藤原俊義

Study about the Efficacy of Metformin to Immune Function in Cancer Patients

JaLCDOI	10.18926/AMO/54514
フルテキストURL	70_4_327.pdf
著者	Watanabe, Mototsugu\| Yamamoto, Hiromasa\| Eikawa, Shingo\| Shien, Kazuhiko\| Shien, Tadahiko\| Soh, Junichi\| Hotta, Katsuyuki\| Wada, Jun\| Hinotsu, Shiro\| Fujiwara, Toshiyoshi\| Kiura, Katsuyuki\| Doihara, Hiroyoshi\| Miyoshi, Shinichiro\| Udono, Heiichiro\| Toyooka, Shinichi\|
抄録	A study to evaluate the effect of metformin on the immune system was commenced in July 2014. Metformin is one of the most commonly prescribed drugs for type 2 diabetes, and previous studies have reported that metformin has an anti-tumor effect. The aim of this study is to evaluate the efficacy of metformin on the immune system in human cancer patients in vivo. The primary outcome parameter will be the rate change in the population of CD8＋ T cells, which produce multiple cytokines.
キーワード	metformin CD8＋ T cells cancer immunology
Amo Type	Clinical Study Protocols
出版物タイトル	Acta Medica Okayama
発行日	2016-08
巻	70巻
号	4号
出版者	Okayama University Medical School
開始ページ	327
終了ページ	330
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	27549683
Web of Science KeyUT	000384748600018

腸骨広範囲切除術後に発生した腹壁瘢痕ヘルニアに対しメッシュ修復術を行った一例

タイトル（別表記）	Incisional hernia repair after wide excision of the iliac bone
フルテキストURL	128_117.pdf
著者	佃和憲\| 浅野博昭\| 万代康弘\| 藤原俊義\|
抄録	The patient was a 46-year old Japanese female who had undergone wide excision of the iliac bone and hip transposition at our institute's orthopedics department 2 years earlier. She presented with a growing incisional hernia and was transferred to our gastroenterological surgery department for surgical treatment. We planned a mesh repair for the incisional hernia, which protruded over the right iliac bone. The dimensions of the abdominal defect were 15×9 cm, and we used prolene mesh to repair the defect. The mesh was fixed at the inner part of the iliac bone, folded back at the iliac horn and fixed to the abdominal oblique muscles. The postoperative course was smooth, and recurrence was not seen at 3.5 years after the operation. An incisional hernia as seen in this patient's case is very rare, but we found that the underlay technique and prolene mesh were very useful for the three-dimensional hernia repair.
キーワード	腹壁瘢痕ヘルニア（incisional hernia）腸骨軟骨肉腫（chondrosarcoma of the iliac bone）腸骨広範囲切除術（wide excision of the iliac bone）プロリーンメッシュ（prolene mesh）
出版物タイトル	岡山医学会雑誌
発行日	2016-08-01
巻	128巻
号	2号
開始ページ	117
終了ページ	120
ISSN	0030-1558
関連URL	isVersionOf https://doi.org/10.4044/joma.128.117
言語	日本語
著作権者	Copyright (c) 2016 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.128.117
NAID	130005262528

Recurrence after Endoscopic Curative Resection of Mucosal Gastric Cancer Associated with an Adjacent Neoplastic Precursor Lesion

