Author Aono, Kaname| Morimoto, Setsuo| Hashimoto, Keiji| Sato, Katashi| Joja, Ikuo| Kimoto, Shin| Ezoe, Hiroshi| Takeda, Yoshihiro| Miyake, Masayoshi| Hayashi, Hidehiro| Wakabayashi, Hisao| Tamai, Toyosato| Morino, Yasuo| Shiraishi, Noriyuki|
Published Date 1980-10-30
Publication Title 岡山医学会雑誌
Volume volume92
Issue issue9-10
Content Type Journal Article
Author Aono, Kaname| Morino, Yasuo| Tamai, Toyosato| Wakabayashi, Hisao| Morimoto, Setsuo| Hashimoto, Keiji| Sato, Katashi| Joja, Ikuo| Kimoto, Shin| Ezoe, Hiroshi| Takeda, Yoshihiro| Miyake, Masayoshi| Hayashi, Hidehiro|
Published Date 1981-02-28
Publication Title 岡山医学会雑誌
Volume volume93
Issue issue1-2
Content Type Journal Article
Author Morino, Yasuo| Takeda, Yoshihiro| Morimoto, Setsuo| Miyake, Masayoshi| Hayashi, Hidehiro| Ezoe, Hiroshi| Kimoto, Shin| Joja, Ikuo| Hashimoto, Keiji| Aono, Kaname| Hayashi, Kyoichi| Takaoka, Kazuko| Oshima, Yukiko|
Published Date 1981-08-30
Publication Title 岡山医学会雑誌
Volume volume93
Issue issue7-8
Content Type Journal Article
Author 竹田 芳弘|
Published Date 1984-03-31
Publication Title
Content Type Thesis or Dissertation
Author Takeda, Yoshihiro|
Published Date 1984-04-30
Publication Title 岡山医学会雑誌
Volume volume96
Issue issue3-4
Content Type Journal Article
Author Ueda, Hiroyuki| Hashimoto, Keiji| Jyoja, Ikuo| Kimoto, Shin| Takeda, Yoshihiro| Kaji, Mitsumasa| Sato, Nobuo| Nakamura, Tetsuya| Hino, Hiroyuki| Koyama, Naoki| Hiraki, Yoshio| Aono, Kaname|
Published Date 1985-02-25
Publication Title 岡山医学会雑誌
Volume volume97
Issue issue1-2
Content Type Journal Article
Author Joja, Ikuo| Sato, Nobuo| Fujishima, Mamoru| Kaji, Mitsumasa| Togami, Izumi| Niiya, Harutaka| Shirakami, Toshiaki| Yamamoto, Hiromichi| Takeda, Yoshihiro| Kimoto, Shin| Hashimoto, Keiji| Morimoto, Setsuo| Sugita, Katsuhiko| Hiraki, Yoshio| Aono, Kaname|
Published Date 1985-02-25
Publication Title 岡山医学会雑誌
Volume volume97
Issue issue1-2
Content Type Journal Article
Author Takeda, Yoshihiro| Hiraki, Yoshio| Morimoto, Setsuo| Togami, Izumi| Shirakami, Toshiaki| Shiraishi, Noriyuki| Kimoto, Shin| Joja, Ikuo| Hashimoto, Keiji| Aono, Kaname|
Published Date 1985-02-25
Publication Title 岡山医学会雑誌
Volume volume97
Issue issue1-2
Content Type Journal Article
Author Togami, Izumi| Hiraki, Yoshio| Kimoto, Shin| Shirakami, Toshiaki| Ueda, Hiroyuki| Satoh, Nobuo| Nakamura, Tetsuya| Yamamoto, Hiromichi| Joja, Ikuo| Hashimoto, Keiji| Morimoto, Setsuo| Aono, Kaname| Takeda, Yoshihiro|
Published Date 1985-10-30
Publication Title 岡山医学会雑誌
Volume volume97
Issue issue9-10
Content Type Journal Article
Author Hashimoto, Keiji| Kimoto, Shin| Shirakami, Toshiaki| Joja, Ikuo| Hayashi, Hidehiro| Takeda, Yoshihiro| Togami, Izumi| Niiya, Harutaka| Ueda, Hiroyuki| Shimizu, Mitsuharu| Sugita, Katsuhiko| Hiraki, Yoshio| Aono, Kaname| Kaji, Mitsumasa|
Published Date 1986-04-30
Publication Title 岡山医学会雑誌
Volume volume98
Issue issue3-4
Content Type Journal Article
Author Nakamura, Tetsuya| Hiraki, Yoshio| Takeda, Yoshihiro| Yamamoto, Hiromichi| Niiya, Harutaka| Togami, Izumi| Shirakami, Toshiaki| Aono, Kaname| Akamatsu, Nobuo| Sekiba, Kaoru|
Published Date 1986-10-31
Publication Title 岡山医学会雑誌
Volume volume98
Issue issue9-10
Content Type Journal Article
Author Hayashi, Hidehiro| Hiraki, Yoshio| Joja, Ikuo| Kashitani, Naoko| Miyake, Masayoshi| Yamamoto, Yoshio| Kanzaki, Noriko| Inoue, Nobuhiro| Noriyasu, Toshiaki| Hashimoto, Keiji| Takeda, Yoshihiro| Mizuta, Akihumi| Sugita, Katsuhiko| Aono, Kaname|
Published Date 1987-02-28
Publication Title 岡山医学会雑誌
Volume volume99
Issue issue1-2
Content Type Journal Article
Author Noriyasu, Toshiaki| Hiraki, Yoshio| Takeda, Yoshihiro| Mimura, Hidehumi| Mitani, Masahiko| Nagayama, Masako| Kimoto, Shin| Kaji, Mitsumasa| Hashimoto, Keiji| Aono, Kaname|
Published Date 1988
Publication Title 岡山医学会雑誌
Volume volume100
