JaLCDOI | 10.18926/AMO/32272 |
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FullText URL | fulltext.pdf |
Author | Miyahara, Nobuaki| Eda, Ryosuke| Takeyama, Hiroyasu| Kunichika, Naomi| Moriyama, Michihiko| Aoe, Keisuke| Kohara, Hiroyuki| Chikamori, Kenichi| Maeda, Tadashi| Harada, Mine| |
Abstract | Although the rehabilitation of patients with chronic obstructive pulmonary disease (COPD) improves both exercise capacity and quality of life, a standard protocol for COPD patients has not been established. To clarify whether physiologic and quality-of-life improvements can be achieved by an inpatient pulmonary rehabilitation program 5 days per week for 3 weeks, 18 patients with COPD were enrolled in a rehabilitation program. The physical exercise training regimen consisted of respiratory muscle stretch gymnastics and cycle ergometer exercise training. Pulmonary function tests, an incremental ergometer exercise test, a 6-min walking test, and a quality of life assessment by the Chronic Respiratory Questionnaire were administered before and after the program. The peak VO2, an indicator of maximal exercise capacity, did not increase, although the 6-min walking distance, an indicator of functional exercise capacity, increased significantly after rehabilitation. There was a significant improvement in the quality of life in terms of dyspnea, fatigue, and emotional state. These findings suggest that even a 3-week program may be beneficial for COPD patients. Increases in functional exercise capacity, even without an increase in maximal exercise capacity, are helpful for reducing dyspnea and improving quality of life parameters in patients with COPD. |
Keywords | exercise tolerance stretch gymnastic dyspnea |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 2000-08 |
Volume | volume54 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 179 |
End Page | 184 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 10985178 |
Web of Science KeyUT | 000089132800006 |
JaLCDOI | 10.18926/AMO/32852 |
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FullText URL | fulltext.pdf |
Author | Iio, Kouji| Iio, Tomoe Ueno| Okui, Yuhei| Ichikawa, Hirohisa| Tanimoto, Yasushi| Miyahara, Nobuaki| Kanehiro, Arihiko| Tanimoto, Mitsune| Nakata, Yasunari| Kataoka, Mikio| |
Abstract | Propionibacterium acnes has been implicated as an etiologic agent of sarcoidosis since the isolation of this bacterium from sarcoid lesions. We experimentally produced a murine pulmonary granuloma model using P. acnes with several features that simulate sarcoidosis. Mice were sensitized with heat-killed P. acnes and complete Freund's adjuvant and were subsequently challenged with heat-killed P. acnes at 2-week intervals. P. acnes-challenged mice developed epitheloid cell granulomas in the lungs. These mice showed a pulmonary immune response characterized by an increased number of T-lymphocytes, especially CD4 cells, and the ratio of CD4/CD8 in bronchoalveolar lavage (BAL) fluid also increased. Furthermore, significant elevations in both angiotensin-converting enzyme (ACE) serum levels and antibody titers against P. acnes were observed. Mice sensitized with P. acnes without complete Freund's adjuvant were capable of forming pulmonary granulomas, which appeared to be caused by indigenous P. acnes. The genome of P. acnes was found in the lungs, BAL cells, hilar lymph nodes, liver, and spleen in non-sensitized mice, which were thought to be germ-free. These results suggest that the immune response against indigenous P. acnes may play an important role in the pathogenesis of granuloma formation in a murine model. |
Keywords | Propionibacterium acnes experimental granuloma sarcoidosis |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2010-04 |
Volume | volume64 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 75 |
End Page | 83 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 20424662 |
Web of Science KeyUT | 000276996900001 |
