result 324 件
| JaLCDOI | 10.18926/AMO/56649 |
|---|---|
| FullText URL | 73_2_135.pdf |
| Author | Maeba, Takahiro| Yonezawa, Tomoko| Ono, Mitsuaki| Tomono, Yasuko| Heljasvaara, Ritva| Pihlajaniemi, Taina| Inagawa, Kiichi| Oohashi, Toshitaka| |
| Abstract | The basement membrane (BM) is composed of various extracellular molecules and regulates tissue regeneration and maintenance. Here, we demonstrate that collagen XVIII was spatiotemporally expressed in the BM during skin wound healing in a mouse excisional wound-splinting model. Re-epithelialization was detected at days 3 and 6 post-wounding. The ultrastructure of epidermal BM was discontinuous at day 3, whereas on day 6 a continuous BM was observed in the region proximal to the wound edge. Immunohistochemistry demonstrated that collagen XVIII was deposited in the BM zone beneath newly forming epidermis in day 3 and 6 wounds. Laminin-332, known to be the earliest BM component appearing in wounds, was colocalized with collagen XVIII in the epidermal BM zone at days 3 and 6. The deposition of α1(IV) collagen and nidogen-1 in the epidermal BM zone occurred later than that of collagen XVIII. We also observed the short isoform of collagen XVIII in the epidermal BM zone at day 3 post-wounding. Collectively, our results suggested that collagen XVIII plays a role in the formation of the dermal-epidermal junction during re-epithelialization, and that it is the short isoform that is involved in the early phase of re-epithelialization. |
| Keywords | collagen XVIII basement membrane wound healing re-epithelialization skin |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-04 |
| Volume | volume73 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 135 |
| End Page | 146 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31015748 |
| JaLCDOI | 10.18926/AMO/56456 |
|---|---|
| FullText URL | 73_1_29.pdf |
| Author | Matsumoto, Atsushi| Nakamura, Takehiro| Shinomiya, Aya| Kawakita, Kenya| Kawanishi, Masahiko| Miyake, Keisuke| Kuroda, Yasuhiro| Keep, Richard F.| Tamiya, Takashi| |
| Abstract | Cerebral vasospasm (CVS) is a major contributor to the high morbidity and mortality of aneurysmal subarachnoid hemorrhage (aSAH) patients. We measured histidine-rich glycoprotein (HRG), a new biomarker of aSAH, in cerebrospinal fluid (CSF) to investigate whether HRG might be an early predictor of CVS. A total of seven controls and 14 aSAH patients (8 males, 6 females aged 53.4±15.4 years) were enrolled, and serial CSF and serum samples were taken. We allocated these samples to three phases (T1-T3) and measured HRG, interleukin (IL)-6, fibrinopeptide A (FpA), and 8-hydroxy-2’-deoxyguanosine (8OHdG) in the CSF, and the HRG in serum. We also examined the release of HRG in rat blood incubated in artificial CSF. In contrast to the other biomarkers examined, the change in the CSF HRG concentration was significantly different between the nonspasm and spasm groups (p<0.01). The rat blood/CSF model revealed a time course similar to that of the human CSF samples in the non-spasm group. HRG thus appears to have the potential to become an early predictor of CVS. In addition, the interaction of HRG with IL-6, FpA, and 8OHdG may form the pathology of CVS. |
| Keywords | biomarker histidine-rich glycoprotein predictor subarachnoid hemorrhage vasospasm |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-02 |
| Volume | volume73 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 29 |
| End Page | 39 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30820052 |
| JaLCDOI | 10.18926/AMO/56452 |
|---|---|
| FullText URL | 73_1_1.pdf |
| Author | Morizane, Shin| |
| Abstract | Excessive protease activity is a characteristic abnormality that affects the epidermal barrier in patients with atopic dermatitis (AD). Kallikrein-related peptidases (KLKs) are excessively expressed in AD lesions, and it is suggested that the abnormal action of KLKs is involved in the skin barrier dysfunction in AD. In other words, overexpressed KLKs disrupt the normal barrier function, and due to that breakdown, external substances that can become antigens of AD easily invade the epidermis, resulting in dermatitis, coupled with the induction of Th2 cytokines. Further investigations are required to elucidate the role of KLKs in AD; this knowledge could contribute to the design of new therapeutic and prophylactic drugs for AD. |
