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JaLCDOI 10.18926/AMO/57373
FullText URL 73_5_427.pdf
Author Owari, Yutaka| Suzuki, Hiromi| Miyatake, Nobuyuki|
Abstract The aim of this study was to examine in a randomized controlled trial how much the sedentary behavior (sitting time) of community-dwelling elderly Japanese subjects decreased as a result of using the “Active Guide” brochure published by the Ministry of Health, Labour and Welfare (2013) and additional documents related to the benefits of reducing sedentary behavior. A total of 86 elderly people who participated in health-club activities for one year were randomly allocated to two groups. Subjects in the intervention group received explanations of the importance of physical activity using the “Active Guide” brochure (n=42) and additional documents, while subjects in the control group did not (n=44). Physical activity was measured using a triaxial accelerometer for two weeks at baseline and again after one year. After one year of intervention, the difference in the sedentary behavior rate from baseline was −2.2% for the intervention group (n=40) and +2.5% for controls (n=40) (Welch’s t-test, p=0.007). Use of the “Active Guide” brochure and additional documents may reduce the sedentary behavior of community dwelling elderly people in Japan.
Keywords Active Guide sedentary behavior elderly people randomized controlled trial health promotion
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2019-10
Volume volume73
Issue issue5
Publisher Okayama University Medical School
Start Page 427
End Page 432
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31649369
Web of Science KeyUT 000491886600008
JaLCDOI 10.18926/AMO/57372
FullText URL 73_5_419.pdf
Author Hishii, Shuhei| Miyatake, Nobuyuki| Nishi, Hiroyuki| Katayama, Akihiko| Ujike, Kazuhiro| Koumoto, Kiichi| Suzuki, Hiromi| Hashimoto, Hiroo|
Abstract We investigated the relationship between sedentary behavior and all-cause mortality in patients undergoing hemodialysis. A total of 71 patients (39 men, 32 women, aged 72.1±11.7 years) were enrolled in this longitudinal study. Their sedentary behavior was measured using a tri-accelerometer that provides relative values per daily wearing time. We classified the sedentary behavior time into 2 groups (under the median: short-sedentary behavior (SB) group; over the median: long-SB group) and compared the groups’ clinical parameters. We compared the groups’ survival rates by using Kaplan-Meier curves and the log-rank test, and we performed multivariate analyses by a Cox-proportional hazard model to evaluate the relationship between the sedentary behavior and the survival rate. Twenty patients (28.2%) died during the observation period. The survival rate of the short-SB group was significantly higher than that of the long-SB group. Sedentary behavior was thus an important factor for all-cause mortality even after adjusting for confounding factors by a Cox-proportional hazard model. Sedentary behavior is closely linked to all-cause mortality, especially total days and non-hemodialysis days, and reducing sedentary behavior may be beneficial to reduce the all-cause mortality of patients on chronic hemodialysis.
Keywords sedentary behavior hemodialysis mortality physical activity
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2019-10
Volume volume73
Issue issue5
Publisher Okayama University Medical School
Start Page 419
End Page 425
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31649368
Web of Science KeyUT 000491886600007
Title Alternative The 2018 Incentive Award of the Okayama Medical Association in General Medical Science (2018 Yuuki Prize)
FullText URL 131_67.pdf
Author Mise, Koki |
Publication Title Journal of Okayama Medical Association
Published Date 2019-08-01
Volume volume131
Issue issue2
Start Page 67
End Page 69
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.131.67
language Japanese
Copyright Holders Copyright (c) 2019 岡山医学会
File Version publisher
DOI 10.4044/joma.131.67
NAID 40021986701
JaLCDOI 10.18926/AMO/56940
FullText URL 73_4_367.pdf
Author Mifune-Morioka, Tomoyo| A. Uchida, Haruhito| Fukushima, Kazuhiko| Watanabe, Mayu| Ouchi, Chihiro| Mise, Koki| Kawakita, Chieko| Kano, Yuzuki| Onishi, Akifumi| Toma, Kishio| Eguchi, Jun| Wada, Nozomu| Ikeda, Fusao| Sasaki, Erika| Suganami, Yu| Kishida, Masayuki| Sugiyama, Hitoshi| Okada, Hiroyuki| Wada, Jun|
Abstract Eight years prior to her present admission, a 61-year-old Japanese woman was diagnosed with autoimmune hepatitis, slowly progressive insulin-dependent diabetes mellitus, and chronic thyroiditis; she had been treated with oral prednisolone (PSL). After she suddenly discontinued PSL, she newly developed systemic lupus erythematosus. A combination therapy of oral PSL and intravenous cyclophosphamide resulted in remission. She was finally diagnosed with autoimmune polyglandular syndrome (APS) type 3 (3A ,3B, 3D), complicated with four different autoimmune diseases. Since patients with type 3 APS may present many manifestations over a long period of time, they should be carefully monitored.
