Author | 白羽 英則| |
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Published Date | 1996-03-31 |
Publication Title | |
Content Type | Thesis or Dissertation |
JaLCDOI | 10.18926/AMO/52898 |
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FullText URL | 68_5_291.pdf |
Author | Tsuzaki, Ryuichiro| Takaki, Akinobu| Yagi, Takahito| Ikeda, Fusao| Koike, Kazuko| Iwasaki, Yoshiaki| Shiraha, Hidenori| Miyake, Yasuhiro| Sadamori, Hiroshi| Shinoura, Susumu| Umeda, Yuzo| Yoshida, Ryuichi| Nobuoka, Daisuke| Utsumi, Masashi| Nakayama, Eiichi| Fujiwara, Toshiyoshi| Yamamoto, Kazuhide| |
Abstract | It is not known how the immune system targets hepatitis C virus (HCV)-infected HLA-mismatched hepatocytes under immune-suppressed conditions after orthotopic liver transplantation (OLT). In addition, the relationship between the HCV-specific immune response and IL28B variants as predictors of HCV clearance has not been well-characterized. We determined the IL28B polymorphisms for 57 post-OLT HCV carriers, and we assessed the HCV-specific immune responses by measuring the peripheral blood mononuclear cell-derived HCV-specific interferon-gamma (IFN-γ) response using an enzyme-linked immunospot assay. At 1-3 years after OLT, patients with no active hepatitis showed higher total spots on the immunospot assay. At>3 years after OLT, patients with resolved HCV showed higher levels of core, NS3, NS5A, and total spots compared to the chronic hepatitis patients. The IL28B major genotype in the donors correlated with higher spot counts for NS5A and NS5B proteins at 1-3 years after OLT. In the post-OLT setting, the HCV-specific immune response could be strongly induced in patients with no active hepatitis with an IL28B major donor or sustained virological response. Strong immune responses in the patients with no active hepatitis could only be maintained for 3 years and diminished later. It may be beneficial to administer IFN treatment starting 3 years after OLT, to induce the maximum immunological effect. |
Keywords | interferon gamma ELISPOT assay single nucleotide polymorphisms dendritic cell CD4 T cell |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2014-10 |
Volume | volume68 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 291 |
End Page | 302 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 25338486 |
Web of Science KeyUT | 000343269300006 |
Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/53129 |
JaLCDOI | 10.18926/AMO/53026 |
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FullText URL | 68_6_369.pdf |
Author | Iwamuro, Masaya| Miyashima, Yuichi| Yoshioka, Takahiro| Murata, Toshihiro| Miyabe, Yoshio| Kawai, Yoshinari| Urata, Haruo| Shiraha, Hidenori| Okada, Hiroyuki| Yamamoto, Kazuhide| |
Abstract | A 67-year-old Japanese man underwent enterotomy because of enterolith ileus. Component analysis by infrared spectroscopy revealed that the enterolith was composed of a high concentration of deoxycholic acid. We further analyzed and compared the ultrastructure of the enterolith and a commercially available powdered form of deoxycholic acid by means of scanning electron microscopy and energy dispersive X-ray spectroscopy. Energy dispersive X-ray spectroscopy analysis revealed that the ratios of carbon and oxygen in the enterolith were equal to those in the deoxycholic acid powder. Scanning electron microscopy analysis showed rectangular prism-shaped particles on the surface of the enterolith. This structure was similar to that of the deoxycholic acid powder. The surgically removed enterolith had a twisted and coiled appearance. Possible mechanisms underlying the formation of this unique form are discussed. |
Keywords | enterolith deoxycholic acid scanning electron microscopy infrared spectroscopy energy dispersive X-ray spectroscopy |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2014-12 |
