Title Alternative Report on adverse reactions to novel coronavirus vaccines
Author Matsumoto, Naomi| Higuchi, Chigusa| Mitsuhashi, Toshiharu| Hagiya, Hideharu| Takao, Soshi| Yorifuji, Takashi|
Keywords COVID-19 m-RNA ワクチン 副反応 BNT162b mRNA-1273
Publication Title Journal of Okayama Medical Association
Published Date 2022-04-01
Volume volume134
Issue issue1
Start Page 35
End Page 42
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.134.35
language Japanese
Copyright Holders Copyright (c) 2022 岡山医学会
File Version publisher
DOI 10.4044/joma.134.35
Title Alternative A descriptive analysis for the comparison of the symptoms and severity of coronavirus disease 2019 (COVID-19) in each epidemic period in Okayama City
Author Matsuo, Rumi| Matsumoto, Naomi| Kadowaki, Tomoka| Mitsuhashi, Toshiharu| Takao, Soshi| Yorifuji, Takashi|
Abstract  Japan experienced four major epidemic periods (i.e., the 3rd-6th waves) of COVID-19 from January 2020 to March 2022. A different strain predominated in each period: the wild-type strain, an Alpha variant, a Delta variant, and an Omicron variant were predominant in waves 3, 4, 5, and 6, respectively. In this study, we conducted a descriptive analysis to investigate the differences in symptoms and severity during each epidemic period. We analyzed a total of 31,037 patients with COVID-19 who were reported to the Okayama City Public Health Center between February 1, 2020 and March 31, 2022. We described and compared the proportion of symptoms, the number and proportion of severe COVID-19 cases, and the number and proportion of deaths for each epidemic period. We also compared the proportion of severe COVID-19 cases depending on the number of vaccinations for the 5th and 6th waves.
 Differences in symptoms and severity were observed in each epidemic period. In the 5th and 6th waves, the results suggested that vaccination had a preventive effect against severe COVID-19.
Keywords 新型コロナウイルス感染症(coronavirus disease 2019 ) COVID-19 症状(symptom) 重症度(severity) ワクチン(vaccination)
Publication Title Journal of Okayama Medical Association
Published Date 2022-12-01
Volume volume134
Issue issue3
Start Page 160
End Page 165
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.134.160
language Japanese
Copyright Holders Copyright (c) 2022 岡山医学会
File Version publisher
DOI 10.4044/joma.134.160
FullText URL fulltext.pdf
Author Nakamura, Naoko| Mitsuhashi, Toshiharu| Matsumoto, Naomi| Hayase, Shunsaku| Yorifuji, Takashi|
Keywords antihypertensive agents COVID-19 health behavior interrupted time series analysis prescription drugs treatment interruption
Published Date 2024-02-21
Publication Title Journal of General and Family Medicine
Volume volume25
Issue issue2
Publisher Wiley
Start Page 102
End Page 109
ISSN 2189-7948
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 The Authors.
File Version publisher
PubMed ID 38481745
DOI 10.1002/jgf2.678
Web of Science KeyUT 001168139300001
Related Url isVersionOf https://doi.org/10.1002/jgf2.678
FullText URL fulltext.pdf
Author Matsumoto, Naomi| Kubo, Toshihide| Nakamura, Kazue| Mitsuhashi, Toshiharu| Takeuchi, Akihito| Tsukahara, Hirokazu| Yorifuji, Takashi|
Published Date 2021-11-26
Publication Title Scientific Reports
Volume volume11
Issue issue1
Publisher Nature Portfolio
Start Page 23004
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2021
File Version publisher
PubMed ID 34837002
DOI 10.1038/s41598-021-02464-z
Web of Science KeyUT 000722925300029
Related Url isVersionOf https://doi.org/10.1038/s41598-021-02464-z
FullText URL fulltext.pdf
Author Kinugasa, Hideaki| Kanzaki, Hiromitsu| Tanaka, Takehiro| Yamamoto, Shumpei| Yamasaki, Yasushi| Nouso, Kazuhiro| Ichimura, Kouichi| Nakagawa, Masahiro| Mitsuhashi, Toshiharu| Okada, Hiroyuki|
Published Date 2021-11
Publication Title Clinical and Translational Gastroenterology
Volume volume12
Issue issue11
Publisher Lippincott Williams & Wilkins
Start Page e00424
ISSN 2155-384X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 The Author(s).
