result 348 件
| JaLCDOI | 10.18926/AMO/64025 |
|---|---|
| FullText URL | 76_5_503.pdf |
| Author | Ogawa, Hirohito| Honda, Tomoyuki| |
| Abstract | Eukaryotic genomes contain numerous copies of endogenous viral elements (EVEs), most of which are considered endogenous retrovirus (ERV) sequences. Over the past decade, non-retroviral endogenous viral elements (nrEVEs) derived from ancient RNA viruses have been discovered. Several functions have been proposed for these elements, including antiviral defense. This review summarizes the current understanding of nrEVEs derived from RNA viruses, particularly endogenous bornavirus-like elements (EBLs) and endogenous filovirus-like elements (EFLs). EBLs are one of the most extensively studied nrEVEs. The EBL derived from bornavirus nucleoprotein (EBLN) is thought to function as a non-coding RNA or protein that regulates host gene expression or inhibits virus propagation. Ebolavirus and marburgvirus, which are filoviruses, induce severe hemorrhagic fever in humans and nonhuman primates. Although the ecology of filoviruses remains unclear, bats are believed to be potential reservoirs. Based on the knowledge from EBLs, it is postulated that EFLs in the bat genome help to maintain the balance between filovirus infection and the bat’s defense system, which may partially explain why bats act as potential reservoirs. Further research into the functions of nrEVEs could reveal novel antiviral systems and inspire novel antiviral approaches. |
| Keywords | EVE nrEVE bornavirus filovirus antiviral |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-10 |
| Volume | volume76 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 503 |
| End Page | 510 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36352796 |
| Web of Science KeyUT | 000884907100002 |
| JaLCDOI | 10.18926/AMO/64024 |
|---|---|
| FullText URL | 76_5_489.pdf |
| Author | Matsumoto, Yuji| Ichikawa, Tomotsugu| Kurozumi, Kazuhiko| Date, Isao| |
| Abstract | Glioblastoma (GBM) is a fatal primary malignant brain tumor in adults. Despite decades of research, the prognosis for GBM patients is still disappointing. One major reason for the intense therapeutic resistance of GBM is inter- and intra-tumor heterogeneity. GBM-intrinsic transcriptional profiling has suggested the presence of at least three subtypes of GBM: the proneural, classic, and mesenchymal subtypes. The mesenchymal subtype is the most aggressive, and patients with the mesenchymal subtype of primary and recurrent tumors tend to have a worse prognosis compared with patients with the other subtypes. Furthermore, GBM can shift from other subtypes to the mesenchymal subtype over the course of disease progression or recurrence. This phenotypic transition is driven by diverse tumor-intrinsic molecular mechanisms or microenvironmental factors. Thus, better understanding of the plastic nature of mesenchymal transition in GBM is pivotal to developing new therapeutic strategies. In this review, we provide a comprehensive overview of the current understanding of the elements involved in the mesenchymal transition of GBM and discuss future perspectives. |
| Keywords | glioma glioblastoma mesenchymal subtype mesenchymal transition heterogeneity |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-10 |
| Volume | volume76 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 489 |
| End Page | 502 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36352795 |
| Web of Science KeyUT | 000884907100001 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sukegawa, Shintaro| Tanaka, Futa| Hara, Takeshi| Yoshii, Kazumasa| Yamashita, Katsusuke| Nakano, Keisuke| Takabatake, Kiyofumi| Kawai, Hotaka| Nagatsuka, Hitoshi| Furuki, Yoshihiko| |
| Published Date | 2022-10-08 |
| Publication Title | Scientific Reports |
| Volume | volume12 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 16925 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022 |
| File Version | publisher |
| PubMed ID | 36209283 |
| DOI | 10.1038/s41598-022-21408-9 |