JaLCDOI	10.18926/AMO/54421
フルテキストURL	70_3_213.pdf
著者	Kikuchi, Satoru\| Kagawa, Shunsuke\| Ohara, Toshiaki\| Kubota, Tetsushi\| Kuwada, Kazuya\| Kagawa, Tetsuya\| Kuroda, Shinji\| Shirakawa, Yasuhiro\| Nishizaki, Masahiko\| Fujiwara, Toshiyoshi\|
抄録	A 69-year-old man underwent endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) at the lesser curvature in the angle of stomach. Histological examination revealed tub1, pM, ly0, v0, pLM(-), pVM(-), and the resection was considered curative. The scar after ESD was followed by esophagogastroduodenoscopy (EGD) and biopsy. Twenty months later, EGD showed an ulcerative lesion in the vicinity of the ESD scar, and histological examination of the biopsy specimen showed adenocarcinoma. A distal gastrectomy with lymph node dissection was then performed. Postoperative pathology showed tub1, pM, pN0, ly0, v0, and Stage 1A. Skip lesions were seen in the specimen resected by ESD, and the histological review confirmed so-called “dysplasia-like atypia” (DLA) between the lesions. It has been reported recently that in DLA, the dysplasia-like change involves only the bases of the pits, without upper pit or surface epithelium involvement, and it is said that the rate of DLA is higher in gastric cancer patients. We speculated that a precancerous lesion close to the resected cancer developed into a local recurrence.
キーワード	dysplasia-like atypia early gastric cancer endoscopic submucosal dissection local recurrence
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2016-06
巻	70巻
号	3号
出版者	Okayama University Medical School
開始ページ	213
終了ページ	216
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	27339211
Web of Science KeyUT	000379406100009

Surgical Outcome of Patients Undergoing Pancreaticoduodenectomy: Analysis of a 17-Year Experience at a Single Center

JaLCDOI	10.18926/AMO/54419
フルテキストURL	70_3_197.pdf
著者	Takagi, Kosei\| Yagi, Takahito\| Yoshida, Ryuichi\| Shinoura, Susumu\| Umeda, Yuzo\| Nobuoka, Daisuke\| Kuise, Takashi\| Watanabe, Nobuyuki\| Sui, Kenta\| Fuji, Tomokazu\| Fujiwara, Toshiyoshi\|
抄録	The operative mortality and morbidity of pancreaticoduodenectomy (PD) remain high. We analyzed PD patientsʼ clinical characteristics and surgical outcomes and discuss how PD clinical outcomes could be improved. We retrospectively reviewed the cases of 400 patients who underwent a PD between January 1998 and April 2014 at Okayama University Hospital, a very-high-volume center. We identified and compared the clinical outcomes between two time periods (period 1: 1998-2006 vs. period 2: 2007-2014). The total postoperative mortality and major complication rates were 0.75 and 15.8 , respectively, and the median postoperative length of stay (LOS) was 32 days. Subsequently, patients who underwent a PD during period 2 had a significantly shorter LOS than those who underwent a PD during period 1 (29 days vs. 38.5 days, p＜0.001). The incidence of mortality and major complications did not differ between the two periods. In our multivariate analysis, period 1 was an independent factor associated with a long LOS (p＜0.001). The improvement of the surgical procedure and perioperative care might be related to the shorter LOS in period 2 and ot the consistently maintained low mortality rate after PD. The development of multimodal strategies to accelerate postoperative recovery may further improve PDʼs clinical outcomes.
キーワード	pancreaticoduodenectomy surgical outcome mortality major complication length of stay
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2016-06
巻	70巻
号	3号
出版者	Okayama University Medical School
開始ページ	197
終了ページ	203
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	27339209
Web of Science KeyUT	000379406100007

Anticancer virus solution provides an alternative to surgery

著者	藤原俊義\|
発行日	2015-02
出版物タイトル	Okayama University Medical Research Updates
巻	7巻
資料タイプ	その他

Innovative non-invasive ‘liquid biopsy’ method to capture circulating tumor cells from blood samples for genetic testing

著者	藤原俊義\|
発行日	2014-07
出版物タイトル	Okayama University Medical Research Updates
巻	1巻
資料タイプ	その他

Neoadjuvant Chemotherapy with or without Concurrent Hormone Therapy in Estrogen Receptor-Positive Breast Cancer:NACED-Randomized Multicenter Phase II Trial