JaLCDOI | 10.18926/AMO/46635 |
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FullText URL | 65_3_215.pdf |
Author | Waseda, Koichi| Tanimoto, Yasushi| Hasegawa, Kenjiro| Miyahara, Nobuaki| Nojima, Daisuke| Ikeda, Genyo| Kanehiro, Arihiko| Okada, Chiharu| Kimata, Yoshihiro| Tanimoto, Mitsune| |
Abstract | Churg-Strauss syndrome (CSS) is a granulomatous necrotizing vasculitis of unknown etiology associated with bronchial asthma. Despite affecting small to medium-sized vessels, necrosis of the digits due to vasculitis is extremely rare. We report a case of CSS with necrosis of the toe tips. A 37-year-old woman with asthma, who had been diagnosed with CSS 2 years ago, was admitted to our hospital with an exacerbation of CSS. The patient had a high grade fever and complained of abdominal pain and numbness of the lower extremities. Blood examination revealed marked eosinophilia. The fever pattern, abdominal pain and blood eosinophilia showed improvement by combination treatment with prednisolone and cyclophosphamide. However, the color of her right toe tips changed, and necrosis finally resulted despite antithrombotic therapy. Arteriography showed narrowing of the dorsalis pedis artery and of the more peripheral arteries of her right leg. Stump plasty with negative pressure dressing therapy for the toe tips, but not amputation, was done to preserve the leg function. While numbness of the extremities remained, no recurrence of necrosis was seen. Clinicians need to be aware that rare complications of CSS, including necrosis of the digits, can occur. |
Keywords | bronchial asthma Churg-Strauss syndrome eosinophilia necrosis of toe tips stump plasty |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2011-06 |
Volume | volume65 |
Issue | issue3 |
Publisher | Okayama University Medical School |
Start Page | 215 |
End Page | 218 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 21709721 |
Web of Science KeyUT | 000292017500010 |
JaLCDOI | 10.18926/AMO/47266 |
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FullText URL | 65_6_403.pdf |
Author | Waseda, Koichi| Tanimoto, Yasushi| Ichiba, Shingo| Miyahara, Nobuaki| Murakami, Toshi| Ochi, Nobuaki| Terado, Michihisa| Nagano, Osamu| Maeda, Yoshinobu| Kanehiro, Arihiko| Ujike, Yoshihito| Tanimoto, Mitsune| |
Abstract | Bronchiolitis obliterans (BO) is a disease with a poor prognosis, and a key factor that limits long-term survival after allogeneic hematopoietic stem cell transplantation (HSCT). We here report a case of a 31-year woman with acute lymphatic leukemia, which was treated by chemotherapy and HSCT, and consequently developed BO 2 years after HSCT. A non-tuberculous mycobacterial infection occurred and showed gradual exacerbation. She started taking anti-mycobacterial drugs, but lost appetite, felt tired and finally lost consciousness one month after beginning medication. Arterial blood gas revealed marked hypercapnia. Using extracorporeal life support (ECLS), the carbon dioxide concentration was reduced and her consciousness recovered. To our knowledge, this is the first case in which ECLS was successfully used for hypercapnia in a patient with BO. |
Keywords | extracorporeal life support hypercapnia bronchiolitis obliterans noninvasive positive pressure ventilation |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2011-12 |
Volume | volume65 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 403 |
End Page | 406 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 22189481 |
Web of Science KeyUT | 000298516900007 |
JaLCDOI | 10.18926/AMO/54422 |
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FullText URL | 70_3_217.pdf |
Author | Waseda, Koichi| Ocho, Kazuki| Hasegawa, Kou| Kimura, Kosuke| Iwamuro, Masaya| Hanayama, Yoshihisa| Kondo, Eisei| Miyahara, Nobuaki| Otsuka, Fumio| |