| Web of Science KeyUT | 000865228800021 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-022-21408-9 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hagiya, Hideharu| Takase, Ryosuke| Honda, Hiroyuki| Nakano, Yasuhiro| Otsuka, Yuki| Kataoka, Hitomi| Uno, Mika| Ueda, Keigo| Takahashi, Misa| Ogawa, Hiroko| Hanayama, Yoshihisa| Otsuka, Fumio| |
| Keywords | Traffic safety Older people Aging Motor vehicle accidents Frailty Dementia Polypharmacy Sarcopenia |
| Published Date | 2022-10-11 |
| Publication Title | BMC Geriatrics |
| Volume | volume22 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 792 |
| ISSN | 1471-2318 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022. |
| File Version | publisher |
| PubMed ID | 36221051 |
| DOI | 10.1186/s12877-022-03490-w |
| Web of Science KeyUT | 000866114200002 |
| Related Url | isVersionOf https://doi.org/10.1186/s12877-022-03490-w |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Naka, Shuhei| Matsuoka, Daiki| Goto, Kana| Misaki, Taro| Nagasawa, Yasuyuki| Ito, Seigo| Nomura, Ryota| Nakano, Kazuhiko| Matsumoto-Nakano, Michiyo| |
| Keywords | Streptococcus mutans collagen-binding protein membrane permeability cell structure RNA-seq |
| Published Date | 2022-09-13 |
| Publication Title | Frontiers In Cellular And Infection Microbiology |
| Volume | volume12 |
| Publisher | Frontiers Media S.A. |
| Start Page | 994014 |
| ISSN | 2235-2988 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Naka, Matsuoka, Goto, Misaki, Nagasawa, Ito, Nomura, Nakano and Matsumoto-Nakano. |
| File Version | publisher |
| PubMed ID | 36176579 |
| DOI | 10.3389/fcimb.2022.994014 |
| Web of Science KeyUT | 000861324100001 |
| Related Url | isVersionOf https://doi.org/10.3389/fcimb.2022.994014 |
| JaLCDOI | 10.18926/AMO/63907 |
|---|---|
| FullText URL | 76_4_473.pdf |
| Author | Tsuboi, Nobushige| Ishida, Joji| Shimazu, Yosuke| Edaki, Hisanori| Uneda, Atsuhito| Otani, Yoshihiro| Fujii, Kentaro| Kurozumi, Kazuhiko| Ennishi, Daisuke| Yanai, Hiroyuki| Date, Isao| |
| Abstract | Glioneuronal tumor with neuropil-like islands (GNTNI) is a very rare subtype of glioneuronal tumor. We present a case of a 62-year-old man with GNTNI. Two adjacent lesions in the left parietal lobe were removed by left parietal craniotomy. The histological findings were glial cell proliferation and scattered rosettes consisting of synaptophysin-positive and NeuN-positive cells, leading to the diagnosis of GNTNI. Target sequencing revealed a genetic alteration similar to glioblastoma, IDH-wild type, which suggested adjuvant therapies. There are few previous reports on the treatment of this disease, and the patient should be followed carefully. |
| Keywords | glioneuronal tumor with neuropil-like islands genomic profiling |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-08 |
| Volume | volume76 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 473 |
| End Page | 477 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36123163 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Soejima, Yoshiaki| Iwata, Nahoko| Nakayama, Nanako| Hirata, Shinichi| Nakano, Yasuhiro| Yamamoto, Koichiro| Suyama, Atsuhito| Oguni, Kohei| Nada, Takahiro| Fujisawa, Satoshi| Otsuka, Fumio| |
| Keywords | bone morphogenetic protein (BMP) clock gonadotropin orexin pituitary |
| Published Date | 2022-08-29 |
| Publication Title | International Journal Of Molecular Sciences |
| Volume | volume23 |
| Issue | issue17 |
| Publisher | MDPI |
| Start Page | 9782 |
| ISSN | 1422-0067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 36077179 |
| DOI | 10.3390/ijms23179782 |
| Web of Science KeyUT | 000851102000001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms23179782 |
| FullText URL | fulltext20220906-1.pdf |
|---|---|
| Author | Kakehi, Ayaka| Hagiya, Hideharu| Iio, Koji| Nakano, Yasuhiro| Ihoriya, Hiromi| Taira, Yuki| Nakamoto, Kenta| Hasegawa, Kou| Higashikage, Akihito| Otsuka, Fumio| |
| Keywords | Candida dubliniensis Candidemia COVID-19 Sequencing analysis |
