result 324 件
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ejiri, Kentaro| Miyoshi, Toru| Kihara, Hajime| Hata, Yoshiki| Nagano, Toshihiko| Takaishi, Atsushi| Toda, Hironobu| Nanba, Seiji| Nakamura, Yoichi| Akagi, Satoshi| Sakuragi, Satoru| Minagawa, Taro| Kawai, Yusuke| Nishii, Nobuhiro| Fuke, Soichiro| Yoshikawa, Masaki| Nakamura, Kazufumi| Ito, Hiroshi| |
| Keywords | B-type natriuretic peptide diabetes mellitus heart failure sodium-glucose cotransporter 2 inhibitor |
| Published Date | 2020-08-18 |
| Publication Title | Journal of the American Heart association |
| Volume | volume9 |
| Issue | issue16 |
| Publisher | Wiley |
| Start Page | e015103 |
| ISSN | 2047-9980 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Authors. |
| File Version | publisher |
| PubMed ID | 32805185 |
| DOI | 10.1161/JAHA.119.015103 |
| Web of Science KeyUT | 000574868200036 |
| Related Url | isVersionOf https://doi.org/10.1161/JAHA.119.015103 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Fujimura, Atsushi| Yasui, Seiji| Igawa, Kazuyo| Ueda, Ai| Watanabe, Kaori| Hanafusa, Tadashi| Ichikawa, Yasuaki| Yoshihashi, Sachiko| Tsuchida, Kazuki| Kamiya, Atsunori| Furuya, Shuichi| |
| Keywords | boron neutron capture therapy (BNCT) BSH-polyR CD44 translational machinery bioinformatics |
| Published Date | 2020-09-23 |
| Publication Title | Cells |
| Volume | volume9 |
| Issue | issue10 |
| Publisher | MDPI |
| Start Page | 2149 |
| ISSN | 2073-4409 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 by the authors. |
| File Version | publisher |
| PubMed ID | 32977522 |
| DOI | 10.3390/cells9102149 |
| Web of Science KeyUT | 000584223000001 |
| Related Url | isVersionOf https://doi.org/10.3390/cells9102149 |
| JaLCDOI | 10.18926/AMO/60807 |
|---|---|
| FullText URL | 74_5_449.pdf |
| Author | Tsuchiya, Junpei| Kondo, Naoki| Fujimoto, Atsushi| Kondo, Rie| Yamada, Masahiko| Kuraishi, Tatsuya| Yoda, Takuya| Abe, Riichiro| Endo, Naoto| |
| Abstract | We report a case of psoriatic arthritis where oligoarthritis preceded the skin lesions. A 57-year-old man complained of left third-finger pain. Laboratory examinations were negative for anti-cyclic citrullinated peptide antibodies and rheumatoid factor; he was treated for suspected rheumatoid arthritis. Six years later, X-ray revealed enthesitis of his fingers and wrist joint. At 9.5 years after the initial visit, skin lesions appeared in the left auricular region and buttock and dermatopathology findings indicated psoriasis vulgaris. The final diagnosis was psoriatic arthritis. In cases of seronegative oligoarthritis, psoriatic arthritis must be considered because some patients demonstrate osteoarticular lesions preceding skin lesions. |
| Keywords | enthesitis psoriatic arthritis seronegative oligoarthritis classification criteria for psoriatic arthritis |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-10 |
| Volume | volume74 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 449 |
| End Page | 453 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33106703 |
| Web of Science KeyUT | 000581970100012 |
| NAID | 120006892933 |
| JaLCDOI | 10.18926/AMO/60797 |
|---|---|
| FullText URL | 74_5_381.pdf |
| Author | Yamamoto, Koichiro| Hanayama, Yoshihisa| Hasegawa, Kou| Tokumasu, Kazuki| Miyoshi, Tomoko| Hagiya, Hideharu| Ogawa, Hiroko| Obika, Mikako| Itoshima, Koichi| Otsuka, Fumio| |
| Abstract | To clarify the relevance of prolactin (PRL) to clinical parameters in patients who visited our general medicine department, medical records of 353 patients in whom serum PRL levels were measured during the period from 2016 to 2018 were retrospectively reviewed. Data for 140 patients (M/F: 42/98) were analyzed after excluding patients lacking detailed records and patients taking dopaminergic agents. Median serum PRL levels were significantly lower in males than females: 6.5 ng/ml (IQR: 4.2-10.3) versus 8.1 ng/ml (5.9-12.9), respectively. Pain and general fatigue were the major symptoms at the first visit, and past histories of hypertension and dyslipidemia were frequent. Male patients with relatively high PRL levels (≥ 10 ng/ml) had significantly lower levels of serum albumin and significantly higher levels of serum LDH than those with low PRL (< 10 ng/ml). There were significant correlations of male PRL level with the erythrocyte sedimentation rate (R=0.62), serum LDH level (R=0.39) and serum albumin level (R=−0.52), while the level of serum CRP (R=0.33) showed an insignificant but weak positive correlation with PRL level. Collectively, these results show that PRL levels had gender-specific relevance to various clinical factors, with PRL levels in males being significantly related to inflammatory status. |
