| JaLCDOI | 10.18926/15345 |
|---|---|
| Title Alternative | 気管支喘息の発症における加齢の影響について |
| FullText URL | 063_142_147.pdf |
| Author | Mitsunobu, Fumihiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Tanizaki, Yoshiro| |
| Abstract | Skin tests, serum total IgE levels, specific IgE antibodies against each allergen, bronchial reactions provoked by allergens and histamine release from basophils are well known as prameters of immediate allergic reactions. The incidence of positive immediate skin reaction to allergens such as house dust, ragweed, Aspergillus Alternaria, Cladosporium and Broncasma decreased with aging. On the other hand, the incidence of positive skin reaction to Candida albicans was higher in cases between the age of 41 and 50 and cases over the age of 61 compared to that in the other groups classified by age. Serum IgE levels was highest in cases aged between 0 and 30. The levels of serum IgE decreased with aging. The incidence of positive RAST scores (more than 2+) and positive bronchial reaction to house dust were highest in cases between 0 and 30, and decreased with aging. However, the positive ratio of these tests against C. albicans were highest in cases between 41 and 50. The degree of histamine release from basophils of asthmatics induced by anti-IgE was consistently high without any correlation to aging when their serum IgE levels were more than 501 IU/ml. In the cases with serum IgE levels of less than 300 IU/ml, basophil reactivity to anti-IgE decreasd with aging. Basophil reactivity to house dust was generally dependent on the levels of specific IgE antibodies against the allergen. Although basophil reactivity to C. albicans was also high in cases with positive RAST scores, some cases with a RAST score of 0+ or 1+ showed high or moderate basophil reactivity. Moderate or high reactivity of basophils was frequently observed in cases between 41 and 50 and cases over age 61. |
| Keywords | Skin test (皮内反応) IgE Provocation test (吸入誘発試験) Basophil reactivity (好塩基球の反応性) Aging (加齢) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 142 |
| End Page | 147 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307130 |
| JaLCDOI | 10.18926/15343 |
|---|---|
| Title Alternative | 抗原および抗ヒトIgEに対する抗塩基球の反応性. 3.Ca2(+)の細胞内流入およびヒスタミン遊離 |
| FullText URL | 063_134_141.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kimura, Ikuro| |
| Abstract | The release mechanism of chemical mediators from basophils and mast cells was discussed when these cells were stimulated by different antigens and anti-IgE. 1. Ca(2+) influx into mast cells increased after stimulation by antigen. The increased Ca(2+) uptake by mast cells was inhibited by antiallergic agents, disodium cromoglycate (DSCG) and tranilast, and calcium antagonists, nifedipine and nicardipine. 2. The dose-response curve of histamine release by antigen was different from that by anti-IgE. The maximum release of histamine by house dust was, however, similar to that by anti-IgE. House dust- and anti-IgE-induced release of histamine increased with higher- serum IgE levels. On the contrary, the release of histamine by Candida albicans was not releated to serum IgE levels, and the release by C. albicans did not parallel therelease by anti-IgE. |
| Keywords | Ca(2+) influx (Ca2+流入) histamine release (ヒスタミン遊離) house dust (ハウスダスト) Candida albicans (カンジダ) anti-lgE (抗ヒトIgE) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 134 |
| End Page | 141 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307872 |
| JaLCDOI | 10.18926/15298 |
|---|---|
| Title Alternative | ステロイド依存性重症難治性喘息に対する複合温泉療法の作用機序 |
| FullText URL | 063_001_006.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Takatori, Akimasa| Okuda, Hiroyuki| Ochi, Koji| Harada, Hideo| Kimura, Ikuro| |
