result 120 件
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kano, Yuzuki| Tanabe, Katsuyuki| Kitagawa, Masashi| Sugiyama, Hitoshi| Yamanoi, Tomoaki| Yoshinaga, Kasumi| Bekku, Kensuke| Nishimura, Shingo| Araki, Motoo| Wada, Jun| |
| Published Date | 2025-03-25 |
| Publication Title | PLoS ONE |
| Volume | volume20 |
| Issue | issue3 |
| Publisher | Public Library of Science |
| Start Page | e0320482 |
| ISSN | 1932-6203 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 Kano et al. |
| File Version | publisher |
| PubMed ID | 40131973 |
| DOI | 10.1371/journal.pone.0320482 |
| Web of Science KeyUT | 001456889900024 |
| Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0320482 |
| Author | Nakashima, Yuri| Tanabe, Katsuyuki| Mifune, Tomoyo| Nakadoi, Takato| Hayashi, Hiroki| Nakagami, Hironori| Sato, Yasufumi| Wada, Jun| |
|---|---|
| Keywords | albuminuria diabetic nephropathy macrophages peptide vaccine vasohibin-2 |
| Note | This is an Accepted Manuscript of an article published by American Physiological Society.| This fulltext file will be available in May 2025.| |
| Published Date | 2024-05-30 |
| Publication Title | American Journal of Physiology-Renal Physiology |
| Volume | volume326 |
| Issue | issue6 |
| Publisher | American Physiological Society |
| Start Page | F1054 |
| End Page | F1065 |
| ISSN | 1931-857X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 the American Physiological Society. |
| File Version | author |
| PubMed ID | 38695075 |
| DOI | 10.1152/ajprenal.00341.2023 |
| Web of Science KeyUT | 001386368400016 |
| Related Url | isVersionOf https://doi.org/10.1152/ajprenal.00341.2023 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Watanabe, Mayu| Eguchi, Jun| Takamoto, Atsushi| Kanzaki, Hiromitsu| Noda, Yohei| Kagawa, Syunsuke| Wada, Jun| |
| Keywords | anti-PD1 immune checkpoint inhibitors insulin secretory capacity cancer prognosis insulin secretion glucose metabolism markers |
| Published Date | 2024-12-11 |
| Publication Title | Frontiers in Endocrinology |
| Volume | volume15 |
| Publisher | Frontiers Media |
| Start Page | 1439705 |
| ISSN | 1664-2392 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 Watanabe, Eguchi, Takamoto, Kanzaki, Noda, Kagawa and Wada. |
| File Version | publisher |
| PubMed ID | 39722806 |
| DOI | 10.3389/fendo.2024.1439705 |
| Web of Science KeyUT | 001382975000001 |
| Related Url | isVersionOf https://doi.org/10.3389/fendo.2024.1439705 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Miyamoto, Satoshi| Heerspink, Hiddo J.L.| de Zeeuw, Dick| Sakamoto, Kota| Yoshida, Michihiro| Toyoda, Masao| Suzuki, Daisuke| Hatanaka, Takashi| Nakamura, Tohru| Kamei, Shinji| Murao, Satoshi| Hida, Kazuyuki| Ando, Shinichiro| Akai, Hiroaki| Takahashi, Yasushi| Kitada, Munehiro| Sugano, Hisashi| Nunoue, Tomokazu| Nakamura, Akihiko| Sasaki, Motofumi| Nakatou, Tatsuaki| Fujimoto, Kei| Kawanami, Daiji| Wada, Takashi| Miyatake, Nobuyuki| Kuramoto, Hiromi| Shikata, Kenichi| |
| Keywords | canagliflozin CANPIONE study chronic kidney disease microalbuminuria preintervention eGFR slope sodium-glucose cotransporter 2 inhibitor |
| Published Date | 2024-11 |
| Publication Title | Kidney International |
| Volume | volume106 |
| Issue | issue5 |
| Publisher | Elsevier BV |
| Start Page | 972 |
| End Page | 984 |
| ISSN | 0085-2538 |
| NCID | AA00710996 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 International Society of Nephrology. |
| File Version | publisher |
| PubMed ID | 39216659 |
| DOI | 10.1016/j.kint.2024.08.019 |
| Web of Science KeyUT | 001343408600001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.kint.2024.08.019 |
