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JaLCDOI 10.18926/AMO/65740
FullText URL 77_4_347.pdf
Author Iwamuro, Masaya| Kondo, Takumi| Ennishi, Daisuke| Fujii, Nobuharu| Matsuoka, Ken-ichi| Takahashi, Takahide| Hirabata, Araki| Tanaka, Takehiro| Otsuka, Fumio| Maeda, Yoshinobu| Okada, Hiroyuki|
Abstract The feasibility of lymphocyte isolation and flow cytometry using a single endoscopic biopsy specimen from the gastrointestinal tract of patients who have undergone hematopoietic stem cell transplantation has not been investigated. We acquired 51 endoscopic biopsy specimens from the gastrointestinal tract of 35 patients. We divided the flow cytometry samples into two groups: group A, successful lymphocyte isolation (n=24), and group B, incomplete isolation (n=27). We compared the backgrounds of the samples between the groups to reveal crucial elements in the successful isolation of lymphocytes residing in the gastrointestinal tract. Comparison between the groups revealed lymphocyte isolation success rates differed between biopsy sites. Isolation was most successful in samples from the duodenum (8/9, 88.9%), followed by the ileum (4/8, 50.0%), large intestine (4/11, 36.4%), and stomach (8/23, 34.8%). Tacrolimus was used more frequently in group B (92.6%) than in group A (62.5%) (p=0.015). Logistic regression analysis revealed that isolation from the duodenum or ileum was a significant factor for successful isolation, while tacrolimus use was not statistically significant. In conclusion, the duodenum and ileum are more suitable sites than the stomach and colorectum for acquiring samples for flow cytometry.
Keywords flow cytometry stem cell transplantation transplantation-associated microangiopathy
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-08
Volume volume77
Issue issue4
Publisher Okayama University Medical School
Start Page 347
End Page 357
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37635134
Web of Science KeyUT 001163659800002
JaLCDOI 10.18926/AMO/65739
FullText URL 77_4_341.pdf
Author Otsuka, Motoyuki|
Abstract Hepatitis B virus is a pathogenic virus that infects 300 million people worldwide and causes chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Hepatitis B virus encodes four proteins. Among them, the HBx protein plays a central role in the HBV pathogenesis. Because the HBx protein is considered to play a central role in the induction of viral replication and hepatocarcinogenesis, the regulation of its function could be a key factor in the development of new interventions against hepatitis B. In this review, HBx protein-related viral replication and hepatocarcinogenesis mechanisms are described, with a focus on the recently reported viral replication mechanisms related to degradation of the Smc5/6 protein complex. We also discuss our recent discovery of a compound that inhibits HBx protein-induced degradation of the Smc5/6 protein complex, and that exerts inhibitory effects on both viral replication and hepatocarcinogenesis. Finally, prospects for future research on the HBx protein are described.
Keywords HBx Smc5/6 DDB1 nitazoxianide DNA repair
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2023-08
Volume volume77
Issue issue4
Publisher Okayama University Medical School
Start Page 341
End Page 345
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37635133
Web of Science KeyUT 001163659800007
FullText URL fulltext.pdf
Author Hirai, Ryosuke| Kawano, Seiji| Inoo, Shoko| Kuraoka, Sakiko| Okanoue, Shotaro| Satomi, Takuya| Hamada, Kenta| Kono, Yoshiyasu| Kanzaki, Hiromitsu| Iwamuro, Masaya| Kawahara, Yoshiro| Okada, Hiroyuki|
Keywords Fibrinolytic agents Endoscopic submucosal resection Postoperative hemorrhage Purinergic P2Y receptor antagonists
Published Date 2022-09-29
Publication Title Gut and Liver
Volume volume17
Issue issue3
Publisher The Editorial Office of Gut and Liver
Start Page 404
End Page 411
ISSN 1976-2283
NCID AA12329814
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Gut and Liver.