File Version publisher
PubMed ID 34797780
DOI 10.14309/ctg.0000000000000424
Web of Science KeyUT 000720492100001
Related Url isVersionOf https://doi.org/10.14309/ctg.0000000000000424
JaLCDOI 10.18926/AMO/54512
FullText URL 70_4_317.pdf
Author Sakurai, Jun| Matsui, Yusuke| Hiraki, Takao| Iguchi, Toshihiro| Fujiwara, Hiroyasu| Gobara, Hideo| Mitsuhashi, Toshiharu| Nagasaka, Takeshi| Susumu Kanazawa, Susumu Kanazawa|
Abstract The present single center prospective phase II clinical trial is designed to evaluate the efficacy and safety of percutaneous radiofrequency (RF) ablation for colorectal lung metastases. Patients who have colorectal lung metastases without extrapulmonary metastases are included in this study. The primary endpoint is 3-year overall survival (OS) after RF ablation. The secondary endpoints are the prevalence of adverse events within 4 weeks, local tumor progression rate, 1- and 5-year OS, cause-specific survival, and relapse-free survival. The recruitment of patients commenced in July 2014, and the enrolment of 45 patients is intended over the 3 years of study period.
Keywords radiofrequency ablation colorectal cancer lung metastasis
Amo Type Clinical Study Protocols
Publication Title Acta Medica Okayama
Published Date 2016-08
Volume volume70
Issue issue4
Publisher Okayama University Medical School
Start Page 317
End Page 321
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27549681
Web of Science KeyUT 000384748600016
FullText URL fulltext.pdf
Author Komaki, Toshiyuki| Hiraki, Takao| Kamegawa, Tetsushi| Matsuno, Takayuki| Sakurai, Jun| Matsuura, Ryutaro| Yamaguchi, Takuya| Sasaki, Takanori| Mitsuhashi, Toshiharu| Okamoto, Soichiro| Uka, Mayu| Matsui, Yusuke| Iguchi, Toshihiro| Gobara, Hideo| Kanazawa, Susumu|
Keywords Robotics Interventional radiology Animal experiments
Published Date 2019-11-26
Publication Title European Radiology
Volume volume30
Issue issue3
Publisher Springer
Start Page 1342
End Page 1349
ISSN 0938-7994
NCID AA10824302
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Authors
File Version publisher
PubMed ID 31773299
DOI 10.1007/s00330-019-06477-1
Web of Science KeyUT 000517458800006
Related Url isVersionOf https://doi.org/10.1007/s00330-019-06477-1
JaLCDOI 10.18926/AMO/66148
FullText URL 77_6_567.pdf
Author Matsumoto, Naomi| Higuchi, Chigusa| Miyaji, Chikara| Mitsuhashi, Toshiharu| Hagiya, Hideharu| Takao, Soshi| Yorifuji, Takashi|
Abstract This paper presents the results of a series of surveys conducted from July 2021 to March 2023 to investigate the post-vaccination adverse reactions to the mRNA-1273 (Moderna) vaccine among faculty, staff, and students at Okayama University. These studies complement the official surveys conducted by the Ministry of Health, Labour and Welfare (MHLW) and provide a more representative picture of adverse reactions in the general population including large numbers of healthy young people. Pain, swelling, redness at the injection site, fever, headache, and malaise were the main adverse reactions reported. The proportion of adverse reactions was generally higher after the second vaccination and decreased with each additional vaccination. No statistically significant differences in the adverse reactions were found for males and females and those with/without a history of allergy, but a lower proportion of fever was observed in older participants and those with underlying medical conditions. We also evaluated the association between adverse reactions and antibody titers after the third vaccination and found no significant differences in antibody levels one month after vaccination. This series of studies highlights the importance of conducting surveys in diverse populations to provide a more representative picture of post-vaccination adverse reactions during a pandemic.