Abstract | KL-6 is a glycoprotein found predominantly on type II pneumocytes and alveolar macrophages, and often shows increased serum levels in patients with interstitial pneumonia. We report a case of mycobacterium avium complex (MAC) infection whose disease activity was correlated with KL-6 levels in serum. During treatment of rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) with prednisolone, chest image findings improved in association with decreased KL-6 levels. Following tapering of prednisolone, chest image findings deteriorated again as levels of KL-6 increased, suggesting recurrence of RA-ILD. Bronchoscopic examination revealed active MAC infection. Treatment of MAC infection not only improved chest image findings but also decreased KL-6 levels in serum, suggesting that KL-6 was increased by active MAC infection by itself, not by recurrence of RA-ILD. To the best of our knowledge, this is the first documentation of KL-6 elevation in serum in association with active MAC infection. |
Keywords | KL-6 mycobacterium avium complex pulmonary nontuberculous mycobacterium infection rheumatoid arthritis-associated interstitial lung disease bronchial alveolar lavage |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2016-06 |
Volume | volume70 |
Issue | issue3 |
Publisher | Okayama University Medical School |
Start Page | 217 |
End Page | 221 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 27339212 |
Web of Science KeyUT | 000379406100010 |
JaLCDOI | 10.18926/AMO/54503 |
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FullText URL | 70_4_273.pdf |
Author | Makimoto, Go| Miyahara, Nobuaki| Yoshikawa, Mao| Taniguchi, Akihiko| Kanehiro, Arihiko| Tanimoto, Mitsune| Kiura, Katsuyuki| |
Abstract | Heerfordtʼs syndrome is a rare manifestation of sarcoidosis and is defined as a combination of facial palsy, parotid swelling, and uveitis, associated with a low-grade fever. We report a case of Heerfordtʼs syndrome presenting with a high fever and increased serum tumor necrosis factor alpha (TNF-α) levels. The patient had facial palsy, parotid swelling, uveitis, and swelling of the right supraclavicular and hilar lymph nodes. Corticosteroid therapy was initiated, and her symptoms soon resolved completely, in tandem with a decrease in TNF-α serum levels. |
Keywords | Heerfordtʼs syndrome sarcoidosis TNF-α |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2016-08 |
Volume | volume70 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 273 |
End Page | 277 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 27549672 |
Web of Science KeyUT | 000384748600007 |
Author | 宮原 信明| |
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Published Date | 1994-12-31 |
Publication Title | |
Content Type | Thesis or Dissertation |
Author | Miyahara, Nobuaki| |
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Published Date | 1994-08 |
Publication Title | 岡山医学会雑誌 |
Volume | volume106 |
Issue | issue7-8 |
Content Type | Journal Article |
Author | Taniguchi, Akihiko| Miyahara, Nobuaki| Nakahara, Atsushi| Takata, Saburo| Sakugawa, Ryo| Nagano, Osamu| Tanimoto, Yasushi| Kanehiro, Arihiko| Kiura, Katsuyuki| Ujike, Yoshito| Tanimoto, Mitsune| |
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Published Date | 2011-12-01 |
Publication Title | 岡山医学会雑誌 |
Volume | volume123 |
Issue | issue3 |
Content Type | Journal Article |
Author | Koga, Hikari| Miyahara, Nobuaki| Fuchimoto, Yasuko| Ikeda, Genyo| Waseda, Koichi| Ono, Katsuichiro| Tanimoto, Yasushi| Kataoka, Mikio| Gelfand, Erwin W.| Tanimoto, Mitsune| Kanehiro, Arihiko| |
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Published Date | 2013-01-24 |
Publication Title | Respiratory Research |
Volume | volume14 |
Content Type | Journal Article |
Author | Kurimoto, Etsuko| Miyahara, Nobuaki| Kanehiro, Arihiko| Waseda, Koichi| Taniguchi, Akihiko| Ikeda, Genyo| Koga, Hikari| Nishimori, Hisakazu| Tanimoto, Yasushi| Kataoka, Mikio| Iwakura, Yoichiro| Gelfand, Erwin W.| Tanimoto, Mitsune| |
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Published Date | 2013-01-20 |