Keywords autoimmune polyglandular syndrome type 3 systemic lupus erythematosus autoimmune hepatitis slowly progressive insulin-dependent diabetes mellitus chronic thyroiditis
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2019-08
Volume volume73
Issue issue4
Publisher Okayama University Medical School
Start Page 367
End Page 372
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31439961
JaLCDOI 10.18926/AMO/56458
FullText URL 73_1_51.pdf
Author Fujii, Masakuni| Fujimoto, Kenji| Yabe, Syuntaro| Nasu, Junichiro| Miyaike, Jiro| Yoshioka, Masao| Shiode, Junji| Yamamoto, Kazuhide| Matsuda, Shinya|
Abstract  We investigated the relationship between body mass index (BMI) and postoperative outcomes in 450 gallbladder cancer patients in Japan. We collected patient information, including sex, age, underlying disease, BMI, stage, surgery method, postoperative time to discharge, and postoperative Medicare fees, from the Japanese administrative database associated with the Diagnosis Procedure Combination system. We classified patient BMIs as underweight (BMI<18.5 kg/m2), normal (BMI≥18.5 kg/m2 and <25 kg/m2) or overweight/obese (BMI≥25 kg/m2), then investigated the relationship between these categories and two postoperative outcomes: time to discharge and postoperative Medicare fees. The median postoperative time to discharge was 12 days in all patients, and 12 days in each of the three weight groups (p=0.62, n.s.). The median postoperative Medicare fees from surgery until discharge were (USD): all patients, $5,002; underweight, $5,875; normal weight, $4,797; and overweight/obese, $5,179 (p=0.146, n.s.). A multivariate analysis with adjustment for competing risk factors revealed that BMI was not associated with increased risk of longer postoperative time to discharge (normal weight: HR 1.17, p=0.29; overweight/obese: HR 1.17, p=0.37) or higher postoperative Medicare fees (OR 0.99, p=0.86, n.s.). Thus, high BMI was not found to be a factor for poor postoperative outcomes in Japanese patients with gallbladder cancer.
Keywords body mass index gallbladder cancer surgery obesity
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2019-02
Volume volume73
Issue issue1
Publisher Okayama University Medical School
Start Page 51
End Page 59
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 30820054
JaLCDOI 10.18926/AMO/56182
FullText URL 72_4_423.pdf
Author Sakakida, Kourin| Wei, Fan-Yan| Senokuchi, Takafumi| Shimoda, Seiya| Kakuma, Tatsuyuki| Araki, Eiichi| Tomizawa, Kazuhito| The Eperisone for Diabetes with Impaired tRNA (EDIT) Study Group|
Abstract Genetic variation in Cdk5 Regulatory Associated Protein 1-Like 1 (CDKAL1) is associated with the development of type 2 diabetes (T2D). Dysfunction of CDKAL1 impairs the translation of proinsulin, which leads to glucose intolerance. Eperisone, an antispasmodic agent, has been shown to ameliorate glucose intolerance in Cdkal1-deficient mice. We have launched a phase II clinical study to investigate the potential anti-diabetic effect of eperisone in T2D patients carrying risk or non-risk alleles of CDKAL1. The primary endpoint is the change of hemoglobin A1c (HbA1c) levels. We also examined whether the efficacy of eperisone in T2D patients is associated with CDKAL1 activity.
