Author | Tokuno, Rinji| |
---|---|
Published Date | 1929-07-31 |
Publication Title | 岡山医学会雑誌 |
Volume | volume41 |
Issue | issue7 |
Content Type | Journal Article |
Author | Takatsuki, Saburo| |
---|---|
Published Date | 1932-03-31 |
Publication Title | 岡山医学会雑誌 |
Volume | volume44 |
Issue | issue3 |
Content Type | Journal Article |
Author | Uchihashi, Reiji| |
---|---|
Published Date | 1935-08-31 |
Publication Title | 岡山医学会雑誌 |
Volume | volume47 |
Issue | issue8 |
Content Type | Journal Article |
Author | Aoyama, Tutomu| |
---|---|
Published Date | 1939-06-30 |
Publication Title | 岡山医学会雑誌 |
Volume | volume51 |
Issue | issue6 |
Content Type | Journal Article |
Author | Aoyama, Tutomu| |
---|---|
Published Date | 1938-10-31 |
Publication Title | 岡山医学会雑誌 |
Volume | volume50 |
Issue | issue10 |
Content Type | Journal Article |
Author | Aoyama, Tutomu| |
---|---|
Published Date | 1939-03-31 |
Publication Title | 岡山医学会雑誌 |
Volume | volume51 |
Issue | issue3 |
Content Type | Journal Article |
Author | Chôda, Toshiki| |
---|---|
Published Date | 1938-08-31 |
Publication Title | 岡山医学会雑誌 |
Volume | volume50 |
Issue | issue8 |
Content Type | Journal Article |
Author | Tachibana, Katsuo| |
---|---|
Published Date | 1935-05-31 |
Publication Title | 岡山医学会雑誌 |
Volume | volume47 |
Issue | issue5 |
Content Type | Journal Article |
Author | Tachibana, Katsuo| |
---|---|
Published Date | 1935-06-30 |
Publication Title | 岡山医学会雑誌 |
Volume | volume47 |
Issue | issue6 |
Content Type | Journal Article |
Author | Murakami, Tatsuo| |
---|---|
Published Date | 1929-02-28 |
Publication Title | 岡山医学会雑誌 |
Volume | volume41 |
Issue | issue2 |
Content Type | Journal Article |
Author | Kashiwagi, Shunji| |
---|---|
Published Date | 1931-07-31 |
Publication Title | 岡山医学会雑誌 |
Volume | volume43 |
Issue | issue7 |
Content Type | Journal Article |
Author | Matsuura, Takashi| |
---|---|
Published Date | 1933-09-30 |
Publication Title | 岡山医学会雑誌 |
Volume | volume45 |
Issue | issue9 |
Content Type | Journal Article |
Author | Inoue, Tomeo| |
---|---|
Published Date | 1933-11-30 |
Publication Title | 岡山医学会雑誌 |
Volume | volume45 |
Issue | issue11 |
Content Type | Journal Article |
Author | Muranaka, Makoto| Hyodo, Isao| Okumura, Wataru| Oshiki, Toshiyuki| |
---|---|
Published Date | 2011-04-30 |
Publication Title | Catalysis Today |
Volume | volume164 |
Issue | issue1 |
Content Type | Journal Article |
Author | Edaki, Akira| |
---|---|
Published Date | 1987-10-31 |
Publication Title | 岡山医学会雑誌 |
Volume | volume99 |
Issue | issue9-10 |
Content Type | Journal Article |
Author | Okada, Koichi| |
---|---|
Published Date | 1960-03-30 |
Publication Title | 岡山医学会雑誌 |
Volume | volume72 |
Issue | issue4 |
Content Type | Journal Article |
FullText URL | fulltext.pdf |
---|---|
Author | Yamamoto, Takahiro| Fujimura, Atsushi| Wei, Fan-Yan| Shinojima, Naoki| Kuroda, Jun-Ichiro| Mukasa, Akitake| Tomizawa, Kazuhito| |
Published Date | 2019-11-22 |
Publication Title | iScience |
Volume | volume21 |
Publisher | Cell Press |
Start Page | 42 |
End Page | 56 |
ISSN | 2589-0042 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2019 The Author(s). |
File Version | publisher |
PubMed ID | 31654853 |
DOI | 10.1016/j.isci.2019.10.012 |
Web of Science KeyUT | 000498899800004 |
Related Url | isVersionOf https://doi.org/10.1016/j.isci.2019.10.012 |
JaLCDOI | 10.18926/AMO/32086 |
---|---|
FullText URL | fulltext.pdf |
Author | Takata, Hidehiko| Tomizawa, Kazuhito| Matsushita, Masayuki| Matsui, Hideki| |
Abstract | Protein transduction therapy using poly-arginine peptide can deliver the biologically active proteins. A previous study showed that 11 poly-arginine fused p53 protein (11R-p53) effectively penetrated across the plasma membrane and inhibited the proliferation of oral cancer cells. However, the intracellular half-life of the delivered protein was less than 36 h. Previous studies also showed that 2-methoxyestradiol (2-ME), an endogenous non-toxic estrogenic metabolite, induces the stabilization of the wild-type p53 protein in human cancer cells posttranscriptionally. In the present study, we examined whether 2-ME induced the stabilization of 11R-p53 and had an inhibitory effect on the proliferation of oral cancer cells. The application of 2-ME significantly enhanced the inhibitory effect of 11R-p53 on the proliferation of oral cancer cells. However, 2-ME had no effect on the intracellular half-life of 11R-p53 in oral cancer cells. Of interest is the finding that 2-ME suppressed the transcriptional activity of NFkappaB, which has an important role in tumorigenesis, but did not affect p53 transcriptional activity. These results suggest that 2-ME synergistically enhances the 11R-p53-induced inhibition of the proliferation of oral cancer cells through the suppression of NFkB transcription. |
Keywords | tumor TAT poly arginine gene therapy protein therapy |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 2004-08 |
Volume | volume58 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 181 |
End Page | 187 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 15551755 |
Web of Science KeyUT | 000223559700002 |
Author | Sawatari, Ikuo| Oshima, Mitsuko| Motomizu, Shoji| Toei, Kyoji| |
---|---|
Published Date | 1984-02-05 |
Publication Title | 分析化学 |
Volume | volume33 |
Issue | issue2 |
Content Type | Journal Article |
Author | Shi, Cheng Rui| Motomizu, Shoji| Toei, Kyoji| |
---|---|
Published Date | 1985-10-05 |
Publication Title | 分析化学 |
Volume | volume34 |
Issue | issue10 |
Content Type | Journal Article |