File Version publisher
PubMed ID 36172713
DOI 10.5009/gnl220196
Web of Science KeyUT 000869939200001
Related Url isVersionOf https://doi.org/10.5009/gnl220196
FullText URL fulltext.pdf
Author Okuda, Kosaku| Nakahara, Kengo| Ito, Akihiro| Iijima, Yuta| Nomura, Ryosuke| Kumar, Ashutosh| Fujikawa, Kana| Adachi, Kazuya| Shimada, Yuki| Fujio, Satoshi| Yamamoto, Reina| Takasugi, Nobumasa| Onuma, Kunishige| Osaki, Mitsuhiko| Okada, Futoshi| Ukegawa, Taichi| Takeuchi, Yasuo| Yasui, Norihisa| Yamashita, Atsuko| Marusawa, Hiroyuki| Matsushita, Yosuke| Katagiri, Toyomasa| Shibata, Takahiro| Uchida, Koji| Niu, Sheng-Yong| Lang, Nhi B.| Nakamura, Tomohiro| Zhang, Kam Y. J.| Lipton, Stuart A.| Uehara, Takashi|
Note The version of record of this article, first published in Nature Communications, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41467-023-36232-6|
Published Date 2023-02-04
Publication Title Nature Communications
Volume volume14
Issue issue1
Publisher Nature Portfolio
Start Page 621
ISSN 2041-1723
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2023
File Version publisher
PubMed ID 36739439
DOI 10.1038/s41467-023-36232-6
Web of Science KeyUT 001024149400011
Related Url isVersionOf https://doi.org/10.1038/s41467-023-36232-6
FullText URL fulltext.pdf
Author Iwamuro, Masaya| Tanaka, Takehiro| Otsuka, Motoyuki|
Keywords autoimmune gastritis esophagogastroduodenoscopy genetic predisposition lymphocyte oxidative stress
Published Date 2023-06-21
Publication Title Current Issues in Molecular Biology
Volume volume45
Issue issue7
Publisher MDPI
Start Page 5263
End Page 5275
ISSN 1467-3037
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 by the authors.
File Version publisher
PubMed ID 37504250
DOI 10.3390/cimb45070334
Web of Science KeyUT 001035130200001
Related Url isVersionOf https://doi.org/10.3390/cimb45070334
FullText URL fulltext.pdf
Author Nogi, Shohei| Noma, Kazuhiro| Hashimoto, Masashi| Kato, Takuya| Maeda, Naoaki| Tanabe, Shunsuke| Shirakawa, Yasuhiro| Fujiwara, Toshiyoshi|
Keywords Heterotopic gastric mucosa Esophagus Adenocarcinoma
Note The version of record of this article, first published in Surgical Case Reports, is available online at Publisher’s website: http://dx.doi.org/10.1186/s40792-023-01707-7|
Published Date 2023-07-20
Publication Title Surgical Case Reports
Volume volume9
Issue issue1
Publisher Springer
Start Page 132
ISSN 2198-7793
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2023.
File Version publisher
PubMed ID 37470880
DOI 10.1186/s40792-023-01707-7
Web of Science KeyUT 001029997500001
Related Url isVersionOf https://doi.org/10.1186/s40792-023-01707-7
FullText URL fulltext.pdf
Author Nakamura, Keiichiro| Shigeyasu, Kunitoshi| Okamoto, Kazuhiro| Matsuoka, Hirofumi| Masuyama, Hisashi|
Note The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-023-30452-y|
Published Date 2023-03-23
Publication Title Scientific Reports
Volume volume13
Issue issue1
Publisher Nature Portfolio
Start Page 4720
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2023
File Version publisher
PubMed ID 36959226
DOI 10.1038/s41598-023-30452-y
Web of Science KeyUT 001024033600064
Related Url isVersionOf https://doi.org/10.1038/s41598-023-30452-y
FullText URL fulltext.pdf
Author Iwamuro, Masaya| Tanaka, Takehiro| Kagawa, Shunsuke| Inoo, Shoko| Otsuka, Motoyuki|
Keywords immune checkpoint inhibitor chemotherapy-induced diarrhea immune-related adverse event colitis colonoscopy collagenous colitis
Published Date 2023-05-25
Publication Title Cureus
Volume volume15
Issue issue5
Publisher Springer
Start Page e39466
ISSN 2168-8184
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Iwamuro et al.