| Abstract | Effects of complex spa therapy, which comprises swimming training in a hot spring pool, inhalation of iodine salt solution and fango therapy, were analyzed in patients with steroid-dependent intractable asthma (SDIA) by comparison between the subjects with and without efficacy of the therapy. 1. The complex spa therapy was effective in the patients with lower levels of FEV(1.0%) and % PEFR. 2. The complex spa therapy was not always effective in the patients with a low value of % V(25), which represents depressed airflow in the small airways. 3. The efficacy of the complex spa therapy was found in the patients showing a low value of % V(25) accompanied by BAL neutrophilia, but not found in those without increased proportion (more than 10% ) of neutrophils in BAL fluid. The results reveal that the complex spa therapy is effective in patients with SDIA showing low values of FEV(1.0%) and % PEFR, and in those with a low value of % V(25) and BAL neutrophilia. |
| Keywords | complex spa therapy (複合温泉療法) ventilatory function (換気機能) BAL neutrophilia (BAL好中球増多) bronchial asthma (気管支喘息) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 1 |
| End Page | 6 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307537 |
| JaLCDOI | 10.18926/15300 |
|---|---|
| Title Alternative | Clinical effects of spa therapy on bronchial asthma. |
| FullText URL | 063_007_013.pdf |
| Author | Mifune, Takashi| Kusaura, Yasuhiro| Honke, Naoko| Tanimizu, Masahiro| Mitunobu, Fumihiro| Okazaki, Morihiro| Kitani, Hikaru| Tanizaki, Yoshiro| |
| Abstract | ステロイド依存性重症難治性喘息を中心に,喘息に対する温泉療法の臨床効果を,症例の背景因子に基づいて検討した｡1.現年令あるいは発症年令が高い症例でより有効であった｡2.非アトピー性の症例において有効率が高率であった｡3.臨床病型別では,細気管支閉塞型において最も有効率が高く,17例中16例(94.1%)が有効であった｡4.ステロイド減量効果は.71症例中43例(60.6%)で認められた｡細気管支閉塞型の症例でステロイド減量不能の症例を多く認めた｡ |
| Keywords | 気管支喘息 (Bronchial asthma) 温泉療法 (Spa therapy) 臨床病型 (clinical asthmaty) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 7 |
| End Page | 13 |
| ISSN | 0913-3771 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307411 |
| JaLCDOI | 10.18926/15302 |
|---|---|
| Title Alternative | 気管支喘息における気道内リンパ球の出現とその意義.IgE系反応との関連について. |
| FullText URL | 063_019_024.pdf |
| Author | Tanizaki, Yosihiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honke, Naoko| Kusaura, Yasuhiro| Kimura, Ikuro| |
| Abstract | Relationship of the proportion of lymphocytes in bronchoalveolar lavage (BAL) fiutd to IgE-mediated reactions and to ventilatory function was studied in two age-matched asthma groups : group A of 11 subjects with BAL lymphocytes over 30% and group B of 11 subjects with BAL leyphocytes less than 10%. Of the eleven subjects in group A, 3 (27.3%) were atopic and 4 (36.4%) were non-atopic. The proportion of BAL lymphocytes in subjects with serum IgE level more than 300 IU/ml, who were all older than 50 years, was significantly higher than that in subjects with serum IgE less than 100 IU/ml in group A (p<0.05). While of the eleven subjects of group B, 5 (45.5%) were atopic and 4 (36.4%) were non-atopic. The value of % V(25) was significantly higher in the atopics compared with the non-atopics in group A (p<0.05), although no significant difference was found in the value of % V(25) between the two asthma types in group B. The results show that an increased number of lymphocytes in BAL fluid may be enhanced by IgE-mediated allergic reactions in the elderly, and that the decreased value of % V(25) may be associated withan increased number of lymphocytes in BAL fluid in non-atopics. |
| Keywords | Lymphocytes (リンパ球) BAL fluid (BAL液) IgE antibody (IgE抗体) bronchial asthma (気管支喘息) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 19 |
| End Page | 24 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307202 |
| JaLCDOI | 10.18926/15304 |
|---|---|
| Title Alternative | 気管支喘息における気道内への好酸球の出現とその意義. 過分泌と関連して. |
| FullText URL | 063_014_018.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kimura, Ikuro| |
| Abstract | A correlation between the proportion of eosinophils in bronochoalveolar lavage (BAL) fluid and amount of expectoration was examined in patients with atopic asthma. The subjects were divided into two groups : cases with high proportion (20% of more) (group A) and low proportion (less than 5%) (group B) of eosinophils in the BAL fluid. Any significant difference was not paesent in the value of each ventilatory parameter between the two groups. The amount of expectoration/day was significantly higher in group A compared with group B (p<0.001). These results suggest that eosinophilia in BAL fluid correlates to mucus hypersecretion in the airways of patients with atopic asthma. |