Keywords diabetes insulin secretion single nucleotide polymorphism glucose
Amo Type Clinical Study Protocol
Publication Title Acta Medica Okayama
Published Date 2018-08
Volume volume72
Issue issue4
Publisher Okayama University Medical School
Start Page 423
End Page 426
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2018 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 30140092
JaLCDOI 10.18926/AMO/55852
FullText URL 72_2_121.pdf
Author Ochiai, Hirotaka| Shirasawa, Takako| Nanri, Hinako| Nishimura, Rimei| Hoshino, Hiromi| Kokaze, Akatsuki|
Abstract Several cross-sectional studies have shown that eating quickly is associated with overweight in children and adolescents. However, few cohort studies have examined this relationship. Here we investigated the relationship between eating quickly and overweight in a cohort study of fourth-grade schoolchildren (aged 9 or 10 years) who attended elementary schools in Ina-town, Japan. The children were followed for 3 years from 2001-2004 (at baseline) to 2004-2007. A questionnaire survey including information about eating speed (fast, medium, or slow) was administered, and height and weight measurements were obtained at baseline and follow-up. Overweight was defined according to the body mass index cutoff points proposed by the International Obesity Task Force. We used a Poisson regression model to examine the association between eating quickly at baseline and being overweight 3 years later. Data from 934 non-overweight children (465 boys, 469 girls) were analyzed. Eating quickly was not significantly associated with being overweight in the boys, whereas it was significantly associated with being overweight in the girls. Our analysis indicates that among girls, eating quickly leads to overweight, and that the modification of eating quickly could help prevent overweight in adolescents.
Keywords eating quickly overweight schoolchildren cohort study
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2018-04
Volume volume72
Issue issue2
Publisher Okayama University Medical School
Start Page 121
End Page 128
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2018 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 29674760
FullText URL Nat_Rev_Nephrol_12_1_13.pdf Nat_Rev_Nephrol_12_1_13_image.pdf
Author Wada, Jun| Makino, Hirofumi|
Note This is an Accepted Manuscript of an article published by Nature Publishing Group|
Published Date 2016-01
Publication Title Nature Reviews Nephrology
Volume volume12
Issue issue1
Publisher Nature Publishing Group
Start Page 13
End Page 26
ISSN 1759-5061
NCID AA12392934
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version author
PubMed ID 26568190
DOI 10.1038/nrneph.2015.175
Web of Science KeyUT 000367758500005
Related Url isVersionOf https://doi.org/10.1038/nrneph.2015.175
FullText URL J. Biol. Chem_292_20_8436.pdf
Author Horiuchi, Takahiro| Sakata, Natsumi| Narumi, Yoshihiro| Kimura, Tomohiro| Hayashi, Takashi| Nagano, Keisuke| Liu, Keyue| Nishibori, Masahiro| Tsukita, Sohei| Yamada, Tetsuya| Katagiri, Hideki| Shirakawa, Ryutaro| Horiuchi, Hisanori|
Keywords cytokine inflammation liver injury metformin p38 MAPK
Published Date 2017-05
Publication Title Journal of Biological Chemistry
Volume volume292
Issue issue20
Publisher American Society for Biochemistry and Molecular Biology
Start Page 8436
End Page 8446
ISSN 0021-9258
NCID AA00251083
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by/4.0/deed.ja
File Version publisher
PubMed ID 28373282
DOI 10.1074/jbc.M116.769380
Web of Science KeyUT 000401788600027
Related Url https://doi.org/10.1074/jbc.M116.769380
Title Alternative The development of a scale to measure stress recognition during the treatment of diabetes patients
FullText URL 129_93.pdf
Author Sumiyoshi, Kazuko| Kawata, Chieko| Okamoto, Tatsuo| Ohashi, Mutsuko| Mikane, Sakae| Takabayashi, Noriko| Futoyu, Yoshiko| Kim, Woesook| Wada, Jun| Shikata, Kenichi| Nakajima, Kazuo|
Abstract  The purpose of this study was to establish a measurement scale for "stress recognition in receiving treatment" in patients with diabetes. A self-completed questionnaire was distributed to 149 type-2 diabetes outpatients in March-May 2015 after authorization from Okayama Prefectural University and the ethics committee of the hospital.  The "stress recognition in receiving treatment" scale was designed as a second-order factor model consisting of 14 items and the following four factors : the respondent's sense of (1) the burden of being sick, (2) the burden on interpersonal relationships, (3) the burden of treatment, and (4) the burden of medical expenses.  Stress recognition in treatment means recognition of being stressed in the burdens related to the illness, interpersonal relationships, treatment and medical expenses.  The suitability of the questionnaire data was then evaluated with a structural equation model. The suitability of the factor model to the data satisfied the statistically acceptable standards as Comparative Fit Index (CFI) =0.931, Root Mean Square Error of Approximation (RMSEA) =0.096, Tucker-Lewis Index (TLI) =0.946.  As the construct validity was not examined by the scale created in this study or by existing scale, it was verified by using the degrees of mental healthiness and HbA1c that were proved to be associated with the sense of burden.  In addition, the construct validity of the questionnaire was supported by a significant correlation between the Japanese version of the WHO-Five Well-being Index (S-WHO-5-J) and the patients' HbA1c levels. The use of this measure is expected to contribute to the early detection of a decline in a diabetic patient's activities of daily living and to the early confirmation of patients' support status.