| FullText URL | fulltext20240924-02.pdf fig20240924-02.pdf suppl_information20240924-02.pdf suppl_fig20240924-02.pdf |
|---|---|
| Author | Nakatsuka, Atsuko| Yamaguchi, Satoshi| Wada, Jun| |
| Note | This is an Accepted Manuscript of an article published by American Diabetes Association.| |
| Published Date | 2024-02-23 |
| Publication Title | Diabetes |
| Volume | volume73 |
| Issue | issue5 |
| Publisher | American Diabetes Association |
| Start Page | 763 |
| End Page | 779 |
| ISSN | 0012-1797 |
| NCID | AA00628057 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by the American Diabetes Association. |
| File Version | author |
| PubMed ID | 38394641 |
| DOI | 10.2337/db23-0581 |
| Web of Science KeyUT | 001288274500014 |
| Related Url | isVersionOf https://doi.org/10.2337/db23-0581 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yokoyama, Sho| Honda, Hiroyuki| Otsuka, Yuki| Tokumasu, Kazuki| Nakano, Yasuhiro| Sakurada, Yasue| Matsuda, Yui| Sunada, Naruhiko| Hasegawa, Toru| Takase, Ryosuke| Omura, Daisuke| Soejima, Yoshiaki| Ueda, Keigo| Kishida, Masayuki| Otsuka, Fumio| |
| Keywords | blood glucose diabetes mellitus long COVID omicron variant post-COVID-19 condition |
| Published Date | 2024-07-13 |
| Publication Title | Journal of Clinical Medicine |
| Volume | volume13 |
| Issue | issue14 |
| Publisher | MDPI |
| Start Page | 4099 |
| ISSN | 2077-0383 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by the authors. |
| File Version | publisher |
| PubMed ID | 39064139 |
| DOI | 10.3390/jcm13144099 |
| Web of Science KeyUT | 001278836700001 |
| Related Url | isVersionOf https://doi.org/10.3390/jcm13144099 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ueno, Asami| Onishi, Yasuhiro| Mise, Koki| Yamaguchi, Satoshi| Kanno, Ayaka| Nojima, Ichiro| Higuchi, Chigusa| Uchida, Haruhito A.| Shikata, Kenichi| Miyamoto, Satoshi| Nakatsuka, Atsuko| Eguchi, Jun| Hida, Kazuyuki| Katayama, Akihiro| Watanabe, Mayu| Nakato, Tatsuaki| Tone, Atsuhito| Teshigawara, Sanae| Matsuoka, Takashi| Kamei, Shinji| Murakami, Kazutoshi| Shimizu, Ikki| Miyashita, Katsuhito| Ando, Shinichiro| Nunoue, Tomokazu| Wada, Jun| |
| Published Date | 2024-05 |
| Publication Title | BMJ Open Diabetes Research and Care |
| Volume | volume12 |
| Issue | issue3 |
| Publisher | BMJ Publishing Group |
| Start Page | e004237 |
| ISSN | 2052-4897 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Author(s) (or their employer(s)) 2024. |
| File Version | publisher |
| PubMed ID | 38816205 |
| DOI | 10.1136/bmjdrc-2024-004237 |
| Web of Science KeyUT | 001236385500001 |
| Related Url | isVersionOf https://doi.org/10.1136/bmjdrc-2024-004237 |
| JaLCDOI | 10.18926/AMO/66927 |
|---|---|
| FullText URL | 78_2_185.pdf |
| Author | Takahashi, Hiroko| Eguchi, Jun| Watanabe, Mayu| Nakayama, Masanori| Wada, Jun| |
| Abstract | The global pandemic of coronavirus infection 2019 (COVID-19) was an unprecedented public health emergency. Several clinical studies reported that heart disease, lung disease, diabetes, hypertension, dyslipidemia, and obesity are critical risk factors for increased severity of and hospitalization for COVID-19. This is largely because patients with these underlying medical conditions can show poor immune responses to the COVID-19 vaccinations. Diabetes is one of the underlying conditions most highly associated with COVID-19 susceptibility and is considered a predictor of poor prognosis of COVID-19. We therefore investigated factors that influence the anti-SARS-CoV-2 spike IgG antibody titer after three doses of vaccination in patients with type 2 diabetes. We found that obesity was associated with low anti-SARS-CoV-2 spike IgG antibody titers following three-dose vaccination in type 2 diabetics. Obese patients with type 2 diabetes may have attenuated vaccine efficacy and require additional vaccination; continuous infection control should be considered in such patients. |
