| JaLCDOI | 10.18926/AMO/31858 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Ogawa, Tomoyuki| Ono, Shigeki| Ichikawa, Tomotsugu| Arimitsu, Seiji| Onoda, Keisuke| Tokunaga, Koji| Sugiu, Kenji| Tomizawa, Kazuhito| Matsui, Hideki| Date, Isao| |
| 抄録 | Many studies have shown that a motif of 11 consecutive arginines (11R) is one of the most effective protein transduction domains (PTD) for introducing proteins into the cell membrane. By conjugating this "11R", all sorts of proteins can effectively and harmlessly be transferred into any kind of cell. We therefore examined the transduction efficiency of 11R in cerebral arteries and obtained results showing that 11R fused enhanced green fluorescent protein (11R-EGFP) immediately and effectively penetrated all layers of the rat basilar artery (BA), especially the tunica media. This method provides a revolutionary approach to cerebral arteries and ours is the first study to demonstrate the successful transductionof a PTD fused protein into the cerebral arteries. In this review, we present an outline of our studies and other key studies related to cerebral vasospasm and 11R, problems to be overcome, and predictions regarding future use of the 11R protein transduction method for cerebral vasospasm (CV). |
| キーワード | cerebral vasospasm 11 consecutive arginines (11R) enhanced green fluorescent protein (EGFP) |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2009-02 |
| 巻 | 63巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 1 |
| 終了ページ | 7 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 19247417 |
| Web of Science KeyUT | 000263730300001 |
| JaLCDOI | 10.18926/AMO/32888 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Yasuhara, Takao| Shingo, Tetsuro| Date, Isao| |
| 抄録 | Many studies using animals clarify that glial cell line-derived neurotrophic factor (GDNF) has strong neuroprotective and neurorestorative effects on dopaminergic neurons. Several pilot studies clarified the validity of continuous intraputaminal GDNF infusion to patients with Parkinson's disease (PD), although a randomized controlled trial of GDNF therapy published in 2006 resulted in negative outcomes, and controversy remains about the efficacy and safety of the treatment. For a decade, our laboratory has investigated the efficacy and the most appropriate method of GDNF administration using animals, and consequently we have obtained some solid data that correspond to the results of clinical trials. In this review, we present an outline of our studies and other key studies related to GDNF, the current state of the research, problems to be overcome, and predictions regarding the use of GDNF therapy for PD in the future. |
| キーワード | cell transplantation clinical trial encapsulation gene therapy neurodegenerative disease |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2007-04 |
| 巻 | 61巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 51 |
| 終了ページ | 56 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 17471304 |
| Web of Science KeyUT | 000245875600001 |
| JaLCDOI | 10.18926/AMO/43832 |
|---|---|
| フルテキストURL | 65_1_59.pdf |
| 著者 | Yasuhara, Takao| Miyoshi, Yasuyuki| Date, Isao| |
| 抄録 | A case of a Chiari malformation with an extraordinarily thick occipital bone is described. The thick occipital bone might make the posterior fossa narrow with consequent herniation of the cerebellar tonsils to the foramen magnum and formation of a syrinx. At dural plasty, well-developed marginal and occipital sinuses should be deliberately handled with the preservation of normal venous drainage. This case gives us the essence of the occurrence mechanisms of Chiari malformation and foramen magnum decompression. |
| キーワード | Chiari malformation dural plasty foramen magnum decompression syrinx venous drainage |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2011-02 |
| 巻 | 65巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 59 |
| 終了ページ | 61 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 21339798 |
| Web of Science KeyUT | 000287620500009 |
| JaLCDOI | 10.18926/AMO/48962 |
|---|---|
| フルテキストURL | 66_6_429.pdf |
