf https://doi.org/10.1038/s41416-024-02583-0

p53-armed oncolytic adenovirus induces autophagy and apoptosis in KRAS and BRAF-mutant colorectal cancer cells

FullText URL	fulltext.pdf
Author	Tamura, Shuta\| Tazawa, Hiroshi\| Hori, Naoto\| Li, Yuncheng\| Yamada, Motohiko\| Kikuchi, Satoru\| Kuroda, Shinji\| Urata, Yasuo\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
Published Date	2023-11-16
Publication Title	PLoS ONE
Volume	volume18
Issue	issue11
Publisher	Public Library of Science
Start Page	e0294491
ISSN	1932-6203
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 Tamura et al.
File Version	publisher
PubMed ID	37972012
DOI	10.1371/journal.pone.0294491
Web of Science KeyUT	001119675000083
Related Url	isVersionOf https://doi.org/10.1371/journal.pone.0294491

Dual antiplatelet therapy inhibits neutrophil extracellular traps to reduce liver micrometastases of intrahepatic cholangiocarcinoma

Author	Yoshimoto, Masashi\| Kagawa, Shunsuke\| Kajioka, Hiroki\| Taniguchi, Atsuki\| Kuroda, Shinji\| Kikuchi, Satoru\| Kakiuchi, Yoshihiko\| Yagi, Tomohiko\| Nogi, Shohei\| Teraishi, Fuminori\| Shigeyasu, Kunitoshi\| Yoshida, Ryuichi\| Umeda, Yuzo\| Noma, Kazuhiro\| Tazawa, Hiroshi\| Fujiwara, Toshiyoshi\|
Keywords	Aspirin Ticagrelor P-selectin Platelet Time-lapse imaging
Note	© 2023 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/\| This fulltext file will be available in Jul. 2024.\|
Published Date	2023-07-28
Publication Title	Cancer Letters
Volume	volume567
Publisher	Elsevier BV
Start Page	216260
ISSN	0304-3835
NCID	AA00598513
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 Elsevier B.V.
File Version	author
PubMed ID	37295551
DOI	10.1016/j.canlet.2023.216260
Web of Science KeyUT	001020524700001
Related Url	isVersionOf https://doi.org/10.1016/j.canlet.2023.216260

ADAR1 is a promising risk stratification biomarker of remnant liver recurrence after hepatic metastasectomy for colorectal cancer

FullText URL	fulltext.pdf
Author	Hata, Nanako\| Shigeyasu, Kunitoshi\| Umeda, Yuzo\| Yano, Shuya\| Takeda, Sho\| Yoshida, Kazuhiro\| Fuji, Tomokazu\| Yoshida, Ryuichi\| Yasui, Kazuya\| Umeda, Hibiki\| Takahashi, Toshiaki\| Kondo, Yoshitaka\| Kishimoto, Hiroyuki\| Mori, Yoshiko\| Teraishi, Fuminori\| Yamamoto, Hideki\| Michiue, Hiroyuki\| Nakamura, Keiichiro\| Tazawa, Hiroshi\| Fujiwara, Toshiyoshi\|
Note	The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-023-29397-z\|
Published Date	2023-02-06
Publication Title	Scientific Reports
Volume	volume13
Issue	issue1
Publisher	Nature Portfolio
Start Page	2078
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2023
File Version	publisher
PubMed ID	36747029
DOI	10.1038/s41598-023-29397-z
Web of Science KeyUT	000989985700018
Related Url	isVersionOf https://doi.org/10.1038/s41598-023-29397-z

Conventional Cancer Therapies Can Accelerate Malignant Potential of Cancer Cells by Activating Cancer-Associated Fibroblasts in Esophageal Cancer Models

FullText URL	fulltext.pdf
Author	Komoto, Satoshi\| Noma, Kazuhiro\| Kato, Takuya\| Kobayashi, Teruki\| Nishiwaki, Noriyuki\| Narusaka, Toru\| Sato, Hiroaki\| Katsura, Yuki\| Kashima, Hajime\| Kikuchi, Satoru\| Ohara, Toshiaki\| Tazawa, Hiroshi\| Fujiwara, Toshiyoshi\|
Keywords	cancer-associated fibroblast chemotherapy radiotherapy esophageal cancer tumor microenvironment
Published Date	2023-05-30
Publication Title	Cancers
Volume	volume15
Issue	issue11
Publisher	MDPI
Start Page	2971
ISSN	2072-6694
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 by the authors.
File Version	publisher
PubMed ID	37296933
DOI	10.3390/cancers15112971
Web of Science KeyUT	001006082400001
Related Url	isVersionOf https://doi.org/10.3390/cancers15112971

Oncolytic virus-mediated reducing of myeloid-derived suppressor cells enhances the efficacy of PD-L1 blockade in gemcitabine-resistant pancreatic cancer