Volume | volume68 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 369 |
End Page | 374 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 25519031 |
Web of Science KeyUT | 000346882200007 |
JaLCDOI | 10.18926/AMO/53558 |
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FullText URL | 69_4_219.pdf |
Author | Toshimori, Junichi| Nouso, Kazuhiro| Nakamura, Shinichiro| Wada, Nozomu| Morimoto, Yuki| Takeuchi, Yasuto| Yasunaka, Tetsuya| Kuwaki, Kenji| Ohnishi, Hideki| Ikeda, Fusao| Shiraha, Hidenori| Takaki, Akinobu| Yamamoto, Kazuhide| |
Abstract | We conducted a retrospective cohort study to investigate the predisposing factors for local recurrence and complications after percutaneous radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC). HCC patients (n=397) consecutively treated with RFA (256 males, 141 females, median age 69 years) were enrolled. In these patients, 1,455 nodules (median size 17mm) were ablated. Predisposing factors for overall recurrence and local recurrence in the context of tumor location and complications were examined. Local recurrence was observed for 113 of the 1,455 nodules. The 1-, 3- and 5-year local recurrence rates were 2.2オ, 7.4オ and 9.5オ, respectively. A multivariate Cox proportional hazard analysis revealed that large tumor size (>2cm), tumor location (adjacent to the major portal branch or hepatic vein), and small ablated margin (<3mm) were independent predisposing factors for local recurrence after RFA (HR=1.70-2.81). Tumor location (adjacent to the major portal branch, hepatic vein, or diaphragm) was also revealed as a risk factor for liver damage due to RFA. HCC adjacent to the major portal vein or hepatic vein was associated with a higher risk for local recurrence and for complications;therefore, special precautions are necessary when applying RFA to HCC near vessels even when the tumors are located at an easy-to-puncture site. |
Keywords | hepatocellular carcinoma radiofrequency ablation ablated margin tumor location |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2015-08 |
Volume | volume69 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 219 |
End Page | 226 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 26289913 |
Web of Science KeyUT | 000365519100005 |
Author | Hanafusa, Tadashi| Shinji, Toshiyuki| Shiraha, Hidenori| Nouso, Kazuhiro| Iwasaki, Yoshiaki| Yumoto, Eichiro| Ono, Toshiro| Koide, Norio| |
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Published Date | 2005-01-20 |
Publication Title | BMC Cancer |
Volume | volume5 |
Content Type | Journal Article |
Author | Matsuo, Noriyuki| Shiraha, Hidenori| Fujikawa, Tatsuya| Takaoka, Nobuyuki| Ueda, Naoki| Tanaka, Shigetomi| Nishina, Shinichi| Nakanishi, Yutaka| Uemura, Masayuki| Takaki, Akinobu| Nakamura, Shinichiro| Kobayashi, Yoshiyuki| Nouso, Kazuhiro| Yagi, Takahito| Yamamoto, Kazuhide| |
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Published Date | 2009-07-18 |
Publication Title | BMC Cancer |
Volume | volume9 |
Content Type | Journal Article |
Author | Nakanishi, Yutaka| Shiraha, Hidenori| Nishina, Shin-ichi| Tanaka, Shigetomi| Matsubara, Minoru| Horiguchi, Shigeru| Iwamuro, Masaya| Takaoka, Nobuyuki| Uemura, Masayuki| Kuwaki, Kenji| Hagihara, Hiroaki| Toshimori, Junichi| Ohnishi, Hideki| Takaki, Akinobu| Nakamura, Shinichiro| Kobayashi, Yoshiyuki| Nouso, Kazuhiro| Yagi, Takahito| Yamamoto, Kazuhide| |
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Published Date | 2011-01-04 |
Publication Title | BMC Cancer |
Volume | volume11 |
Content Type | Journal Article |
Author | Tanaka, Shigetomi| Shiraha, Hidenori| Nakanishi, Yutaka| Nishina, Shin-Ichi| Matsubara, Minoru| Horiguchi, Shigeru| Takaoka, Nobuyuki| Iwamuro, Masaya| Kataoka, Junro| Kuwaki, Kenji| Hagihara, Hiroaki| Toshimori, Junichi| Ohnishi, Hideki| Takaki, Akinobu| Nakamura, Shinichiro| Nouso, Kazuhiro| Yagi, Takahito| Yamamoto, Kazuhide| |