| Note | © 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.jiac.2022.07.007] . | |
| Published Date | 2022-10 |
| Publication Title | Journal of Infection and Chemotherapy |
| Volume | volume28 |
| Issue | issue10 |
| Publisher | Elsevier BV |
| Start Page | 1433 |
| End Page | 1435 |
| ISSN | 1341-321X |
| NCID | AA11057978 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. |
| File Version | author |
| PubMed ID | 35863730 |
| DOI | 10.1016/j.jiac.2022.07.007 |
| Web of Science KeyUT | 000843880400016 |
| Related Url | isVersionOf https://doi.org/10.1016/j.jiac.2022.07.007 |
| FullText URL | fulltext20220830-4.pdf CMT2Z Figure NCN revise.tif CMT2Z Table NCN revise.tif |
|---|---|
| Author | Nomura, Emi| Tadokoro, Koh| Sasaki, Ryo| Nakata, Yumi| Nakano, Yumiko| Yunoki, Taijun| Takemoto, Mami| Morihara, Ryuta| Ando, Masahiro| Takashima, Hiroshi| Yamashita, Toru| |
| Keywords | Charcot-Marie-Tooth disease type 2Z MORC2 retinitis pigmentosa |
| Note | This is the peer reviewed version of the following article: [Nomura, E, Tadokoro, K, Sasaki, R, et al. Japanese case of Charcot–Marie–Tooth disease type 2Z with severe retinitis pigmentosa. Neurol Clin Neurosci. 2022; 10: 266-268. doi: 10.1111/ncn3.12660], which has been published in final form at [https://doi.org/10.1111/ncn3.12660]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| |
| Published Date | 2022-08-15 |
| Publication Title | Neurology and Clinical Neuroscience |
| Volume | volume10 |
| Issue | issue5 |
| Publisher | Wiley |
| Start Page | 266 |
| End Page | 268 |
| ISSN | 2049-4173 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Japanese Society of Neurology and John Wiley & Sons Australia, Ltd. |
| File Version | author |
| DOI | 10.1111/ncn3.12660 |
| Web of Science KeyUT | 000843400700001 |
| Related Url | isVersionOf https://doi.org/10.1111/ncn3.12660 |
| FullText URL | fulltext20220830-3.pdf |
|---|---|
| Author | Amioka, Naofumi| Takaishi, Atsushi| Nakamura, Kazufumi| Endo, Toyohiro| Iida, Toshihiro| Yamaji, Tatsuya| Mori, Hisatoshi| Kishinoue, Takao| Yasuhara, Kentaro| Matsuo, Naoaki| Tanimoto, Masafumi| Nakano, Yukari| Onishi, Nobuhiko| Ueeda, Masayuki| Ito, Hiroshi| |
| Keywords | Clinical pathway Acute decompensated heart failure Tolvaptan Cardiac rehabilitation Prognosis |
| Note | © 2022 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.jjcc.2022.03.014] . | |
| Published Date | 2022-09 |
| Publication Title | Journal of Cardiology |
| Volume | volume80 |
| Issue | issue3 |
| Publisher | Elsevier BV |
| Start Page | 232 |
| End Page | 239 |
| ISSN | 0914-5087 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Elsevier B.V. |
| File Version | author |
| PubMed ID | 35428556 |
| DOI | 10.1016/j.jjcc.2022.03.014 |
| Web of Science KeyUT | 000838175500008 |
| Related Url | isVersionOf https://doi.org/10.1016/j.jjcc.2022.03.014 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sukegawa, Shintaro| Tanaka, Futa| Nakano, Keisuke| Hara, Takeshi| Yoshii, Kazumasa| Yamashita, Katsusuke| Ono, Sawako| Takabatake, Kiyofumi| Kawai, Hotaka| Nagatsuka, Hitoshi| Furuki, Yoshihiko| |
| Published Date | 2022-08-02 |
| Publication Title | Scientific Reports |
| Volume | volume12 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 13281 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022 |
| File Version | publisher |
| PubMed ID | 35918498 |
| DOI | 10.1038/s41598-022-17602-4 |
| Web of Science KeyUT | 000836651200038 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-022-17602-4 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tokumasu, Kazuki| Honda, Hiroyuki| Sunada, Naruhiko| Sakurada, Yasue| Matsuda, Yui| Yamamoto, Koichiro| Nakano, Yasuhiro| Hasegawa, Toru| Yamamoto, Yukichika| Otsuka, Yuki| Hagiya, Hideharu| Kataoka, Hitomi| Ueda, Keigo| Otsuka, Fumio| |
| Keywords | general fatigue post-exertional malaise long COVID myalgic encephalomyelitis chronic fatigue syndrome post COVID-19 condition |
| Published Date | 2022-06-25 |
| Publication Title | Medicina |
| Volume | volume58 |