FullText URL	fulltext20221215-1.pdf figures20221215-1.pdf Supple_Figures20221215-1.pdf Supple_Table20221215-1.pdf
Author	Kajiwara, Yoshinori\| Tazawa, Hiroshi\| Yamada, Motohiko\| Kanaya, Nobuhiko\| Fushimi, Takuro\| Kikuchi, Satoru\| Kuroda, Shinji\| Ohara, Toshiaki\| Noma, Kazuhiro\| Yoshida, Ryuichi\| Umeda, Yuzo\| Urata, Yasuo\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
Keywords	Pancreatic cancer Chemoresistance MDSC GM-CSF Oncolytic virus
Note	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00262-022-03334-x\| This full-text of the article will be available in Nov. 2023.\|
Published Date	2022-11-27
Publication Title	Cancer Immunology, Immunotherapy
Volume	volume72
Issue	issue5
Publisher	Springer Science and Business Media LLC
Start Page	1285
End Page	1300
ISSN	0340-7004
NCID	AA00598499
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022
File Version	author
PubMed ID	36436021
DOI	10.1007/s00262-022-03334-x
Web of Science KeyUT	000889040300003
Related Url	isVersionOf https://doi.org/10.1007/s00262-022-03334-x

Dual-targeted near-infrared photoimmunotherapy for esophageal cancer and cancer-associated fibroblasts in the tumor microenvironment

FullText URL	fulltext.pdf
Author	Sato, Hiroaki\| Noma, Kazuhiro\| Ohara, Toshiaki\| Kawasaki, Kento\| Akai, Masaaki\| Kobayashi, Teruki\| Nishiwaki, Noriyuki\| Narusaka, Toru\| Komoto, Satoshi\| Kashima, Hajime\| Katsura, Yuki\| Kato, Takuya\| Kikuchi, Satoru\| Tazawa, Hiroshi\| Kagawa, Shunsuke\| Shirakawa, Yasuhiro\| Kobayashi, Hisataka\| Fujiwara, Toshiyoshi\|
Published Date	2022-11-23
Publication Title	Scientific Reports
Volume	volume12
Issue	issue1
Publisher	Nature Portfolio
Start Page	20152
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2022
File Version	publisher
PubMed ID	36418422
DOI	10.1038/s41598-022-24313-3
Web of Science KeyUT	000887936300054
Related Url	isVersionOf https://doi.org/10.1038/s41598-022-24313-3

Oncolytic virus-mediated p53 overexpression promotes immunogenic cell death and efficacy of PD-1 blockade in pancreatic cancer

FullText URL	fulltext.pdf
Author	Araki, Hiroyuki\| Tazawa, Hiroshi\| Kanaya, Nobuhiko\| Kajiwara, Yoshinori\| Yamada, Motohiko\| Hashimoto, Masashi\| Kikuchi, Satoru\| Kuroda, Shinji\| Yoshida, Ryuichi\| Umeda, Yuzo\| Urata, Yasuo\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
Published Date	2022-12-15
Publication Title	Molecular Therapy - Oncolytics
Volume	volume27
Publisher	Cell Press
Start Page	3
End Page	13
ISSN	2372-7705
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 The Author(s).
File Version	publisher
PubMed ID	36212775
DOI	10.1016/j.omto.2022.09.003
Web of Science KeyUT	000870232500001
Related Url	isVersionOf https://doi.org/10.1016/j.omto.2022.09.003

RNA editing facilitates the enhanced production of neoantigens during the simultaneous administration of oxaliplatin and radiotherapy in colorectal cancer

FullText URL	fulltext.pdf
Author	Komatsu, Yasuhiro\| Shigeyasu, Kunitoshi\| Yano, Shuya\| Takeda, Sho\| Takahashi, Kazutaka\| Hata, Nanako\| Umeda, Hibiki\| Yoshida, Kazuhiro\| Mori, Yoshiko\| Yasui, Kazuya\| Yoshida, Ryuichi\| Kondo, Yoshitaka\| Kishimoto, Hiroyuki\| Teraishi, Fuminori\| Umeda, Yuzo\| Kagawa, Shunsuke\| Michiue, Hiroyuki\| Tazawa, Hiroshi\| Goel, Ajay\| Fujiwara, Toshiyoshi\|
Published Date	2022-08-08
Publication Title	Scientific Reports
Volume	volume12
Issue	issue1
Publisher	Nature Portfolio
Start Page	13540
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© TheAuthor(s)2022
File Version	publisher
PubMed ID	35941214
DOI	10.1038/s41598-022-17773-0
Web of Science KeyUT	000837764800013
Related Url	isVersionOf https://doi.org/10.1038/s41598-022-17773-0

Modulation of p53 expression in cancer-associated fibroblasts prevents peritoneal metastasis of cancer

