result 48721 件
| JaLCDOI | 10.18926/CTED/54020 |
|---|---|
| Title Alternative | The Effects of Video Self-Modeling on Improving Stretching Postures of a Student with Autism Spectrum Disorder |
| FullText URL | cted_006_049_058.pdf |
| Author | Matsushita, Yoshimasa| Ohtake, Yoshihisa| |
| Abstract | 本研究では，自閉症スペクトラム障害のある生徒に対して，ストレッチ時の姿勢改善のためにビデオセルフモデリング（VSM）による指導を実施し，その効果を検証した。実験デザインとしては，ストレッチを構成する4つの姿勢（「伸展」「前屈」「捻転」「側屈」）間の多層ベースラインデザインを用いた。さらに，「伸展」については反転デザインを合わせて用いた。その結果，「伸展」と「前屈」で，VSM 導入直後の行動変容が確認された。また，「伸展」では，VSM の導入と除去，再導入のいずれにおいても行動変容が確認された。「捻転」については，VSM のみでは行動変容が確認されず，リハーサルと視覚的明示を追加する中で初めて行動変容が確認された。「側屈」では，それらの方略を加えても行動に変容が見られなかった。標的行動間でVSMの効果に差が認められたことについて，日常生活におけるこれら4種類の体操姿勢の使用頻度の違いの視点で考察された。 |
| Keywords | ビデオセルフモデリング 自閉症スペクトラム障害 体操姿勢 |
| Publication Title | 岡山大学教師教育開発センター紀要 |
| Published Date | 2016-03-04 |
| Volume | volume6 |
| Start Page | 49 |
| End Page | 58 |
| ISSN | 2186-1323 |
| language | Japanese |
| Copyright Holders | Copyright © 2016 岡山大学教師教育開発センター |
| File Version | publisher |
| NAID | 120005723288 |
| JaLCDOI | 10.18926/CTED/54019 |
|---|---|
| Title Alternative | The Process of the Changing of the Childcare Workers in Accordance with “Noticing” as Autobiographical Memory |
| FullText URL | cted_006_038_048.pdf |
| Author | Yoshida, Mitsuho| Takahashi, Toshiyuki| Nishiyama, Osamu| |
| Abstract | 本論は，保育者の内的な気付きの変容と，それに伴う保育実践の変容を合わせて保育者の変容と捉え，その変容過程を探ることを目的とした。具体的には，中堅保育者の自伝的記憶としての気付き体験の語りを収集し，質的分析を行った。保育者の気付きは，「保護者等から知る自らの保育の課題」「子どもの様子」「繰り返しの体験」「自らの保育観」「上司，同僚の存在」が契機になることが明らかになった。さらに，気付きの契機で，保育者自身が「いけない・どうしよう」「こうしたい」「嬉しい・良かった」「こうあらねば」の意識を持ち，それが起因となり，気付きが広がり深まるという変容が起こる。その気付きの変容により保育実践の変容が促されることが見出された。以上の結果から，気付きの契機とそれに伴う保育者の思いに焦点化した働きかけにより，保育者の変容を図る可能性が示唆された。 |
| Keywords | 気付き体験 自伝的記憶 保育者の変容 中堅保育者 |
| Publication Title | 岡山大学教師教育開発センター紀要 |
| Published Date | 2016-03-04 |
| Volume | volume6 |
| Start Page | 38 |
| End Page | 48 |
| ISSN | 2186-1323 |
| language | Japanese |
| Copyright Holders | Copyright © 2016 岡山大学教師教育開発センター |
| File Version | publisher |
| NAID | 120005723287 |
| JaLCDOI | 10.18926/CTED/54018 |
|---|---|
| Title Alternative | An Analysis of Court Cases Relating to Special Education in Japan: Perspective towards Inclusive Education |
| FullText URL | cted_006_031_037.pdf |
| Author | Ikeuchi, Mikako| Tsuji, Saki| Nishino, Masumi| MINAMI, Kyoko| Yoshimitsu, Miharu| Yoshitoshi, Munehisa| |
| Abstract | 本稿では，わが国における特別支援教育システムの構築に示唆的な近時の裁判例を要約し，新たな動向を把握することを試みた。具体的には，特別支援教育をめぐる裁判のなかでも，①通常の学校における特別支援教育の問題を争点に含むもの，②過去10年間（2005年以降）に判決が下されたもの，を条件として5つの裁判例を抽出した。それらの裁判における主な経緯や争点の評釈から，通常の学校における特別支援教育が推進されるとともに，多様な教育課題が誘発されており，新たな争点も生じていることが明らかとなった。すなわち，情報開示の範囲，就学先の決定，教員の専門性，学校の情報共有体制といった実践的課題が提起されており，障害のある児童生徒および保護者の権利を重視する判断が示されてきた。「障害者の権利に関する条約」の批准をふまえ，インクルーシブ教育の実現に向けた特別支援教育システムのいっそうの発展が望まれる。 |
| Keywords | 特別支援教育 インクルーシブ教育 裁判 就学 |
| Publication Title | 岡山大学教師教育開発センター紀要 |
| Published Date | 2016-03-04 |
| Volume | volume6 |
| Start Page | 31 |
| End Page | 37 |
| ISSN | 2186-1323 |
| language | Japanese |
| Copyright Holders | Copyright © 2016 岡山大学教師教育開発センター |
| File Version | author |
| NAID | 120005723286 |
| JaLCDOI | 10.18926/CTED/54017 |
|---|---|
| Title Alternative | Desirable Way to Support for Guardians and Cooperation among Nursery Teachers in Case Study |
| FullText URL | cted_006_021_030.pdf |
| Author | Nakahira, Ayako| Baba, Noriko| Takeuchi, Keiko| Takahashi, Toshiyuki| |
| Abstract | 子どもの健やかな成長と発達のためには，保育士と保護者が円滑な関係にあることが望ましい。経験年数の短い若手保育士と中堅・熟練保育士では，保護者対応に違いはあるのだろうか。本論では，経験年数別に保護者対応について聴き取り調査を行った。さらに，中堅・熟練保育士自身が若手保育士だった頃の振り返りから，現在の保護者対応を比較し検討した。その結果，保護者対応には経験の蓄積と先輩保育士の助言・指導等が必要であることが分かった。 |
| Keywords | 保育所保育士 経験年数 保護者支援 連携 |
| Publication Title | 岡山大学教師教育開発センター紀要 |
| Published Date | 2016-03-04 |
| Volume | volume6 |