JaLCDOI	10.18926/AMO/53675
フルテキストURL	69_5_291.pdf
著者	Sugiu, Kumi\| Iwamoto, Takayuki\| Kelly, Catherine M.\| Watanabe, Naoki\| Motoki, Takayuki\| Itoh, Mitsuya\| Ohtani, Shoichiro\| Higaki, Kenji\| Imada, Takako\| Yuasa, Takeshi\| Omori, Masako\| Sonobe, Hiroshi\| Fujiwara, Toshiyoshi\| Matsuoka, Junji\|
抄録	Although in the neoadjuvant setting for estrogen receptor (ER)-positive breast cancers, chemotherapy or hormone therapy alone does not result in satisfactory tumor response, it is unknown whether concurrent chemo-endocrine therapy is superior to chemotherapy alone in clinical outcomes. We conducted a randomized phase II trial to test the responses of ER-positive patients to concurrent administration of chemo-endocrine therapy in the neoadjuvant setting. Women with stage II-III, ER-positive, invasive breast cancer (n=28) received paclitaxel followed by fluorouracil, epirubicin, cyclophosphamide (T-FEC) and were randomized to receive concurrent chemo-endocrine therapy consisting of goserelin administered subcutaneously for premenopausal women or an aromatase inhibitor for postmenopausal women. The primary endpoint was the pathological complete response (pCR) rate after neoadjuvant therapy. Twenty-eight patients were randomized. There were no significant differences in pCR rate between the concurrent group (12.5%;2/16) and the chemotherapy alone group (8.3%;1/12). Tumor size after therapy was significantly reduced in the concurrent therapy group (p=0.035), but not in the chemotherapy-alone group (p=0.622). Neoadjuvant chemotherapy with concurrent hormone therapy provided no significant improvement in pCR rate in ER-positive breast cancers. These preliminary results should be followed up by further studies.
キーワード	breast cancer neoadjuvant chemotherapy concurrent hormone therapy estrogen receptor positive tumor response
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2015-10
巻	69巻
号	5号
出版者	Okayama University Medical School
開始ページ	291
終了ページ	299
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	26490026
Web of Science KeyUT	000365519600005

A Case-matched Comparative Study of Laparoscopic and Open Total Proctocolectomy for Ulcerative Colitis

JaLCDOI	10.18926/AMO/53672
フルテキストURL	69_5_267.pdf
著者	Inada, Ryo\| Nagasaka, Takeshi\| Kondo, Yoshitaka\| Watanabe, Ayako\| Toshima, Toshiaki\| Kubota, Nobuhito\| Kikuchi, Satoru\| Ishida, Michihiro\| Kuroda, Shinji\| Mori, Yoshiko\| Kishimoto, Hiroyuki\| Fujiwara, Toshiyoshi\|
抄録	The aim of this single-institution, retrospective, observational case-control study was to evaluate the safety and feasibility of laparoscopic proctocolectomy (PC) for ulcerative colitis (UC), by comparing it with a case-control series of open PC. Twenty UC patients who underwent laparoscopic PC were retrospectively compared with the open PC group of 12 patients matched for age, sex, and urgency of the operation. In the laparoscopic PC group, the operative time was significantly longer, but the amount of blood loss was significantly smaller. The open PC patients underwent an intraoperative blood transfusion significantly more often, and the serum C-reactive protein level on the first postoperative day was significantly higher in the open PC group. In the laparoscopic PC group, the rate of severe postoperative morbidities, grades 3 and 4 on the Clavien-Dindo classification, was significantly lower, and the median length of hospital stay was significantly shorter. Laparoscopic PC for patients with UC showed superior perioperative outcomes to open PC, except for longer operative time.
キーワード	laparoscopic surgery total proctocolectomy open proctocolectomy ulcerative colitis case-matched study
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2015-10
巻	69巻
号	5号
出版者	Okayama University Medical School
開始ページ	267
終了ページ	273
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	26490023
Web of Science KeyUT	000365519600002