FullText URL	fulltext.pdf
Author	Ogawa, Toshihiro\| Kikuchi, Satoru\| Tabuchi, Motoyasu\| Mitsui, Ema\| Une, Yuta\| Tazawa, Hiroshi\| Kuroda, Shinji\| Noma, Kazuhiro\| Ohara, Toshiaki\| Kagawa, Shunsuke\| Urata, Yasuo\| Fujiwara, Toshiyoshi\|
Published Date	2022-06-16
Publication Title	Molecular Therapy-Oncolytics
Volume	volume25
Publisher	Cell Press
Start Page	249
End Page	261
ISSN	2372-7705
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 The Author(s).
File Version	publisher
PubMed ID	35615263
DOI	10.1016/j.omto.2022.04.009
Web of Science KeyUT	000800437000008
Related Url	isVersionOf https://doi.org/10.1016/j.omto.2022.04.009

Tumor-targeted fluorescence labeling systems for cancer diagnosis and treatment

FullText URL	fulltext.pdf
Author	Tazawa, Hiroshi\| Shigeyasu, Kunitoshi\| Noma, Kazuhiro\| Kagawa, Shunsuke\| Sakurai, Fuminori\| Mizuguchi, Hiroyuki\| Kobayashi, Hisataka\| Imamura, Takeshi\| Fujiwara, Toshiyoshi\|
Keywords	adenovirus EMT survivin telomerase vimentin
Published Date	2022-04-09
Publication Title	Cancer Science
Publisher	Wiley
ISSN	1347-9032
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 The Authors.
File Version	publisher
PubMed ID	35398956
DOI	10.1111/cas.15369
Web of Science KeyUT	000783300600001
Related Url	isVersionOf https://doi.org/10.1111/cas.15369

Overexpression of Adenovirus E1A Reverses Transforming Growth Factor-β-induced Epithelial-mesenchymal Transition in Human Esophageal Cancer Cells

JaLCDOI	10.18926/AMO/63425
FullText URL	76_2_203.pdf
Author	Masuda, Tomoya\| Tazawa, Hiroshi\| Hashimoto, Yuuri\| Ieda, Takeshi\| Kikuchi, Satoru\| Kuroda, Shinji\| Noma, Kazuhiro\| Urata, Yasuo\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
Abstract	The epithelial-mesenchymal transition (EMT), a normal biological process by which epithelial cells acquire a mesenchymal phenotype, is associated with migration, metastasis, and chemoresistance in cancer cells, and with poor prognosis in patients with esophageal cancer. However, therapeutic strategies to inhibit EMT in tumor environments remain elusive. Here, we show the therapeutic potential of telomerase-specific replication- competent oncolytic adenovirus OBP-301 in human esophageal cancer TE4 and TE6 cells with an EMT phenotype. Transforming growth factor-β (TGF-β) administration induced the EMT phenotype with spindleshaped morphology, upregulation of mesenchymal markers and EMT transcription factors, migration, and chemoresistance in TE4 and TE6 cells. OBP-301 significantly inhibited the EMT phenotype via E1 accumulation. EMT cancer cells were susceptible to OBP-301 via massive autophagy induction. OBP-301 suppressed tumor growth and lymph node metastasis of TE4 cells co-inoculated with TGF-β-secreting fibroblasts. Our results suggest that OBP-301 inhibits the TGF-β-induced EMT phenotype in human esophageal cancer cells. OBP-301-mediated E1A overexpression is a promising antitumor strategy to inhibit EMT-mediated esophageal cancer progression.
Keywords	esophageal cancer EMT TGF-β oncolytic adenovirus E1A
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2022-04
Volume	volume76
Issue	issue2
Publisher	Okayama University Medical School
Start Page	203
End Page	215
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	Copyright Ⓒ 2022 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	35503449
Web of Science KeyUT	000792291900003

Local oncolytic adenovirotherapy produces an abscopal effect via tumor-derived extracellular vesicles

FullText URL	fulltext20211015-3.pdf figure20211015-3.pdf Suppl_Information20211015-3.pdf
Author	Kakiuchi, Yoshihiko\| Kuroda, Shinji\| Kanaya, Nobuhiko\| Kumon, Kento\| Tsumura, Tomoko\| Hashimoto, Masashi\| Yagi, Chiaki\| Sugimoto, Ryoma\| Hamada, Yuki\| Kikuchi, Satoru\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Tazawa, Hiroshi\| Urata, Yasuo\| Fujiwara, Toshiyoshi\|
Keywords	Extracellular vesicles Exosome Abscopal effect Oncolytic adenovirus Local treatment Systemic delivery Drug delivery system
Note	© 2021 The American Society of Gene and Cell Therapy. This manuscript version is made available under the CC-BY-NC-ND 4.0 License.http://creativecommons.org/licenses/by-nc-nd/4.0/.This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.ymthe.2021.05.015] .\|
Published Date	2021-05-21
Publication Title	Molecular Therapy
Volume	volume29
Issue	issue10
Publisher	The American Society of Gene and Cell Therapy
Start Page	2920
End Page	2930
ISSN	15250016
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 The American Society of Gene and Cell Therapy.
File Version	author
PubMed ID	34023506
DOI	10.1016/j.ymthe.2021.05.015
Web of Science KeyUT	000708324600008
Related Url	isVersionOf https://doi.org/10.1016/j.ymthe.2021.05.015

