FullText URL fulltext.pdf
Author Kojima, Toru| Umeda, Yuzo| Fuji, Tomokazu| Niguma, Takefumi| Satoh, Daisuke| Endo, Yoshikatsu| Sui, Kenta| Inagaki, Masaru| Oishi, Masahiro| Ota, Tetsuya| Hioki, Katsuyoshi| Matsuda, Tadakazu| Aoki, Hideki| Hirai, Ryuji| Kimura, Masashi| Yagi, Takahito| Fujiwara, Toshiyoshi|
Published Date 2020-09-03
Publication Title PLOS ONE
Volume volume15
Issue issue9
Publisher PUBLIC LIBRARY SCIENCE
Start Page e0238392
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 Kojima et al.
File Version publisher
PubMed ID 32881910
DOI 10.1371/journal.pone.0238392
Web of Science KeyUT 000571063300054
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0238392
FullText URL fulltext.pdf
Author Takagi, Kosei| Kuise, Takashi| Umeda, Yuzo| Yoshida, Ryuichi| Teraishi, Fuminori| Yagi, Takahito| Fujiwara, Toshiyoshi|
Keywords Laparoscopic Liver Segment seven
Published Date 2020
Publication Title International Journal of Surgery Case Reports
Volume volume73
Publisher Elsevier
Start Page 168
End Page 171
ISSN 2210-2612
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Author(s).
File Version publisher
PubMed ID 32688239
DOI 10.1016/j.ijscr.2020.06.107
Web of Science KeyUT 000558775100010
Related Url isVersionOf https://doi.org/10.1016/j.ijscr.2020.06.107
Title Alternative The 32th Annual Meeting of the Japan Society for Biological Therapy
FullText URL 132_41.pdf
Author Fujiwara, Toshiyoshi|
Publication Title Journal of Okayama Medical Association
Published Date 2020-04-01
Volume volume132
Issue issue1
Start Page 41
End Page 43
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.132.41
language Japanese
Copyright Holders Copyright (c) 2020 岡山医学会
File Version publisher
DOI 10.4044/joma.132.41
NAID 130007840310
FullText URL fulltext.pdf
Author Maeda, Naoaki| Shirakawa, Yasuhiro| Tanabe, Shunsuke| Sakurama, Kazufumi| Noma, Kazuhiro| Fujiwara, Toshiyoshi|
Published Date 2020-06-26
Publication Title World Journal of Surgical Oncology
Volume volume18
Issue issue1
Publisher BMC
Start Page 143
ISSN 1477-7819
NCID AA12048269
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2020
File Version publisher
PubMed ID 32591002
DOI 10.1186/s12957-020-01908-6
Web of Science KeyUT 000545948700003
Related Url isVersionOf https://doi.org/10.1186/s12957-020-01908-6
FullText URL fulltext.pdf
Author Koujima, Takeshi| Tazawa, Hiroshi| Ieda, Takeshi| Araki, Hiroyuki| Fushimi, Takuro| Shoji, Ryohei| Kuroda, Shinji| Kikuchi, Satoru| Yoshida, Ryuichi| Umeda, Yuzo| Teraishi, Fuminori| Urata, Yasuo| Mizuguchi, Hiroyuki| Fujiwara, Toshiyoshi|
Published Date 2020-06-26
Publication Title Molecular Therapy - Oncolytics
Volume volume17
Publisher Cell Press
Start Page 107
End Page 117
ISSN 2372-7705
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Author(s).