File Version publisher
PubMed ID 37378156
DOI 10.7759/cureus.39466
Web of Science KeyUT 001023091300016
Related Url isVersionOf https://doi.org/10.7759/cureus.39466
FullText URL fulltext.pdf
Author Kondo Sr., Yoshitaka| Fujiwara, Toshiyoshi|
Keywords anterior cutaneous nerve entrapment syndrome low pain threshold intraperitoneal approach laparoscopic neurectomy refractory abdominal pain acnes
Published Date 2023-05-23
Publication Title Cureus
Volume volume15
Issue issue5
Publisher Springer
Start Page e39366
ISSN 2168-8184
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Kondo et al.
File Version publisher
PubMed ID 37362460
DOI 10.7759/cureus.39366
Web of Science KeyUT 001013172800020
Related Url isVersionOf https://doi.org/10.7759/cureus.39366
FullText URL fulltext20230720-02.pdf fig20230720-02.pdf suppl_table20230720-02.pdf suppl_fig20230720-02.pdf
Author Yoshimoto, Masashi| Kagawa, Shunsuke| Kajioka, Hiroki| Taniguchi, Atsuki| Kuroda, Shinji| Kikuchi, Satoru| Kakiuchi, Yoshihiko| Yagi, Tomohiko| Nogi, Shohei| Teraishi, Fuminori| Shigeyasu, Kunitoshi| Yoshida, Ryuichi| Umeda, Yuzo| Noma, Kazuhiro| Tazawa, Hiroshi| Fujiwara, Toshiyoshi|
Keywords Aspirin Ticagrelor P-selectin Platelet Time-lapse imaging
Note © 2023 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Jul. 2024.|
Published Date 2023-07-28
Publication Title Cancer Letters
Volume volume567
Publisher Elsevier BV
Start Page 216260
ISSN 0304-3835
NCID AA00598513
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Elsevier B.V.
File Version author
PubMed ID 37295551
DOI 10.1016/j.canlet.2023.216260
Web of Science KeyUT 001020524700001
Related Url isVersionOf https://doi.org/10.1016/j.canlet.2023.216260
FullText URL fulltext.pdf
Author Hata, Nanako| Shigeyasu, Kunitoshi| Umeda, Yuzo| Yano, Shuya| Takeda, Sho| Yoshida, Kazuhiro| Fuji, Tomokazu| Yoshida, Ryuichi| Yasui, Kazuya| Umeda, Hibiki| Takahashi, Toshiaki| Kondo, Yoshitaka| Kishimoto, Hiroyuki| Mori, Yoshiko| Teraishi, Fuminori| Yamamoto, Hideki| Michiue, Hiroyuki| Nakamura, Keiichiro| Tazawa, Hiroshi| Fujiwara, Toshiyoshi|
Note The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-023-29397-z|
Published Date 2023-02-06
Publication Title Scientific Reports
Volume volume13
Issue issue1
Publisher Nature Portfolio
Start Page 2078
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2023
File Version publisher
PubMed ID 36747029
DOI 10.1038/s41598-023-29397-z
Web of Science KeyUT 000989985700018
Related Url isVersionOf https://doi.org/10.1038/s41598-023-29397-z
FullText URL fulltext.pdf
Author Matsumoto, Tasuku| Noma, Kazuhiro| Maeda, Naoaki| Kato, Takuya| Moriwake, Kazuya| Kawasaki, Kento| Hashimoto, Masashi| Tanabe, Shunsuke| Shirakawa, Yasuhiro| Fujiwara, Toshiyoshi|
Keywords T4 esophageal cancer Chemoradiotherapy Esophagectomy Two-stage operation
Note The version of record of this article, first published in Surgical Case Reports, is available online at Publisher’s website: http://dx.doi.org/10.1186/s40792-023-01692-x|
Published Date 2023-06-26
Publication Title Surgical Case Reports
Volume volume9
Issue issue1
Publisher Springer
Start Page 119
ISSN 2198-7793
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2023.
File Version publisher
PubMed ID 37358692
DOI 10.1186/s40792-023-01692-x
Web of Science KeyUT 001016770100001
Related Url isVersionOf https://doi.org/10.1186/s40792-023-01692-x
FullText URL fulltext20230911-02.pdf
Author Ninomiya, Kiichiro| Inoue, Daisuke| Sugimoto, Ken| Tanaka, Chie| Murofushi, Keiko| Okuyama, Toru| Watanuki, Shigeaki| Imamura, Chiyo K.| Sakai, Daisuke| Sakurai, Naomi| Watanabe, Kiyotaka| Tamura, Kazuo| Saeki, Toshiaki| Ishiguro, Hiroshi|
Keywords Comprehensive geriatric assessment Guideline Systematic review
Published Date 2023-06-11
Publication Title Journal of Geriatric Oncology
Volume volume14
Issue issue5
Publisher Elsevier
Start Page 101485
ISSN 18794068
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 The Authors.