超高齢者（95歳）の進行盲腸癌に対して腹腔鏡下回盲部切除を施行した1例

タイトル（別表記）	Successful laparoscopic resection of a cecal tumor in a 95-year-old man
フルテキストURL	127_117.pdf
著者	渡邉彩子\| 稲田涼\| 永坂岳司\| 八木朝彦\| 松本聖\| 戸嶋俊明\| 菊池覚次\| 黒田新士\| 近藤喜太\| 母里淑子\| 岸本浩行\| 藤原俊義\|
抄録	We report a successful laparoscopic resection of a cecal tumor in a 95-year-old Japanese man. The patient visited an initial hospital with a complaint of constipation in March 2014. Computed tomography scan and colonoscopy showed a stenotic ileocecal cancer with pericolic lymph node metastases, and he was referred to our department for management. Since his general condition was maintained, we performed a laparoscopic ileocecal resection with regional lymph node dissection for the patient. The operation achieved curative resection, and the tumor was diagnosed as a moderately differentiated adenocarcinoma and graded as pStage IIIa (pT3, pN0, pM0) according to the Japanese Classification of Colorectal Carcinoma, eighth edition. He was discharged on the 11th postoperative day without perioperative complications. Several large-scale randomized controlled trials （RCTs） revealed that laparoscopic surgeries for colorectal cancers have some advantages compared to open surgeries, including superior short-term outcomes and comparable long-term outcomes. Unfortunately, since these RCTs did not include enough elderly patients, the safety and feasibility of laparoscopic surgery for extremely elderly patients are still unknown. With respect to less-invasive procedures, these advantages of laparoscopic surgery are also thought to be the advantages for elderly colorectal cancer patients.
キーワード	超高齢者（extremely elderly patient）大腸癌（colorectal cancer）腹腔鏡手術（laparoscopic surgery）
出版物タイトル	岡山医学会雑誌
発行日	2015-08-03
巻	127巻
号	2号
開始ページ	117
終了ページ	121
ISSN	0030-1558
関連URL	isVersionOf https://doi.org/10.4044/joma.127.117
言語	日本語
著作権者	Copyright (c) 2015 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.127.117
NAID	130005096253

Prone-Position Thoracoscopic Ligation of the Thoracic Duct for Chyle Leak Following Radical Neck Dissection in a Patient with a Right Aortic Arch

JaLCDOI	10.18926/AMO/53524
フルテキストURL	69_3_173.pdf
著者	Shirakawa, Yasuhiro\| Noma, Kazuhiro\| Ohara, Toshiaki\| Kashima, Hajime\| Maeda, Naoaki\| Tanabe, Shunsuke\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
抄録	A chyle leak can occur as a complication after neck or chest surgery. Such a leak prolongs the hospital stay and is sometimes life-threatening. The treatment options are conservative management, interventional radiologic embolization, and surgery. Thoracoscopic ligation of the thoracic duct has emerged as a promising and definitive treatment. The case of a 65-year-old Japanese male patient with a rare congenital right aortic arch (typeⅢB1 of Edwardʼs classification) and a severe chyle leak that occurred after a total pharyngolaryngo-esophagectomy (TPLE) is described. The chyle leak was successfully managed by thoracoscopic ligation of the thoracic duct via a left-side approach with the patient in the prone position.
キーワード	chyle leak thoracic duct thoracoscopy prone position
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2015-06
巻	69巻
号	3号
出版者	Okayama University Medical School
開始ページ	173
終了ページ	176
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	26101193
Web of Science KeyUT	000356903000006

