result 632 件
| FullText URL | fulltext.pdf |
|---|---|
| Author | Moriwake, Kazuya| Noma, Kazuhiro| Kawasaki, Kento| Matsumoto, Tasuku| Hashimoto, Masashi| Kato, Takuya| Maeda, Naoaki| Tanabe, Shunsuke| Shirakawa, Yasuhiro| Fujiwara, Toshiyoshi| |
| Keywords | Reconstruction with the free jejunum flap Subtotal esophagectomy After pancreatoduodenectomy |
| Note | The version of record of this article, first published in Surgical Case Reports, is available online at Publisher’s website: http://dx.doi.org/10.1186/s40792-024-01919-5| |
| Published Date | 2024-05-22 |
| Publication Title | Surgical Case Reports |
| Volume | volume10 |
| Issue | issue1 |
| Publisher | Springer |
| Start Page | 128 |
| ISSN | 2198-7793 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024. |
| File Version | publisher |
| PubMed ID | 38775882 |
| DOI | 10.1186/s40792-024-01919-5 |
| Web of Science KeyUT | 001229350000001 |
| Related Url | isVersionOf https://doi.org/10.1186/s40792-024-01919-5 |
| FullText URL | K0006986_abstract_review.pdf K0006986_fulltext.pdf K0006986_summary.pdf |
|---|---|
| Author | MORIMOTO, Kosaku| |
| Published Date | 2024-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6986号 |
| Granted Date | 2024-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | © The Author(s), 2023. |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Takahashi, Yosuke| Noma, Kazuhiro| Hashimoto, Masashi| Maeda, Naoaki| Tanabe, Shunsuke| Fujiwara, Toshiyoshi| |
| Keywords | Parahiatal hernia Esophageal hiatal hernia Laparoscopic repair Three-dimensional laparoscopy |
| Published Date | 2024-04 |
| Publication Title | International Journal of Surgery Case Reports |
| Volume | volume117 |
| Publisher | Elsevier |
| Start Page | 109565 |
| ISSN | 2210-2612 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 The Author(s). |
| File Version | publisher |
| PubMed ID | 38547697 |
| DOI | 10.1016/j.ijscr.2024.109565 |
| Web of Science KeyUT | 001224601000001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.ijscr.2024.109565 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tsutsumi, Koichiro| Otsuka, Motoyuki| |
| Keywords | biomarker early diagnosis high-grade PanIN IPMN liquid biopsy pancreatic ductal carcinoma pancreatic juice small extracellular vesicle treatment |
| Published Date | 2023-03-28 |
| Publication Title | Clinical and Translational Discovery |
| Volume | volume3 |
| Issue | issue2 |
| Publisher | Wiley |
| Start Page | e177 |
| ISSN | 2768-0622 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 The Authors. |
| File Version | publisher |
| DOI | 10.1002/ctd2.177 |
| Web of Science KeyUT | 001224381800004 |
| Related Url | isVersionOf https://doi.org/10.1002/ctd2.177 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Iwamuro, Masaya| Kawano, Seiji| Otsuka, Motoyuki| |
| Keywords | Diagnosis Esophagogastroduodenoscopy Non-neoplastic lesions Esophageal lesions Gastric lesions Duodenal lesions |
| Published Date | 2024-04-28 |
| Publication Title | World Journal of Gastroenterology |
| Volume | volume30 |
| Issue | issue16 |
| Publisher | Baishideng Publishing Group |
| Start Page | 2220 |
| End Page | 2232 |
| ISSN | 1007-9327 |
| NCID | AA11690631 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024. |
| File Version | publisher |
| PubMed ID | 38690017 |
| DOI | 10.3748/wjg.v30.i16.2220 |
| Web of Science KeyUT | 001214282500009 |
| Related Url | isVersionOf https://doi.org/10.3748/wjg.v30.i16.2220 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Oyama, Atsushi| Takaki, Akinobu| Adachi, Takuya| Wada, Nozomu| Takeuchi, Yasuto| Onishi, Hideki| Shiraha, Hidenori| Okada, Hiroyuki| Otsuka, Motoyuki| |
| Keywords | Primary sclerosing cholangitis Oxidative stress marker Prognosis Serum reactive oxygen metabolite Total serum antioxidant capacity Revised Mayo risk score Child–Pugh score MELD score FIB-4 index Serum dROM Serum OXY-adsorbent test Immunoglobulin A |
| Note | The version of record of this article, first published in Hepatology International, is available online at Publisher’s website: http://dx.doi.org/10.1007/s12072-023-10557-2| |
| Published Date | 2023-07-26 |
| Publication Title | Hepatology International |
| Volume | volume17 |