| Keywords | obesity type 2 diabetes COVID-19 vaccination |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 185 |
| End Page | 191 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688836 |
| Web of Science KeyUT | 001227932200002 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kano, Yuzuki| Yamaguchi, Satoshi| Mise, Koki| Kawakita, Chieko| Onishi, Yasuhiro| Kurooka, Naoko| Sugawara, Ryosuke| Albuayjan, Haya Hamed Hassan| Nakatsuka, Atsuko| Eguchi, Jun| Wada, Jun| |
| Keywords | diabetes mellitus diabetic nephropathy metabolism obesity tubular epithelium |
| Published Date | 2023-12-08 |
| Publication Title | Kidney360 |
| Volume | volume5 |
| Issue | issue2 |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Start Page | 182 |
| End Page | 194 |
| ISSN | 2641-7650 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | Copyright © 2023 The Author(s). |
| File Version | publisher |
| PubMed ID | 38062578 |
| DOI | 10.34067/kid.0000000000000333 |
| Web of Science KeyUT | 001178403800002 |
| Related Url | isVersionOf https://doi.org/10.34067/kid.0000000000000333 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nakano, Yasuhiro| Sunada, Naruhiko| Tokumasu, Kazuki| Honda, Hiroyuki| Otsuka, Yuki| Sakurada, Yasue| Matsuda, Yui| Hasegawa, Toru| Omura, Daisuke| Ochi, Kanako| Yasuda, Miho| Hagiya, Hideharu| Ueda, Keigo| Otsuka, Fumio| |
| Keywords | Diabetes mellitus Endocrine disorders Long COVID Metabolic disorders Thyroid disease |
| Note | The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-024-55526-3| |
| Published Date | 2024-03-05 |
| Publication Title | Scientific Reports |
| Volume | volume14 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 5446 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024 |
| File Version | publisher |
| PubMed ID | 38443459 |
| DOI | 10.1038/s41598-024-55526-3 |
| Web of Science KeyUT | 001180457200009 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-024-55526-3 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sang, Yizhen| Tsuji, Kenji| Nakanoh, Hiroyuki| Fukushima, Kazuhiko| Kitamura, Shinji| Wada, Jun| |
| Keywords | semaphorin 3A neuropilin-1 podocyte diabetic nephropathy acute kidney injury chronic kidney injury lupus nephritis fibrosis apoptosis inflammation |
| Published Date | 2023-09-25 |
| Publication Title | Diagnostics |
| Volume | volume13 |
| Issue | issue19 |
| Publisher | MDPI |
| Start Page | 3038 |
| ISSN | 2075-4418 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 by the authors. |
| File Version | publisher |
| PubMed ID | 37835781 |
| DOI | 10.3390/diagnostics13193038 |
| Web of Science KeyUT | 001083705600001 |
| Related Url | isVersionOf https://doi.org/10.3390/diagnostics13193038 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ichikawa, Keishi| Miyoshi, Toru| Osawa, Kazuhiro| Miki, Takashi| Toda, Hironobu| Ejiri, Kentaro| Yoshida, Masashi| Nakamura, Kazufumi| Morita, Hiroshi| Ito, Hiroshi| |
| Keywords | Coronary artery disease Computed tomography angiography Atherosclerotic plaque Risk assessment Hepatic steatosis |
| Published Date | 2021-07-19 |
| Publication Title | European Journal of Preventive Cardiology |
| Volume | volume28 |
| Issue | issue18 |
| Publisher | Oxford University Press (OUP) |
| Start Page | 2059 |
| End Page | 2066 |
| ISSN | 2047-4873 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2021. |
| File Version | publisher |
| PubMed ID | 34279027 |
| DOI | 10.1093/eurjpc/zwab120 |
| Web of Science KeyUT | 000753584300031 |