Aggressive Multimodality Treatment for Advanced Rectal Cancer

JaLCDOI	10.18926/AMO/53340
フルテキストURL	69_2_113.pdf
著者	Inada, Ryo\| Nagasaka, Takeshi\| Toshima, Toshiaki\| Mori, Yoshiko\| Kondo, Yoshitaka\| Kishimoto, Hiroyuki\| Hiraki, Takao\| Oshiro, Taihei\| Kanemitsu, Yukihide\| Fujiwara, Toshiyoshi\|
抄録	A case of advanced rectal cancer treated by aggressive local and systemic treatment who has survived more than 7 years from initial recurrence is presented. A 55-year-old woman was diagnosed with advanced lower rectal cancer and underwent a low anterior resection with complete removal of all regional lymph nodes and total mesorectal excision. The tumor was diagnosed as a moderately differentiated adenocarcinoma, pStage IIIB (T3, N2a, M0). Twenty-six months after the initial surgery, local recurrence in the pelvis was detected by computed tomography, and total pelvic exenteration with distal sacrectomy (TPES) was performed after systemic chemotherapy with a molecular-targeted drug. Six months after the TPES, multiple lung metastases were detected. Consequently, the patient underwent radiofrequency ablation (RFA) and chemotherapy. The disease has since been controlled for 38 months. As volume control is essential for cancer treatment, it may be important to combine appropriate local therapy with systemic therapy to metastatic or recurrent sites in order to achieve much longer disease control.
キーワード	colorectal cancer recurrence total pelvic exenteration radiofrequency ablation systemic chemotherapy
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2015-04
巻	69巻
号	2号
出版者	Okayama University Medical School
開始ページ	113
終了ページ	118
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	25899633
Web of Science KeyUT	000353181700006

Biological Ablation of Sentinel Lymph Node Metastasis in Submucosally Invaded Early Gastrointestinal Cancer

著者	Kikuchi, Satoru\| Kishimoto, Hiroyuki\| Tazawa, Hiroshi\| Hashimoto, Yuuri\| Kuroda, Shinji\| Nishizaki, Masahiko\| Nagasaka, Takeshi\| Shirakawa, Yasuhiro\| Kagawa, Shunsuke\| Urata, Yasuo\| Robert M Hoffman\| Fujiwara, Toshiyoshi\|
発行日	2014-12-19
出版物タイトル	Molecular Therapy
資料タイプ	学術雑誌論文

Management Of Peritoneal Effusion by Sealing with a Self-Assembling Nanofiber Polypeptide Following Pelvic Surgery

著者	Kondo, Yoshitaka\| Nagasaka, Takeshi\| Kobayashi, Satoru\| Kobayashi, Naoya\| Fujiwara, Toshiyoshi\|
発行日	2014-03
出版物タイトル	Hepato-Gastroenterology
巻	61巻
号	130号
資料タイプ	学術雑誌論文

Protective Effect of Eicosapentaenoic Acid on Insulin Resistance in Hyperlipidemic Patients and on the Postoperative Course of Cardiac Surgery Patients: The Possible Involvement of Adiponectin

JaLCDOI	10.18926/AMO/53024
フルテキストURL	68_6_349.pdf
著者	Yamamoto, Tsuyoshi\| Kajikawa, Yutaka\| Otani, Satoru\| Yamada, Yuki\| Takemoto, Syunji\| Hirota, Minoru\| Ikeda, Masae\| Iwagaki, Hiromi\| Saito, Shinya\| Fujiwara, Toshiyoshi\|
抄録	Accumulated studies have shown that ω-3 polyunsaturated fatty acids such as eicosapentaenoic acid (EPA) have protective roles against inflammatory responses such as hyperlipidemia, diabetes mellitus (DM) and cardiovascular diseases. Here we examined the effects of administering EPA to hyperlipidemic patients and other patients undergoing cardiac surgery to determine whether this treatment would increase plasma EPA levels and to clarify the association between EPA treatment and adiponectin production in hyperlipidemic patients. We also assessed the effect of preoperative EPA administration on postoperative adverse events such as postoperative atrial fibrillation (POAF) and postoperative infection in the cardiac surgery patients. The EPA administration significantly increased the serum EPA concentrations in both patient populations (p＜0.001). In the hyperlipidemic patients, the EPA administration significantly increased plasma adiponectin levels (p＜0.05), accompanied by a decrease in insulin resistance designated by the HOMA-IR (homeostasis model assessment of insulin resistance) score (p＜0.05) and Hs-CRP (high sensitivity C-reactive protein) value (p＜0.05). In the cardiac surgery patients, no significant effect of EPA on cardiac adverse events such as POAF was observed. However, our results clearly demonstrated that both the neutrophil-to-lymphocyte ratio and the 2nd-line antibiotic requirement in the EPA group were significantly decreased compared to the untreated control group (p＜0.05). We suggest that EPA administration may exert anti-inflammatory effects in patients with hyperlipidemia and in those undergoing cardiac surgery, possibly through an increase in plasma adiponectin levels.
キーワード	eicosapentaenoic acid adiponectin hyperlipidemic patients cardiac surgery atrial fibrillation
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2014-12
巻	68巻
号	6号
出版者	Okayama University Medical School
開始ページ	349
終了ページ	361
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	25519029
Web of Science KeyUT	000346882200005
関連URL	http://ousar.lib.okayama-u.ac.jp/metadata/53125