| Start Page | 21 |
| End Page | 30 |
| ISSN | 2186-1323 |
| language | Japanese |
| Copyright Holders | Copyright © 2016 岡山大学教師教育開発センター |
| File Version | publisher |
| NAID | 120005723285 |
| JaLCDOI | 10.18926/CTED/54016 |
|---|---|
| Title Alternative | An Exploratory Study about Family Support by Young Preschool Teachers and Child-care Providers ―Some Implication for Professional Education Program in an Education Period― |
| FullText URL | cted_006_011_020.pdf |
| Author | Katayama, Mika| |
| Abstract | 本研究では，近年，就学前の教育・保育において重視されている保護者への支援について，保育経験５年未満の若手保育者37名（幼稚園教諭：18名，保育所保育士19名）を対象に，幼稚園や保育所における保護者支援の目標，困難感の実態や，重視していること等について調査した。ＫＪ法を用いて整理したところ，所属や経験年数によらず，多様な支援が見いだされ，とくに送迎時の会話を重視しており，園と家庭の連続性を大切にしながら発達や個々に直面する課題に応じて，保育者間の連携の下に支援していることが明らかになった。発達につまずきのある子どもをもつ保護者への支援に困難感が生じていたが、保護者との相互理解や信頼関係の構築を重視していることも確認された。今後の学習ニーズとしては，課題を持つ子どもの保護者や，保護者自身が課題を持つ際の支援法が挙げられた。養成校では入職後の自己をイメージ化しながら、理論知を固めることの重要性が示唆された。 |
| Keywords | 保護者支援 幼稚園教師 保育所保育士 保育経験５年未満 養成教育 |
| Publication Title | 岡山大学教師教育開発センター紀要 |
| Published Date | 2016-03-04 |
| Volume | volume6 |
| Start Page | 11 |
| End Page | 20 |
| ISSN | 2186-1323 |
| language | Japanese |
| Copyright Holders | Copyright © 2016 岡山大学教師教育開発センター |
| File Version | publisher |
| NAID | 120005723284 |
| JaLCDOI | 10.18926/CTED/54015 |
|---|---|
| Title Alternative | Consideration about the State of Future's New Teacher Education and Scholastic One for Morality Subject-ization ―Inspection of the True Moral Education Considered from an Overall Unit-like Morality Class Curriculum― |
| FullText URL | cted_006_001_010_1.pdf |
| Author | Sakuda, Kiyohiro| Nakayama, Yoshikazu| |
| Abstract | 文部科学省が実施する道徳教科化に向け，今日の学校教育において，道徳教育が必要とされている理由と今後の在り方について検討した。その際に，これまでに実施されてきた総合単元的な道徳教育による「学校教育活動全体として」の視点が強化された学校教育の在り方に加え，さらなる地域，家庭等と連携した綿密な道徳教育の在り方を必要とする。 本研究では，これらを踏まえた図式化をもとに，評価方法等の道徳教科化における効果と課題について考察分析した。その結果，道徳教科化により，道徳への意識が強調され，各個人への意識付けである道徳的価値意識が高まりやすくなることが示唆された。 また，学校教育における自然・空間・人間環境づくりの重要性と「善く生きる」ための道徳教育に向けた教師教育の在り方について明らかにした。 |
| Keywords | 道徳の評価方法 道徳教科化による効果 学校教育の環境設定 総合単元的な道徳授業カリキュラム |
| Publication Title | 岡山大学教師教育開発センター紀要 |
| Published Date | 2016-03-04 |
| Volume | volume6 |
| Start Page | 1 |
| End Page | 10 |
| ISSN | 2186-1323 |
| language | Japanese |
| Copyright Holders | Copyright © 2016 岡山大学教師教育開発センター |
| File Version | publisher |
| NAID | 120005723283 |
| Author | 岡山大学教師教育開発センター| |
|---|---|
| Published Date | 2016-03-04 |
| Publication Title | 岡山大学教師教育開発センター紀要 |
| Volume | volume6 |
| Content Type | Others |
| Author | 岡山大学教師教育開発センター| |
|---|---|
| Published Date | 2016-03-04 |
| Publication Title | 岡山大学教師教育開発センター紀要 |
| Volume | volume6 |
| Content Type | Others |
| Author | Yamada, Satoshi| |
|---|---|
| Published Date | 2015-06 |
| Publication Title | 江原法學 |
| Issue | issue45 |
| Content Type | Journal Article |
| Author | Taniguchi, Masanari| Fukunaka, Ayako| Hagihara, Mitsue| Watanabe, Keiko| Kamino, Shinichiro| Kambe, Taiho| Enomoto, Shuichi| Hiromura, Makoto| |
|---|---|
| Published Date | 2013-03-07 |
| Publication Title | PLOS ONE |
| Volume | volume8 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Watanabe, Mayu| Nakatsuka, Atsuko| Murakami, Kazutoshi| Inoue, Kentaro| Terami, Takahiro| Higuchi, Chigusa| Katayama, Akihiro| Teshigawara, Sanae| Eguchi, Jun| Ogawa, Daisuke| Watanabe, Eijiro| Wada, Jun| Makino, Hirofumi| |
|---|---|
| Published Date | 2014-05-25 |
| Publication Title | PLOS ONE |
| Volume | volume9 |
| Issue | issue3 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/54008 |
|---|---|
| FullText URL | 70_1_67.pdf |
| Author | Senoo, Miki| Nakatsuka, Mikiya| |