File Version publisher
PubMed ID 32322667
DOI 10.1016/j.omto.2020.03.016
Web of Science KeyUT 000544101600010
Related Url isVersionOf https://doi.org/10.1016/j.omto.2020.03.016
FullText URL fulltext.pdf
Author Tazawa, Hiroshi| Hasei, Joe| Yano, Shuya| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi|
Keywords oncolytic adenovirus hTERT autophagy GFP p53
Published Date 2020-02-18
Publication Title Cancers
Volume volume12
Issue issue2
Publisher MDPI
ISSN 2072-6694
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 32085583
DOI 10.3390/cancers12020478
Web of Science KeyUT 000522477300224
Related Url isVersionOf https://doi.org/10.3390/cancers12020478
FullText URL fulltext.pdf
Author Matsubara, Takehiro| Soh, Junichi| Morita, Mizuki| Uwabo, Takahiro| Tomida, Shuta| Fujiwara, Toshiyoshi| Kanazawa, Susumu| Toyooka, Shinichi| Hirasawa, Akira|
Published Date 2020-02-27
Publication Title BioMed Research International
Volume volume2020
Publisher Hindawi
Start Page 9349132
ISSN 2314-6133
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 Takehiro Matsubara et al.
File Version publisher
PubMed ID 32185225
DOI 10.1155/2020/9349132
Web of Science KeyUT 000522222100002
Related Url isVersionOf https://doi.org/10.1155/2020/9349132
FullText URL fulltext.pdf
Author Yoshioka, Takahiro| Shien, Kazuhiko| Takeda, Tatsuaki| Takahashi, Yuta| Kurihara, Eisuke| Ogoshi, Yusuke| Namba, Kei| Torigoe, Hidejiro| Sato, Hiroki| Tomida, Shuta| Yamamoto, Hiromasa| Soh, Junichi| Fujiwara, Toshiyoshi| Toyooka, Shinichi|
Keywords afatinib gastric cancer HER2 MET YES1
Published Date 2019-06-04
Publication Title Cancer Science
Volume volume110
Issue issue8
Publisher Wiley Open Access
Start Page 2549
End Page 2557
ISSN 1347-9032
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2019 The Authors.
File Version publisher
PubMed ID 31162771
DOI 10.1111/cas.14089
Web of Science KeyUT 000478616800022
Related Url isVersionOf https://doi.org/10.1111/cas.14089
FullText URL fulltext.pdf Graphical_Abstract.pptx Figure1-6.pdf Supp_Info.pdf
Author Kanaya, Nobuhiko| Kuroda, Shinji| Kakiuchi, Yoshihiko| Kumon, Kento| Tsumura, Tomoko| Hashimoto, Masashi| Morihiro, Toshiaki| Kubota, Tetsushi| Aoyama, Katsuyuki| Kikuchi, Satoru| Nishizaki, Masahiko| Kagawa, Shunsuke| Tazawa, Hiroshi| Mizuguchi, Hiroyuki| Urata, Yasuo| Fujiwara, Toshiyoshi|
Keywords immune checkpoint programmed death-1 oncolytic adenovirus combined immunotherapy immunogenic cell death tumor infiltrating lymphocytes CD8 abscopal effect
Published Date 2020-01-10
Publication Title Molecular Therapy
Volume volume28
Issue issue3
Publisher Cell Press
Start Page 794
End Page 804
ISSN 15250016
NCID AA11475060
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 31991110
DOI 10.1016/j.ymthe.2020.01.003
Web of Science KeyUT 000518887200012
Related Url isVersionOf https://doi.org/10.1016/j.ymthe.2020.01.003
Author Ieda, Takeshi| Tazawa, Hiroshi| Okabayashi, Hiroki| Yano, Shuya| Shigeyasu, Kunitoshi| Kuroda, Shinji| Ohara, Toshiaki| Noma, Kazuhiro| Kishimoto, Hiroyuki| Nishizaki, Masahiko| Kagawa, Shunsuke| Shirakawa, Yasuhiro| Saitou, Takashi| Imamura, Takeshi| Fujiwara, Toshiyoshi|
Published Date 2019-11-8
Publication Title Scientific Reports
