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Author Mizuki, Yutaka| Sakamoto, Shinji| Okahisa, Yuko| Yada, Yuji| Hashimoto, Nozomu| Takaki, Manabu| Yamada, Norihito|
Keywords DISC1 kalirin ARHGEF11 Akt/GSK3 beta Wnt beta-catenin
Published Date 2020-12-14
Publication Title International Journal of Neuropsychopharmacology
Volume volume24
Issue issue5
Publisher Oxford Univ Press
Start Page 367
End Page 382
ISSN 1461-1457
NCID AA11545519
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2020.
File Version publisher
PubMed ID 33315097
NAID 120007045004
DOI 10.1093/ijnp/pyaa097
Web of Science KeyUT 000656192700001
Related Url isVersionOf https://doi.org/10.1093/ijnp/pyaa097
FullText URL fulltext.pdf
Author Liang, Yin| Wang, Mengxue| Wang, Chen| Liu, Yun| Naruse, Keiji| Takahashi, Ken|
Keywords prediabetes atherosclerosis metabolic syndrome obesity endothelial dysfunction exosome microRNA
Published Date 2021-04-15
Publication Title International Journal of Molecular Sciences
Volume volume22
Issue issue8
Publisher MDPI
Start Page 4108
ISSN 1422-0067
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 by the authors.
File Version publisher
PubMed ID 33921168
NAID 120007034439
DOI 10.3390/ijms22084108
Web of Science KeyUT 000644360200001
Related Url isVersionOf https://doi.org/10.3390/ijms22084108
FullText URL fulltext.pdf
Author Nakatsuka, Atsuko| Yamaguchi, Satoshi| Eguchi, Jun| Kakuta, Shigeru| Iwakura, Yoichiro| Sugiyama, Hitoshi| Wada, Jun|
Published Date 2021-03-19
Publication Title Communications Biology
Volume volume4
Issue issue1
Publisher Nature
Start Page 373
ISSN 2399-3642
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2021
File Version publisher
PubMed ID 33742129
NAID 120007004153
DOI 10.1038/s42003-021-01902-y
Web of Science KeyUT 000631555700003
Related Url isVersionOf https://doi.org/10.1038/s42003-021-01902-y
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Author Matsumoto, Namiko| Ohta, Yasuyuki| Deguchi, Kentaro| Kishida, Masayuki| Sato, Kota| Shang, Jingwei| Takemoto, Mami| Hishikawa, Nozomi| Yamashita, Toru| Watanabe, Aki| Yokote, Koutaro| Takemoto, Minoru| Oshima, Junko| Abe, Koji|
Keywords werner syndrome compound heterozygous Japanese
Published Date 2019-04-01
Publication Title Internal Medicine
Volume volume58
Issue issue7
Publisher Japanese Society of Internal Medicine
Start Page 1033
End Page 1036
ISSN 0918-2918
NCID AA10827774
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2019 by The Japanese Society of Internal Medicine
File Version publisher
PubMed ID 30568144
DOI 10.2169/internalmedicine.1816-18
Web of Science KeyUT 000463190700024
Related Url isVersionOf https://doi.org/10.2169/internalmedicine.1816-18
JaLCDOI 10.18926/AMO/61424
FullText URL 75_1_1.pdf
Author Hamahara, Jun| Honda, Hiroyuki| Yamamoto, Koichiro| Tokumasu, Kazuki| Hanayama, Yoshihisa| Hagiya, Hideharu| Obika, Mikako| Ueda, Keigo| Kishida, Masayuki| Otsuka, Fumio|
Abstract To determine the clinical characteristics of low androgen status in adult males with diabetes, we retrospectively analyzed the medical records of patients with type 2 diabetes mellitus in whom serum free testosterone (FT) levels were examined for 1 year. Among the 46 patients (56 ± 1.5 years old), decreases in serum FT levels to < 8.5 pg/ml (indicating the occurrence of late-onset hypogonadism [LOH]) were detected in 18 (39%). The per-centages of patients with low FT levels were high in the ≥ 50 years age group (83%), the HbA1c < 7% group (67%), and the 25 ≤ BMI < 30 kg/m2 group (56%). The serum FT levels tended to decrease age-dependently. The level of HbA1c was significantly correlated with the Heinemann Aging Male Symptoms (AMS) score (R = 0.47). The low-FT group had decreased levels of hemoglobin. Of note, the serum FSH level (R = −0.32) was negatively correlated with the serum FT level, whereas the serum TSH level (R = 0.36) was positively correlated with the serum FT level. Collectively, these results revealed that many diabetic males may have low FT levels and that the AMS score is related to the HbA1c level. A slightly anemic condition, thyroid dysfunction, and obesity (class 1) might be involved in LOH in middle-aged diabetic males.