| Related Url | isVersionOf https://doi.org/10.1093/eurjpc/zwab120 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Miyamoto, Satoshi| Heerspink, Hiddo J. L.| de Zeeuw, Dick| Toyoda, Masao| Suzuki, Daisuke| Hatanaka, Takashi| Nakamura, Tohru| Kamei, Shinji| Murao, Satoshi| Hida, Kazuyuki| Ando, Shinichiro| Akai, Hiroaki| Takahashi, Yasushi| Koya, Daisuke| Kitada, Munehiro| Sugano, Hisashi| Nunoue, Tomokazu| Nakamura, Akihiko| Sasaki, Motofumi| Nakatou, Tatsuaki| Fujimoto, Kei| Kawanami, Daiji| Wada, Takashi| Miyatake, Nobuyuki| Yoshida, Michihiro| Shikata, Kenichi| the CANPIONE study Investigators| |
| Keywords | canagliflozin CANPIONE study diabetic kidney disease eGFR slope SGLT2 inhibitor urinary albumin-to-creatinine ratio |
| Published Date | 2022-05-18 |
| Publication Title | Diabetes, Obesity and Metabolism |
| Volume | volume24 |
| Issue | issue8 |
| Publisher | Wiley |
| Start Page | 1429 |
| End Page | 1438 |
| ISSN | 1462-8902 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Authors. |
| File Version | publisher |
| PubMed ID | 35491532 |
| DOI | 10.1111/dom.14731 |
| Web of Science KeyUT | 000822653700001 |
| Related Url | isVersionOf https://doi.org/10.1111/dom.14731 |
| JaLCDOI | 10.18926/AMO/65749 |
|---|---|
| FullText URL | 77_4_387.pdf |
| Author | Kataoka, Takahiro| Habu, Hiroshi| Tanaka, Ayumi| Naoe, Shota| Murakami, Kaito| Fujimoto, Yuki| Yukimine, Ryohei| Takao, Soshi| Mitsunobu, Fumihiro| Yorifuji, Takashi| Yamaoka, Kiyonori| |
| Abstract | No epidemiological studies have examined the health effects of daily bathing in radon hot springs. In this cross-sectional study, we investigated the associations between radon hot spring bathing and health conditions. The target population was 5,250 adults ≥ 20 years old in the town of Misasa, Japan. We collected information about the participants’ bathing habits and alleviation of a variety of disease symptoms, and their self-rated health (SRH). Unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (CI) were calculated. In both the adjusted and unadjusted models of hypertension, significant associations between the > 1×/week hot spring bathing and the alleviation of hypertension symptoms were observed compared to the group whose hot spring bathing was <1×/week: adjusted model, OR 5.40 (95%CI: 1.98-14.74); unadjusted model, 3.67 (1.50-8.99) and for gastroenteritis: adjusted model, 9.18 (1.15-72.96); unadjusted model, 7.62 (1.59-36.49). Compared to the no-bathing group, higher SRH was significantly associated with both bathing < 1×/week: unadjusted model, 2.27 (1.53-3.37) and > 1×/week: adjusted model, 1.91 (1.15-3.19). These findings suggest that bathing in radon hot springs is associated with higher SRH and the alleviation of hypertension and gastroenteritis. |
| Keywords | radon hot spring bathing habit self-rated health cross-section study |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-08 |
| Volume | volume77 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 387 |
| End Page | 394 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37635139 |
| Web of Science KeyUT | 001163659800003 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kurooka, Naoko| Eguchi, Jun| Wada, Jun| |
| Keywords | Dibaetes GPIHBP1 Lipoprotein lipase |
| Published Date | 2023-07-13 |
| Publication Title | Journal of Diabetes Investigation |
| Volume | volume14 |
| Issue | issue10 |
| Publisher | Wiley |
| Start Page | 1148 |
| End Page | 1156 |
| ISSN | 2040-1116 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 The Authors. |
| File Version | publisher |
| PubMed ID | 37448184 |
| DOI | 10.1111/jdi.14056 |
| Web of Science KeyUT | 001024517600001 |