| Keywords | atopic dermatitis kallikrein-related peptidases epidermal barrier dysfunction |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-02 |
| Volume | volume73 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 1 |
| End Page | 6 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30820048 |
| FullText URL | O0004485_abstract_review.pdf O0004485_summary.pdf O0004485_fulltext.pdf |
|---|---|
| Author | Ikeda, Atsushi| |
| Published Date | 2018-03-23 |
| Content Type | Thesis or Dissertation |
| Grant Number | 乙第4485号 |
| Granted Date | 2018-03-23 |
| Thesis Type | Doctor of Philosophy in Dental Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005639_abstract_review.pdf K0005639_summary.pdf K0005639_fulltext.pdf K0005639_other.pdf |
|---|---|
| Author | Ochi, Kanako| |
| Published Date | 2017-12-27 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5639号 |
| Granted Date | 2017-12-27 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| JaLCDOI | 10.18926/AMO/55582 |
|---|---|
| FullText URL | 71_6_459.pdf |
| Author | Sakaguchi, Masakiyo| Kinoshita, Rie| Endy Widya Putranto| I Made Winarsa Ruma| I Wayan Sumardika| Youyi, Chen| Tomonobu, Naoko| Yamamoto, Ken-ichi| Murata, Hitoshi| |
| Abstract | The receptor for advanced glycation end products (RAGE) is involved in inflammatory pathogenesis. It functions as a receptor to multiple ligands such as AGEs, HMGB1 and S100 proteins, activating multiple intracellular signaling pathways with each ligand binding. The molecular events by which ligand-activated RAGE controls diverse signaling are not well understood, but some progress was made recently. Accumulating evidence revealed that RAGE has multiple binding partners within the cytoplasm and on the plasma membrane. It was first pointed out in 2008 that RAGE’s cytoplasmic tail is able to recruit Diaphanous-1 (Dia-1), resulting in the acquisition of increased cellular motility through Rac1/Cdc42 activation. We also observed that within the cytosol, RAGE’s cytoplasmic tail behaves similarly to a Toll-like receptor (TLR4)-TIR domain, interacting with TIRAP and MyD88 adaptor molecules that in turn activate multiple downstream signals. Subsequent studies demonstrated the presence of an alternative adaptor molecule, DAP10, on the plasma membrane. The coupling of RAGE with DAP10 is critical for enhancing the RAGE-mediated survival signal. Interestingly, RAGE interaction on the membrane was not restricted to DAP10 alone. The chemotactic G-protein-coupled receptors (GPCRs) formyl peptide receptors1 and 2 (FPR1 and FPR2) also interacted with RAGE on the plasma membrane. Binding interaction between leukotriene B4 receptor 1 (BLT1) and RAGE was also demonstrated. All of the interactions affected the RAGE signal polarity. These findings indicate that functional interactions between RAGE and various molecules within the cytoplasmic area or on the membrane area coordinately regulate multiple ligand-mediated RAGE responses, leading to typical cellular phenotypes in several pathological settings. Here we review RAGE’s signaling diversity, to contribute to the understanding of the elaborate functions of RAGE in physiological and pathological contexts. |
| Keywords | receptor for advanced glycation end products RAGE adaptor protein signal transduction inflammatory pathogenesis |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2017-12 |
| Volume | volume71 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 459 |
| End Page | 465 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 29276218 |
| FullText URL | Reprod_Fertil_Dev_28_10_1479.pdf fig.pdf |
|---|---|
| Author | Nishimura, Ryo| Okuda, Kiyoshi| |
| Keywords | angiogenesis apoptosis corpus luteum follicular development luteal formation luteal regression steroidogenesis |