Fluorescence virus-guided capturing system of human colorectal circulating tumour cells for non-invasive companion diagnostics

著者	Shigeyasu, Kunitoshi\| Tazawa, Hiroshi\| Hashimoto, Yuuri\| Mori, Yoshiko\| Nishizaki, Masahiko\| Kishimoto, Hiroyuki\| Nagasaka, Takeshi\| Kuroda, Shinji\| Urata, Yasuo\| Goel, Ajay\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
発行日	2014-05-28
出版物タイトル	Gut
資料タイプ	学術雑誌論文

Jejunal interposition reconstruction with a stomach preserving esophagectomy improves postoperative weight loss and reflux symptoms for esophageal cancer patients

著者	Yamada, Eiji\| Shirakawa, Yasuhiro\| Yamatsuji, Tomoki\| Sakuma, Leon\| Takaoka, Munenori\| Yamada, Takako\| Noma, Kazuhiro\| Sakurama, Kazufumi\| Fujiwara, Yasuhiro\| Tanabe, Shunsuke\| Nagasaka, Takeshi\| Fujiwara, Toshiyoshi\| Naomoto, Yoshio\|
発行日	2012-12
出版物タイトル	Journal of Surgical Research
巻	178巻
号	2号
資料タイプ	学術雑誌論文

Hepatitis C Virus-specific T-cell Response Correlates with Hepatitis Activity and Donor IL28B Genotype Early after Liver Transplantation

JaLCDOI	10.18926/AMO/52898
フルテキストURL	68_5_291.pdf
著者	Tsuzaki, Ryuichiro\| Takaki, Akinobu\| Yagi, Takahito\| Ikeda, Fusao\| Koike, Kazuko\| Iwasaki, Yoshiaki\| Shiraha, Hidenori\| Miyake, Yasuhiro\| Sadamori, Hiroshi\| Shinoura, Susumu\| Umeda, Yuzo\| Yoshida, Ryuichi\| Nobuoka, Daisuke\| Utsumi, Masashi\| Nakayama, Eiichi\| Fujiwara, Toshiyoshi\| Yamamoto, Kazuhide\|
抄録	It is not known how the immune system targets hepatitis C virus (HCV)-infected HLA-mismatched hepatocytes under immune-suppressed conditions after orthotopic liver transplantation (OLT). In addition, the relationship between the HCV-specific immune response and IL28B variants as predictors of HCV clearance has not been well-characterized. We determined the IL28B polymorphisms for 57 post-OLT HCV carriers, and we assessed the HCV-specific immune responses by measuring the peripheral blood mononuclear cell-derived HCV-specific interferon-gamma (IFN-γ) response using an enzyme-linked immunospot assay. At 1-3 years after OLT, patients with no active hepatitis showed higher total spots on the immunospot assay. At＞3 years after OLT, patients with resolved HCV showed higher levels of core, NS3, NS5A, and total spots compared to the chronic hepatitis patients. The IL28B major genotype in the donors correlated with higher spot counts for NS5A and NS5B proteins at 1-3 years after OLT. In the post-OLT setting, the HCV-specific immune response could be strongly induced in patients with no active hepatitis with an IL28B major donor or sustained virological response. Strong immune responses in the patients with no active hepatitis could only be maintained for 3 years and diminished later. It may be beneficial to administer IFN treatment starting 3 years after OLT, to induce the maximum immunological effect.
キーワード	interferon gamma ELISPOT assay single nucleotide polymorphisms dendritic cell CD4 T cell
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2014-10
巻	68巻
号	5号
出版者	Okayama University Medical School
開始ページ	291
終了ページ	302
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	25338486
Web of Science KeyUT	000343269300006
関連URL	http://ousar.lib.okayama-u.ac.jp/metadata/53129