| Related Url | isVersionOf https://doi.org/10.1111/jdi.14056 |
| JaLCDOI | 10.18926/AMO/65489 |
|---|---|
| FullText URL | 77_3_243.pdf |
| Author | Shibata, Yusuke| Eguchi, Jun| Wada, Jun| |
| Abstract | Brown adipose tissue (BAT) plays a critical role in metabolic homeostasis. BAT dysfunction is associated with the development of obesity through an imbalance between energy expenditure and energy intake. The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) is the master regulator of adipogenesis. However, the roles of PPARγ and thiazolidinediones (TZDs) in the regulation of BAT metabolism remain unclear. TZDs, which are selective PPARγ activators, improve systemic insulin resistance in animals and humans. In the present study, we generated brown adipocyte-specific PPARγ-deficient mice (BATγKO) to examine the in vivo roles of PPARγ and TZDs in BAT metabolism. In electron microscopic examinations, brown adipocyte-specific PPARγ deletion promoted severe whitening of brown fat and morphological alteration of mitochondria. Brown adipocyte-specific PPARγ deletion also reduced mRNA expression of BAT-selective genes. Although there was no difference in energy expenditure between control and BATγKO mice in calorimetry, norepinephrine-induced thermogenesis was impaired in BATγKO mice. Moreover, pioglitazone treatment improved diet-induced insulin resistance in the control mice but not in the BATγKO mice. These findings suggest that BAT PPARγ is necessary for the maintenance of brown adipocyte function and for the insulin-sensitizing action of TZDs. |
| Keywords | PPARγ brown adipose tissue thiazolidinediones |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-06 |
| Volume | volume77 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 243 |
| End Page | 254 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37357625 |
| Web of Science KeyUT | 001026279600002 |
| JaLCDOI | 10.18926/AMO/65143 |
|---|---|
| FullText URL | 77_2_139.pdf |
| Author | Namio, Keiichi| Kondo, Takashi| Miyatake, Nobuyuki| Hishii, Shuhei| Nishi, Hiroyuki| Katayama, Akihiko| Ujike, Kazuhiro| Suzuki, Hiromi| Koumoto, Kiichi| |
| Abstract | We investigated the link between prolonged sedentary bouts and all-cause mortality in patients on chronic hemodialysis, using a prospective cohort. A total of 104 outpatients on chronic hemodialysis from 2013 to 2019, aged 71.4±11.4 years, were enrolled. Prolonged sedentary bouts (≥ 30 min and ≥60 min) (min and bouts) and relative prolonged sedentary bouts (≥ 30 min and ≥ 60 min) (%) on the patients’ non-hemodialysis days were measured by a tri-accelerometer, and we also analyzed the patients’ clinical parameters. The relationship between prolonged sedentary bouts and all-cause mortality was evaluated by a survival analysis and the Cox proportional hazard model. Thirty-five patients died during the follow-up period. A Kaplan-Meier analysis detected significant differences in the survival rate between two groups stratified by the median for all prolonged sedentary-bout parameters. After the adjustment for confounding factors, all of the prolonged sedentary-bout parameters were determinant factors for all-cause mortality. These results indicate that prolonged sedentary bouts on non-hemodialysis days were closely related to all-cause mortality in the patients on hemodialysis. |
| Keywords | sedentary bout mortality hemodialysis survival analysis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-04 |
| Volume | volume77 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 139 |
| End Page | 145 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37094951 |
| Web of Science KeyUT | 000982503800003 |
| JaLCDOI | 10.18926/AMO/64358 |