Keywords androgen diabetes mellitus late-onset hypogonadism testosterone thyroid function
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2021-02
Volume volume75
Issue issue1
Publisher Okayama University Medical School
Start Page 1
End Page 8
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33649607
FullText URL fulltext.pdf
Author Kajiwara, Koichiro| Sawa, Yoshihiko| Fujita, Takahiro| Tamaoki, Sachio|
Keywords P. gingivalis LPS Diabetic nephropathy VCAM-1 E-selectin ACE2 FGF23
Published Date 2021-01-06
Publication Title BMC Nephrology
Volume volume22
Issue issue1
Publisher BMC
Start Page 3
ISSN 1471-2369
NCID AA12035314
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2020
File Version publisher
PubMed ID 33407253
DOI 10.1186/s12882-020-02203-y
Web of Science KeyUT 000608270800002
Related Url isVersionOf https://doi.org/10.1186/s12882-020-02203-y
FullText URL K0006293_abstract_review.pdf K0006293_summary.pdf K0006293_fulltext.pdf
Author Nojima, Ichiro|
Published Date 2020-12-27
Content Type Thesis or Dissertation
Grant Number 甲第6293号
Granted Date 2020-12-27
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
FullText URL fulltext.pdf
Author Iwamuro, Masaya| Tanaka, Takehiro| Yamauchi, Nao| Nakashima, Yuri| Wada, Takahira| Hiraoka, Sakiko| Kawahara, Yoshiro| Okada, Hiroyuki|
Keywords cytomegalovirus colitis pseudolipomatosis gastric emphysema post-resuscitation diabetes mellitus
Published Date 2020-02-15
Publication Title Internal Medicine
Volume volume59
Issue issue4
Publisher The Japanese Society of Internal Medicine
Start Page 519
End Page 525
ISSN 0918-2918
NCID AA10827774
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by The Japanese Society of Internal Medicine
File Version publisher
PubMed ID 31645533
NAID 130007798412
DOI 10.2169/internalmedicine.3633-19
Web of Science KeyUT 000516549400009
Related Url isVersionOf https://doi.org/10.2169/internalmedicine.3633-19
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Author Nishizawa, Hitomi| Sato, Yoshihiko| Ishikawa, Masumi| Arakawa, Yuko| Iijima, Mari| Akiyama, Tomoyuki| Takano, Kyoko| Watanabe, Atsushi| Kosho, Tomoki|
Keywords Hypophosphatasia Alkaline phosphatase Genetic disease Asfotase alfa Recombinant gene therapy Motor function
Published Date 2020-12
Publication Title Molecular Genetics and Metabolism Reports
Volume volume25
Publisher Elsevier
Start Page 100643
ISSN 2214-4269
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Authors.