| Note | This is an Accepted Manuscript of an article published by CSIRO Publishing| |
| Published Date | 2015-05 |
| Publication Title | Reproduction, Fertility and Development |
| Volume | volume28 |
| Issue | issue10 |
| Publisher | CSIRO Publishing |
| Start Page | 1479 |
| End Page | 1486 |
| ISSN | 1031-3613 |
| NCID | AA10718189 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| File Version | author |
| PubMed ID | 25940685 |
| DOI | 10.1071/RD15010 |
| Web of Science KeyUT | 000383600500002 |
| Related Url | isVersionOf https://doi.org/10.1071/RD15010 |
| FullText URL | plosone_7_11_e50082.PDF |
|---|---|
| Author | Kobuchi, Hirotsugu| Moriya, Koko| Ogino, Tetsuya| Fujita, Hirofumi| Inoue, Keiji| Shuin, Taro| Yasuda, Tatsuji| Utsumi, Kozo| Utsumi, Toshihiko| |
| Published Date | 2012-11-26 |
| Publication Title | PLoS ONE |
| Volume | volume7 |
| Issue | issue11 |
| Publisher | Public Library of Science |
| Start Page | e50082 |
| ISSN | 1932-6203 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| File Version | publisher |
| PubMed ID | 23189181 |
| DOI | 10.1371/journal.pone.0050082 |
| Web of Science KeyUT | 000311929800058 |
| Related Url | https://doi.org/10.1371/journal.pone.0050082 |
| FullText URL | J_Comp_Neurol_525_7_1586.pdf |
|---|---|
| Author | Tamura, Kei| Kobayashi, Yasuhisa| Hirooka, Asuka| Takanami, Keiko| Oti, Takumi| Jogahara, Takamichi| Oda, Sen-ichi| Sakamoto, Tatsuya| Sakamoto, Hirotaka| |
| Keywords | RRID AB_2060157 RRID: AB_2571636 RRID: AB_626757 Suncus murinus (suncus) gastrin-releasing peptide male reproductive function sexual dimorphism spinal cord |
| Note | This is the peer reviewed version of the following article: Tamura K. Kobayashi Y. Hirooka A. et al. Identification of the sexually dimorphic gastrin-releasing peptide system in the lumbosacral spinal cord that controls male reproductive function in the mouse and Asian house musk shrew (Suncus murinus). J Comp Neurol. 2017;525:1601–1613. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.| 2018年5月公開予定| |
| Published Date | 2017-05-01 |
| Publication Title | Journal of Comparative Neurology |
| Volume | volume525 |
| Issue | issue7 |
| Publisher | Wistar Institute of Anatomy and Biology |
| Start Page | 1586 |
| End Page | 1598 |
| ISSN | 0021-9967 |
| NCID | AA00695917 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 27804131 |
| DOI | 10.1002/cne.24138 |
| Web of Science KeyUT | 000397559700004 |
| Related Url | https://doi.org/10.1002/cne.24138 |
| Title Alternative | Drug interaction (38. Combination with novel hypnotic drugs : ramelteon and suvorexant) |
|---|---|
| FullText URL | 129_53.pdf |
| Author | Kubo, Kazuko| Esumi, Satoru| Kitamura, Yoshihisa| Sendo, Toshiaki| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2017-04-03 |
| Volume | volume129 |
| Issue | issue1 |
| Start Page | 53 |
| End Page | 57 |
| ISSN | 0030-1558 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2017 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.129.53 |
| NAID | 130005632075 |
| FullText URL | K0005391_abstract_review.pdf K0005391_fulltext.pdf |
|---|---|
| Author | Toma, Kishio| |
| Published Date | 2016-06-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5391号 |
| Granted Date | 2016-06-30 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Author | Ohtsuki, Takashi| Miki, Shunya| Kobayashi, Shouhei| Haraguchi, Tokuko| Nakata, Eiji| Hirakawa, Kazutaka| Sumita, Kensuke| Watanabe, Kazunori| Okazaki, Shigetoshi| |
|---|---|
| Published Date | 2015-12 |
| Publication Title | Scientific Reports |
| Volume | volume5 |
| Content Type | Journal Article |
| Title Alternative | The 2015 Incentive Award of the Okayama Medical Association in General Medical Science (2015 Yuuki Prize) |
|---|---|
| FullText URL | 128_91.pdf |
| Author | Kajita, Ai| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2016-08-01 |
| Volume | volume128 |
| Issue | issue2 |
| Start Page | 91 |
| End Page | 94 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.128.91 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2016 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.128.91 |
| NAID | 130005262638 |