| Issue | issue7 |
| Publisher | MDPI |
| Start Page | 850 |
| ISSN | 1010-660X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 35888568 |
| DOI | 10.3390/medicina58070850 |
| Web of Science KeyUT | 000834490500001 |
| Related Url | isVersionOf https://doi.org/10.3390/medicina58070850 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Shimizu, Rieko| Sukegawa, Shintaro| Sukegawa, Yuka| Hasegawa, Kazuaki| Ono, Sawako| Nakamura, Tomoya| Fujimura, Ai| Fujisawa, Ayaka| Nakano, Keisuke| Takabatake, Kiyofumi| Kawai, Hotaka| Nagatsuka, Hitoshi| Furuki, Yoshihiko| |
| Keywords | anti-resorptive agent-related osteonecrosis of the jaw bisphosphonate denosumab retrospective study risk factor tooth extraction |
| Published Date | 2022-07-18 |
| Publication Title | Healthcare |
| Volume | volume10 |
| Issue | issue7 |
| Publisher | MDPI |
| Start Page | 1332 |
| ISSN | 2227-9032 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 35885858 |
| DOI | 10.3390/healthcare10071332 |
| Web of Science KeyUT | 000831605200001 |
| Related Url | isVersionOf https://doi.org/10.3390/healthcare10071332 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sukegawa, Shintaro| Sukegawa, Yuka| Hasegawa, Kazuaki| Ono, Sawako| Nakamura, Tomoya| Fujimura, Ai| Fujisawa, Ayaka| Nakano, Keisuke| Takabatake, Kiyofumi| Kawai, Hotaka| Mukainaka, Yumika| Nagatsuka, Hitoshi| Furuki, Yoshihiko| |
| Keywords | hepatitis B hepatitis C human immunodeficiency virus pre-operative examination |
| Published Date | 2022-07-20 |
| Publication Title | Healthcare |
| Volume | volume10 |
| Issue | issue7 |
| Publisher | MDPI |
| Start Page | 1348 |
| ISSN | 2227-9032 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 35885875 |
| DOI | 10.3390/healthcare10071348 |
| Web of Science KeyUT | 000832459200001 |
| Related Url | isVersionOf https://doi.org/10.3390/healthcare10071348 |
| FullText URL | fulltext20220708-3.pdf |
|---|---|
| Author | Nomura, Emi| Omote, Yoshio| Takemoto, Mami| Hishikawa, Nozomi| Nakano, Yumiko| Yunoki, Taijun| Morihara, Ryuta| Sasaki, Tatsuya| Akagawa, Hiroyuki| Abe, Koji| Yamashita, Toru| |
| Keywords | CCM2 cerebral cavernous malformation drug-resistant epilepsy |
| Note | This is the peer reviewed version of the following article: [Nomura, E, Omote, Y, Takemoto, M, et al. A Japanese case of successful surgical resection of cerebral cavernous malformations with a CCM2 mutation. Neurol Clin Neurosci. 2022; 10: 255- 258. doi: 10.1111/ncn3.12649], which has been published in final form at [https://doi.org/10.1111/ncn3.12649]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| |
| Published Date | 2022-06-15 |
| Publication Title | Neurology and Clinical Neuroscience |
| Volume | volume10 |
| Issue | issue5 |
| Publisher | Wiley |
| Start Page | 255 |
| End Page | 258 |
| ISSN | 2049-4173 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Japanese Society of Neurology and John Wiley & Sons Australia, Ltd. |
| File Version | author |
| DOI | 10.1111/ncn3.12649 |
| Web of Science KeyUT | 000818581000001 |
| Related Url | isVersionOf https://doi.org/10.1111/ncn3.12649 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tokumasu, Kazuki| Ueda, Keigo| Honda, Hiroyuki| Sunada, Naruhiko| Sakurada, Yasue| Matsuda, Yui| Nakano, Yasuhiro| Hasegawa, Toru| Otsuka, Yuki| Obika, Mikako| Hagiya, Hideharu| Kataoka, Hitomi| Otsuka, Fumio| |
| Keywords | general fatigue herbal medicine Kampo medicine long COVID |
| Published Date | 2022-05-28 |
| Publication Title | Medicina |
| Volume | volume58 |
| Issue | issue6 |
| Publisher | MDPI |
| Start Page | 730 |
| ISSN | 1010-660X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 35743993 |
| DOI | 10.3390/medicina58060730 |
| Web of Science KeyUT | 000818259300001 |
| Related Url | isVersionOf https://doi.org/10.3390/medicina58060730 |
| JaLCDOI | 10.18926/AMO/63746 |
|---|---|
| FullText URL | 76_3_343.pdf |
| Author | Maki, Yuho| Kiriyama, Yosuke| Ueno, Tsuyoshi| Suehisa, Hiroshi| Shigematsu, Hisayuki| Saeki, Kazuhiko| Harada, Daijiro| Kozuki, Toshiyuki| Teramoto, Norihiro| Yamashita, Motohiro| |