|---|---|
| FullText URL | 77_1_29.pdf |
| Author | Yamamoto, Shusei| Sato, Ikumi| Fujii, Moe| Kakimoto, Mai| Honma, Koki| Akiyama, Natsumi| Sakai, Miku| Fukuhama, Natsuki| Kumazaki, Shota| Hirohata, Satoshi| Kitamori, Kazuya| Yamori, Yukio| Watanabe, Shogo| |
| Abstract | The SHRSP5/Dmcr is a useful animal model for the development of nonalcoholic steatohepatitis (NASH) pathology when fed a high-fat, high-cholesterol diet, and further drug interventions can lead to concomitant cardiovascular disease. While SHRSP5/Dmcr rats have been used for basic research related to NASH, details of their bile acid metabolism in this condition are unknown. In this study, we aimed to clarify the changes in the serum bile acid (BA) fractions associated with NASH and found that glycine-conjugated and unconjugated bile acid increased with worsening NASH and cardiovascular disease while taurine-conjugated BA relatively decreased. |
| Keywords | SHRSP5/Dmc nonalcoholic steatohepatitis cardiovascular disease glycine-conjugated bile acids unconjugated bile acids |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-02 |
| Volume | volume77 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 29 |
| End Page | 36 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36849143 |
| Web of Science KeyUT | 000953019200001 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nojima, Ichiro| Wada, Jun| |
| Keywords | CD8 T cells AMPK mTORC OXPHOS autoimmune disease aging cancer |
| Published Date | 2023-01-01 |
| Publication Title | International Journal Of Molecular Sciences |
| Volume | volume24 |
| Issue | issue1 |
| Publisher | MDPI |
| Start Page | 755 |
| ISSN | 1422-0067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 by the authors. |
| File Version | publisher |
| PubMed ID | 36614197 |
| DOI | 10.3390/ijms24010755 |
| Web of Science KeyUT | 000908631300001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms24010755 |
| JaLCDOI | 10.18926/AMO/64123 |
|---|---|
| FullText URL | 76_6_723.pdf |
| Author | Zhang, Quan| Yang, Lixia| Wan, Guozhen| Zhang, Xiaoqiang| Wang, Ying| Zhao, Guannan| |
| Abstract | The diagnostic value of microRNA-377 (miR-377) in patients with acute coronary syndrome (ACS) and explored miR-377’s potential mechanisms. We performed an qRT-PCR to assess serum miR-377 levels in ACS patients and coronary artery ligation rat models. The diagnostic value of miR-377 was evaluated by determining the ROC curve. An ELISA assay was conducted to detect the model rat endothelial damage markers von Willebrand factor (vWF) and heart-type fatty acid binding protein (H-FABP), and proinflammatory cytokines TNF-α, IL-6, and IL-1β. The serum miR-377 level was elevated in the ACS patients and significantly increased in the ACS rats. MiR-377 has a high diagnostic value in ACS patients, with a 0.844 ROC, 76.47% specificity, and 87.10% sensitivity. MiR-377 was positively correlated with the expressions of vWF, H-FABP, cTnI, TNF-α, IL-6, and IL-1β. In ACS rats, reducing the expression of miR-377 significantly inhibited the increases in vWF, H-FABP, TNF-α, IL-6, and IL-1β. An elevated miR-377 level can be used as a diagnostic marker in patients with ACS. A reduction of miR-377 may alleviate ACS by improving myocardial damage such as endothelial injury and the inflammatory response. |
| Keywords | microRNA-377 acute coronary syndrome diagnosis endothelial injury inflammatory |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-12 |
| Volume | volume76 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 723 |
| End Page | 730 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36549775 |
| Web of Science KeyUT | 000905195100013 |