Keywords coronavirus disease 2019 adverse reactions mRNA vaccine antibody titers young adults
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2023-12
Volume volume77
Issue issue6
Publisher Okayama University Medical School
Start Page 567
End Page 575
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38145930
Web of Science KeyUT 001164631200001
FullText URL fulltext.pdf
Author Toyosawa, Junki| Yamasaki, Yasushi| Fujimoto, Tsuyoshi| Tanaka, Shouichi| Tanaka, Takehiro| Mitsuhashi, Toshiharu| Okada, Hiroyuki|
Published Date 2022-05-13
Publication Title Endoscopy International Open
Volume volume10
Issue issue05
Publisher Georg Thieme Verlag KG
Start Page E602
End Page E608
ISSN 2364-3722
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022. The Author(s).
File Version publisher
PubMed ID 35571476
DOI 10.1055/a-1785-8616
Web of Science KeyUT 000794976400009
Related Url isVersionOf https://doi.org/10.1055/a-1785-8616
FullText URL fulltext.pdf
Author Mitoma, Tomohiro| Maki, Jota| Ooba, Hikaru| Eto, Eriko| Takahashi, Kasumi| Kondo, Tsunemasa| Ikeda, Tomohiro| Sakamoto, Yoko| Mitsuhashi, Toshiharu| Masuyama, Hisashi|
Keywords Oestrogen replacement therapy Knee osteoarthritis Muscle resistance exercise Sarcopenia Physical performance
Published Date 2023-02-18
Publication Title BMC Geriatrics
Volume volume23
Issue issue1
Publisher BMC
Start Page 104
ISSN 1471-2318
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2023.
File Version publisher
PubMed ID 36800940
DOI 10.1186/s12877-023-03828-y
Web of Science KeyUT 000936860000001
Related Url isVersionOf https://doi.org/10.1186/s12877-023-03828-y
FullText URL fulltext.pdf
Author Iguchi, Toshihiro| Matsui, Yusuke| Toji, Tomohiro| Sakurai, Jun| Tomita, Koji| Uka, Mayu| Umakoshi, Noriyuki| Kawabata, Takahiro| Munetomo, Kazuaki| Mitsuhashi, Toshiharu| Hiraki, Takao|
Keywords Biopsy Kidney Tumor Computed tomography Ultrasound
Note The version of record of this article, first published in Japanese Journal of Radiology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s11604-023-01496-x|
Published Date 2023-10-14
Publication Title Japanese Journal of Radiology
Volume volume42
Issue issue3
Publisher Springer Science and Business Media LLC
Start Page 319
End Page 325
ISSN 1867-1071
NCID AA12375935
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2023
File Version publisher
PubMed ID 37833443
DOI 10.1007/s11604-023-01496-x
Web of Science KeyUT 001086535200001
Related Url isVersionOf https://doi.org/10.1007/s11604-023-01496-x
JaLCDOI 10.18926/AMO/66916
FullText URL 78_2_135.pdf
Author Higaki, Fumiyo| Morimitsu, Yusuke| Iguchi, Toshihiro| Saito, Hayato| Takaki, Haruhiko| Nakagoshi, Ayako| Wada, Maki| Uka, Mayu| Akagi, Noriaki| Mitsuhashi, Toshiharu| Matsui, Yusuke| Hiraki, Takao|
Abstract This study aimed to evaluate the potential reduction in contrast medium utilization using photon-counting detector computed tomography (PCD-CT). One PCD-CT scan (CT1) and three conventional (non-PCD-CT) CT scans (CT2-CT4) were performed using a multi-energy CT phantom that contained eight rods with different iodine concentrations (0.2, 0.5, 1, 2, 5, 10, 15, and 20 mg/ml). The CT values of the seven groups (CT1 for 40, 50, 60, and 70 keV; and CT2-4) were measured. Noise and contrast-to-noise ratio (CNR) were assessed for the eight rods at various iodine concentrations. CT2 and CT1 (40 keV) respectively required 20 mg/ml and 5 mg/ml of iodine, indicating that a comparable contrast effect could be obtained with approximately one-fourth of the contrast medium amount. The standard deviation values increased at lower energy levels irrespective of the iodine concentration. The CNR exhibited a decreasing trend with lower iodine concentrations, while it remained relatively stable across all iodine levels (40-70 keV). This study demonstrated that virtual monochromatic 40 keV images offer a similar contrast effect with a reduced contrast medium amount when compared to conventional CT systems at 120 kV.