| Keywords | hormones hyperprolactinemia inflammation pituitary prolactin |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-10 |
| Volume | volume74 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 381 |
| End Page | 389 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33106693 |
| Web of Science KeyUT | 000581970100002 |
| NAID | 120006892923 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nojima, Ichiro| Eikawa, Shingo| Tomonobu, Nahoko| Hada, Yoshiko| Kajitani, Nobuo| Teshigawara, Sanae| Miyamoto, Satoshi| Tone, Atsuhito| Uchida, Haruhito A.| Nakatsuka, Atsuko| Eguchi, Jun| Shikata, Kenichi| Udono, Heiichiro| Wada, Jun| |
| Keywords | Cytokines Diabetes Endocrine system and metabolic diseases Immunology Tumour immunology |
| Published Date | 2020-09-10 |
| Publication Title | Scientific Reports |
| Volume | volume10 |
| Issue | issue1 |
| Publisher | Nature Research |
| Start Page | 14928 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2020 |
| File Version | publisher |
| PubMed ID | 32913271 |
| DOI | 10.1038/s41598-020-71946-3 |
| Web of Science KeyUT | 000571915100049 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-020-71946-3 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kawakami, Natsuko| Otubo, Akito| Maejima, Sho| Talukder, Ashraf H.| Satoh, Keita| Oti, Takumi| Takanami, Keiko| Ueda, Yasumasa| Itoi, Keiichi| Morris, John F.| Sakamoto, Tatsuya| Sakamoto, Hirotaka| |
| Keywords | copeptin hypothalamo‐pituitary–adrenal system immunohistochemistry paraventricular nucleus of the hypothalamus processing vasopressin RRID: AB_2722604 RRID: AB_2061966 RRID: AB_2314234 RRID: AB_10013361 RRID: AB_2313960 RRID: AB_2722605 RRID: AB_90782 |
| Published Date | 2020-09-06 |
| Publication Title | Journal of Comparative Neurology |
| Volume | volume529 |
| Issue | issue7 |
| Publisher | Wiley |
| Start Page | 1372 |
| End Page | 1390 |
| ISSN | 0021-9967 |
| NCID | AA00695917 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Authors. |
| File Version | publisher |
| PubMed ID | 32892351 |
| DOI | 10.1002/cne.25026 |
| Web of Science KeyUT | 000571267600001 |
| Related Url | isVersionOf https://doi.org/10.1002/cne.25026 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tsutsui, Naoaki| Kobayashi, Yasuhisa| Izumikawa, Kouichi| Sakamoto, Tatsuya| |
| Keywords | peptide hormone Marsupenaeus japonicus ovary reproduction transcriptome vitellogenesis |
| Published Date | 2020-08-19 |
| Publication Title | Frontiers in Endocrinology |
| Volume | volume11 |
| Publisher | Frontiers Media |
| Start Page | 541 |
| ISSN | 1664-2392 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 Tsutsui, Kobayashi, Izumikawa and Sakamoto. |
| File Version | publisher |
| DOI | 10.3389/fendo.2020.00541 |
| Web of Science KeyUT | 000566191000001 |
| Related Url | isVersionOf https://doi.org/10.3389/fendo.2020.00541 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kobashi, Motoi| Shimatani, Yuichi| Fujita, Masako| Mitoh, Yoshihiro| Yoshida, Ryusuke| Matsuo, Ryuji| |
| Keywords | GLP-1 orexin SB334867 swallowing NTS rats |
| Published Date | 2020-06-22 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume21 |
| Issue | issue12 |
| Publisher | MDPI |
| Start Page | 4422 |
| ISSN | 1661-6596 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 by the authors. |
| File Version | publisher |
| PubMed ID | 32580304 |
| DOI | 10.3390/ijms21124422 |
| Web of Science KeyUT | 000553935000001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms21124422 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nakamura, Shunsuke| Matsuno, Aya| Ueda, Masashi| |