Publication Title | Respiratory Research |
Volume | volume14 |
Content Type | Journal Article |
FullText URL | fulltext.pdf |
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Author | Itano, Junko| Ohashi, Kadoaki| Senoo, Satoru| Oda, Naohiro| Nishii, Kazuya| Taniguchi, Akihiko| Miyahara, Nobuaki| Maeda, Yoshinobu| Kiura, Katsuyuki| |
Keywords | Axillary lymphadenitis Mycobacterium avium complex infection Mycobacterium intracellulare |
Published Date | 2019 |
Publication Title | Respiratory Medicine Case Reports |
Volume | volume28 |
Publisher | Elsevier |
Start Page | 100947 |
ISSN | 2213-0071 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2019 The Authors. |
File Version | publisher |
PubMed ID | 31681532 |
DOI | 10.1016/j.rmcr.2019.100947 |
Web of Science KeyUT | 000511444900001 |
Related Url | isVersionOf https://doi.org/10.1016/j.rmcr.2019.100947 |
FullText URL | fulltext.pdf |
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Author | Makimoto, Go| Ohashi, Kadoaki| Taniguchi, Kohei| Soh, Junichi| Taniguchi, Akihiko| Miyahara, Nobuaki| Toyooka, Shinichi| Yoshino, Tadashi| Maeda, Yoshinobu| Kiura, Katsuyuki| |
Keywords | IgG4-related disease Pleural effusion Adenosine deaminase Pleural biopsy Spontaneous remission |
Published Date | 2019 |
Publication Title | Respiratory Medicine Case Reports |
Volume | volume28 |
Publisher | Elsevier |
Start Page | 100938 |
ISSN | 2213-0071 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2019 The Authors. |
File Version | publisher |
PubMed ID | 31667074 |
DOI | 10.1016/j.rmcr.2019.100938 |
Web of Science KeyUT | 000511444900052 |
Related Url | isVersionOf https://doi.org/10.1016/j.rmcr.2019.100938 |
FullText URL | fulltext.pdf figs.pdf tables.pdf |
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Author | Itano, Junko| Higo, Hisao| Ohashi, Kadoaki| Makimoto, Go| Nishii, Kazuya| Hotta, Katsuyuki| Miyahara, Nobuaki| Maeda, Yoshinobu| Kiura, Katsuyuki| |
Keywords | osimertinib drug-induced ILD reversed halo sign organizing pneumonia pattern re-administration |
Published Date | 2020-03-15 |
Publication Title | Internal Medicine |
Volume | volume59 |
Issue | issue6 |
Publisher | The Japanese Society of Internal Medicine |
Start Page | 823 |
End Page | 828 |
ISSN | 0918-2918 |
NCID | AA10827774 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 by The Japanese Society of Internal Medicine |
File Version | author |
PubMed ID | 31787696 |
DOI | 10.2169/internalmedicine.3689-19 |
Web of Science KeyUT | 000521137500011 |
Related Url | isVersionOf https://doi.org/10.2169/internalmedicine.3689-19 |
FullText URL | fulltext.pdf figure.pptx |
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Author | Higo, Hisao| Miyahara, Nobuaki| Taniguchi, Akihiko| Senoo, Satoru| Itano, Junko| Watanabe, Hiromi| Oda, Naohiro| Kayatani, Hiroe| Ichikawa, Hirohisa| Shibayama, Takuo| Kajimoto, Kazuhiro| Tanimoto, Yasushi| Kanehiro, Arihiko| Maeda, Yoshinobu| Kiura, Katsuyuki| OKAYAMA respiratory disease study group (ORDSG)| |
Keywords | Idiopathic pulmonary fibrosis High-resolution computed tomography Pirfenidone Forced vital capacity |
Note | This fulltext is available in Feb. 2021.| |
Published Date | 2020-02-23 |
Publication Title | Respiratory Investigation |
Volume | volume58 |
Issue | issue3 |
Publisher | Elsevier |
Start Page | 185 |
End Page | 189 |
ISSN | 22125345 |
NCID | AA12579673 |
Content Type | Journal Article |
language | English |
File Version | author |
PubMed ID | 32102769 |
DOI | 10.1016/j.resinv.2019.12.007 |
Web of Science KeyUT | 000531841500009 |
Related Url | isVersionOf https://doi.org/10.1016/j.resinv.2019.12.007 |
FullText URL | fulltext.pdf |
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Author | Senoo, Satoru| Miyahara, Nobuaki| Taniguchi, Akihiko| Oda, Naohiro| Itano, Junko| Higo, Hisao| Hara, Naofumi| Watanabe, Hiromi| Kano, Hirohisa| Suwaki, Toshimitsu| Fuchimoto, Yasuko| Kajimoto, Kazuhiro| Ichikawa, Hirohisa| Kudo, Kenichiro| Shibayama, Takuo| Tanimoto, Yasushi| Kuyama, Shoichi| Kanehiro, Arihiko| Maeda, Yoshinobu| Kiura, Katsuyuki| Okayama Respiratory Disease Study Group (ORDSG)| |