| Abstract | Pregnant women with uterine leiomyomas may experience anxiety toward their pregnancies and unfavorable feelings toward their infants. From March to July 2010, we distributed anonymous self-recorded questionnaires to 200 pregnant women who visited Okayama Central Hospital for an antenatal check-up after informed consent was provided, and 132 women (23 pregnant women with uterine leiomyomas) were included in our study. Among the multiparous women in their first trimester, the women with uterine leiomyomas had a higher rate of anxiety than those without uterine leiomyomas. ʻAvoidanceʼ scores on the Feeling Toward the Baby Scale were significantly higher in the leiomyoma group. The conflict index scores tended to be higher in the leiomyoma group. A multivariate analysis revealed no factors associated with trait-anxiety scores, whereas high state-anxiety scores were correlated with low age;however, there was no correlation between these scores and uterine leiomyomas. Although no factors were associated with State-Trait Anxiety Inventory (STAI) and approach scores toward the baby, avoidance and conflict index scores were associated with the existence of uterine leiomyomas. In pregnant women with uterine leiomyomas, efforts should be made to reduce anxiety in the first trimester, and support should be provided to help these women develop positive feelings toward their babies. |
| Keywords | pregnancy uterine leiomyomas anxiety feelings toward the baby pregnancy loss |
| Amo Type | Erratum |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-02 |
| Volume | volume70 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 67 |
| End Page | 68 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26899613 |
| Related Url | http://doi.org/10.18926/AMO/53908 |
| JaLCDOI | 10.18926/AMO/54007 |
|---|---|
| FullText URL | 70_1_63.pdf |
| Author | Torigoe, Hidejiro| Toyooka, Shinichi| Katsui, Kuniaki| Soh, Junichi| Maki, Yuho| Kiura, Katsuyuki| Miyoshi, Shinichiro| |
| Abstract | We present the case of a 77-year-old Japanese man diagnosed with lung squamous cell carcinoma with mediastinal lymph node metastasis. He was treated with induction chemoradiotherapy for T1bN2M0 stage IIIA disease. Considering his age, we selected S-1 as the chemotherapeutic drug. Observing an objective response with no severe adverse events, we performed a left upper lobectomy with sleeve resection of the pulmonary artery. No residual tumor cells were found in the resected specimens, and no critical complication was observed in the clinical course. This case suggests that induction chemoradiotherapy using S-1 combined with concurrent radiation followed by surgery can be a therapeutic option for elderly patients with locally advanced non-small-cell lung cancer. |
| Keywords | lung cancer S-1 elderly induction chemoradiotherapy |
| Amo Type | Case Reports |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-02 |
| Volume | volume70 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 63 |
| End Page | 65 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26899612 |
| Web of Science KeyUT | 000371288700009 |
| JaLCDOI | 10.18926/AMO/54005 |
|---|---|
| FullText URL | 70_1_57.pdf |
| Author | Sumiyoshi, Kumi| Ishihara, Yoshihito| Komori, Hiroki| Yamashiro, Takashi| Kamioka, Hiroshi| |
| Abstract | Permanent canines are thought to play a pivotal role in obtaining an ideal occlusion. Dentists occasionally encounter patients who lack canines and are therefore missing a key to harmonious guidance during functional mandibular excursions. This case report describes the substitution of maxillary first premolars for congenitally missing canines in the context of an orthodontic treatment plan. A boy, age 10 years and 11 months, with a chief complaint of crooked teeth was diagnosed with Class II division 2 malocclusion associated with a high mandibular plane angle and deep overbite. A stable occlusion with a satisfactory facial profile and functional excursions without interference were achieved after a comprehensive two-stage orthodontic treatment process. The resulting occlusion and satisfactory facial profile were maintained for 12 months. These results indicate that substituting the first premolars for the canines is an effective option in treating patients with missing canines while maintaining functional goals. |