| Keywords | Eosinophilia (好酸球) Hypersecretion (過分泌) BAL fluid (BAL) bronchial asthma (気管支喘息) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 14 |
| End Page | 18 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307156 |
| JaLCDOI | 10.18926/AMO/32675 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Ochi, Koji| Harada, Hideo| Kimura, Ikuro| |
| Abstract | The improvement of ventilatory function by spa therapy was examined in 37 patients with steroid-dependent intractable asthma (SDIA) in relation to clinical asthma types. All subjects had been on long-term corticosteroid therapy before spa therapy. Spa therapy was found to improve the values of ventilatory parameters. The percent improvement in all subjects was +4.1% in %FVC, +8.9% in FEV1.0%, +9.8% in %PEFR, +22.0% in %MMF, +19.7% in %V50 and +28.2% in %V25, respectively. Relating to clinical asthma types, moderate improvement in %MMF and %V25 from 16.7% to 16.9% was observed in type Ia cases, and marked increase in %MMF, %V50 and %V25 was observed from 42.2% to 43.2% in type Ib cases. However, no significant increase was found in these parameters of types Ia or Ib after spa therapy. In patients with type II, a significant increase was shown in %V50 (p less than 0.05) and %V25 (p less than 0.01) after spa therapy. The results show that spa therapy improves the condition of small airways disorder in patients with SDIA. |
| Keywords | spa therapy bronchial asthma ventilatory function small airways |
| Amo Type | Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 1992-06 |
| Volume | volume46 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 175 |
| End Page | 178 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 1502922 |
| Web of Science KeyUT | A1992JB50400005 |
| JaLCDOI | 10.18926/11668 |
|---|---|
| Title Alternative | カンジダ特異的IgG(4)抗体と気管支喘息 |
| FullText URL | 062_001_004.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Takatori, Akimasa| Okuda, Hiroyuki| Harada, Hideo| |
| Abstract | Serum levels of Candida-specific IgG(4) antibodies were examined in 66 patients with bronchial asthma, relating to patient age and asthma severity. 1. The levels of Candida-specific IgG(4) antibodies were the highest in patients with 60+years of age, compared to the levels in cases with 0-39 and 40-59 years of age. 2. In cases with 40-59 years of age, the levels of Candida-specific IgG(4) were significantly higher in cases with long-term steroid therapy (severe intractable asthma) than in cases without steroid regimen. The results suggest that increased levels of Candida-specific IgG(4) were observed in relation to patient age and asthma severity. |
| Keywords | Candida (カンジダ) Sepcific IgG(4) (特異的IgG(4)) Bronchial asthma (気管支喘息) Aging (加齢) Asthma severity (喘息重症度) |
| Publication Title | 環境病態研報告 |
| Published Date | 1991-08 |
| Volume | volume62 |
| Start Page | 1 |
| End Page | 4 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002313495 |
| JaLCDOI | 10.18926/AMO/32167 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Okazaki, Morihiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Asaumi, Noboru| Tanizaki, Yoshiro| Harada, Hideo| Takahashi, Kiyoshi| Kimura, Ikuro| |
| Abstract | Serum levels of total IgE, specific IgE, IgG and IgG4 against house dust mite were measured in mite-sensitive asthma patients receiving immunotherapy with house dust. Serum levels of total IgE, mite specific IgE and IgG did not significantly change during the course of hyposensitization. Increased levels of mite specific IgG4 were observed in patients during immunotherapy. The increase in specific IgG4 was dependent on the total dose of house dust administered in both children (r = 0.636, p less than 0.001) and adults (r = 0.629, p less than 0.01). However, the increase of specific IgG4 in adults was not as apparent as in children. These results might suggest that mite specific IgG4 is a useful immunological marker in the immunotherapy for allergic asthma, and that IgG4 antibody acts as a blocking antibody in atopic bronchial asthma. |
| Keywords | house dust mite bronchial asthma hyposensitization specific IgG4 |
| Amo Type | Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 1991-08 |
| Volume | volume45 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 267 |