| FullText URL | K0005343_abstract_review.pdf K0005343_fulltext.pdf |
|---|---|
| Author | Ochi, Takumi| |
| Published Date | 2016-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5343号 |
| Granted Date | 2016-03-25 |
| Thesis Type | Doctor of Philosophy in Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005275_abstract_review.pdf K0005275_fulltext.pdf |
|---|---|
| Author | Katsuyama, Takayuki| |
| Published Date | 2016-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5275号 |
| Granted Date | 2016-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | O0004451_abstract_review.pdf O0004451_fulltext.pdf |
|---|---|
| Author | Fujiwara, Daisuke| |
| Published Date | 2015-12-31 |
| Content Type | Thesis or Dissertation |
| Grant Number | 乙第4451号 |
| Granted Date | 2015-12-31 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Author | Taketa, Hiroaki| Gulsan, Ara Sathi| Mahmoud, Farahat| Kazi, Anisur Rahman| Sakai, Takayoshi| Hirano, Yoshiaki| Kuboki, Takuo| Torii, Yasuhiro| Matsumoto, Takuya| |
|---|---|
| Published Date | 2015 |
| Publication Title | Scientific reports |
| Volume | volume5 |
| Content Type | Journal Article |
| Author | Matsumoto, Takuya| |
|---|---|
| Published Date | 2015-08 |
| Publication Title | Okayama University Medical Research Updates |
| Volume | volume13 |
| Content Type | Others |
| Author | Sato, Takamaro| Soga, Yoshihiko| Yamaguchi, Tomoko| Meguro, Michio| Maeda, Hiroshi| Tada, Joji| Otani, Takayuki| Seno, Masaharu| Takashiba, Shogo| |
|---|---|
| Published Date | 2013-12 |
| Publication Title | Asian Pacific Journal of Allergy And Immunology |
| Volume | volume31 |
| Issue | issue4 |
| Content Type | Journal Article |
| Title Alternative | Non-high-output cardiac failure in patients undergoing hemodialysis through an arteriovenous shunt |
|---|---|
| FullText URL | 127_203.pdf |
| Author | Ugawa, Toyomu| |
| Abstract | Background: Hemodialysis-related heart failure has been considered to be associated with excessive blood flow through the arteriovenous (AV) shunt used for vascular access. However, some patients undergoing dialysis have heart failure in the absence of an increase in cardiac output (CO) related to shunt blood-flow loading because the loading cannot be compensated for by increasing CO. This condition may be challenging to manage ; thus, early diagnosis is important. Methods and Results: Twelve patients (mean age, 71 years ; 9 men) with end-stage renal disease, dialysis-related heart failure, a high brain natriuretic peptide (BNP) level, and a mean New York Heart Association (NYHA) class of II underwent AV shunt closure. Their cardiac index (CI), pre- and post-dialysis BNP levels, and several cardiac variables were assessed pre- and postoperatively. All patients achieved relief of heart failure symptoms and a reduction in NYHA class after AV closure, but six patients had a postoperative increase in CI (the "non-high-output" cardiac failure group), whereas the other six had a decrease in CI (the "high-output" cardiac failure group). The high-output patients had greater improvements in BNP levels and most cardiac variables compared to the non-high-output group ; therefore, the heart failure in the non-high-output patients was considered more serious than that in the high-output group. Conclusions: The selection of effective strategies for treating dialysis-related heart failure may depend partly on identifying which patients have non-high-output failure. Such identification requires serial measurements of BNP levels and evaluations of cardiac variables other than the ejection fraction. |
| Keywords | 心拍出量（cardiac output） 心不全（heart failure） 脳性ナトリウム利尿ペプチド（brain natriuretic peptide） 非過大シャント心不全（non-high-output cardiac failure） 腎臓（kidney） |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2015-12-01 |
| Volume | volume127 |
| Issue | issue3 |
| Start Page | 203 |
| End Page | 207 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.127.203 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2015 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.127.203 |
| NAID | 130005116810 |