| Issue | issue5 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 1215 |
| End Page | 1224 |
| ISSN | 1936-0533 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 37493884 |
| DOI | 10.1007/s12072-023-10557-2 |
| Web of Science KeyUT | 001034200900001 |
| Related Url | isVersionOf https://doi.org/10.1007/s12072-023-10557-2 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Takagi, Kosei| Umeda, Yuzo| Yoshida, Ryuichi| Fuji, Tomokazu| Yasui, Kazuya| Yagi, Takahito| Fujiwara, Toshiyoshi| |
| Keywords | Hepaticojejunostomy Robotic surgery Pancreatoduodenectomy Biliary complications |
| Note | The version of record of this article, first published in Langenbeck's Archives of Surgery, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00423-023-03020-1| |
| Published Date | 2023-07-20 |
| Publication Title | Langenbeck's Archives of Surgery |
| Volume | volume408 |
| Issue | issue1 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 284 |
| ISSN | 1435-2451 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 37468703 |
| DOI | 10.1007/s00423-023-03020-1 |
| Web of Science KeyUT | 001032102900001 |
| Related Url | isVersionOf https://doi.org/10.1007/s00423-023-03020-1 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Takagi, Kosei| Hata, Nanako| Kimura, Jiro| Kikuchi, Satoru| Noma, Kazuhiro| Yasui, Kazuya| Fuji, Tomokazu| Yoshida, Ryuichi| Umeda, Yuzo| Yagi, Takahito| Fujiwara, Toshiyoshi| |
| Keywords | Virtual reality Robotic simulations Educational video Robotic surgery Learning curve Cumulative sum analysis |
| Note | The version of record of this article, first published in Journal of Robotic Surgery, is available online at Publisher’s website: http://dx.doi.org/10.1007/s11701-023-01556-4| |
| Published Date | 2023-03-11 |
| Publication Title | Journal of Robotic Surgery |
| Volume | volume17 |
| Issue | issue4 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 1547 |
| End Page | 1553 |
| ISSN | 1863-2491 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 36905486 |
| DOI | 10.1007/s11701-023-01556-4 |
| Web of Science KeyUT | 000946947400001 |
| Related Url | isVersionOf https://doi.org/10.1007/s11701-023-01556-4 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kawasaki, Kento| Noma, Kazuhiro| Kato, Takuya| Ohara, Toshiaki| Tanabe, Shunsuke| Takeda, Yasushige| Matsumoto, Hijiri| Nishimura, Seitaro| Kunitomo, Tomoyoshi| Akai, Masaaki| Kobayashi, Teruki| Nishiwaki, Noriyuki| Kashima, Hajime| Maeda, Naoaki| Kikuchi, Satoru| Tazawa, Hiroshi| Shirakawa, Yasuhiro| Fujiwara, Toshiyoshi| |
| Keywords | Esophageal cancer Cancer-associated fibroblasts Programmed cell death 1 Program cell death ligand 1 Immune checkpoint inhibitors |
| Note | The version of record of this article, first published in Cancer Immunology, Immunotherapy, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00262-023-03531-2| |
| Published Date | 2023-09-05 |
| Publication Title | Cancer Immunology, Immunotherapy |
| Volume | volume72 |
| Issue | issue11 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 3787 |
| End Page | 3802 |
| ISSN | 0340-7004 |
| NCID | AA00598499 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 37668710 |
| DOI | 10.1007/s00262-023-03531-2 |
| Web of Science KeyUT | 001062743200002 |
| Related Url | isVersionOf https://doi.org/10.1007/s00262-023-03531-2 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Iwamuro, Masaya| Ennishi, Daisuke| Fujii, Nobuharu| Matsuoka, Ken-Ichi| Tanaka, Takehiro| Inokuchi, Toshihiro| Hiraoka, Sakiko| Otsuka, Motoyuki| |
| Keywords | Colonoscopy Esophagogastroduodenoscopy Graft-versus-host disease Hematopoietic stem cell transplantation Intestinal transplant-associated microangiopathy iTAM |
| Note | The version of record of this article, first published in BMC Gastroenterology, is available online at Publisher’s website: http://dx.doi.org/10.1186/s12876-024-03221-y| |
| Published Date | 2024-04-22 |
| Publication Title | BMC Gastroenterology |
| Volume | volume24 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 140 |
| ISSN | 1471-230X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024. |
| File Version | publisher |
| PubMed ID | 38649868 |
| DOI | 10.1186/s12876-024-03221-y |
| Web of Science KeyUT | 001206319800003 |