| End Page | 273 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 1962533 |
| Web of Science KeyUT | A1991GD78000009 |
| JaLCDOI | 10.18926/15167 |
|---|---|
| Title Alternative | A case of rheumatoid arthritis with hypoproteinemia probably induced by diseasemodifying antirheumatic drug, D-Penicillamine |
| FullText URL | 062_080_083.pdf |
| Author | Kitani, Hikaru| Mitsunobu, Fumihiro| Mifune, Takashi| Okazaki, Morihiro| Tanizaki, Yoshiro| |
| Abstract | 症例は52歳女性で，慢性関節リウマチ（RA）はclassical，stageIV， class 2であった。症状は進行性で加療を行うも改善がみられなかった。平成元年11月RA症状の増悪のための再入院後，Penicillamine 100～200 mg，Sulfasalazine 500mgを合せて投与を行ったところ，血沈，CRP等の検査所見は改善傾向を示したが入院時には正常値であった血清蛋白量がその後5.1g／dlまで低下し，下肢浮腫が出現，その後さらに血清蛋白量は4.1g／dlにまで減少した。治療により蛋白量は5.8g／dlにまで回復したが，低蛋白血症の原因としてはD－Penicillamineの関与が疑われた。 |
| Keywords | 慢性関節リウマチ (Rheumatoid arthritis) 低蛋白血症 (Hypoproteinemia) D-ペニシラミン (D-Penicittamine) 抗リウマチ剤 (Disease-modifying antirheumatic drug) |
| Publication Title | 環境病態研報告 |
| Published Date | 1991-08 |
| Volume | volume62 |
| Start Page | 80 |
| End Page | 83 |
| ISSN | 0913-3771 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307840 |
| JaLCDOI | 10.18926/15097 |
|---|---|
| Title Alternative | Possible participation of viral infection in the onset mechanisms of bronchial asthma |
| FullText URL | 062_076_079.pdf |
| Author | Mifune, Takashi| Mitunobu, Fumihiro| Okazaki, Morihiro| Kitani, Hikaru| Tanizaki, Yoshiro| |
| Abstract | ウイルスなどの気道感染により，気管支喘息症状が発症したり，あるいは増悪したりすることが知られている。自験例は65歳の女性で，上気道炎症状に引き続いて，気管支喘息が発症した。臨床症状の軽快とともに気道過敏性・IgE値は低下し，感染による気道過敏性の亢進，IgE型アレルギー反応の機序が関与していると考えられた。これらの結果は喘息患者は気道感染（特にウイルス感染）の予防が必要であり，感染した場合には抗喘息剤とともに抗炎症剤の使用が有用である可能性を示している。 |
| Keywords | 気道感染 (Respiratory infection, Virus infection) 気道過敏性 (Bronchial hypersensitivity) lgEアレルギー反応 (Allergic reaction mediated by IgE) |
| Publication Title | 環境病態研報告 |
| Published Date | 1991-08 |
| Volume | volume62 |
| Start Page | 76 |
| End Page | 79 |
| ISSN | 0913-3771 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307679 |
| JaLCDOI | 10.18926/15065 |
|---|---|
| Title Alternative | The biochemical and biological activities of JUN. |
| FullText URL | 062_071_075.pdf |
| Author | Mitsunobu, Fumihiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Asaumi, Noboru| Tanizaki, Yoshiro| |
| Abstract | c-junはニワトリの癌ウイルスから分離された癌遺伝子（v-jun）のproto－oncogeneであり，その遺伝子産物は細胞内転写促進因子AP－1の主成分である。v－jun，c-junのトランスフォーム能を検討するために，我々はv-jun，ニワトリc-jun遺伝子さらにJUN遺伝子の種々の組換え体を複製能を持つレトロウイルスベクター（RCAS）に挿入し，CEF細胞（ニワトリ胎児線維芽細胞）にトランスフェクションした。その結果4か所存在する両者の構造的相違のうち，アミノ末端近くの27アミノ酸の欠損と3' untranslated regionの欠損が十分なトランスフォーム能と転写促進能発現に必須であることが明らかとなった。これらの部分がどのように機能発現に関与しているかは，これからの研究を待たねばならない。 |
| Keywords | 癌遺伝子 (Oncogene) JUN遺伝子 (JUN gene) レトロウイルスベクター (Retrovirus Vector) トランスフェクション (Transfection) トランスフォーム (Transform) |
| Publication Title | 環境病態研報告 |
| Published Date | 1991-08 |
| Volume | volume62 |
| Start Page | 71 |
| End Page | 75 |
| ISSN | 0913-3771 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307874 |
| JaLCDOI | 10.18926/14493 |
|---|---|
| Title Alternative | Motility of basophilic granulocytes and histaminerelease |
| FullText URL | 062_047_051.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Nakagawa, Saburo| Soda, Ryo| Tada, Shinya| Takahashi, Kiyoshi| Kimura, Ikuro| |
| Abstract | 各種刺激物質添加時の好塩基球の形態的変化―運動亢進と膨化，脱顆粒―と化学伝達物質遊離との関連を中心に若干の知見をのべた。まず，抗原刺激時には，(1)運動亢進をきたし，洋梨状を示す好塩基球と膨化，脱顆粒を示す好塩基球の2種類が観察されること，(2)アトピー型喘息の好塩基球は健康人と比べて全般的に運動が抑制されていること，(3)運動亢進の状態としては，random movementとoriented movementがあり，抗原に対応した特徴的な運動亢進はoriented movementであること，(4)運動亢進と膨化，脱顆粒は，連続した一連のものではなく，それぞれ独立した過程を持っていること，などが観察されている。また，刺激物質の種類によって，好塩基球の形態的変化や化学伝達物質遊離の状態が異なることについても報告した。 |
| Keywords | 好塩基球 (Basophils) 抗原 (Antigen) 運動亢進 (lncreased motility) 脱顆粒 (Degranulation) ヒスタミン遊離 (Histamine release) |
| Publication Title | 環境病態研報告 |
| Published Date | 1991-08 |
| Volume | volume62 |
| Start Page | 47 |
| End Page | 51 |
| ISSN | 0913-3771 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308512 |
| Author | 光延 文裕| |
|---|---|
| Published Date | 1988-03-31 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Mitsunobu, Fumihiro| |
|---|---|
| Published Date | 1988 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume100 |
| Issue | issue5-6 |
| Content Type | Journal Article |