| Abstract | Localized malignant mesothelioma is a rare disease and little is known about its treatment strategy. We herein report a case of localized malignant pleural mesothelioma that had infiltrated into the anterior mediastinum, which was successfully treated using chemotherapy and conversion surgery. A 63-year-old man with a mediastinal tumor was referred to our hospital. Pathologic analysis of the biopsy specimen showed malignant mesothelioma. Significant tumor shrinkage by cisplatin and pemetrexed was observed and he underwent radical surgery via a median sternotomy. The patient has been disease free for 12 months. |
| Keywords | localized mesothelioma mediastinum cisplatin pemetrexed conversion surgery |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-06 |
| Volume | volume76 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 343 |
| End Page | 347 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35790367 |
| Web of Science KeyUT | 000823568300015 |
| JaLCDOI | 10.18926/AMO/63718 |
|---|---|
| FullText URL | 76_3_247.pdf |
| Author | Yoshida, Shohei| Fujii, Nobuharu| Kamoi, Chihiro| Kitamura, Wataru| Fujiwara, Hideaki| Asada, Noboru| Nishimori, Hisakazu| Fujii, Keiko| Matsuoka, Ken-ichi| Maeda, Yoshinobu| |
| Abstract | Vaccine-preventable disease (VPD) infections are more severe in immunocompromised hosts. Vaccination against measles, mumps, rubella, and varicella zoster (VZV) (MMRV) is therefore recommended for hematopoietic stem cell transplantation (HCT) recipients. However, studies on adult HCT recipients with VPD infections are limited. At our institution, we have systematically conducted serological MMRV tests as a part of check-up examinations during long-term follow-up (LTFU) after HCT since 2015. This retrospective study aimed to evaluate changes in the serostatus between before and 2 years after allogeneic HCT. Among 161 patients, the pre-transplant seropositivity was 82.7% for measles, 86.8% for mumps, 84.2% for rubella, and 94.3% for VZV. Among 56 patients who underwent LTFU including serological MMRV tests at 2 years after HCT, the percentages maintaining seroprotective antibody levels for measles, mumps, rubella and VZV were 71.5% (40/56), 51.8% (29/56), 48.2% (27/56), and 60.7% (34/56), respectively. Vaccination was recommended for 22 patients, and 12 were vaccinated. Among the 12 vaccinated patients, rates of seroconversion were examined in 2-6 patients for each of the four viruses. They were 100% (3/3) for measles, 33.3% (1/3) for mumps, 50% (3/6) for rubella, and 0% (0/2) for VZV. Further studies are warranted to clarify the effect of vaccination in adult HCT recipients. |
| Keywords | vaccine-preventable disease vaccination allogeneic hematopoietic stem cell transplantation adult |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-06 |
| Volume | volume76 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 247 |
| End Page | 253 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35790354 |
| Web of Science KeyUT | 000823568300003 |
| FullText URL | K0006571_abstract_review.pdf K0006571_summary.pdf K0006571_fulltext.pdf |
|---|---|
| Author | Takase, Ryosuke| |
| Published Date | 2022-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6571号 |
| Granted Date | 2022-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sukegawa, Shintaro| Shimizu, Rieko| Sukegawa, Yuka| Hasegawa, Kazuaki| Ono, Sawako| Fujimura, Ai| Yamamoto, Izumi| Nakano, Keisuke| Takabatake, Kiyofumi| Kawai, Hotaka| Nagatsuka, Hitoshi| Furuki, Yoshihiko| |
| Keywords | retrospective cohort study endoscope endodontic surgery prognostic factors |
| Published Date | 2022-05-07 |
| Publication Title | Materials |
| Volume | volume15 |
| Issue | issue9 |
| Publisher | MDPI |
| Start Page | 3353 |
| ISSN | 1996-1944 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 35591687 |
| DOI | 10.3390/ma15093353 |
| Web of Science KeyUT | 000794818400001 |
| Related Url | isVersionOf https://doi.org/10.3390/ma15093353 |