| Keywords | αvβ6 integrin Pancreatic ductal adenocarcinoma (PDAC) A20FMDV2 Aspartic acids Electric charge |
| Note | This is a post-peer-review, pre-copyedit version of an article published in Annals of Nuclear Medicine. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12149-020-01483-6.| |
| Published Date | 2020-06-08 |
| Publication Title | Annals of Nuclear Medicine |
| Volume | volume34 |
| Publisher | Springer |
| Start Page | 575 |
| End Page | 582 |
| ISSN | 0914-7187 |
| NCID | AA10708017 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 32514725 |
| DOI | 10.1007/s12149-020-01483-6 |
| Web of Science KeyUT | 000539348100001 |
| Related Url | isVersionOf https://doi.org/10.1007/s12149-020-01483-6 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kaito, Chikara| Yoshikai, Hirono| Wakamatsu, Ai| Miyashita, Atsushi| Matsumoto, Yasuhiko| Fujiyuki, Tomoko| Kato, Masaru| Ogura, Yoshitoshi| Hayashi, Tetsuya| Isogai, Takao| Sekimizu, Kazuhisa| |
| Published Date | 2020-04-23 |
| Publication Title | PLoS Pathogens |
| Volume | volume16 |
| Issue | issue4 |
| Publisher | Public Library of Science |
| Start Page | e1008469 |
| ISSN | 1553-7366 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 Kaito et al. |
| File Version | publisher |
| PubMed ID | 32324807 |
| DOI | 10.1371/journal.ppat.1008469 |
| Web of Science KeyUT | 000531365400025 |
| Related Url | isVersionOf https://doi.org/10.1371/journal.ppat.1008469 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ui, Takashi| Ueda, Masashi| Higaki, Yusuke| Kamino, Shinichiro| Sano, Kohei| Kimura, Hiroyuki| Saji, Hideo| Enomoto, Shuichi| |
| Keywords | αvβ6 integrin Pancreatic ductal adenocarcinoma Gallium-68 A20FMDV2 peptide Positron emission tomography |
| Note | © 2019 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 License.http://creativecommons.org/licenses/by-nc-nd/4.0/.This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.bmc.2019.115189] .| |
| Published Date | 2020-01-01 |
| Publication Title | Bioorganic & Medicinal Chemistry |
| Volume | volume28 |
| Issue | issue1 |
| Publisher | Elsevier |
| Start Page | 115189 |
| ISSN | 0968-0896 |
| NCID | AA10938083 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 Elsevier Ltd |
| File Version | author |
| PubMed ID | 31740201 |
| DOI | 10.1016/j.bmc.2019.115189 |
| Web of Science KeyUT | 000503435200011 |
| Related Url | isVersionOf https://doi.org/10.1016/j.bmc.2019.115189 |
| JaLCDOI | 10.18926/AMO/58269 |
|---|---|
| FullText URL | 74_2_115.pdf |
| Author | Kotani, Sayoko| Kamada, Yasuhiko| Shimizu, Keiko| Sakamoto, Ai| Nakatsuka, Mikiya| Hiramatsu, Yuji| Masuyama, Hisashi| |
| Abstract | Thrombosis in decidual vessels is one of the mechanisms of pregnancy loss. However, few studies have assessed the relation between platelet activation, which is known to cause of thrombosis, and recurrent pregnancy loss (RPL). We investigated platelet activation in women with RPL compared to controls by measuring plasma levels of platelet factor 4 (PF4) and β-thromboglobulin (βTG), and assessed correlations between PF4/βTG and coagulative risk factors associated with RPL. The study group included 135 women who had experienced two or more consecutive pregnancy losses. The control group included 28 age-matched healthy women who had never experienced pregnancy loss. PF4 and βTG plasma levels were significantly higher in the women with RPL than controls (PF4: 14.0 [8.0-20.0] vs. 9.0 [6.0-12.0] ng/ml, p=0.043; βTG: 42.0 [24.3-59.8] vs. 31.5 [26.6-36.4] ng/ml, p=0.002). There was a significant association between βTG and anti-phosphatidylethanolamine antibody immunoglobulin M (aPE IgM) (p=0.048). Among the women with RPL, 18 of those who were positive for PF4 (45%) and 18 of those who were positive for βTG (37%) were negative for all known coagulative risk factors associated with RPL. Measurements of PF4 and βTG may be important because they help identify women who are at risk of RPL. |
