ID | 62882 |
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Kinugasa, Hideaki
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
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Kanzaki, Hiromitsu
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
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Tanaka, Takehiro
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
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Yamamoto, Shumpei
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Yamasaki, Yasushi
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
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Nouso, Kazuhiro
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
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Ichimura, Kouichi
Department of Pathology, Hiroshima City Hiroshima Citizens Hospital
Nakagawa, Masahiro
Department of Endoscopy, Hiroshima City Hiroshima Citizens Hospital
Mitsuhashi, Toshiharu
Center for Innovative Clinical Medicine, OkayamaUniversity Hospital
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Okada, Hiroyuki
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
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Abstract | INTRODUCTION: The genomic characterization of primary nonampullary duodenal adenocarcinoma indicates a genetic resemblance to gastric and colorectal cancers. However, a correlation between the clinical and molecular characteristics of these cancers has not been established. This study aimed to elucidate the clinicopathological features of sporadic nonampullary duodenal epithelial tumors, including their molecular characteristics and prognostic factors.
METHODS: One hundred forty-eight patients with sporadic nonampullary duodenal epithelial tumors were examined in this study. Patient sex, age, TNM stage, tumor location, treatment methods, histology, KRAS mutation, BRAF mutation, Fusobacterium nucleatum, mucin phenotype, and programmed death-ligand 1 (PD-L1) status were evaluated. KRAS and BRAF mutations, Fusobacterium nucleatum, mucin phenotype, and PD-L1 status were analyzed by direct sequencing, quantitative polymerase chain reaction, and immunochemical staining. RESULTS: The median follow-up duration was 119.4 months. There were no deaths from duodenal adenoma (the primary disease). Kaplan-Meier analysis for duodenal adenocarcinoma showed a significant effect of TNM stage (P < 0.01). In univariate analysis of primary deaths from duodenal adenocarcinoma, TNM stage II or higher, undifferentiated, KRAS mutations, gastric phenotype, intestinal phenotype, and PD-L1 status were significant factors. In multivariate analysis, TNM stage II or higher (hazard ratio: 1.63 x 10(10), 95% confidence interval: 18.66-6.69 x 10(36)) and KRAS mutation (hazard ratio: 3.49, confidence interval: 1.52-7.91) were significant factors. DISCUSSION: Only KRAS mutation was a significant prognostic factor in primary sporadic nonampullary duodenal adenocarcinoma in cases in which TNM stage was considered. |
Published Date | 2021-11
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Publication Title |
Clinical and Translational Gastroenterology
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Volume | volume12
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Issue | issue11
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Publisher | Lippincott Williams & Wilkins
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Start Page | e00424
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ISSN | 2155-384X
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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Copyright Holders | © 2021 The Author(s).
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File Version | publisher
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Related Url | isVersionOf https://doi.org/10.14309/ctg.0000000000000424
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License | https://creativecommons.org/licenses/by/4.0/
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Citation | Kinugasa, Hideaki MD, PhD1; Kanzaki, Hiromitsu MD, PhD1; Tanaka, Takehiro MD, PhD2; Yamamoto, Shumpei MD1; Yamasaki, Yasushi MD, PhD1; Nouso, Kazuhiro MD, PhD1; Ichimura, Kouichi MD, PhD3; Nakagawa, Masahiro MD, PhD4; Mitsuhashi, Toshiharu MD, PhD5; Okada, Hiroyuki MD, PhD1 The Impact of KRAS Mutation in Patients With Sporadic Nonampullary Duodenal Epithelial Tumors, Clinical and Translational Gastroenterology: November 2021 - Volume 12 - Issue 11 - p e00424 doi: 10.14309/ctg.0000000000000424
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