| 著者 | Wang, Feifei| Maeda, Nagamasa| Yasuhara, Takao| Kameda, Masahiro| Tsuru, Emi| Yamashita, Tatsuyuki| Shen, Yuan| Tsuda, Masayuki| Date, Isao| Sagara, Yusuke| |
| 抄録 | Human umbilical cord blood (HUCB) cells are rich source of immature stem cells, which have the potential to repair lost tissue. Intractable central nervous system (CNS) disorders are important targets for regenerative medicine, and the application of HUCB cells is being investigated in animal models of CNS disorders. Transplantation of HUCB has induced functional improvements in these animal models due to multiple therapeutic effects including neuroprotection, anti-inflammation, angiogenesis, and neurogenesis. HUCB cells are easily available and safer than other stem cells used in transplantation therapy. In this review, we focus on HUCB transplantation as an encouraging therapeutic approach for animal models of neonatal hypoxic-ischemic brain injury and ischemic stroke. |
| キーワード | umbilical cord blood cell transplantation neonatal hypoxic-ischemic brain injury ischemic stroke stem cells |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2012-12 |
| 巻 | 66巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 429 |
| 終了ページ | 434 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2012 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23254576 |
| Web of Science KeyUT | 000312966100001 |
| JaLCDOI | 10.18926/AMO/49045 |
|---|---|
| フルテキストURL | 66_6_487.pdf |
| 著者 | Agari, Takashi| Mihara, Tadahiro| Baba, Koichi| Kobayashi, Katsuhiro| Usui, Naotaka| Terada, Kiyohito| Nakamura, Fumihiro| Matsuda, Kazumi| Date, Isao| |
| 抄録 | We report on a case of successful surgical treatment of drug-resistant epilepsy associated with a solitary lesion of periventricular nodular heterotopia (PNH). In the reported patient, intracranial ictal electroencephalography disclosed that seizures did not originate from the heterotopic nodules. However, the seizures were completely suppressed by lesionectomy of PNH alone. Epileptogenesis associated with PNH likely involves a very complex network between PNH and the surrounding cortex, and the disruption of this network may be an effective means of curing intractable, PNH-associated epilepsy. |
| キーワード | periventricular nodular heterotopia epilepsy surgery ictal electroencephalography |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2012-12 |
| 巻 | 66巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 487 |
| 終了ページ | 492 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2012 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23254583 |
| Web of Science KeyUT | 000312966100008 |
| JaLCDOI | 10.18926/AMO/50414 |
|---|---|
| フルテキストURL | 67_3_197.pdf |
| 著者 | Yasuhara, Takao| Takahashi, Yuichi| Kumamoto, Shinji| Nakahara, Masayuki| Yoneda, Kotaro| Niimura, Tatsuomi| Tanoue, Takashi| Kusumegi, Akira| Sennari, Takashi| Hijikata, Yasukazu| Manabe, Hiroaki| Miyoshi, Yasuyuki| Date, Isao| Ogawa, Koichi| Nishida, Kenki| |
| 抄録 | Some cases with lumbar degenerative diseases require multi-level fusion surgeries. At our institute, 27 and 4 procedures of 3- and 4-level fusion were performed out of a total 672 posterior lumbar interfusions (PLIFs) on patients with lumbar degenerative disease from 2005 to 2010. We present 2 osteoporotic patients who developed proximal vertebral body fracture after 4-level fusion. Both cases presented with gait disability for leg pain by degenerative lumbar scoliosis and canal stenosis at the levels of L1/2-4/5. After 4-level fusion using L1 as the upper instrumented vertebra, proximal vertebral body fractures were found along with the right pedicle fractures of L1 in both cases. One of these patients, aged 82 years, was treated as an outpatient using a hard corset for 24 months, but the fractures were exacerbated over time. In the other patient, posterolateral fusion was extended from Th10 to L5. Both patients can walk alone and have been thoroughly followed up. In both cases, the fracture of the right L1 pedicle might be related to the subsequent fractures and fusion failure. In consideration of multi-level fusion, L1 should be avoided as an upper instrumented vertebra to prevent junctional kyphosis, especially in cases with osteoporosis and flat back posture. |