Issue issue9-10
Content Type Journal Article
JaLCDOI 10.18926/AMO/31576
FullText URL fulltext.pdf
Author Fujishima, Mamoru| Suemitsu, Ichizou| Sei, Tetsurou| Takeda, Yoshihiro| Hiraki, Yoshio|
Abstract <p>A total of 124 lesions from 1 to 6cm in diameter, including 31 cavernous hemangiomas, 32 metastases and 61 hepatocellular carcinomas (HCC) were analyzed to study the usefulness of magnetic resonance imaging (MRI) at 0.5 Tesla to differentiate focal hepatic lesions on the basis of qualitative criteria. Each focal hepatic lesion was assessed for shape, internal architecture and signal intensity relative to normal liver parenchyma. While all cavernous hemangiomas and metastases except one lesion could be detected, detection rate of HCC was significantly inferior to that of the other two diseases. A tumor capsule and a hyperintense focus on T1-weighted images were demonstrated in only HCC lesions in strong contrast with the other two diseases; however, metastases with slow-growing characteristics or subacute hematoma may appear as similar images. Cavernous hemangiomas appeared markedly hyperintense on T2-weighted images in 23 of 31 lesions, but one metastasis and one HCC had similar images. A multivariate analysis of several MRI resulted in the following mean discriminant scores: cavernous hemangioma, -1.2652; metastasis, 0.1830; and HCC, 0.7138. It appeared to be possible to differentiate the three diseases with 84.4 percent accuracy.</p>
Keywords magnetic resonance imaging liver neoplasms multivariate analysis
Amo Type Article
Published Date 1993-04
Publication Title Acta Medica Okayama
Volume volume47
Issue issue2
Publisher Okayama University Medical School
Start Page 117
End Page 120
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 8389524
Web of Science KeyUT A1993LA45200008
JaLCDOI 10.18926/AMO/31599
FullText URL fulltext.pdf
Author Kuroda, Masahiro| Tsushima, Tomoyasu| Nasu, Yasutomo| Asaumi, Junichi| Nishikawa, Koji| Gao, Xian Shu| Joja, Ikuo| Takeda, Yoshihiro| Togami, Izumi| Makihata, Eiichi| Kawasaki, Shoji| Ohmori, Hiroyuki| Hiraki, Yoshio|
Abstract <p>We performed a long-term follow-up of 4 patients with penile cancer who underwent hyperthermotherapy from August 1985 until August 1992. Hyperthermia was applied using a frequency of 350 MHz with a waveguide applicator twice a week for 60 min each for an average of 9.5 times (varying from 6 to 13 times). The total heating time that the temperature of urethra could be kept above 42 degrees C, was 166 min on the average (ranging from 0 to 463 min). Two patients classified as stage I according to the Jackson classification and 1 patient classified as stage IV underwent combined radiotherapy and received an average radiation dose of 53 Gy (range, 40-70 Gy). Among these patients 2 underwent combined chemotherapy with bleomycin or peplomycin. Malignant cells disappeared posttherapeutically and in August 1992, after an average of 5 years and 9 months (varying from 4 years 6 months to 6 years 10 months), the patients were free of recurrences. The one patient on stage IV had extensive invasion of the abdominal wall, but still recovered completely. One patient on stage III underwent combined chemotherapy and hyperthermotherapy, but heating had obviously been insufficient. There was a residue of malignant cells after the treatment and we performed a penectomy. Regarding functional preservation of the penis a multidisciplinary therapy incorporating hyperthermotherapy can be expected to increase the curativity. This indicates that it could induce in an advanced case, where an operation would be difficult, complete remission.</p>
Keywords penile cancer hyperthermia radiotherapy chemotherapy
Amo Type Article
Published Date 1993-06
Publication Title Acta Medica Okayama
Volume volume47
Issue issue3