Estrogen receptor (ER) mRNA expression and molecular subtype distribution in ER-negative/progesterone receptor-positive breast cancers

著者	Itoh, Mitsuya\| Iwamoto, Takayuki\| Matsuoka, Junji\| Nogami, Tomohiro\| Motoki, Takayuki\| Shien, Tadahiko\| Taira, Naruto\| Niikura, Naoki\| Hayashi, Naoki\| Ohtani, Shoichiro\| Higaki, Kenji\| Fujiwara, Toshiyoshi\| Doihara, Hiroyoshi\| Symmans, W. Fraser\| Pusztai, Lajos\|
発行日	2014-01
出版物タイトル	Breast Cancer Research and Treatment
巻	143巻
号	2号
資料タイプ	学術雑誌論文

A Genetically Engineered Oncolytic Adenovirus Decoys and Lethally Traps Quiescent Cancer Stem-like Cells in S/G(2)/M Phases

著者	Yano, Shuya\| Tazawa, Hiroshi\| Hashimoto, Yuuri\| Shirakawa, Yasuhiro\| Kuroda, Shinji\| Nishizaki, Masahiko\| Kishimoto, Hiroyuki\| Uno, Futoshi\| Nagasaka, Takeshi\| Urata, Yasuo\| Kagawa, Shunsuke\| Hoffman, Robert M.\| Fujiwara, Toshiyoshi\|
発行日	2013-12-01
出版物タイトル	Clinical Cancer Research
巻	19巻
号	23号
資料タイプ	学術雑誌論文

Assistant-Based Standardization of Prone Position Thoracoscopic Esophagectomy

JaLCDOI	10.18926/AMO/52407
フルテキストURL	68_2_111.pdf
著者	Shirakawa, Yasuhiro\| Noma, Kazuhiro\| Maeda, Naoaki\| Katsube, Ryoichi\| Tanabe, Shunsuke\| Ohara, Toshiaki\| Sakurama, Kazufumi\| Fujiwara, Toshiyoshi\|
抄録	Thoracoscopic esophagectomy in the prone position (TEPP) might enable solo-surgery in cases requiring resection of the esophagus and the surrounding lymph nodes due to the associated advantages of good exposure of the surgical field and ergonomic considerations for the surgeon. However, no one approach can be for all patients requiring extensive lymphadenectomy. We recently developed an assistant-based procedure to standardize exposure of the surgical field. Patients were divided into 1 of 2 groups:a pre-standardization group (n＝37) and a post-standardization group (n＝28). The thoracoscopic operative time was significantly shorter (p＝0.0037) in the post-standardization group (n＝28; 267±31min) than in the pre-standardization group (n＝37;301±53min). Further, learning curve analysis using the moving average method showed stabilization of the thoracoscopic operative time after the standardization. No significant differences were found in the number of mediastinal lymph nodes dissected or intraoperative blood loss between the 2 groups. There were also no significant differences in the complication rate. Assistant-based surgery and standardization of the procedure resulted in a well-exposed and safe surgical field. TEPP decreased the operative time, even in patients requiring extensive lymphadenectomy.
キーワード	thoracoscopic esophagectomy prone position standardization
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2014-04
巻	68巻
号	2号
出版者	Okayama University Medical School
開始ページ	111
終了ページ	117
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	24743786
Web of Science KeyUT	000334652700006

藤原 俊義