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Published Date | 2012-12-01 |
Publication Title | International Journal of Cancer |
Volume | volume131 |
Issue | issue11 |
Content Type | Journal Article |
FullText URL | fulltext.pdf |
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Author | Adachi, Takuya| Takeuchi, Yasuto| Takaki, Akinobu| Oyama, Atsushi| Wada, Nozomu| Onishi, Hideki| Shiraha, Hidenori| Okada, Hiroyuki| |
Keywords | tolvaptan liver cirrhosis ascites |
Published Date | 2021-05-25 |
Publication Title | International Journal of Molecular Sciences |
Volume | volume22 |
Issue | issue11 |
Publisher | MDPI |
Start Page | 5582 |
ISSN | 1422-0067 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2021 by the authors. |
File Version | publisher |
PubMed ID | 34070416 |
NAID | 120007089839 |
DOI | 10.3390/ijms22115582 |
Web of Science KeyUT | 000660134900001 |
Related Url | isVersionOf https://doi.org/10.3390/ijms22115582 |
FullText URL | fulltext.pdf |
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Author | Ueta, Eijiro| Tsutsumi, Koichiro| Kato, Hironari| Matsushita, Hiroshi| Shiraha, Hidenori| Fujii, Masakuni| Matsumoto, Kazuyuki| Horiguchi, Shigeru| Okada, Hiroyuki| |
Published Date | 2021-06-10 |
Publication Title | Scientific Reports |
Volume | volume11 |
Issue | issue1 |
Publisher | Nature Research |
Start Page | 12298 |
ISSN | 2045-2322 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2021 |
File Version | publisher |
PubMed ID | 34112884 |
DOI | 10.1038/s41598-021-91804-0 |
Web of Science KeyUT | 000663785600048 |
Related Url | isVersionOf https://doi.org/10.1038/s41598-021-91804-0 |
FullText URL | fulltext.pdf |
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Author | Iwamuro, Masaya| Shiraha, Hidenori| Kobashi, Mayu| Horiguchi, Shigeru| Okada, Hiroyuki| |
Keywords | cancer progression extracellular matrix gastric cancer cells laminin 511-E8 fragment laminin isoforms |
Published Date | 2022-04-05 |
Publication Title | Current Issues In Molecular Biology |
Volume | volume44 |
Issue | issue4 |
Publisher | MDPI |
Start Page | 1539 |
End Page | 1551 |
ISSN | 1467-3037 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022 by the authors. |
File Version | publisher |
DOI | 10.3390/cimb44040105 |
Web of Science KeyUT | 000785101600001 |
Related Url | isVersionOf https://doi.org/10.3390/cimb44040105 |
Author | Matsubara, Minoru| Shiraha, Hidenori| Kataoka, Jyunro| Iwamuro, Masaya| Horiguchi, Shigeru| Nishina, Shin-ichi| Takaoka, Nobuyuki| Uemura, Masayuki| Takaki, Akinobu| Nakamura, Shinichiro| Kobayashi, Yoshiyuki| Nouso, Kazuhiro| Yamamoto, Kazuhide| |
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Published Date | 2012-10 |
Publication Title | Journal of Gastroenterology and Hepatology |
Volume | volume27 |
Issue | issue10 |
Content Type | Journal Article |
Author | Kinugasa, Hideaki| Nouso, Kazuhiro| Takeuchi, Yasuto| Yasunaka, Tetsuya| Onishi, Hideki| Nakamura, Shin-ichiro| Shiraha, Hidenori| Kuwaki, Kenji| Hagihara, Hiroaki| Ikeda, Fusao| Miyake, Yasuhiro| Takaki, Akinobu| Yamamoto, Kazuhide| |
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Published Date | 2012-04 |
Publication Title | Journal of Gastroenterology |
Volume | volume47 |
Issue | issue4 |
Content Type | Journal Article |
Author | Tatsukawa, Masashi| Takaki, Akinobu| Shiraha, Hidenori| Koike, Kazuko| Iwasaki, Yoshiaki| Kobashi, Haruhiko| Fujioka, Shin-Ichi| Sakaguchi, Kohsaku| Yamamoto, Kazuhide| |
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Published Date | 2011-10-21 |
Publication Title | BMC Cancer |
Volume | volume11 |
Content Type | Journal Article |
FullText URL | fulltext.pdf |
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Author | Takeuchi, Yasuto| Kato, Hironari| Horiguchi, Shigeru| Oyama, Atsushi| Adachi, Takuya| Wada, Nozomu| Onishi, Hideki| Shiraha, Hidenori| Takaki, Akinobu| |