File Version publisher
PubMed ID 32983894
DOI 10.1016/j.ymgmr.2020.100643
Web of Science KeyUT 000600655200010
Related Url isVersionof https://doi.org/10.1016/j.ymgmr.2020.100643
FullText URL fulltext.pdf
Author Sada, Ken-Ei| Ohashi, Keiji| Asano, Yosuke| Hayashi, Keigo| Morishita, Michiko| Watanabe, Haruki| Matsumoto, Yoshinori| Fujimoto, Shouichi| Takasaki, Yoshinari| Yamagata, Kunihiro| Banno, Shogo| Dobashi, Hiroaki| Amano, Koichi| Harigai, Masayoshi| Arimura, Yoshihiro| Makino, Hirofumi| the Japan Research Committee of the Ministry of Health, Labour, and Welfare for Intractable Vasculitis (JPVAS) and the Research Committee of Intractable Renal Disease of the Ministry of Health, Labour, and Welfare of Japan|
Keywords ANCA-associated vasculitis Chronic damage Elderly patients Glucocorticoids
Published Date 2020-10-12
Publication Title Arthritis Research & Therapy
Volume volume22
Issue issue1
Publisher BMC
Start Page 236
ISSN 1478-6354
NCID AA11830978
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2020
File Version publisher
PubMed ID 33046139
DOI 10.1186/s13075-020-02341-6
Web of Science KeyUT 000582369300003
Related Url isVersionOf https://doi.org/10.1186/s13075-020-02341-6
FullText URL fulltext.pdf
Author Nojima, Ichiro| Eikawa, Shingo| Tomonobu, Nahoko| Hada, Yoshiko| Kajitani, Nobuo| Teshigawara, Sanae| Miyamoto, Satoshi| Tone, Atsuhito| Uchida, Haruhito A.| Nakatsuka, Atsuko| Eguchi, Jun| Shikata, Kenichi| Udono, Heiichiro| Wada, Jun|
Keywords Cytokines Diabetes Endocrine system and metabolic diseases Immunology Tumour immunology
Published Date 2020-09-10
Publication Title Scientific Reports
Volume volume10
Issue issue1
Publisher Nature Research
Start Page 14928
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2020
File Version publisher
PubMed ID 32913271
DOI 10.1038/s41598-020-71946-3
Web of Science KeyUT 000571915100049
Related Url isVersionOf https://doi.org/10.1038/s41598-020-71946-3
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Author Shikata, Kenichi| Haneda, Masakazu| Ninomiya, Toshiharu| Koya, Daisuke| Suzuki, Yoshiki| Suzuki, Daisuke| Ishida, Hitoshi| Akai, Hiroaki| Tomino, Yasuhiko| Uzu, Takashi| Nishimura, Motonobu| Maeda, Shiro| Ogawa, Daisuke| Miyamoto, Satoshi| Makino, Hirofumi| the Diabetic Nephropathy Remission and Regression Team Trial in Japan (DNETT‐Japan) collaborative group|
Keywords Diabetic kidney disease Diabetic nephropathy Diabetic Nephropathy Remission and Regression Team Trial in Japan
Published Date 2020-08-08
Publication Title Journal of Diabetes Investigation
Volume volume12
Issue issue2
Publisher Wiley
Start Page 207
End Page 216
ISSN 2040-1116
NCID AA12488319
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Authors
File Version publisher
PubMed ID 32597548
NAID 120006880216
DOI 10.1111/jdi.13339
Web of Science KeyUT 000557091100001
Related Url isVersionOf https://doi.org/10.1111/jdi.13339
FullText URL fulltext.pdf
Author Kitamura, Shinji| Takahashi, Kensaku| Sang, Yizhen| Fukushima, Kazuhiko| Tsuji, Kenji| Wada, Jun|
Keywords immunofluorescent image renal pathology artificial intelligence deep learning diabetic nephropathy
Published Date 2020-07-09
Publication Title Diagnostics
Volume volume10
Issue issue7
Publisher MDPI
Start Page 466
ISSN 2075-4418
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 32660112
DOI 10.3390/diagnostics10070466
Web of Science KeyUT 000557155500001
Related Url isVersionOf https://doi.org/10.3390/diagnostics10070466
JaLCDOI 10.18926/AMO/59950
FullText URL 74_3_199.pdf
Author Fujita, Hirofumi| Bando, Tetsuya| Oyadomari, Seiichi| Ochiai, Kazuhiko| Watanabe, Masami| Kumon, Hiromi| Ohuchi, Hideyo|
Abstract Dickkopf 3 (Dkk3) is a secreted protein belonging to the Dkk family and encoded by the orthologous gene of REIC. Dkk3/REIC is expressed by mouse and human adrenal glands, but the understanding of its roles in this organ is still limited. To determine the functions of Dkk3 in the mouse adrenal gland, we first identified that the mouse Dkk3 protein is N-glycosylated in the adrenal gland as well as in the brain. We performed proteome analysis on adrenal glands from Dkk3-null mice, in which exons 5 and 6 of the Dkk3 gene are deleted. Twodimensional polyacrylamide gel electrophoresis of adrenal proteins from wild-type and Dkk3-null mice revealed 5 protein spots whose intensities were altered between the 2 genotypes. Mass spectrometry analysis of these spots identified binding immunoglobulin protein (BiP), an endoplasmic reticulum (ER) chaperone. To determine whether mouse Dkk3 is involved in the unfolded protein response (UPR), we carried out a reporter assay using ER-stress responsive elements. Forced expression of Dkk3 resulted in the induction of distinct levels of reporter expression, showing the UPR initiated by the ER membrane proteins of activating transcription factor 6 (ATF6) and inositol-requring enzyme 1 (IRE1). Thus, it is possible that Dkk3 is a physiological ER stressor in the mouse adrenal gland.