| Keywords | orthodontics missing canines stomatognathic function |
| Amo Type | Case Reports |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-02 |
| Volume | volume70 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 57 |
| End Page | 62 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26899611 |
| Web of Science KeyUT | 000371288700008 |
| JaLCDOI | 10.18926/AMO/54004 |
|---|---|
| FullText URL | 70_1_51.pdf |
| Author | Tanaka, Masato| Sugimoto, Yoshiharu| Arataki, Shinya| Takigawa, Tomoyuki| Ozaki, Toshifumi| |
| Abstract | Computer-assisted spinal surgery is becoming more common; however, this is the first technical report to describe the technique of minimally invasive spinal posterior lumbar interbody fusion (MIS-PLIF) without using C-arm fluoroscopy. The authors report 2 years of follow-up of a 49-year-old female patient with L4 degenerative spondylolisthesis. The patient suffered from low back pain and intermittent claudication for more than 6 years. The authors performed computer-assisted MIS-PLIF without C-arm fluoroscopy. Instead, O-arm® navigation, the use of which reduces radiation exposure to patients as well as others in the operating room, was employed. Surgery was successful, and correct lumbar alignment was maintained. She had neither neurological deficits nor low back pain at her 12-month final follow-up. In conclusion, computer-assisted MIS-PLIF without C-arm fluoroscopy is a useful technique that reduces radiation exposure to the surgeon and operating room staff. |
| Keywords | computer-assisted surgery posterior lumbar interbody fusion O-arm |
| Amo Type | Case Reports |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-02 |
| Volume | volume70 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 51 |
| End Page | 55 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26899610 |
| Web of Science KeyUT | 000371288700007 |
| JaLCDOI | 10.18926/AMO/54003 |
|---|---|
| FullText URL | 70_1_45.pdf |
| Author | Maruyama, Hidehiko| Nakata, Yusei| Kanazawa, Akane| Kikkawa, Kiyoshi| |
| Abstract | Mothers of preterm infants may find it difficult to express breast milk. There is a low breast milk rate among preterm infants at discharge at our hospital, and here we tested the hypothesis that milk expression factors were the cause of the low rate. The study subjects were born before 33 gestational weeks at our hospital between March 2005 and June 2014. Nutritional evaluation was performed at discharge and noted whether breast milk, infant formula, or a mix of the 2 was being given. We compared the group given breast milk or the mix versus the group given formula. Of the 337 infants, 40 cases were excluded. Data from 297 infants were analyzed. The mean (SD) gestational age and birth weight were 29.5 (2.4) weeks and 1,230 (391) g, respectively. At discharge, 26 (8.8%), 102 (33.3%), and 174 (57.9%) infants were given breast milk, formula, and the mix, respectively. A multivariate logistic regression analysis showed that the first milk expression (h) was the risk factor for the formula group: adjusted odds ratio (95% confidence interval) 1.06 (1.02-1.09) and p=0.002. Delayed first milk expression could affect the low breast milk rate at discharge. Improvement of milk expression should be achieved to promote breastfeeding. |