| Related Url | isVersionOf https://doi.org/10.1186/s12876-024-03221-y |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Uotani, Koji| Tazawa, Hiroshi| Hasei, Joe| Fujiwara, Tomohiro| Yoshida, Aki| Yamakawa, Yasuaki| Omori, Toshinori| Sugiu, Kazuhisa| Komatsubara, Tadashi| Kondo, Hiroya| Morita, Takuya| Kiyono, Masahiro| Yokoo, Suguru| Hata, Toshiaki| Kunisada, Toshiyuki| Takeda, Ken| Urata, Yasuo| Fujiwara, Toshiyoshi| Ozaki, Toshifumi| |
| Published Date | 2024-02-20 |
| Publication Title | PLoS ONE |
| Volume | volume19 |
| Issue | issue2 |
| Publisher | Public Library of Science |
| Start Page | e0298292 |
| ISSN | 1932-6203 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 Uotani et al. |
| File Version | publisher |
| PubMed ID | 38377118 |
| DOI | 10.1371/journal.pone.0298292 |
| Web of Science KeyUT | 001176939600021 |
| Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0298292 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kobashi, Mayu| Ishikawa, Shigenao| Inaba, Tomoki| Iwamuro, Masaya| Aoyama, Yuki| Kagawa, Tomo| Takeuchi, Yasuto| Ando, Midori| Nakamura, Satoko| Okada, Hiroyuki| |
| Keywords | Frozen section Pathological diagnosis Diagnostic accuracy Early gastric cancer Endoscopic submucosal dissection Lateral margin |
| Note | The version of record of this article, first published in Surgical Endoscopy, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00464-023-10100-2| |
| Published Date | 2023-05-22 |
| Publication Title | Surgical Endoscopy |
| Volume | volume37 |
| Issue | issue9 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 6736 |
| End Page | 6748 |
| ISSN | 0930-2794 |
| NCID | AA10750363 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 37217685 |
| DOI | 10.1007/s00464-023-10100-2 |
| Web of Science KeyUT | 000993678400007 |
| Related Url | isVersionOf https://doi.org/10.1007/s00464-023-10100-2 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ihara, Hiroki| Yoshio, Kotaro| Tanabe, Shunsuke| Sugiyama, Soichi| Hashimoto, Masashi| Maeda, Naoaki| Akagi, Shinsuke| Takao, Soshi| Noma, Kazuhiro| Hiraki, Takao| |
| Keywords | Radiation therapy Esophageal squamous cell carcinoma Recurrence 18F-fluorodeoxyglucose positron emission tomography Survival |
| Note | The version of record of this article, first published in Esophagus, is available online at Publisher’s website: http://dx.doi.org/10.1007/s10388-023-01000-4| |
| Published Date | 2023-04-07 |
| Publication Title | Esophagus |
| Volume | volume20 |
| Issue | issue3 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 548 |
| End Page | 556 |
| ISSN | 1612-9059 |
| NCID | AA11885266 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 37027045 |
| DOI | 10.1007/s10388-023-01000-4 |
| Web of Science KeyUT | 000964113700001 |
| Related Url | isVersionOf https://doi.org/10.1007/s10388-023-01000-4 |
| JaLCDOI | 10.18926/AMO/66931 |
|---|---|
| FullText URL | 78_2_201.pdf |
| Author | Masunaga, Akari| Tabuchi, Motoyasu| Sakamoto, Shinya| Yoshimatsu, Rika| Matsumoto, Manabu| Iwata, Jun| Okabayashi, Takehiro| |
| Abstract | Trousseau syndrome is characterized by cancer-associated systemic thrombosis. We describe the first case of a successfully treated gallbladder adenocarcinoma accompanied by Trousseau syndrome. A 66-year-old woman presented with right hemiplegia. Magnetic resonance imaging identified multiple cerebral infarctions. Her serum carbohydrate antigen 19-9 and D-dimer levels were markedly elevated, and a gallbladder tumor was detected via abdominal computed tomography. Venous ultrasonography of the lower limbs revealed a deep venous thrombus in the right peroneal vein. These findings suggested that the brain infarctions were likely caused by Trousseau syndrome associated with her gallbladder cancer. Radical resection of the gallbladder tumor was performed. The resected gallbladder was filled with mucus and was pathologically diagnosed as an adenocarcinoma. Her postoperative course was uneventful, and she received a one-year course of adjuvant therapy with oral S-1. No cancer recurrence or thrombosis was noted 26 months postoperatively. Despite concurrent Trousseau syndrome, a radical cure of the primary tumor and thrombosis could be achieved with the appropriate treatment. |