Keywords Dkk3 knockout mouse adrenal gland glucose-regulated protein 78 proteome endoplasmic reticulum stress
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-06
Volume volume74
Issue issue3
Publisher Okayama University Medical School
Start Page 199
End Page 208
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32577017
Web of Science KeyUT 000543363400003
NAID 120006862792
FullText URL fulltext.pdf
Author Katayama, Akihiro| Tone, Atsuhito| Watanabe, Mayu| Teshigawara, Sanae| Miyamoto, Satoshi| Eguchi, Jun| Nakatsuka, Atsuko| Shikata, Kenichi| Wada, Jun|
Keywords Hypoglycemia Predictive low glucose management (PLGM) Type 1 diabetes mellitus (T1DM) Sensor-augmented pump therapy (SAP)
Note This is a post-peer-review, pre-copyedit version of an article published in Diabetology International. The final authenticated version is available online at: http://dx.doi.org/10.1007/s13340-019-00408-7.|
Published Date 2019-09-16
Publication Title Diabetology International
Volume volume11
Issue issue2
Publisher Springer
Start Page 97
End Page 104
ISSN 2190-1678
NCID AA12503387
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 32206479
NAID 40022198977
DOI 10.1007/s13340-019-00408-7
Web of Science KeyUT 000520711100004
Related Url isVersionOf https://doi.org/10.1007/s13340-019-00408-7
JaLCDOI 10.18926/AMO/57955
FullText URL 74_1_65.pdf
Author Akiyama, Tomoyuki| Saigusa, Daisuke| Hyodo, Yuki| Umeda, Keiko| Saijo, Reina| Koshiba, Seizo| Kobayashi, Katsuhiro|
Abstract To characterize metabolic profiles within the central nervous system in epilepsy, we performed gas chromatography-tandem mass spectrometry (GC-MS/MS)-based metabolome analysis of the cerebrospinal fluid (CSF) in pediatric patients with and without epilepsy. The CSF samples obtained from 64 patients were analyzed by GC-MS/MS. Multivariate analyses were performed for two age groups, 0-5 years of age and 6-17 years of age, to elucidate the effects of epilepsy and antiepileptic drugs on the metabolites. In patients aged 0-5 years (22 patients with epilepsy, 13 without epilepsy), epilepsy patients had reduced 2-ketoglutaric acid and elevated pyridoxamine and tyrosine. In patients aged 6-17 years (12 with epilepsy, 17 without epilepsy), epilepsy patients had reduced 1,5-anhydroglucitol. Valproic acid was associated with elevated 2-aminobutyric acid, 2-ketoisocaproic acid, 4-hydroxyproline, acetylglycine, methionine, N-acetylserine, and serine. Reduced energy metabolism and alteration of vitamin B6 metabolism may play a role in epilepsy in young children. The roles of 1,5-anhydroglucitol in epilepsy in older children and in levetiracetam and zonisamide treatment remain to be explained. Valproic acid influenced the levels of amino acids and related metabolites involved in the metabolism of serine, methionine, and leucine.