| キーワード | degenerative lumbar scoliosis osteoporosis pedicle fracture posterior lumbar interbody fusion vertebral body fracture |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2013-06 |
| 巻 | 67巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 197 |
| 終了ページ | 202 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2013 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23804144 |
| Web of Science KeyUT | 000320747900010 |
| JaLCDOI | 10.18926/AMO/54497 |
|---|---|
| フルテキストURL | 70_4_229.pdf |
| 著者 | Hishikawa, Tomohito| Sugiu, Kenji| Date, Isao| |
| 抄録 | About 5 decades have passed since the concept of moyamoya disease (MMD) was established in Japan. In that time, many clinical MMD studies have been performed from several different points of view, such as epidemiology, pathophysiology, surgical procedures, and prognosis. In addition, rapid developments in MMD genetic analysis have occurred. In light of all this activity, clinicians must continually update their knowledge of MMD in order to improve the prognosis of MMD patients. In this review article, we summarize the clinical MMD studies and introduce cutting-edge findings regarding MMD. |
| キーワード | clinical research moyamoya disease |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2016-08 |
| 巻 | 70巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 229 |
| 終了ページ | 236 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2016 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 27549666 |
| Web of Science KeyUT | 000384748600001 |
| JaLCDOI | 10.18926/AMO/54813 |
|---|---|
| フルテキストURL | 70_6_493.pdf |
| 著者 | Yasuhara, Takao| Kuwahara, Ken| Sasada, Susumu| Toyoshima, Atsuhiko| Morimoto, Jun| Kin, Kyohei| Manabe, Hiroaki| Miyoshi, Yasuyuki| Kusumegi, Akira| Takahashi, Yuichiro| Ito, Kiyoshi| Date, Isao| |
| 抄録 | Unexpected injuries can have a profound effect on a surgeonʼs performance and thus on patients and surgical departments. Here we describe a technique for performing surgery in the standing position, as done by a surgeon with an Achilles tendon rupture. During his prescribed 45-day non-weight-bearing period for the left ankle after surgery for an Achilles tendon rupture, the surgeon was able to participate in 15 surgeries as an operator or assistant, due to his use of a combination of injured-leg genuflection on a stool and a ʻSurgical Body Supportʼ device. Similarly injured surgeons may benefit from such support. |
| キーワード | Achilles tendon rupture electromyogram genuflection injured leg standing position |
| Amo Type | Short Communication |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2016-12 |
| 巻 | 70巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 493 |
| 終了ページ | 496 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2016 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28003675 |
| JaLCDOI | 10.18926/AMO/54987 |
|---|---|
| フルテキストURL | 71_2_179.pdf |
| 著者 | Nosaka, Nobuyuki| Tsukahara, Kohei| Knaup, Emily| Yabuuchi, Toshihiko| Kikkawa, Tomonobu| Fujii, Yosuke| Yashiro, Masato| Yasuhara, Takao| Okada, Ayumi| Ugawa, Toyomu| Nakao, Atsunori| Tsukahara, Hirokazu| Date, Isao| |
| 抄録 | Newly published clinical practice guidelines recommend intracranial pressure (ICP) monitoring in critical care for the management of pediatric acute encephalopathy (pAE), but the utility of ICP monitoring for pAE has been poorly studied. We recently performed direct ICP monitoring for two patients. We observed that although the direct ICP monitoring had clinical benefits with less body weight gain and no vasopressor use in both cases, this monitoring technique is still invasive. Future studies should determine the utility of non-invasive ICP monitoring systems in pAE to further improve the quality of intensive-care management. |
| キーワード | cerebral perfusion encephalopathy child intracranial pressure neurological intensive care |
| Amo Type | Short Communication |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-04 |
| 巻 | 71巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 179 |
| 終了ページ | 180 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28420900 |
| JaLCDOI | 10.18926/AMO/55201 |
|---|---|