| Keywords | gallbladder cancer Trousseau syndrome radical surgery |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 201 |
| End Page | 204 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688839 |
| Web of Science KeyUT | 001227932200001 |
| JaLCDOI | 10.18926/AMO/66930 |
|---|---|
| FullText URL | 78_2_197.pdf |
| Author | Teraishi, Fuminori| Matsumi, Yuki| Tachibana, Kota| Watanabe, Toshiyuki| Fujiwara, Toshiyoshi| |
| Abstract | A 90-year-old Japanese woman who had been aware of a subcutaneous mass on the right perineal region for 5 years was referred to our hospital for further examination and treatment because of the rapid growth of the mass and bleeding that began 3 months earlier. A biopsy of the mass revealed a diagnosis of well-differentiated squamous cell carcinoma. On preoperative examination, the tumor was 90×40 mm in size and was suspected to have partially invaded the levator ani muscle and external sphincter. Since a preoperative cardiac evaluation indicated severe aortic stenosis, we performed transcatheter aortic valve implantation. A radical resection was then performed with general anesthesia. The skin and subcutaneous tissue defects were reconstructed with a posterior gluteal-thigh propeller flap, and a sigmoid colostomy was created. The patient had a good postoperative course and was transferred to a rehabilitation facility 28 days after the surgery. Epidermal cysts are a common benign tumor, and clinicians should keep in mind that these cysts can become malignant. |
| Keywords | squamous cell carcinoma epidermoid cyst gluteal thigh flap |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 197 |
| End Page | 200 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688838 |
| Web of Science KeyUT | 001227932200004 |
| FullText URL | fulltext20240423-01.pdf fig20240423-01.pdf table20240423-01.pdf suppl20240423-01.pdf |
|---|---|
| Author | Hanzawa, Shunya| Kikuchi, Satoru| Kuroda, Shinji| Shoji, Ryohei| Kashima, Hajime| Matsumi, Yuki| Takahashi, Ayako| Kakiuchi, Yoshihiko| Takagi, Kosei| Tanabe, Shunsuke| Noma, Kazuhiro| Kagawa, Shunsuke| Shikata, Kenichi| Fujiwara, Toshiyoshi| |
| Note | This is an Accepted Manuscript of an article published by Taylor & Francis in Nutrition and Cancer on 15 Apr 2024, available at: https://doi.org/10.1080/01635581.2024.2340782.| This fulltext file will be available in Apr. 2025.| |
| Published Date | 2024-04-15 |
| Publication Title | Nutrition and Cancer |
| Volume | volume76 |
| Issue | issue6 |
| Publisher | Informa UK Limited |
| Start Page | 476 |
| End Page | 485 |
| ISSN | 0163-5581 |
| NCID | AA00325612 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 38619145 |
| DOI | 10.1080/01635581.2024.2340782 |
| Web of Science KeyUT | 001202947500001 |
| Related Url | isVersionOf https://doi.org/10.1080/01635581.2024.2340782 |
| JaLCDOI | 10.18926/AMO/66928 |
|---|---|
| FullText URL | 78_2_193.pdf |
| Author | Kashima, Hajime| Teraishi, Fuminori| Matsumi, Yuki| Shimamura, Hiroshi| Fujiwara, Toshiyoshi| |
| Abstract | Tailgut cyst is a rare cystic disease of the anterior sacral surface and the remains of an embryonic tail gut. Tailgut cysts have a potential for malignancy, and complete resection with an adequate surgical margin is necessary. Even if incomplete resection does not result in recurrence of malignant disease, there is a risk of local infection leading to refractory fistulas. The optimal treatment for such refractory recurrent lesions has not been reported. We describe a case in which the combination of laparoscopic and transsacral approaches was effective for resecting a recurrent refractory fistula after incomplete resection of a tail gut cyst. |
| Keywords | tailgut cyst laparoscopic resection fistula formation |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 193 |
| End Page | 196 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688837 |
| Web of Science KeyUT | 001227932200003 |
| JaLCDOI | 10.18926/AMO/66924 |
|---|---|
| FullText URL | 78_2_151.pdf |
| Author | Komatsubara, Tadashi| Tazawa, Hiroshi| Hasei, Joe| Omori, Toshinori| Sugiu, Kazuhisa| Mochizuki, Yusuke| Demiya, Koji| Yoshida, Aki| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi| |