Published Date | 2020-08-27 |
Publication Title | PLoS ONE |
Volume | volume15 |
Issue | issue8 |
Publisher | Public Library of Science |
Start Page | e0236935 |
ISSN | 1932-6203 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 Senoo et al. |
File Version | publisher |
PubMed ID | 32853277 |
DOI | 10.1371/journal.pone.0236935 |
Web of Science KeyUT | 000566948800009 |
Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0236935 |
FullText URL | fulltext.pdf |
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Author | Ichihara, Eiki| Miyahara, Nobuaki| Maeda, Yoshinobu| Kiura, Katsuyuki| |
Keywords | lung cancer interstitial pneumonia |
Published Date | 2020-01-15 |
Publication Title | Internal Medicine |
Volume | volume59 |
Issue | issue2 |
Publisher | 日本内科学会 |
Start Page | 163 |
End Page | 167 |
ISSN | 0918-2918 |
NCID | AA10827774 |
Content Type | Journal Article |
language | English |
Copyright Holders | © 2020 by The Japanese Society of Internal Medicine |
File Version | publisher |
PubMed ID | 31534086 |
NAID | 130007785095 |
DOI | 10.2169/internalmedicine.3481-19 |
Web of Science KeyUT | 000507577600002 |
Related Url | isVersionOf https://doi.org/10.2169/internalmedicine.3481-19 |
FullText URL | fulltext.pdf |
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Author | Okawa, Sachi| Rai, Kammei| Fujii, Nobuharu| Gion, Yuka| Ninomiya, Kiichiro| Kato, Yuka| Taniguchi, Akihiko| Kubo, Toshio| Ichihara, Eiki| Ohashi, Kadoaki| Miyahara, Nobuaki| Hotta, Katsuyuki| Tabata, Masahiro| Maeda, Yoshinobu| Kiura, Katsuyuki| |
Keywords | EGFR IgG4-related disease marginal zone lymphoma osimertinib |
Published Date | 2021-09-01 |
Publication Title | Internal Medicine |
Volume | volume60 |
Issue | issue17 |
Publisher | The Japanese Society of Internal Medicine |
Start Page | 2831 |
End Page | 2837 |
ISSN | 0918-2918 |
NCID | AA10827774 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2021 The Japanese Society of Internal Medicine |
File Version | publisher |
PubMed ID | 33775999 |
DOI | 10.2169/internalmedicine.6470-20 |
Web of Science KeyUT | 000695856000020 |
Related Url | isVersionOf https://doi.org/10.2169/internalmedicine.6470-20 |
FullText URL | fulltext.pdf |
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Author | Aokage, Toshiyuki| Seya, Mizuki| Hirayama, Takahiro| Nojima, Tsuyoshi| Iketani, Masumi| Ishikawa, Michiko| Terasaki, Yasuhiro| Taniguchi, Akihiko| Miyahara, Nobuaki| Nakao, Atsunori| Ohsawa, Ikuroh| Naito, Hiromichi| |
Keywords | Acute respiratory distress syndrome Bleomycin-induced lung injury Macrophage Molecular hydrogen Lung fibrosis |
Published Date | 2021-10-31 |
Publication Title | BMC Pulmonary Medicine |
Volume | volume21 |
Issue | issue1 |
Publisher | BMC |
Start Page | 339 |
ISSN | 1471-2466 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2021. |
File Version | publisher |
PubMed ID | 34719405 |
DOI | 10.1186/s12890-021-01712-2 |
Web of Science KeyUT | 000713091800001 |
Related Url | isVersionOf https://doi.org/10.1186/s12890-021-01712-2 |
FullText URL | fulltext.pdf |
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Author | Taniguchi, Akihiko| Tsuge, Mitsuru| Miyahara, Nobuaki| Tsukahara, Hirokazu| |
Keywords | reactive oxygen species nitric oxide oxidant antioxidant oxidative stress chronic obstructive pulmonary disease cigarette smoke asymmetric dimethylarginine arginine biomarker |
Published Date | 2021-09-28 |
Publication Title | Antioxidants |
Volume | volume10 |
Issue | issue10 |
Publisher | MDPI |
Start Page | 1537 |
ISSN | 2076-3921 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2021 by the authors. |
File Version | publisher |
PubMed ID | 34679673 |
DOI | 10.3390/antiox10101537 |
Web of Science KeyUT | 000712653600001 |
Related Url | isVersionOf https://doi.org/10.3390/antiox10101537 |