| Keywords | breast milk breastfeeding formula milk expression preterm |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-02 |
| Volume | volume70 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 45 |
| End Page | 49 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26899609 |
| Web of Science KeyUT | 000371288700006 |
| JaLCDOI | 10.18926/AMO/54002 |
|---|---|
| FullText URL | 70_1_37.pdf |
| Author | Yun, So Hui| Park, Jong Cook| Kim, Sang Rim| Choi, Yun Suk| |
| Abstract | The beneficial effects of dexmedetomidine (DEX) have not been extensively investigated in elderly patients receiving spinal anesthesia. This study evaluated the effects of intravenous DEX infusion on stress and hemodynamic response, as well as on postoperative analgesia in elderly patients undergoing total knee arthroplasty (TKA). We randomly allocated 45 adult patients to 3 patient groups (n=15 each): uni-saline group patients underwent unilateral TKA with saline administration, uni-DEX group patients underwent unilateral TKA with DEX administration, and bilateral-DEX group patients underwent bilateral TKA with DEX administration. Serum interleukin-6 (IL-6) levels were significantly lower in the bilateral-DEX group than in the uni-saline group 6 and 24h postoperatively, and were negatively correlated with total DEX dosage 24h postoperatively. Bradycardia occurred more frequently in the uni-DEX and bilateral-DEX groups than in the uni-saline group. The total dose of required supplementary analgesics was significantly higher in the uni-saline group than in the uni-DEX and bilateral-DEX groups 6h postoperatively. The results indicate that perioperative intravenous DEX administration decreases postoperative serum IL-6 levels in patients undergoing bilateral TKA, and has a postoperative analgesic effect in patients undergoing unilateral or bilateral TKA. |
| Keywords | analgesic effect dexmedetomidine hemodynamic response stress response |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-02 |
| Volume | volume70 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 37 |
| End Page | 43 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26899608 |
| Web of Science KeyUT | 000371288700005 |
| JaLCDOI | 10.18926/AMO/54001 |
|---|---|
| FullText URL | 70_1_31.pdf |
| Author | Hanada, Takae| Kanamitsu, Kiichiro| Chayama, Kosuke| Miyamura, Takako| Kanazawa, Yui| Muraoka, Michiko| Washio, Kana| Imada, Masahide| Kageyama, Misao| Takeuchi, Akihito| Tamai, Kei| Oda, Megumi| Shimada, Akira| |
| Abstract | The treatment of patients with congenital leukemia is difficult and often results in a poor prognosis. We present here the case of a female child with congenital acute myeloid leukemia (AML) with t(8 ; 16) (p11 ; p13) who received chemotherapy and survived for more than 10 years without relapse. A novel MOZ-CBP chimera was found in her diagnostic sample. Although adult AML patients with MOZ-CBP have mainly been reported as having therapy-related AML and showed poor prognoses, the present case supports the idea that AML with MOZ-CBP in the pediatric population might show better prognoses. |
| Keywords | congenital leukemia AML t(8 ; 16)(p11 ; p13) MOZ-CBP |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-02 |
| Volume | volume70 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 31 |
| End Page | 35 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26899607 |
| Web of Science KeyUT | 000371288700004 |
| JaLCDOI | 10.18926/AMO/54000 |
|---|---|
| FullText URL | 70_1_25.pdf |
| Author | Otsuki, Hideo| Yoshioka, Takashi| Shimizu, Toshihiro| Nakanishi, Yusuke| Fujio, Kei| Murao, Wataru| Uehara, Shinya| Kikuchi, Hirosato| Fujio, Koji| |