| Abstract | Soft-tissue sarcoma (STS) is a heterogeneous group of rare tumors originating predominantly from the embryonic mesoderm. Despite the development of combined modalities including radiotherapy, STSs are often refractory to antitumor modalities, and novel strategies that improve the prognosis of STS patients are needed. We previously demonstrated the therapeutic potential of two telomerase-specific replication-competent oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in human STS cells. Here, we demonstrate in vitro and in vivo antitumor effects of OBP-702 in combination with ionizing radiation against human STS cells (HT1080, NMS-2, SYO-1). OBP-702 synergistically promoted the antitumor effect of ionizing radiation in the STS cells by suppressing the expression of B-cell lymphoma-X large (BCL-xL) and enhancing ionizing radiation-induced apoptosis. The in vivo experiments demonstrated that this combination therapy significantly suppressed STS tumors’ growth. Our results suggest that OBP-702 is a promising antitumor reagent for promoting the radiosensitivity of STS tumors. |
| Keywords | soft-tissue sarcoma radiotherapy oncolytic adenovirus p53 BCL-xL |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 151 |
| End Page | 161 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688833 |
| Web of Science KeyUT | 001229151800007 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kawai, Daisuke| Iwamuro, Masaya| Takenaka, Ryuta| Obata, Taisuke| Yamamoto, Takashi| Hirata, Shoichiro| Miura, Ko| Takemoto, Koji| Tsugeno, Hirofumi| Fujiki, Shigeatsu| |
| Keywords | endoscopic submucosal dissection antithrombotic agents thienopyridine gastric tumor postoperative bleeding delayed bleeding |
| Published Date | 2024-03-25 |
| Publication Title | Journal of Clinical Medicine |
| Volume | volume13 |
| Issue | issue7 |
| Publisher | MDPI |
| Start Page | 1886 |
| ISSN | 2077-0383 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by the authors. |
| File Version | publisher |
| PubMed ID | 38610651 |
| DOI | 10.3390/jcm13071886 |
| Web of Science KeyUT | 001200991800001 |
| Related Url | isVersionOf https://doi.org/10.3390/jcm13071886 |
| JaLCDOI | 10.18926/AMO/66913 |
|---|---|
| FullText URL | 78_2_107.pdf |
| Author | Han, Dongxiang| Du, Jianxiu| Wang, Wei| Wang, Cui| |
| Abstract | Vertical transmission of hepatitis B virus (HBV), especially in Asia, is a key target in the global elimination of HBV. This study assessed the effects of tenofovir disoproxil fumarate (TDF) in pregnant women for mother-to-infant transmission of HBV. A total of 122 pregnant women at our hospital met the inclusion criteria for high HBV DNA viral loads. They were randomly divided into TDF-treatment (n=70) and placebo (n=52) groups. Maternal liver function and serum HBV DNA load were tested before and after treatment. Clinical and laboratory data of infants were assayed at delivery and 7-months post-partum visit and compared between the two groups. There was no difference in clinical characteristics of participants between the two groups. There were no significant differences in liver function markers, including alanine aminotransferase, total bilirubin, blood creatinine, and blood urea nitrogen levels before and after TDF treatment. The serum HBV DNA viral load of the TDF-treated group became significantly lower than those of the control group and their own pre-medication levels. Infants showed no significant difference in body growth, including weight, height, head size, and five-min Apgar score. At 7 months after birth, 94.29% of infants in the TDF group and 86.54% of control-group infants had protective HBsAb levels ≥ 10 mIU/ml (p>0.05). The HBV infection rate of infants in the TDF-treated group was lower than that in the non-treated group. In high-HBV-DNA-load pregnant women, TDF administered from 28 weeks gestational age to delivery was associated with a lower risk of mother-to-infant transmission of HBV. |
| Keywords | mother-to-infant transmission tenofovir disoproxil fumarate hepatitis B virus |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 107 |
| End Page | 113 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688828 |
| Web of Science KeyUT | 001229151800002 |