Keywords | NETs TAE clinical trial |
Published Date | 2022 |
Publication Title | Clinical Medicine Insights-Oncology |
Volume | volume16 |
Publisher | Sage Publications Ltd. |
Start Page | 1 |
End Page | 5 |
ISSN | 1179-5549 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2022 |
File Version | publisher |
PubMed ID | 36387610 |
DOI | 10.1177/11795549221127750 |
Web of Science KeyUT | 000888437000001 |
Related Url | isVersionOf https://doi.org/10.1177/11795549221127750 |
Title Alternative | Fermented persimmon extract (kaki-shibu) is useful as a standard for component analyses of persimmon phytobezoars |
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FullText URL | 126_127.pdf |
Author | Iwamuro, Masaya| Okamoto, Yuko| Murata, Toshihiro| Kawai, Yoshinari| Shiraha, Hidenori| Okada, Hiroyuki| Yamamoto, Kazuhide| |
Abstract | The definite diagnosis of persimmon phytobezoar (i.e., diospyrobezoar) is often accomplished by a component analysis using infrared spectroscopy. However, no studies have been conducted to investigate which substance is the best as a standard for the component analysis. Here we analyzed tannic acid, Japanese persimmon (kaki), fermented persimmon extract (kaki-shibu), conventional dried persimmon, and dried persimmon smoked in sulfur (ampo-kaki) by infrared spectroscopy to determine which would be optimal as a component analysis standard. The spectrum between 1,600 to 600cm-1 of a persimmon phytobezoar was quite similar to the spectrum of kaki-shibu rather than that of tannic acid. Consequently, we conclude that kaki-shibu should be used as a standard for infrared spectroscopy analyses of persimmon phytobezoars. |
Keywords | 柿胃石(gastric phytobezoar) タンニン酸(tannic acid) 消化管異物(gastrointestinal foreign body) 成分分析(component analysis) |
Publication Title | 岡山医学会雑誌 |
Published Date | 2014-08-01 |
Volume | volume126 |
Issue | issue2 |
Start Page | 127 |
End Page | 131 |
ISSN | 0030-1558 |
language | Japanese |
Copyright Holders | Copyright (c) 2014 岡山医学会 |
File Version | publisher |
DOI | 10.4044/joma.126.127 |
NAID | 130004685263 |
Author | Takayama, Hiroki| Miyake, Yasuhiro| Nouso, Kazuhiro| Ikeda, Fusao| Shiraha, Hidenori| Takaki, Akinobu| Kobashi, Haruhiko| Yamamoto, Kazuhide| |
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Published Date | 2011-01 |
Publication Title | Journal of Gastroenterology and Hepatology |
Volume | volume26 |
Issue | issue1 |
Content Type | Journal Article |
Author | Ohnishi, Atsuyuki| Miyake, Yasuhiro| Matsushita, Hiroshi| Matsumoto, Kazuyuki| Takaki, Akinobu| Yasunaka, Tetsuya| Koike, Kazuko| Ikeda, Fusao| Shiraha, Hidenori| Nouso, Kazuhiro| Yamamoto, Kazuhide| |
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Published Date | 2012 |
Publication Title | Digestion |
Volume | volume86 |
Issue | issue2 |
Content Type | Journal Article |
Author | Takeuchi, Yasuto| Ikeda, Fusao| Moritou, Yuki| Hagihara, Hiroaki| Yasunaka, Tetsuya| Kuwaki, Kenji| Miyake, Yasuhiro| Ohnishi, Hideki| Nakamura, Shinichiro| Shiraha, Hidenori| Takaki, Akinobu| Iwasaki, Yoshiaki| Nouso, Kazuhiro| Yamamoto, Kazuhide| |
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Published Date | 2013-03 |
Publication Title | Journal of Gastroenterology |
Volume | volume48 |
Issue | issue3 |
Content Type | Journal Article |
Author | Uchida, Daisuke| Shiraha, Hidenori| Kato, Hironari| Nagahara, Teruya| Iwamuro, Masaya| Kataoka, Junro| Horiguchi, Shigeru| Watanabe, Masami| Takaki, Akinobu| Nouso, Kazuhiro| Nasu, Yasutomo| Yagi, Takahito| Kumon, Hiromi| Yamamoto, Kazuhide| |
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Published Date | 2014-05 |
Publication Title | Journal of Gastroenterology and Hepatology |
Volume | volume29 |
Issue | issue5 |
Content Type | Journal Article |