Phase I dose-escalation study of endoscopic intratumoral injection of OBP-301 (Telomelysin) with radiotherapy in oesophageal cancer patients unfit for standard treatments

FullText URL	fulltext20210831-3.pdf
Author	Shirakawa, Yasuhiro\| Tazawa, Hiroshi\| Tanabe, Shunsuke\| Kanaya, Nobuhiko\| Noma, Kazuhiro\| Koujima, Takeshi\| Kashima, Hajime\| Kato, Takuya\| Kuroda, Shinji\| Kikuchi, Satoru\| Kagawa, Shunsuke\| Katsui, Kuniaki\| Kanazawa, Susumu\| Urata, Yasuo\| Fujiwara, Toshiyoshi\|
Keywords	Telomerase adenovirus radiotherapy esophageal cancer immunotherapy
Note	© 2021 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.ejca.2021.04.043] .\|
Published Date	2021-8
Publication Title	European Journal of Cancer
Volume	volume153
Publisher	Elsevier BV
Start Page	98
End Page	108
ISSN	0959-8049
NCID	AA1075407X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 Elsevier Ltd.
File Version	author
PubMed ID	34153720
DOI	10.1016/j.ejca.2021.04.043
Web of Science KeyUT	000686051300013
Related Url	isVersionOf https://doi.org/10.1016/j.ejca.2021.04.043

Oncolytic virotherapy reverses chemoresistance in osteosarcoma by suppressing MDR1 expression

FullText URL	fulltext20210628-1.pdf Figure_20210628-1.pdf Supple_Figure_20210628-1.pdf Supple_Table_20210628-1.pdf
Author	Sugiu, Kazuhisa\| Tazawa, Hiroshi\| Hasei, Joe\| Yamakawa, Yasuaki\| Omori, Toshinori\| Komatsubara, Tadashi\| Mochizuki, Yusuke\| Kondo, Hiroya\| Osaki, Shuhei\| Fujiwara, Tomohiro\| Yoshida, Aki\| Kunisada, Toshiyuki\| Ueda, Koji\| Urata, Yasuo\| Kagawa, Shunsuke\| Ozaki, Toshifumi\| Fujiwara, Toshiyoshi\|
Keywords	Osteosarcoma Chemoresistance MDR1 Oncolytic adenovirus p53
Note	This is a post-peer-review, pre-copyedit version of an article published in Cancer Chemotherapy and Pharmacology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00280-021-04310-5\|
Published Date	2021-6-10
Publication Title	Cancer Chemotherapy and Pharmacology
Volume	volume88
Issue	issue3
Publisher	Springer Science and Business Media LLC
Start Page	513
End Page	524
ISSN	0344-5704
NCID	AA00598397
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
File Version	author
PubMed ID	34114067
DOI	10.1007/s00280-021-04310-5
Web of Science KeyUT	000659839700002
Related Url	isVersionOf https://doi.org/10.1007/s00280-021-04310-5

Oncolytic virotherapy promotes radiosensitivity in soft tissue sarcoma by suppressing anti-apoptotic MCL1 expression

FullText URL	fulltext.pdf
Author	Omori, Toshinori\| Tazawa, Hiroshi\| Yamakawa, Yasuaki\| Osaki, Shuhei\| Hasei, Joe\| Sugiu, Kazuhisa\| Komatsubara, Tadashi\| Fujiwara, Tomohiro\| Yoshida, Aki\| Kunisada, Toshiyuki\| Urata, Yasuo\| Kagawa, Shunsuke\| Ozaki, Toshifumi\| Fujiwara, Toshiyoshi\|
Keywords	Gastric yolk sac Tumor-like carcinoma Adenocarcinoma; Alpha-fetoprotein
Published Date	2021-04-22
Publication Title	PLoS ONE
Volume	volume16
Issue	issue4
Publisher	Public Library Science
Start Page	e0250643
ISSN	1932-6203
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 Omori et al.
File Version	publisher
PubMed ID	33886686
NAID	120007045007
DOI	10.1371/journal.pone.0250643
Web of Science KeyUT	000644138300019
Related Url	isVersionOf https://doi.org/10.1371/journal.pone.0250643