| Keywords | recurrent pregnancy loss platelet factor 4 β-thromboglobulin platelet activation |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-04 |
| Volume | volume74 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 115 |
| End Page | 122 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32341585 |
| Web of Science KeyUT | 000528278500004 |
| NAID | 120006839448 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Wang, Pingyu| Yao, Shaolun| Kosami, Ken-ichi| Guo, Ting| Li, Jing| Zhang, Yuanyuan| Fukao, Yoichiro| Kaneko-Kawano, Takako| Zhang, Heng| She, Yi-Min| Wang, Pengcheng| Xing, Weiman| Hanada, Kousuke| Liu, Renyi| Kawano, Yoji| |
| Keywords | immunity Magnaporthe oryzae proteomics transcriptomics rice signalling peptide small secreted protein |
| Published Date | 2019-07-13 |
| Publication Title | Plant Biotechnology Journal |
| Volume | volume18 |
| Issue | issue2 |
| Publisher | Wiley |
| Start Page | 415 |
| End Page | 428 |
| ISSN | 1467-7644 |
| NCID | AA11805223 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 The Authors. |
| File Version | publisher |
| PubMed ID | 31301098 |
| DOI | 10.1111/pbi.13208 |
| Web of Science KeyUT | 000481134300001 |
| Related Url | isVersionOf https://doi.org/10.1111/pbi.13208 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | El-Aarag, Bishoy| Magdy, Mohamed| AlAjmi, Mohamed F.| Khalifa, Shaden A. M.| El-Seedi, Hesham R.| |
| Keywords | paraquat lung injury melittin oxidative stress apoptosis |
| Published Date | 2019-04-16 |
| Publication Title | Molecures |
| Volume | volume24 |
| Issue | issue8 |
| Publisher | MDPI |
| ISSN | 1420-3049 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 by the authors. |
| File Version | publisher |
| PubMed ID | 30995821 |
| DOI | 10.3390/molecules24081498 |
| Web of Science KeyUT | 000467765700053 |
| Related Url | isVersionOf https://doi.org/10.3390/molecules24081498 |
| FullText URL | SR9_1_3745.pdf |
|---|---|
| Author | Matsushima, Ryo| Hisano, Hiroshi| |
| Published Date | 2019-3-6 |
| Publication Title | Scientific Reports |
| Volume | volume9 |
| Publisher | Nature Publishing Group |
| Start Page | 3745 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2019 |
| File Version | publisher |
| PubMed ID | 30842645 |
| DOI | 10.1038/s41598-019-40424-w |
| Web of Science KeyUT | 000460392200013 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-019-40424-w |
| JaLCDOI | 10.18926/AMO/57374 |
|---|---|
| FullText URL | 73_5_433.pdf |
| Author | Tamada, Shoko| Mitsui, Takashi| Ohira, Akiko| Tani, Kazumasa| Maki, Jota| Eguchi, Takeshi| Eto, Eriko| Hayata, Kei| Masuyama, Hisashi| |
| Abstract | An association between preeclampsia and (pro)renin was recently reported. Intracellular signaling of the (pro) renin receptor [(P)RR] increases the expressions of TGF-β and PAI-1. In this study we sought to clarify the involvement of (pro)renin in the pathogenesis of preeclampsia via the intracellular signaling of (P)RR on preeclampsia placentas. Activated (pro)renin plasma concentrations were compared between pregnant women with (n=15) and without (n=28) preeclampsia. The placentas were immunohistochemically evaluated with anti-HIF-1α and anti-(P)RR antibodies. HTR-8/SVneo cells were cultured under hypoxic conditions and treated with human recombinant (pro)renin. The mRNA expressions of HIF-1α, (P)RR, PAI-1, TGF-β, and ET-1 were also examined by real-time RCR. The activated (pro)renin plasma concentration was significantly higher in the third vs. the second trimester in the preeclampsia patients. HIF-1α and (P)RR expressions were significantly increased in the preeclampsia placentas. The mRNA expressions of PAI-1, TGF-β, and ET-1 were significantly increased in the experiments using recombinant (pro)renin vs. hypoxic conditions. (P)RR expression in preeclampsia placentas is increased by persistent hypoxia through the second and third trimesters, and PAI-1, TGF-β, and ET-1 production is increased via (P)RR. Our results suggest that ET-1 production via the intracellular signaling of (P)RR is important in the pathogenesis of preeclampsia. |
| Keywords | preeclampsia (pro)renin (pro)renin receptor endothelin-1 HTR-8/SVneo |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-10 |