Keywords 糖尿病患者 (diabetes patients) 治療 (treatment) ストレス認知 (stress recognition) 尺度開発 (development of a scale)
Publication Title Journal of Okayama Medical Association
Published Date 2017-08-01
Volume volume129
Issue issue2
Start Page 93
End Page 99
ISSN 0030-1558
Related Url https://doi.org/10.4044/joma.129.93
language Japanese
Copyright Holders Copyright (c) 2017 岡山医学会
File Version publisher
DOI 10.4044/joma.129.93
NAID 130006039367
FullText URL K0005453_other1.pdf
Author Nobumoto, Etsuko| Masuyama, Hisashi| Hiramatsu, Yuji| Sugiyama, Takashi| Kusaka, Hideto| Toyoda, Nagayasu|
Keywords New GDM criteria Perinatal complications Obesity 75-g oral glucose tolerance test
Note The final publication is available at Springer| 学位審査副論文|
Published Date 2015-09
Publication Title Diabetology International
Volume volume6
Issue issue3
Publisher Springer Japan
Start Page 226
End Page 231
ISSN 21901678
NCID AA12503387
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version author
DOI 10.1007/s13340-014-0193-8
Web of Science KeyUT 000366631000009
Related Url http://doi.org/10.1007/s13340-014-0193-8 http://ousar.lib.okayama-u.ac.jp/55005
JaLCDOI 10.18926/AMO/54514
FullText URL 70_4_327.pdf
Author Watanabe, Mototsugu| Yamamoto, Hiromasa| Eikawa, Shingo| Shien, Kazuhiko| Shien, Tadahiko| Soh, Junichi| Hotta, Katsuyuki| Wada, Jun| Hinotsu, Shiro| Fujiwara, Toshiyoshi| Kiura, Katsuyuki| Doihara, Hiroyoshi| Miyoshi, Shinichiro| Udono, Heiichiro| Toyooka, Shinichi|
Abstract A study to evaluate the effect of metformin on the immune system was commenced in July 2014. Metformin is one of the most commonly prescribed drugs for type 2 diabetes, and previous studies have reported that metformin has an anti-tumor effect. The aim of this study is to evaluate the efficacy of metformin on the immune system in human cancer patients in vivo. The primary outcome parameter will be the rate change in the population of CD8+ T cells, which produce multiple cytokines.
Keywords metformin CD8+ T cells cancer immunology
Amo Type Clinical Study Protocols
Publication Title Acta Medica Okayama
Published Date 2016-08
Volume volume70
Issue issue4
Publisher Okayama University Medical School
Start Page 327
End Page 330
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27549683
Web of Science KeyUT 000384748600018
Title Alternative Identification of the adipokine ‘vaspin’ and its significance in metabolic syndrome
FullText URL 128_103.pdf
Author Wada, Jun|
Keywords metabolic syndrome adipokine atherosclerosis endothelial cells apoptosis
Publication Title Journal of Okayama Medical Association
Published Date 2016-08-01
Volume volume128
Issue issue2
Start Page 103
End Page 109
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.128.103
language Japanese
Copyright Holders Copyright (c) 2016 岡山医学会
File Version publisher
DOI 10.4044/joma.128.103
NAID 130005262534
Title Alternative The 2015 Incentive Award of the Okayama Medical Association in General Medical Science (2015 Yuuki Prize)
FullText URL 128_87.pdf
Author Katayama, Akihiro|
Publication Title Journal of Okayama Medical Association
Published Date 2016-08-01
Volume volume128
Issue issue2
Start Page 87
End Page 89
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.128.87
language Japanese
Copyright Holders Copyright (c) 2016 岡山医学会
File Version publisher
NAID 130005262634
JaLCDOI 10.18926/AMO/54413
FullText URL 70_3_151.pdf
Author Wada, Jun| Nakatsuka, Atsuko|
Abstract The mitochondria are involved in active and dynamic processes, such as mitochondrial biogenesis, fission, fusion and mitophagy to maintain mitochondrial and cellular functions. In obesity and type 2 diabetes, impaired oxidation, reduced mitochondrial contents, lowered rates of oxidative phosphorylation and excessive reactive oxygen species (ROS) production have been reported. Mitochondrial biogenesis is regulated by various transcription factors such as peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), peroxisome proliferator-activated receptors (PPARs), estrogen-related receptors (ERRs), and nuclear respiratory factors (NRFs). Mitochondrial fusion is promoted by mitofusin 1 (MFN1), mitofusin 2 (MFN2) and optic atrophy 1 (OPA1), while fission is governed by the recruitment of dynamin-related protein 1 (DRP1) by adaptor proteins such as mitochondrial fission factor (MFF), mitochondrial dynamics proteins of 49 and 51 kDa (MiD49 and MiD51), and fission 1 (FIS1). Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) and PARKIN promote DRP1-dependent mitochondrial fission, and the outer mitochondrial adaptor MiD51 is required in DRP1 recruitment and PARKIN-dependent mitophagy. This review describes the molecular mechanism of mitochondrial dynamics, its abnormality in diabetes and obesity, and pharmaceuticals targeting mitochondrial biogenesis, fission, fusion and mitophagy.
