| JaLCDOI | 10.18926/AMO/65748 |
|---|---|
| FullText URL | 77_4_377.pdf |
| Author | Morimoto, Kosaku| Takeuchi, Yasuto| Takaki, Akinobu| Wada, Nozomu| Oyama, Atsushi| Adachi, Takuya| Onishi, Hideki| Shiraha, Hidenori| Okada, Hiroyuki| |
| Abstract | Liver fibrosis is an important phenomenon in non-alcoholic fatty liver disease (NAFLD) progression. Standard markers reflecting liver fibrosis, including the FIB-4 index, increase with age. This study aimed to identify fibrosis progression-related markers that are diagnostically beneficial even in aged individuals. Serum levels of pro- and anti-inflammatory cytokines were measured by multiple enzyme-linked immunosorbent assay. Two standard NAFLD or fibrosis progression-related markers — the FIB-4 index and APRI score — were analyzed along with cytokine levels to define the best approach to discriminate advanced fibrosis. Ninety-eight NAFLD patients were enrolled: 59 and 39 patients with fibrosis stages 1-2 and 3-4 respectively. In addition to the FIB-4 index and APRI score, the following factors showed significant differences between stages 1-2 and stages 3-4 in a multivariate analysis: platelet counts, IP-10, and RANTES. The fibrosis stage, FIB-4, APRI, PDGF-BB, and RANTES were related to the prognosis. In aged patients, IP-10, GM-CSF, and RANTES differed between stages 1-2 and stages 3-4. FIB-4 and APRI were beneficial for their correlation with fibrosis. However, to stratify either young or elderly advanced fibrosis patients, and to identify patients likely to have a bad outcome, RANTES was the best marker. |
| Keywords | NAFLD NASH liver fibrosis chemokine FIB-4 |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-08 |
| Volume | volume77 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 377 |
| End Page | 385 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37635138 |
| Web of Science KeyUT | 001163659800009 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Takeuchi, Yasuto| Kato, Hironari| Horiguchi, Shigeru| Oyama, Atsushi| Adachi, Takuya| Wada, Nozomu| Onishi, Hideki| Shiraha, Hidenori| Takaki, Akinobu| |
| Keywords | NETs TAE clinical trial |
| Published Date | 2022 |
| Publication Title | Clinical Medicine Insights－Oncology |
| Volume | volume16 |
| Publisher | Sage Publications Ltd. |
| Start Page | 1 |
| End Page | 5 |
| ISSN | 1179-5549 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022 |
| File Version | publisher |
| PubMed ID | 36387610 |
| DOI | 10.1177/11795549221127750 |
| Web of Science KeyUT | 000888437000001 |
| Related Url | isVersionOf https://doi.org/10.1177/11795549221127750 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Iwamuro, Masaya| Shiraha, Hidenori| Kobashi, Mayu| Horiguchi, Shigeru| Okada, Hiroyuki| |
| Keywords | cancer progression extracellular matrix gastric cancer cells laminin 511-E8 fragment laminin isoforms |
| Published Date | 2022-04-05 |
| Publication Title | Current Issues In Molecular Biology |
| Volume | volume44 |
| Issue | issue4 |
| Publisher | MDPI |
| Start Page | 1539 |
| End Page | 1551 |
| ISSN | 1467-3037 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| DOI | 10.3390/cimb44040105 |
| Web of Science KeyUT | 000785101600001 |
| Related Url | isVersionOf https://doi.org/10.3390/cimb44040105 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ueta, Eijiro| Tsutsumi, Koichiro| Kato, Hironari| Matsushita, Hiroshi| Shiraha, Hidenori| Fujii, Masakuni| Matsumoto, Kazuyuki| Horiguchi, Shigeru| Okada, Hiroyuki| |
| Published Date | 2021-06-10 |
| Publication Title | Scientific Reports |
| Volume | volume11 |
| Issue | issue1 |
| Publisher | Nature Research |
| Start Page | 12298 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2021 |
| File Version | publisher |
| PubMed ID | 34112884 |
| DOI | 10.1038/s41598-021-91804-0 |