Keywords photon-counting detector CT energy integrating detector CT computed tomography contrast medium amount reduction
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2024-04
Volume volume78
Issue issue2
Publisher Okayama University Medical School
Start Page 135
End Page 142
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
FullText URL fulltext.pdf
Author Matsumoto, Naomi| Sasaki, Ayako| Kadowaki, Tomoka| Mitsuhashi, Toshiharu| Takao, Soshi| Yorifuji, Takashi|
Note The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-024-55245-9|
Published Date 2024-02-25
Publication Title Scientific Reports
Volume volume14
Issue issue1
Publisher Nature Portfolio
Start Page 4564
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2024
File Version publisher
PubMed ID 38403650
DOI 10.1038/s41598-024-55245-9
Web of Science KeyUT 001177180300006
Related Url isVersionOf https://doi.org/10.1038/s41598-024-55245-9
FullText URL fulltext.pdf
Author Yasutomi, Eriko| Inokuchi, Toshihiro| Hiraoka, Sakiko| Takei, Kensuke| Igawa, Shoko| Yamamoto, Shumpei| Ohmori, Masayasu| Oka, Shohei| Yamasaki, Yasushi| Kinugasa, Hideaki| Takahara, Masahiro| Harada, Keita| Furukawa, Masaki| Itoshima, Kouichi| Okada, Ken| Otsuka, Fumio| Tanaka, Takehiro| Mitsuhashi, Toshiharu| Kato, Jun| Okada, Hiroyuki|
Published Date 2021-05-27
Publication Title Scientific Reports
Volume volume11
Issue issue1
Publisher Nature Research
Start Page 11086
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2021
File Version publisher
PubMed ID 34045529
NAID 120007089817
DOI 10.1038/s41598-021-90441-x
Web of Science KeyUT 000658389400001
Related Url isVersionOf https://doi.org/10.1038/s41598-021-90441-x
Author Waki, Takahiro| Katsui, Kuniaki| Mitsuhashi, Toshiharu| Ogata, Takeshi| Katayama, Norihisa| Takemoto, Mitsuhiro| Nasu, Yasutomo| Kumon, Hiromi| Kanazawa, Susumu|
Published Date 2017-02
Publication Title Acta Medica Okayama
Volume volume71
Issue issue1
Content Type Journal Article
JaLCDOI 10.18926/AMO/54823
FullText URL fulltext20210928-1.pdf
Author Umeda, Yuzo| Mitsuhashi, Toshiharu| Kojima, Toru| Satoh, Daisuke| Sui, Kenta| Endo, Yoshikatsu| Inagaki, Masaru| Oishi, Masahiro| Yagi, Takahito| Fujiwara, Toshiyoshi|
Keywords intrahepatic cholangiocarcinoma lymph node excision multicenter study propensity score retrospective studies
Note This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.|
Published Date 2021-9-16
Publication Title Journal of Hepato-Biliary-Pancreatic Sciences
Publisher Wiley
Start Page 1
End Page 13
ISSN 1868-6974
NCID AA12507209
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 The Authors. Journal of Hepato-Biliary-Pancreatic Sciences published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Hepato-Biliary-Pancreatic Surgery.