Publisher Okayama University Medical School
Start Page 169
End Page 174
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 8379345
Web of Science KeyUT A1993LL12400005
JaLCDOI 10.18926/AMO/31557
FullText URL fulltext.pdf
Author Kuroda, Masahiro| Hizuta, Akio| Iwagaki, Hiromi| Makihata, Eiichi| Asaumi, Junichi| Nishikawa, Koji| Gao, Xian Shu| Nakagawa, Tomio| Togami, Izumi| Takeda, Yoshihiro| Joja, Ikuo| Kawasaki, Shoji| Orita, Kunzo| Hiraki, Yoshio|
Abstract <p>Between November 1984 and August 1992 we used hyperthermotherapy in six cases of local recurrence of rectal cancer. Hyperthermotherapy was performed on the average 8.7 times (range: 3-18) for each patient for 60 min each. All patients underwent combined radiotherapy and received a mean radiation dose of 42.5 Gy (range: 9-60 Gy). Five patients underwent heating within 1 h after irradiation and one patient simultaneously with the irradiation. Four patients underwent combined chemotherapy and two patients immunotherapy. Before the treatment all patients had painful lesions, but pain decreased posttherapeutically in five patients. Performance status improved in two patients. High carcinoembryonic antigen levels prior to the therapy in four patients decreased in all cases after treatment. Posttherapeutical computed tomograms revealed only minor response or no changes. After the treatment, four patients died of exacerbations of recurrent tumors and one patient of distant metastases. The patient who underwent simultaneous radiohyperthermotherapy is presently alive, in August 1992, 38 months after initiation of the treatment. The 50% survival time after initiation of the treatment was 25 months (range: 10-38 months). Hyperthermotherapy combined with radiotherapy, chemotherapy and/or immunotherapy was useful for the alleviation of pain in patients who developed local recurrence after surgery, and improved survival after recurrences can be expected.</p>
Keywords rectal cancer local recurrence hyperthermia radiotherapy chemotherapy
Amo Type Article
Published Date 1993-08
Publication Title Acta Medica Okayama
Volume volume47
Issue issue4
Publisher Okayama University Medical School
Start Page 249
End Page 254
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 8213219
Web of Science KeyUT A1993LV73800005
JaLCDOI 10.18926/AMO/31118
FullText URL fulltext.pdf
Author Tsunoda, Masatoshi| Kimoto, Shin| Hamazaki, Keisuke| Takeda, Yoshihiro| Hiraki, Yoshio|
Abstract <p>A non-invasive method for measuring portal blood flow by magnetic resonance (MR) phase contrast was evaluated in a flow phantom and 20 healthy volunteers. In a flow phantom study, the flow volumes and mean flow velocities measured by MR phase contrast showed close correlations with those measured by electromagnetic flowmetry. In 20 healthy volunteers, the cross-sectional areas, flow volumes and mean flow velocities measured by MR phase contrast correlated well with those measured by the Doppler ultrasound method. Portal blood flow averaged during the imaging time could be measured under natural breathing conditions by using a large number of acquisitions without the limitations imposed on the Doppler ultrasound method. MR phase contrast is considered to be useful for the non-invasive measurement of portal blood flow.</p>
Keywords portal blood flow magnetic resonance imaging phase contrast
Amo Type Article
Published Date 1994-10
Publication Title Acta Medica Okayama
Volume volume48
Issue issue5
Publisher Okayama University Medical School
Start Page 283
End Page 288
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 7863800
Web of Science KeyUT A1994PP23600009
JaLCDOI 10.18926/11730
Title Alternative Measurement of intracellular pH by flow cytometry using pH sensitive fluorescence dye, and influence of hyperthermia and amiloride derivatives on the intracellular pH