| Web of Science KeyUT | 000663785600048 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-021-91804-0 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Adachi, Takuya| Takeuchi, Yasuto| Takaki, Akinobu| Oyama, Atsushi| Wada, Nozomu| Onishi, Hideki| Shiraha, Hidenori| Okada, Hiroyuki| |
| Keywords | tolvaptan liver cirrhosis ascites |
| Published Date | 2021-05-25 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume22 |
| Issue | issue11 |
| Publisher | MDPI |
| Start Page | 5582 |
| ISSN | 1422-0067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 by the authors. |
| File Version | publisher |
| PubMed ID | 34070416 |
| NAID | 120007089839 |
| DOI | 10.3390/ijms22115582 |
| Web of Science KeyUT | 000660134900001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms22115582 |
| Author | Shoji, Bon| Ikeda, Fusao| Fujioka, Shin-ichi| Kobashi, Haruhiko| Yasunaka, Tetsuya| Miyake, Yasuhiro| Shiraha, Hidenori| Takaki, Akinobu| Nouso, Kazuhiro| Iwasaki, Yoshiaki| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2010-11 |
| Publication Title | Journal of Gastroenterology |
| Volume | volume45 |
| Issue | issue11 |
| Content Type | Journal Article |
| Author | Ishikawa, Hisashi| Takaki, Akinobu| Tsuzaki, Ryuichiro| Yasunaka, Tetsuya| Koike, Kazuko| Shimomura, Yasuyuki| Seki, Hiroyuki| Matsushita, Hiroshi| Miyake, Yasuhiro| Ikeda, Fusao| Shiraha, Hidenori| Nouso, Kazuhiro| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2014-07-01 |
| Publication Title | PLoS ONE |
| Volume | volume9 |
| Issue | issue7 |
| Content Type | Journal Article |
| Author | Uchida, Daisuke| Shiraha, Hidenori| Kato, Hironari| Nagahara, Teruya| Iwamuro, Masaya| Kataoka, Junro| Horiguchi, Shigeru| Watanabe, Masami| Takaki, Akinobu| Nouso, Kazuhiro| Nasu, Yasutomo| Yagi, Takahito| Kumon, Hiromi| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2014-05 |
| Publication Title | Journal of Gastroenterology and Hepatology |
| Volume | volume29 |
| Issue | issue5 |
| Content Type | Journal Article |
| Author | Takeuchi, Yasuto| Ikeda, Fusao| Moritou, Yuki| Hagihara, Hiroaki| Yasunaka, Tetsuya| Kuwaki, Kenji| Miyake, Yasuhiro| Ohnishi, Hideki| Nakamura, Shinichiro| Shiraha, Hidenori| Takaki, Akinobu| Iwasaki, Yoshiaki| Nouso, Kazuhiro| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2013-03 |
| Publication Title | Journal of Gastroenterology |
| Volume | volume48 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Ohnishi, Atsuyuki| Miyake, Yasuhiro| Matsushita, Hiroshi| Matsumoto, Kazuyuki| Takaki, Akinobu| Yasunaka, Tetsuya| Koike, Kazuko| Ikeda, Fusao| Shiraha, Hidenori| Nouso, Kazuhiro| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2012 |
| Publication Title | Digestion |
| Volume | volume86 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Takayama, Hiroki| Miyake, Yasuhiro| Nouso, Kazuhiro| Ikeda, Fusao| Shiraha, Hidenori| Takaki, Akinobu| Kobashi, Haruhiko| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2011-01 |
| Publication Title | Journal of Gastroenterology and Hepatology |
| Volume | volume26 |
| Issue | issue1 |
| Content Type | Journal Article |
| Title Alternative | Fermented persimmon extract (kaki-shibu) is useful as a standard for component analyses of persimmon phytobezoars |
|---|---|
| FullText URL | 126_127.pdf |
| Author | Iwamuro, Masaya| Okamoto, Yuko| Murata, Toshihiro| Kawai, Yoshinari| Shiraha, Hidenori| Okada, Hiroyuki| Yamamoto, Kazuhide| |
| Abstract | The definite diagnosis of persimmon phytobezoar (i.e., diospyrobezoar) is often accomplished by a component analysis using infrared spectroscopy. However, no studies have been conducted to investigate which substance is the best as a standard for the component analysis. Here we analyzed tannic acid, Japanese persimmon (kaki), fermented persimmon extract (kaki-shibu), conventional dried persimmon, and dried persimmon smoked in sulfur (ampo-kaki) by infrared spectroscopy to determine which would be optimal as a component analysis standard. The spectrum between 1,600 to 600cm－1 of a persimmon phytobezoar was quite similar to the spectrum of kaki-shibu rather than that of tannic acid. Consequently, we conclude that kaki-shibu should be used as a standard for infrared spectroscopy analyses of persimmon phytobezoars. |