File Version publisher
PubMed ID 34473411
DOI 10.1002/jhbp.1038
Web of Science KeyUT 000696321700001
Related Url isVersionOf https://doi.org/10.1002/jhbp.1038
JaLCDOI 10.18926/AMO/66152
FullText URL 77_6_607.pdf
Author Tani, Yasunari| Kashima, Saori| Mitsuhashi, Toshiharu| Suzuki, Etsuji| Takao, Soshi| Yorifuji, Takashi|
Abstract Many studies have shown an association between long-term exposure to particulate matter having an aerodynamic diameter of 2.5 μm or less (PM2.5) and diabetes mellitus (DM), but few studies have focused on Asian subjects. We thus examined the association between long-term exposure to PM2.5 and DM prevalence in Okayama City, Japan. We included 76,591 participants who had received basic health checkups in 2006 and 2007. We assigned the census-level modeled PM2.5 data from 2006 and 2007 to each participant and defined DM using treatment status and the blood testing. PM2.5 was associated with DM prevalence, and the prevalence ratio (95% confidence interval) was 1.10 (1.00-1.20) following each interquartile range increase (2.1 μg/m3) in PM2.5. This finding is consistent with previous results and suggests that long-term exposure to PM2.5 is associated with an increased prevalence of DM in Okayama City, Japan, where the PM2.5 level is lower than in other cities in Asian countries.
Keywords air pollution diabetes mellitus epidemiology glycosylated hemoglobin particulate matter
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-12
Volume volume77
Issue issue6
Publisher Okayama University Medical School
Start Page 607
End Page 612
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38145934
Web of Science KeyUT 001164631200005
FullText URL fulltext20230112-4.pdf figures20230112-4.pdf online-supplemental-figures20230112-4.pdf online-supplemental-Tables20230112-4.pdf
Author Matsumoto, Naomi| Hagiya, Hideharu| Nakayama, Masanori| Furukawa, Masanori| Mitsuhashi, Toshiharu| Takao, Soshi| Otsuka, Fumio| Yorifuji, Takashi|
Keywords SARS-CoV-2 Vaccine Antibody Reactogenicity Adverse reaction Mixed-effects model
Note © 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.jiac.2022.09.012] . | This full-text file will be available in Nov. 2023.|
Published Date 2022-11-12
Publication Title Journal of Infection and Chemotherapy
Volume volume29
Issue issue1
Publisher Elsevier BV
Start Page 39
End Page 42
ISSN 1341-321X
NCID AA11057978
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases
File Version author
PubMed ID 36168999
DOI 10.1016/j.jiac.2022.09.012
Web of Science KeyUT 000894818300007
Related Url isVersionOf https://doi.org/10.1016/j.jiac.2022.09.012
FullText URL fulltext.pdf
Author Mitsuhashi, Toshiharu|
Keywords Medical student Peer instruction ConcepTest Medical education Epidemiology
Published Date 2020-08-12
Publication Title PeerJ
Volume volume8
Publisher PeerJ
Start Page e9640
ISSN 2167-8359
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 Mitsuhashi
File Version publisher
DOI 10.7717/peerj.9640
Web of Science KeyUT 000558591500005
Related Url isVersionOf https://doi.org/10.7717/peerj.9640
FullText URL fulltext20220104-5.pdf
Author Suzuki, Etsuji| Tsuda, Toshihide| Mitsuhashi, Toshiharu| Mansournia, Mohammad Ali| Yamamoto, Eiji|
Keywords bias causality epidemiologic methods
Note © 2016 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/.
This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.annepidem.2016.09.008] .|
Published Date 2016-11
Publication Title Annals of Epidemiology
Volume volume26
Issue issue11
Publisher Elsevier BV
Start Page 788
End Page 793
ISSN 1047-2797
NCID AA10761439
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2016 Elsevier Inc.
File Version author
PubMed ID 27771142
DOI 10.1016/j.annepidem.2016.09.008
Web of Science KeyUT 000388546300011
Related Url isVersionOf https://doi.org/10.1016/j.annepidem.2016.09.008