Volume volume9
Publisher Nature Publishing Group
Start Page 16378
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2019
File Version publisher
PubMed ID 31705021
DOI 10.1038/s41598-019-52816-z
Web of Science KeyUT 000495372900001
Related Url isVersionOf https://doi.org/10.1038/s41598-019-52816-z
FullText URL SR9_1_4633.pdf
Author Morihiro, Toshiaki| Kuroda, Shinji| Kanaya, Nobuhiko| Kakiuchi, Yoshihiko| Kubota, Tetsushi| Aoyama, Katsuyuki| Tanaka, Takehiro| Kikuch, Satoru| Nagasaka, Takeshi| Nishizaki, Masahiko| Kagawa, Shunsuke| Tazawa, Hiroshi| Fujiwara, Toshiyoshi|
Published Date 2019-3-15
Publication Title Scientific Reports
Volume volume9
Publisher Nature Publishing Group
Start Page 4633
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2019
File Version publisher
PubMed ID 30874607
DOI 10.1038/s41598-019-41177-2
Web of Science KeyUT 000461303000015
Related Url isVersionOf https://doi.org/10.1038/s41598-019-41177-2
FullText URL AGS3_1_96.pdf SI.pdf
Author Kuroda, Shinji| Choda, Yasuhiro| Otsuka, Shinya| Ueyama, Satoshi| Tanaka, Norimitsu| Muraoka, Atsushi| Hato, Shinji| Kimura, Toshikazu| Tanakaya, Kohji| Kikuchi, Satoru| Tanabe, Shunsuke| Noma, Kazuhiro| Nishizaki, Masahiko| Kagawa, Shunsuke| Shirakawa, Yasuhiro| Kamikawa, Yasuaki| Fujiwara, Toshiyoshi|
Keywords Kamikawa procedure antireflux surgery double‐flap technique esophagogastrostomy proximal gastrectomy
Published Date 2018-10-11
Publication Title Annals of Gastroenterological Surgery
Volume volume3
Issue issue1
Publisher Woley
Start Page 96
End Page 103
ISSN 2475-0328
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2018 The Authors
File Version publisher
PubMed ID 30697614
DOI 10.1002/ags3.12216
Web of Science KeyUT 000456643500012
Related Url isVersionOf https://doi.org/10.1002/ags3.12216
FullText URL cancers_11_2_177.pdf
Author Katsura, Yuki| Ohara, Toshiaki| Noma, Kazuhiro| Ninomiya, Takayuki| Kashima, Hajime| Kato, Takuya| Sato, Hiroaki| Komoto, Satoshi| Narusaka, Toru| Tomono, Yasuko| Xing, Boyi| Chen, Yuehua| Tazawa, Hiroshi| Kagawa, Shunsuke| Shirakawa, Yasuhiro| Kasai , Tomonari| Seno, Masaharu| Matsukawa, Akihiro| Fujiwara, Toshiyoshi|
Keywords cancer stem cells combination therapy iron stemness
Published Date 2019-02-03
Publication Title Cancers
Volume volume11
Issue issue2
Publisher MDPI
Start Page 177
ISSN 2072-6694
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2019 by the authors
File Version publisher
PubMed ID 30717462
DOI 10.3390/cancers11020177
Web of Science KeyUT 000460747200051
Related Url isVersionOf https://doi.org/10.3390/cancers11020177
FullText URL OncoImmunol_8_12_1671760.pdf
Author Sakamoto, Shuichi| Kagawa, Shunsuke| Kuwada, Kazuya| Ito, Atene| Kajioka, Hiroki| Kakiuchi, Yoshihiko| Watanabe, Megumi| Kagawa, Tetsuya| Yoshida, Ryuichi| Kikuchi, Satoru| Kuroda, Shinji| Tazawa, Hiroshi| Fujiwara, Toshiyoshi|
Keywords Gastric cancer tumor-associated macrophages tumor microenvironment peritoneal dissemination
Published Date 2019-10-22
Publication Title OncoImmunology
Volume volume8
Issue issue12
Publisher TAYLOR & FRANCIS
Start Page e1671760
ISSN 2162402X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2019 The Author(s).