| Keywords | 柿胃石（gastric phytobezoar） タンニン酸（tannic acid） 消化管異物（gastrointestinal foreign body） 成分分析（component analysis） |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2014-08-01 |
| Volume | volume126 |
| Issue | issue2 |
| Start Page | 127 |
| End Page | 131 |
| ISSN | 0030-1558 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2014 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.126.127 |
| NAID | 130004685263 |
| Author | Tatsukawa, Masashi| Takaki, Akinobu| Shiraha, Hidenori| Koike, Kazuko| Iwasaki, Yoshiaki| Kobashi, Haruhiko| Fujioka, Shin-Ichi| Sakaguchi, Kohsaku| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2011-10-21 |
| Publication Title | BMC Cancer |
| Volume | volume11 |
| Content Type | Journal Article |
| Author | Kinugasa, Hideaki| Nouso, Kazuhiro| Takeuchi, Yasuto| Yasunaka, Tetsuya| Onishi, Hideki| Nakamura, Shin-ichiro| Shiraha, Hidenori| Kuwaki, Kenji| Hagihara, Hiroaki| Ikeda, Fusao| Miyake, Yasuhiro| Takaki, Akinobu| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2012-04 |
| Publication Title | Journal of Gastroenterology |
| Volume | volume47 |
| Issue | issue4 |
| Content Type | Journal Article |
| Author | Matsubara, Minoru| Shiraha, Hidenori| Kataoka, Jyunro| Iwamuro, Masaya| Horiguchi, Shigeru| Nishina, Shin-ichi| Takaoka, Nobuyuki| Uemura, Masayuki| Takaki, Akinobu| Nakamura, Shinichiro| Kobayashi, Yoshiyuki| Nouso, Kazuhiro| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2012-10 |
| Publication Title | Journal of Gastroenterology and Hepatology |
| Volume | volume27 |
| Issue | issue10 |
| Content Type | Journal Article |
| Author | Tanaka, Shigetomi| Shiraha, Hidenori| Nakanishi, Yutaka| Nishina, Shin-Ichi| Matsubara, Minoru| Horiguchi, Shigeru| Takaoka, Nobuyuki| Iwamuro, Masaya| Kataoka, Junro| Kuwaki, Kenji| Hagihara, Hiroaki| Toshimori, Junichi| Ohnishi, Hideki| Takaki, Akinobu| Nakamura, Shinichiro| Nouso, Kazuhiro| Yagi, Takahito| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2012-12-01 |
| Publication Title | International Journal of Cancer |
| Volume | volume131 |
| Issue | issue11 |
| Content Type | Journal Article |
| Author | Nakanishi, Yutaka| Shiraha, Hidenori| Nishina, Shin-ichi| Tanaka, Shigetomi| Matsubara, Minoru| Horiguchi, Shigeru| Iwamuro, Masaya| Takaoka, Nobuyuki| Uemura, Masayuki| Kuwaki, Kenji| Hagihara, Hiroaki| Toshimori, Junichi| Ohnishi, Hideki| Takaki, Akinobu| Nakamura, Shinichiro| Kobayashi, Yoshiyuki| Nouso, Kazuhiro| Yagi, Takahito| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2011-01-04 |
| Publication Title | BMC Cancer |
| Volume | volume11 |
| Content Type | Journal Article |
| Author | Matsuo, Noriyuki| Shiraha, Hidenori| Fujikawa, Tatsuya| Takaoka, Nobuyuki| Ueda, Naoki| Tanaka, Shigetomi| Nishina, Shinichi| Nakanishi, Yutaka| Uemura, Masayuki| Takaki, Akinobu| Nakamura, Shinichiro| Kobayashi, Yoshiyuki| Nouso, Kazuhiro| Yagi, Takahito| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2009-07-18 |
| Publication Title | BMC Cancer |
| Volume | volume9 |
| Content Type | Journal Article |
| Author | Hanafusa, Tadashi| Shinji, Toshiyuki| Shiraha, Hidenori| Nouso, Kazuhiro| Iwasaki, Yoshiaki| Yumoto, Eichiro| Ono, Toshiro| Koide, Norio| |
|---|---|
| Published Date | 2005-01-20 |
| Publication Title | BMC Cancer |
| Volume | volume5 |
| Content Type | Journal Article |
| Author | Kobayashi, Yoshiyuki| Nakamura, Shinichiro| Ohnishi, Hideki| Toshimori, Junichi| Kuwaki, Kenji| Hagihara, Hiroaki| Miyake, Yasuhiro| Shiraha, Hidenori| Nouso, Kazuhiro| Yagi, Takahito| Tanaka, Noriaki| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2009-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume121 |
| Issue | issue1 |
| Content Type | Journal Article |