FullText URL 006_001_005.pdf
Author Asaumi, Jun-ichi| Kawasaki, Shoji| Kuroda, Masahiro| Takeda, Yoshihiro| Hiraki, Yoshio|
Abstract エールリッヒ腹水癌細胞とそのアドリアマイシン耐性細胞において蛍光pH指示薬2'、7'-bis-(2-carboxyethyl) carboxyfluorescein] (BCECF) の蛍光量をフローサイトメトリーで測定することによって細胞内pHの検量曲線を作成することができた。このことより、これらの細胞においてBCECFの蛍光量で細胞内pHの変化を簡易に比較できることを示唆した。さらに、温熱、Na(+)/H(+) exchanger の阻害例であるアミロライド[3,5-diamino-6-chloro-N-(diaminomethylene) pyrazinecarboxamide]、およびアミロライド誘導隊MH-12-43[N-amidino-3-amino-6-chloro-5-(N-ethyliso-propylamino) pyrazinecarboxyamide] の細胞内pHへの影響をエールリッヒ腹水癌細胞で観察した。37℃では、0.5mMアミロライド、0.05mM MH-12-43により細胞内pHは減少し、42℃処理によりさらに減少した。42℃において、0.05mM MH-12-43による細胞内pHの減少は、0.5mMアミロライドによる減少より大きかった。
Abstract Alternative We examined relationship between intensity of intracellular fluorescence of [2', 7'-bis-(2'-carboxyethyl) carboxyfluorescein] (BCECF) and intracellular pH in Ehrlich ascites tumor cells and their adriamycin-resistant strain, and found a good correlation between them at both strains. This suggests that changes in the intracellular pH on these strains may be obtained through measurement of intracellular fluorescence of BCECF by flow cytometry. Further, we examined influence of hyperthermia, 3, 5-diamino-6-chloro-N-(diaminomethylene)pyrazinecarboxamide (amiloride), an inhibitor of Na(+)/H(+) exchanger, and its derivative; N-amidino-3-amino-6-chloro-5-(N-ethylisopropylamino) pyrazinecarboxyamide (MH-12-43) on the intracellular pH in Ehrlich ascites tumor cells. The treatment of 0.5mM amiloride or 0.05mM MH-12-43 reduced intracellular pH at 37℃, while the more reduction was observed by the treatment at 42℃. The reduction of intracellular pH by 0.05mM MH-12-43 was more substantial than that of 0.5mM amiloride at 42℃.
Keywords BCECF 細胞内pH (Intracellular pH) フローサイトメトリー (Flow Cytometry) アミロライド (Amiloride) MH-12-43
Publication Title 岡山大学医療技術短期大学部紀要
Published Date 1996-02-29
Volume volume6
Start Page 1
End Page 5
ISSN 0917-4494
language 日本語
File Version publisher
NAID 120002313855
JaLCDOI 10.18926/11735
Title Alternative Clinical application of the contrast media containing soft drinks for the X-ray examination of the stomach
FullText URL 006_015_021.pdf
Author Shibuya, Koichi| Nakagiri, Yoshitada| Azuma, Yoshiharu| Goto, Sachiko| Maruyama, Toshinori| Sugita, Katsuhiko| Okura, Yasuhiko| Natsukawa, Koichi| Tandani, Nobuyoshi| Nobuhara, Eitaro| Morioka, Yasuki| Takeda, Yoshihiro| Hiraki, Yoshio|
Abstract 胃X線検査の被験者を増やし、検査を円滑に行う上で造影剤である硫酸バリウム懸濁液の飲みにくさが障害の一つとなっている。これを改善する目的で、懸濁液に市販の粉末清涼飲料を混入したところ、64.2%の人が通常のものよりも飲みやすいと答えた。臨床上も造影剤の付着が悪くなったり、胃の蠕動を促進する等の問題は生じず、有用であると考えられた。
Abstract Alternative Barium sulfate suspensions are disliked by many people. This is one of the obstacles to increase persons who consult doctors and to have medical examinations smoothly. We mixed soft drinks into the suspensions to improve this problem. As a result, they were popular among 64.2% people, there were not any clinical troubles that the suspensions did not stick to the mucous membrane of the stomach well, the peristalsis of the sotmach were promoted, and so on. These results suggest that the contrast media containing soft drinks is useful for the X-ray examinations of the stomach.
Keywords 造影剤 (contrast media) 硫酸バリウム (barium sulfate suspension) 清涼飲料 (soft drinks) 消化管検査 (barium examination)
Publication Title 岡山大学医療技術短期大学部紀要
Published Date 1996-02-29
Volume volume6
Start Page 15
End Page 21
ISSN 0917-4494
language 日本語
File Version publisher
NAID 120002313345
Author Gao, Xianshu| Nakagawa, Tomio| Yamamoto, Michinori| Kuroda, Masahiro| Sakae, Katsuyoshi| Shimizu, Mitsuharu| Niiya, Harutaka| Takeda, Yoshihiro| Joja, Ikuo| Hiraki, Yoshio| Kawasaki, Shoji|
Published Date 1996-06-29
Publication Title 岡山医学会雑誌
Volume volume108
Issue issue3-6
Content Type Journal Article