File Version publisher
DOI 10.1080/2162402X.2019.1671760
Web of Science KeyUT 000494085400001
Related Url isVersionOf https://doi.org/10.1080/2162402X.2019.1671760
FullText URL AnnGastroenterolSurg_3_4_396.pdf
Author Fujiwara, Toshiyoshi|
Keywords adenovirus clinical trial esophageal cancer radiotherapy telomerase
Published Date 2019-07-05
Publication Title Annals of gastroenterological surgery
Volume volume3
Issue issue4
Publisher John Wiley & Sons
Start Page 396
End Page 404
ISSN 24750328
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2019 The Authors
File Version publisher
PubMed ID 31346579
DOI 10.1002/ags3.12270
Web of Science KeyUT 000475745100009
Related Url isVersionOf https://doi.org/10.1002/ags3.12270
JaLCDOI 10.18926/AMO/54981
FullText URL 71_2_127.pdf
Author Shirakawa, Yasuhiro| Noma, Kazuhiro| Maeda, Naoaki| Tanabe, Shunsuke| Kuroda, Shinji| Kagawa, Shunsuke| Katsui, Kuniaki| Katayama, Norihisa| Kanazawa, Susumu| Fujiwara, Toshiyoshi|
Abstract Currently, chemoradiation is the most widely used nonsurgical treatment for esophageal cancer. However, some patients, particularly the very elderly or those with severe vital organ dysfunction, face difficulty with the chemotherapy component. We therefore examined the outcome of radiation therapy (RT) alone for patients with esophageal cancer at our facility. Between January 2005 and December 2014, 84 patients underwent RT at our hospital, and 78 of these patients received concomitant chemotherapy. The remaining 6 patients underwent RT alone; these patients were considered to be high-risk and to have no lymph node metastasis (stage I). Five of them received irradiation up to a curative dose: 4 showed a complete response (CR) and 1 showed a partial response (PR). Of the patients exhibiting CR, 3 are currently living recurrence-free, whereas 1 patient underwent endoscopic submucosal dissection (ESD) as salvage therapy for local recurrence, with no subsequent recurrence. High-risk stage I esophageal cancer patients can be treated radically with RT alone under certain conditions. In the future, to broaden the indications for RT monotherapy to include some degree of advanced cancers, a novel concurrent therapy should be identified.
Keywords esophageal cancer radiation therapy high-risk patient
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2017-04
Volume volume71
Issue issue2
Publisher Okayama University Medical School
Start Page 127
End Page 133
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28420894
Title Alternative Thoracoscopic esophagectomy was effective in a case of lower esophageal stenosis due to recurrence of achalasia after myotomy 40 years previously
FullText URL 129_41.pdf
Author Katsura, Yuki| Shirakawa, Yasuhiro| Tanabe, Shunsuke| Maeda, Naomi| Noma, Kazuhiro| Fujiwara, Toshiyoshi|
Abstract When planning surgery for achalasia, it is important to plan for adequate myotomy and prevention of reflux. However, achalasia may recur if the procedure was inadequate or in patients with a long-term course. The present case is a 68-year-old woman who underwent myotomy of the lower esophageal sphincter 40 years ago, but recently reported difficulty in swallowing. Dilatation of the thoracic esophagus and stenosis of the abdominal esophagus were identified by examination, and the patient was diagnosed with recurrence of achalasia. After percutaneous endoscopic gastrostomy was performed to recover nutritional status, thoracoscopic esophagectomy was carried out. The patient'spost-operative course was uneventful and oral intake was enabled. At the time of writing, there has been no re-recurrence. There is no standard therapy for post-operative recurrence of achalasia. We believe that thoracoscopic esophagectomy for the recurrence of achalasia is a safe and minimally invasive alternative to conventional surgery.