| Abstract | The effects of stone composition on transurethral lithotripsy (TUL) have not been sufficiently elucidated. The purpose of this study was to identify how calcium phosphate stone composition impacts TUL. Two hundred eighty-nine cases of semi-rigid and/or flexible TUL for upper urinary tract calculi were reviewed retrospectively. Inclusion criteria were a preoperative assessment by noncontrast computed tomography (NCCT) and a stone composition analysis. Small stones and those without calcium composition were excluded. Stone core radiodensity (SCR) was measured by taking the average of the upper 3 of 5 points in the proximity of the center of the stone on NCCT. Fifty-three patients with calcium phosphate composition (CaP) and 118 patients with calcium oxalate and without phosphate composition were eligible for analysis. SCR was significantly higher in the CaP group (p<0.01). The CaP patient group needed a significantly longer operation time (p=0.014) and more laser energy (p=0.085), and tended to have a lower rate of complete lithotripsy (p=0.096) and higher incidence of postoperative pyelonephritis (p=0.181). Stones containing calcium phosphate are harder, demand more laser energy, and require a longer operating time. NCCT evaluation can estimate stone composition preoperatively, and may be a useful tool for predicting operative outcomes. |
| Keywords | ureteroscopic lithotripsy stone composition calcium phosphate radiodensity complication |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-02 |
| Volume | volume70 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 25 |
| End Page | 29 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26899606 |
| Web of Science KeyUT | 000371288700003 |
| JaLCDOI | 10.18926/AMO/53999 |
|---|---|
| FullText URL | 70_1_13.pdf |
| Author | Arum Tri Wahyuningsih| Shen, Lianhua| Kobayashi, Kazuko| Sasaki, Takanori| Takenaka, Fumiaki| Hanada, Takahisa| Akehi, Masaru| Akahoshi, Akiya| Ozeki, Eiichi| Ando, Eiji| Matsuura, Eiji| |
| Abstract | Intact β2-glycoprotein I (iβ2GPI) is a glycoprotein that regulates coagulation and fibrinolysis. Nicked β2GPI (nβ2GPI) possesses an angiogenic property at a relatively low concentration, and an antiangiogenic property at a high concentration. Here we investigated the functions of βi 2GPI and nβ2GPI in vascular endothelial growth factor (VEGF)-A-induced endothelial cell proliferation and tube formation. We used noninvasive PET imaging to analyze the in vivo distribution of intravenously injected β2GPI variants in tumor lesions in mice. iβ2GPI was incubated with plasmin to obtain nβ2GPI, and its N-terminal sequence was analyzed. nβ2GPI had at least one other cleavage site upstream of the β2GPIʼs domain V, whereas the former plasmin-cleavage site locates between K317 and T318. Both of intact and nicked β2GPI significantly inhibited the VEGF-A-induced cell proliferation and the tube formation of human umbilical vein endothelial cells (HUVECs). PET imaging visualized considerably distributed intensities of all tested β2GPI variants in tumor lesions of pancreatic tumor cell-xenografts. These results indicate that β2GPI may be physiologically and pathophysiologically important in the regulation of not only coagulation and fibrinolysis, but also angiogenesis. |
| Keywords | β2-glycoprotein I (β2GPI) angiogenesis vascular endothelial growth factor-A (VEGF-A) positron emission tomography (PET) imaging |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-02 |
| Volume | volume70 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 13 |
| End Page | 24 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26899605 |
| Web of Science KeyUT | 000371288700002 |