| フルテキストURL | 71_3_191.pdf |
| 著者 | Kobayashi, Katsuhiro| Akiyama, Tomoyuki| Agari, Takashi| Sasaki, Tatsuya| Shibata, Takashi| Hanaoka, Yoshiyuki| Akiyama, Mari| Endoh, Fumika| Oka, Makio| Date, Isao| |
| 抄録 | Electroencephalogram (EEG) data include broadband electrical brain activity ranging from infra-slow bands (< 0.1 Hz) to traditional frequency bands (e.g., the approx. 10 Hz alpha rhythm) to high-frequency bands of up to 500 Hz. High-frequency oscillations (HFOs) including ripple and fast ripple oscillations (80-200 Hz and>200 / 250 Hz, respectively) are particularly of note due to their very close relationship to epileptogenicity, with the possibility that they could function as a surrogate biomarker of epileptogenicity. In contrast, physiological high-frequency activity plays an important role in higher brain functions, and the differentiation between pathological / epileptic and physiological HFOs is a critical issue, especially in epilepsy surgery. HFOs were initially recorded with intracranial electrodes in patients with intractable epilepsy as part of a long-term invasive seizure monitoring study. However, fast oscillations (FOs) in the ripple and gamma bands (40-80 Hz) are now noninvasively detected by scalp EEG and magnetoencephalography, and thus the scope of studies on HFOs /FOs is rapidly expanding. |
| キーワード | fast oscillations, epilepsy electroencephalogram time-frequency analysis |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-06 |
| 巻 | 71巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 191 |
| 終了ページ | 200 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28655938 |
| JaLCDOI | 10.18926/AMO/55302 |
|---|---|
| フルテキストURL | 71_4_263.pdf |
| 著者 | Toyoshima, Atsuhiko| Yasuhara, Takao| Date, Isao| |
| 抄録 | To date, many animal studies have indicated the neuroprotective effects of mesenchymal stem cell (MSC) transplantation in ischemic stroke. Several clinical studies have also revealed the safety, feasibility, and neuroprotective effects in ischemic stroke patients. In this review, we present the main approaches of MSC transplantation in ischemic stroke, the mechanisms of MSC therapy, and the current clinical studies on MSC transplantation in ischemic stroke patients. We also explore the safety of MSC transplantation and conclude that MSC therapy will play an important role in the future treatment of ischemic stroke. The optimal timing, approach, and cell dose in the transplantation are important issues for successful clinical application. |
| キーワード | mesenchymal stem cell ischemic stroke cell transplantation clinical trial |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-08 |
| 巻 | 71巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 263 |
| 終了ページ | 268 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28824181 |
| JaLCDOI | 10.18926/AMO/64367 |
|---|---|
| フルテキストURL | 77_1_85.pdf |
| 著者 | Matsuda, Yuki| Otani, Yoshihiro| Yasuhara, Takao| Ando, Mizuo| Higaki, Takaya| Makino, Takuma| Matsumoto, Hiroshi| Oyama, Tadashi| Nishimori, Hisakazu| Date, Isao| |
| 抄録 | A 35-year-old female presented with headache, photophobia and developed sudden loss of vision after having undergone right-side ophthalmectomy and radiochemotherapy for retinoblastoma in infancy. A neoplastic lesion was found in the left middle cranial fossa and was surgically removed. The diagnosis was radiation-induced osteosarcoma with RB1 gene alteration. Although she received chemotherapy for the residual tumor, it progressed 17 months later. Maximal surgical resection with craniofacial reconstruction was required. We utilized two three-dimensional models for surgical planning. She was discharged without neurological deficits other than loss of light perception subsequent to left ophthalmectomy. In cases where retinoblastoma is treated with radiotherapy, long-term follow-up is necessary to monitor for radiation-induced tumor development. |
| キーワード | bone model skull base surgery radiation-induced osteosarcoma RB1 gene alteration |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-02 |
| 巻 | 77巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 85 |
| 終了ページ | 90 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36849151 |