Keywords fusion fission oxidative stress mitochondria diabetes
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2016-06
Volume volume70
Issue issue3
Publisher Okayama University Medical School
Start Page 151
End Page 158
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27339203
Web of Science KeyUT 000379406100001
Author Ogawa, Daisuke| Eguchi, Jun| Wada, Jun| Terami, Naoto| Hatanaka, Takashi| Tachibana, Hiromi| Nakatsuka, Atsuko| Sato Horiguchi, Chikage| Nishii, Naoko| Makino, Hirofumi|
Published Date 2014-01-22
Publication Title PLOS ONE
Volume volume9
Issue issue1
Content Type Journal Article
Author Katayama, Akihiro| Nakatsuka, Atsuko| Eguchi, Jun| Murakami, Kazutoshi| Teshigawara, Sanae| Kanzaki, Motoko| Nunoue, Tomokazu| Hida, Kazuyuki| Wada, Nozomu| Yasunaka, Tetsuya| Ikeda, Fusao| Takaki, Akinobu| Yamamoto, Kazuhide| Kiyonari, Hiroshi| Makino, Hirofumi| Wada, Jun|
Published Date 2015
Publication Title Scientific reports
Volume volume5
Content Type Journal Article
FullText URL K0005215_abstract_review.pdf K0005215_fulltext.pdf K0005215_fulltext_other1.pdf K0005215_fulltext_other2.pdf
Author Higuchi, Chigusa|
Published Date 2015-09-30
Content Type Thesis or Dissertation
Grant Number 甲第5215号
Granted Date 2015-09-30
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Title Alternative Cholecystokinin plays a novel protective role in diabetic kidney through anti-inflammatory actions on macrophages
FullText URL 126_1.pdf
Author Miyamoto, Satoshi| Shikata, Kenichi| Miyasaka, Kyoko| Okada, Shinichi| Sasaki, Motofumi| Kodera, Ryo| Hirota, Daisho| Kajitani, Nobuo| Takatsuka, Tetsuharu| Kataoka Usui, Hitomi| Nishishita, Shingo| Horiguchi Sato, Chikage| Funakoshi, Akihiro| Nishimori, Hisakazu| Uchida, Haruhito Adam| Ogawa, Daisuke| Makino, Hirofumi|
Keywords cholecystokinin 糖尿病性腎症 抗炎症作用 腎保護効果
Publication Title 岡山医学会雑誌
Published Date 2014-04-01
Volume volume126
Issue issue1
Start Page 1
End Page 6
ISSN 0030-1558
Related Url http://www.okayama-u.ac.jp/user/oma/
language Japanese
Copyright Holders Copyright (c) 2014 岡山医学会
File Version publisher
DOI 10.4044/joma.126.1
Author Iwanaga, Suketaka| Sakano, Noriko| Taketa, Kazuhisa| Takahashi, Noriko| Wang, Da-Hong| Takahashi, Hidekazu| Kubo, Masayuki| Miyatake, Nobuyuki| Ogino, Keiki|
Published Date 2013-02-01
Publication Title Obesity Research & Clinical Practice
Content Type Journal Article