Keywords 食道アカラシア (achalasia) 再手術 (reoperation) 食道亜全摘 (esophagectomy)
Publication Title Journal of Okayama Medical Association
Published Date 2017-04-03
Volume volume129
Issue issue1
Start Page 41
End Page 44
ISSN 0030-1558
language Japanese
Copyright Holders Copyright (c) 2017 岡山医学会
File Version publisher
DOI 10.4044/joma.129.41
NAID 130005632071
Author Takagi, Kosei| Yagi, Takahito| Shinoura, Susumu| Umeda, Yuzo| Yoshida, Ryuichi| Nobuoka, Daisuke| Watanabe, Nobuyuki| Kuise, Takashi| Fuji, Tomokazu| Araki, Hiroyuki| Fujiwara, Toshiyoshi|
Published Date 2017-02
Publication Title Acta Medica Okayama
Volume volume71
Issue issue1
Content Type Journal Article
JaLCDOI 10.18926/AMO/54830
JaLCDOI 10.18926/AMO/54601
FullText URL 70_5_401.pdf
Author Kuroda, Shinji| Kikuchi, Satoru| Nishizaki, Masahiko| Kagawa, Shunsuke| Hinotsu, Shiro| Fujiwara, Toshiyoshi|
Abstract Although intermittent pneumatic compression (IPC) has become common as perioperative prophylaxis for venous thromboembolism (VTE) consisting of pulmonary thromboembolism (PE) and deep vein thrombosis (DVT), the prophylactic effect against VTE, especially lethal PE, is not yet satisfactory. Therefore, pharmacologic prophylaxis, such as with enoxaparin, is desirable. While the efficacy and safety of enoxaparin have been proven in several clinical trials, concern about bleeding with longterm (at least 7 days) use have potentially decreased its widespread adoption. We have launched a phase II study to evaluate the efficacy and safety of short-term (3 days) enoxaparin, in which a total of 70 gastric cancer patients undergoing gastrectomy will be recruited, and the primary endpoint is the incidence of DVT. This study could contribute to making pharmacologic prophylaxis for VTE more common.
Keywords venous thromboembolism enoxaparin short-term use gastric cancer surgery
Amo Type Clinical Study Protocols
Publication Title Acta Medica Okayama
Published Date 2016-10
Volume volume70
Issue issue5
Publisher Okayama University Medical School
Start Page 401
End Page 404
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27777435
Web of Science KeyUT 000388098700012
JaLCDOI 10.18926/AMO/54594
FullText URL 70_5_363.pdf
Author Takagi, Kosei| Yagi, Takahito| Yoshida, Ryuichi| Shinoura, Susumu| Umeda, Yuzo| Nobuoka, Daisuke| Kuise, Takashi| Watanabe, Nobuyuki| Fujiwara, Toshiyoshi|
Abstract Sarcopenia following liver surgery has been reported as a predictor of poor prognosis. Here we investigated predictors of outcomes in patients with hepatocellular carcinoma (HCC) and attempted to establish a new comprehensive preoperative assessment protocol. We retrospectively analyzed the cases of 254 patients who underwent curative hepatectomy for HCC with Child-Pugh classification A at our hospital between January 2007 and December 2013. Sarcopenia was evaluated by computed tomography measurement. The influence of sarcopenia on outcomes was evaluated. We used multivariate analyses to assess the impact of prognostic factors associated with outcomes, including sarcopenia. Of the 254 patients, 118 (46.5%) met the criteria for sarcopenia, and 32 had an American Society of Anesthesiologists (ASA) physical status ≥3. The sarcopenic group had a significantly lower 5-year overall survival rate than the non-sarcopenic group (58.2% vs. 82.4% , p=0.0002). In multivariate analyses of prognostic factors, sarcopenia was an independent predictor of poor survival (hazard ratio [HR]=2.28, p=0.002) and poor ASA status (HR=3.17, p=0.001). Sarcopenia and poor ASA status are independent preoperative predictors for poor outcomes after hepatectomy. The preoperative identification of sarcopenia and ASA status might enable the development of comprehensive approaches to assess surgical eligibility.
Keywords sarcopenia American Society of Anesthesiologists physical status hepatectomy hepatocellular carcinoma prognostic factor
Amo Type Original Articles
Publication Title Acta Medica Okayama
Published Date 2016-10
Volume volume70
Issue issue5
Publisher Okayama University Medical School
Start Page 363
End Page 370
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27777428
Web of Science KeyUT 000388098700005