File Version publisher
PubMed ID 37062639
DOI 10.1016/j.jgo.2023.101485
Web of Science KeyUT 001049053400001
Related Url isVersionOf https://doi.org/10.1016/j.jgo.2023.101485
FullText URL fulltext20230629-01.pdf
Author Hirai, Ryosuke| Hirai, Mami| Otsuka, Motoyuki| Mitsuhashi, Toshiharu| Shimodate, Yuichi| Mouri, Hirokazu| Matsueda, Kazuhiro| Yamamoto, Hiroshi| Mizuno, Motowo|
Keywords Cancer screening Gastric cancer Helicobacter pylori Gastrointestinal endoscopy Atrophic gastritis
Note The version of record of this article, first published in Journal of Gastroenterology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00535-023-02010-w|
Published Date 2023-06-21
Publication Title Journal of Gastroenterology
Volume volume58
Issue issue9
Publisher Springer Science and Business Media LLC
Start Page 848
End Page 855
ISSN 0944-1174
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2023
File Version publisher
PubMed ID 37340218
DOI 10.1007/s00535-023-02010-w
Web of Science KeyUT 001009624700001
Related Url isVersionOf https://doi.org/10.1007/s00535-023-02010-w
FullText URL fulltext.pdf
Author Komoto, Satoshi| Noma, Kazuhiro| Kato, Takuya| Kobayashi, Teruki| Nishiwaki, Noriyuki| Narusaka, Toru| Sato, Hiroaki| Katsura, Yuki| Kashima, Hajime| Kikuchi, Satoru| Ohara, Toshiaki| Tazawa, Hiroshi| Fujiwara, Toshiyoshi|
Keywords cancer-associated fibroblast chemotherapy radiotherapy esophageal cancer tumor microenvironment
Published Date 2023-05-30
Publication Title Cancers
Volume volume15
Issue issue11
Publisher MDPI
Start Page 2971
ISSN 2072-6694
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 by the authors.
File Version publisher
PubMed ID 37296933
DOI 10.3390/cancers15112971
Web of Science KeyUT 001006082400001
Related Url isVersionOf https://doi.org/10.3390/cancers15112971
JaLCDOI 10.18926/AMO/65494
FullText URL 77_3_291.pdf
Author Himei, Hitomi| Kato, Hironari| Saragai, Yosuke| Fujii, Yuki| Yamazaki, Tatsuhiro| Uchida, Daisuke| Matsumoto, Kazuyuki| Horiguchi, Shigeru| Tsutsumi, Koichiro| Okada, Hiroyuki|
Abstract We investigated the efficacy and safety of endoscopic plastic stent (PS) placement for hilar benign biliary strictures (BBSs) and compared cases with PS placement above (inside stent, IS) and across (usual stent, US) the sphincter of Oddi. Patients who underwent initial endoscopic PS placement for hilar BBSs between August 2012 and December 2021 were retrospectively analyzed. Hilar BBSs in 88 patients were investigated. Clinical success was achieved in 81 of these cases (92.0%), including 38 patients in the IS group and 43 patients in the US group. Unexpected stent exchange (uSE) before the first scheduled PS exchange occurred in 18 cases (22.2%). The median time from first stent placement to uSE was 35 days. There was no significant difference in the rate and median time to uSE between the two groups. The rates of adverse events such as pancreatitis or cholangitis in the two groups did not significantly differ. However, the rate of difficult stent removal in the IS group (15.8%) was significantly higher than that in the US group (0%) (p=0.0019). US placement is preferable to IS placement for scheduled stent exchange, as it offers the same effectiveness and risk of adverse events with easier stent removal.