| Web of Science KeyUT | 000952978000001 |
| フルテキストURL | K000871.pdf |
|---|---|
| 著者 | 伊達 勲| |
| キーワード | MHC locus immune reactions |
| 発行日 | 1990-09-30 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第871号 |
| 学位授与年月日 | 1990-09-30 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 日本語 |
| タイトル（別表記） | Novel protein transduction method for cerebral arteries using 11R |
|---|---|
| フルテキストURL | 120_129.pdf |
| 著者 | 小川 智之| 小野 成紀| 市川 智継| 有光 帥二| 小野田 惠介| 徳永 浩司| 杉生 憲志| 富澤 一仁| 松井 秀樹| 伊達 勲| |
| キーワード | cerebral vasospasm 11R protein transduction method |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2008-08-01 |
| 巻 | 120巻 |
| 号 | 2号 |
| 開始ページ | 129 |
| 終了ページ | 133 |
| ISSN | 00301558 |
| 言語 | 日本語 |
| 著作権者 | 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.120.129 |
| NAID | 120002310545 |
| タイトル（別表記） | Adult neural stem and progenitor cell transplantation in CNS diseases |
|---|---|
| フルテキストURL | 120_153.pdf |
| 著者 | 亀田 雅博| 新郷 哲郎| 村岡 賢一郎| 高橋 和也| 安原 隆雄| 伊達 勲| |
| キーワード | 成体由来神経幹細胞 脳内移植 グリア細胞株由来神経栄養因子（GDNF) 脳虚血 パーキンソン病 |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2008-08-01 |
| 巻 | 120巻 |
| 号 | 2号 |
| 開始ページ | 153 |
| 終了ページ | 157 |
| ISSN | 00301558 |
| 言語 | 日本語 |
| 著作権者 | 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.120.153 |
| NAID | 120002310550 |
| フルテキストURL | 118_99.pdf |
|---|---|
| 著者 | 安原 隆雄| 新郷 哲郎| 小林 和樹| 竹内 亮| 矢野 昭正| 村岡 賢一郎| 亀田 雅博| 元 文姫| 早瀬 仁志| 上利 崇| 松井 利浩| 三好 康之| 伊達 勲| |
| キーワード | カプセル化細胞移植 グリア細胞株由来神経栄養因子 (GDNF) 血管内皮成長因子 (VEGF) 脳虚血 パーキンソン病 |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2006-09-01 |
| 巻 | 118巻 |
| 号 | 2号 |
| 開始ページ | 99 |
| 終了ページ | 103 |
| ISSN | 0030-1558 |
| 言語 | 日本語 |
| 著作権者 | Copyright© 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma1947.118.2_99 |
| NAID | 10018059355 |
| フルテキストURL | 118_205.pdf |
|---|---|
| 著者 | 道上 宏之| 富澤 一仁| 魏 范研| 松下 正之| 陸 雲飛| 市川 智継| 田宮 隆| 松井 秀樹| 伊達 勲| |
| キーワード | プロテインセラピー 悪性脳腫瘍 p 53 エンドソーム 蛋白導入ドメイン |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2007-01-04 |
| 巻 | 118巻 |
| 号 | 3号 |
| 開始ページ | 205 |
| 終了ページ | 208 |
| ISSN | 00301558 |
| 言語 | 日本語 |
| 著作権者 | Copyright© 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma1947.118.3_205 |
| NAID | 10018454083 |
| フルテキストURL | 115_145.pdf |
|---|---|
| 著者 | 松井 利浩| 伊達 勲| |
| キーワード | neuroendoscope neurosurgery hydrocephalus third ventriculostomy biopsy |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2005-09-30 |
| 巻 | 115巻 |
| 号 | 2号 |
| 開始ページ | 145 |
| 終了ページ | 150 |
| ISSN | 0030-1558 |
| 言語 | 日本語 |
| 著作権者 | Copyright© 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma1947.115.2_145 |
| NAID | 10011896852 |
| タイトル（別表記） | Parkinson's disease from a viewpoint of regenerative medicine |
|---|---|
| フルテキストURL | 116_17.pdf |
| 著者 | 伊達 勲| |
| 抄録 | It has long been considered that central nervous system would not regenerate after injury, but this concept has recently been changing due to the development of neuroscience research. Cell grafting, gene transfer and neurotrophic factor administration into the brain and spinal cord are the examples of methods to perform protection and repair. These techniques are expected to be applied to certain neurological disorders such as Parkinson's disease, cerebral ischemia and spinal cord injury. Parkinson's disease is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the nigrostriatal system. Fetal neurons, chromaffin cells, cell lines, certain genes, neural stem cells, ES cells and bone marrow cells have been investigated as donor cells and vectors to treat Parkinson's disease. This review will summarize the history of neural transplantation in Parkinson's disease and features and prospects of each donor will be discussed. |
| キーワード | Parkinson's disease neural transplantation regeneration |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2004-05-31 |
| 巻 | 116巻 |
| 号 | 1号 |
| 開始ページ | 17 |
| 終了ページ | 27 |
| ISSN | 0030-1558 |
| 言語 | 日本語 |
| 著作権者 | Copyright© 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma1947.116.1_17 |
| NAID | 10013089196 |
| 著者 | 市川 智継| 黒住 和彦| 伊達 勲| |
|---|---|
| 発行日 | 2008-12-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 120巻 |
| 号 | 3号 |
| 資料タイプ | 学術雑誌論文 |