Keywords antiepileptic drugs gas chromatography-tandem mass spectrometry metabolome analysis metabolomics
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-02
Volume volume74
Issue issue1
Publisher Okayama University Medical School
Start Page 65
End Page 72
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32099251
Web of Science KeyUT 000516606200010
NAID 120006795622
JaLCDOI 10.18926/AMO/57950
FullText URL 74_1_33.pdf
Author Honda, Hiroyuki| Hanayama, Yoshihisa| Obika, Mikako| Hasegawa, Kou| Hamahara, Jun| Kishida, Masayuki| Hagiya, Hideharu| Ogawa, Hiroko| Kataoka, Hitomi| Otsuka, Fumio|
Abstract A relationship between diabetes and depression is apparent. To clarify the clinical relevance of diabetic patients’ gastroesophageal symptoms to their psychological status, we retrospectively analyzed the data from a Selfrating Depression Scale (SDS) and a Frequency Scale for Symptoms of Gastroesophageal reflux disease (FSSG) among 143 type 2 diabetic patients who visited a general medicine department. Among the 45 Japanese patients enrolled, the group with relatively high SDS scores (≥ 36) showed higher (FSSG) dysmotility symptom scores versus the low-SDS (< 36) group, although the 2 groups’ characteristics and laboratory data were not significantly different. Positive correlations of postprandial plasma glucose (PPG) levels with FSSG scores (R=0.321, p<0.05), particularly with reflux scores (R=0.455, p<0.01) were revealed. PPG and HbA1c levels were not correlated with SDS scores. The patients’ SDS scores were significantly correlated with their FSSG scores (R=0.41, p<0.01), suggesting that depressive status is linked to GERD-related manifestations. Considering that the patients’ PPG levels were correlated with GERD-related symptoms, diabetic patients’ blood glucose levels are associated with depressive status. Collectively, key symptoms related to GERD and glucose level values would be helpful
Keywords blood glucose type 2 diabetes mellitus gastroesophageal reflux depressive status postprandial plasma glucose
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-02
Volume volume74
Issue issue1
Publisher Okayama University Medical School
Start Page 33
End Page 40
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32099246
Web of Science KeyUT 000516606200005
NAID 120006795617
JaLCDOI 10.18926/AMO/57710
FullText URL 73_6_475.pdf
Author Umebayashi, Ryoko| Uchida, Haruhito A.| Wada, Junzo|
Abstract Abdominal aortic aneurysms (AAAs) usually expand asymptomatically until the occurrence of a life-threatening event such as aortic rupture, which is closely associated with high mortality. AAA and aortic dissection are ranked among the top 10 causes of death in Japan. The major risk factors for AAA are age over 65 years, male gender, family history, and smoking. Thus, for prevention, smoking cessation is the most important lifestyle-intervention. For treatment, since AAA generally affects elderly people, less invasive treatment is preferable. However, the only established treatment for AAA is open repair and endovascular repair. This review describes potential medical treatments to slow aneurysm growth or prevent AAA rupture.
Keywords abdominal aortic aneurysms medical treatment anti-platelet drugs
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2019-12
Volume volume73
Issue issue6
Publisher Okayama University Medical School
Start Page 475
End Page 477
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31871328
Web of Science KeyUT 000503431400001
FullText URL FI_10_17.pdf
Author Ohkura, Takahiro| Yoshimura, Teizo| Fujisawa, Masayoshi| Ohara, Toshiaki| Marutani, Rie| Usami, Kaya| Matsukawa, Akihiro|
Keywords Ras/Raf/ERK/MAPK Spred2 adipocyte inflammation macrophage obesity
Published Date 2019-01-22
Publication Title Frontiers in Immunology
Volume volume10
Publisher Frontiers Media S.A
Start Page 17
ISSN 1664-3224
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders Copyright © 2019 Authors
File Version publisher
PubMed ID 30723473
DOI 10.3389/fimmu.2019.00017
Web of Science KeyUT 000456196900002
Related Url isVersionOf https://doi.org/10.3389/fimmu.2019.00017
FullText URL EBioMedicine_2017_154.pdf
Author Kunisada, Yuki| Eikawa, Shingo| Tomonobu, Nahoko| Domae, Shohei| Uehara, Takenori| Hori, Shohei| Furusawa, Yukihiro| Hase, Koji| Sasaki, Akira| Udono, Heiichiro|
Keywords Glycolysis Regulatory T cell (Treg) Tumor immunity Tumor microenvironment mTOR
Published Date 2017-10-16
Publication Title EBioMedicine
Volume volume25
Publisher Elsevier Science
Start Page 154
End Page 164
ISSN 23523964
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2017 The Authors.
File Version publisher
PubMed ID 29066174
DOI 10.1016/j.ebiom.2017.10.009
Web of Science KeyUT 000417440500026
Related Url isVersionOf https://doi.org/10.1016/j.ebiom.2017.10.009