Keywords benign biliary stricture inside stent plastic stent
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-06
Volume volume77
Issue issue3
Publisher Okayama University Medical School
Start Page 291
End Page 299
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37357630
Web of Science KeyUT 001026279600007
JaLCDOI 10.18926/AMO/65488
FullText URL 77_3_235.pdf
Author Kuraoka, Sakiko| Iwamuro, Masaya| Satomi, Takuya| Yamazaki, Tatsuhiro| Hamada, Kenta| Kono, Yoshiyasu| Kanzaki, Hiromitsu| Kato, Hironari| Otsuka, Fumio| Okada, Hiroyuki|
Abstract Changes in hormone levels in patients with cancer cachexia after anamorelin administration have not been fully investigated. This study aimed to determine how anamorelin affects the endocrine system in patients with gastrointestinal cancer and cachexia. We prospectively enrolled 13 patients and comprehensively investigated their body weight and levels of serum albumin, hemoglobin A1c (HbA1c), and hormones before (week 0) and 3 and 12 weeks after anamorelin administration. The variables were evaluated at week 3 in 9 patients and at week 12 in 5 patients. At week 3, anamorelin administration resulted in body weight gain and increased the levels of growth hormone and HbA1c, as well as insulin-like growth factor-1 standard deviation scores (IGF-1 SD scores). At the same time, negative correlations were observed between ΔIGF-1 SD score and Δthyroidstimulating hormone (TSH) and between ΔIGF-1 SD score and Δfree testosterone. ΔBody weight and ΔIGF-1 SD score correlated positively at week 12. These results suggest that TSH and free testosterone levels can be affected 3 weeks after anamorelin administration; however, those variables tend to return to a state of equilibrium, and anabolic effects of anamorelin appear in long-term (≥ 12 weeks) users.
Keywords anamorelin body weight cancer cachexia endocrine system
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-06
Volume volume77
Issue issue3
Publisher Okayama University Medical School
Start Page 235
End Page 241
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37357624
Web of Science KeyUT 001026279600001
FullText URL fulltext.pdf
Author Iwamuro, Masaya| Tanaka, Takehiro| Okada, Hiroyuki|
Keywords Diagnosis Diffuse large B-cell lymphoma Duodenal neoplasms Esoph-agogastroduodenoscopy Follicular lymphoma Gastrointestinal lymphoma
Published Date 2023-03-28
Publication Title World Journal of Gastroenterology
Volume volume29
Issue issue12
Publisher Baishideng Publishing Group
Start Page 1852
End Page 1862
ISSN 1007-9327
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2023.
File Version publisher
PubMed ID 37032723
DOI 10.3748/wjg.v29.i12.1852
Web of Science KeyUT 000982154800007
Related Url isVersionOf https://doi.org/10.3748/wjg.v29.i12.1852
FullText URL fulltext.pdf
Author Kashima, Hajime| Kikuchi, Satoru| Kuroda, Shinji| Fujiwara, Toshiyoshi|
Keywords lecs local resection esophagogastric junction hiatal hernia laparoscopic surgery leiomyoma gastric submucosal tumor
Published Date 2023-04-20
Publication Title Cureus
Volume volume15
Issue issue4
Publisher Springer
Start Page e37902
ISSN 2168-8184
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Kashima et al.
File Version publisher
PubMed ID 37223198
DOI 10.7759/cureus.37902
Web of Science KeyUT 000995995400012
Related Url isVersionOf https://doi.org/10.7759/cureus.37902
FullText URL fulltext20230530-03.pdf
Author Iwamuro, Masaya| Kusumoto, Chiaki| Nakagawa, Masahiro| Matsueda, Kazuhiro| Kobayashi, Sayo| Yoshioka, Masao| Inaba, Tomoki| Toyokawa, Tatsuya| Sakaguchi, Chihiro| Tanaka, Shouichi| Tanaka, Takehiro| Okada, Hiroyuki|
Keywords Gastric adenocarcinoma of the fundic gland type (GA-FG) gastric neoplasms oxyntic gland adenoma submucosal invasion
Published Date 2023-03-16
Publication Title Journal of Gastrointestinal Oncology
Volume volume14
Issue issue2
Publisher AME Publishing Company
Start Page 554
End Page 562
ISSN 2078-6891
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Journal of Gastrointestinal Oncology.
File Version publisher
PubMed ID 37201070
DOI 10.21037/jgo-22-870
Web of Science KeyUT 000992116200001
Related Url isVersionOf https://dx.doi.org/10.21037/jgo-22-870