| Volume | volume73 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 433 |
| End Page | 440 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31649370 |
| Web of Science KeyUT | 000491886600009 |
| JaLCDOI | 10.18926/AMO/57366 |
|---|---|
| FullText URL | 73_5_379.pdf |
| Author | Wake, Hidenori| |
| Abstract | Histidine-rich glycoprotein (HRG) is a 75 kDa glycoprotein synthesized in the liver whose plasma concentration is 100-150 μg/ml. HRG has been shown to modulate sepsis-related biological reactions by binding to several substances and cells, including heparin, factor XII, fibrinogen, thrombospondin, plasminogen, C1q, IgG, heme, LPS, dead cells, bacteria, and fungi. Therefore, reduction of plasma HRG levels in sepsis leads to dysregulation of coagulation, fibrinolysis, and immune response, resulting in disseminated intravascular coagulation and multiple organ failure. This review summarizes the binding and functional properties of HRG in sepsis. |
| Keywords | htidine-rich glycoprotein septic pathogenesis immunothrombosis |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-10 |
| Volume | volume73 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 379 |
| End Page | 382 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31649362 |
| Web of Science KeyUT | 000491886600001 |
| FullText URL | K0006019_abstract_review.pdf K0006019_summary.pdf K0006019_fulltext.pdf K0006019_figure.pdf |
|---|---|
| Author | Fujisawa, Satoshi| |
| Published Date | 2019-06-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6019号 |
| Granted Date | 2019-06-30 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | PLoSONE_0050082.PDF |
|---|---|
| Author | Kobuchi, Hirotsugu| Moriya, Koko| Ogino, Tetsuya| Fujita, Hirofumi| Inoue, Keiji| Shuin, Taro| Yasuda, Tatsuji| Utsumi, Kozo| Utsumi, Toshihiko| |
| Published Date | 2012-11-26 |
| Publication Title | PLoS ONE |
| Volume | volume7 |
| Issue | issue11 |
| Publisher | Public Library of Science |
| Start Page | e50082 |
| ISSN | 1932-6203 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| PubMed ID | 23189181 |
| DOI | 10.1371/journal.pone.0050082 |
| Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0050082 |
| JaLCDOI | 10.18926/AMO/56930 |
|---|---|
| FullText URL | 73_4_285.pdf |
| Author | Otani, Yoshihiro| Ichikawa, Tomotsugu| Kurozumi, Kazuhiko| Date, Isao| |
| Abstract | Gliomas are characterized as highly diffuse infiltrating tumors, and currently available treatments such as surgery, radiation and chemotherapy are unfeasible or show limited efficacy against these tumors. Recent genetic and epigenetic analyses of glioma have revealed increasing evidence of the role of driver genetic alterations in glioma development and led to the identification of prognostic factors. Despite these findings, the survival rates of glioma patients remain low, and alternative treatments and novel targets are needed. Recent studies identified neural stem cells as the possible origin of gliomas, and some evidence has revealed shared functions and mechanisms between glioma cells and neurons, also supporting their similarity. The cytoskeleton plays important roles in the migration of normal cells as well as cancer cells. Recent reports have described a role for microtubules, a component of the cytoskeleton, in glioma invasion. Notably, several factors that regulate microtubule functions, such as microtubule-associated proteins, plus-end tracking proteins, or motor proteins, are upregulated in glioma tissues compared with normal tissue, and upregulation of these factors is associated with high invasiveness of glioma cells. In this review, we describe the mechanism of microtubules in glioma invasion and discuss the possibility of microtubule-targeted therapy to inhibit glioma invasion. |
| Keywords | glioma cytoskeletons invasion microtubules |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-08 |
| Volume | volume73 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 285 |
| End Page | 297 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31439951 |
